Transactivation of prothymosin α and c-myc promoters by human papillomavirus type 16 E6 protein

Virology

Volumn 232, Issue 1, 1997, Pages 53-61

  Kinoshita, Tomoaki ^a   Shirasawa, Hiroshi ^a   Shino, Yuji ^a   Moriya, Hideshige ^a   Desbarats, Laurie ^b   Eilers, Martin ^b   Simizu, Bunsiti ^a  

^a CHIBA UNIVERSITY   (Japan)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; PROTHYMOSIN ALPHA; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; GENE ACTIVATION; GENE DISRUPTION; GENE EXPRESSION REGULATION; INTRON; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSACTIVATION; WART VIRUS;

EID: 0031009211     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1997.8536     Document Type: Article

References (64)

1. Akutsu N., Shirasawa H., Asano T., Isono K., Simizu B. p53-dependent and -independent transactivation by the E6 protein of human papillomavirus type 16. J. Gen. Virol. 77:1996;459-463.
2. Band V., De Caprio J. A., Delmolino L., Kulesa V., Sager R. Loss of p53 in human papillomavirus type 16 E6-immortalized human mammary epithelial cells. J. Virol. 65:1991;6671-6676.
3. Band V., Dalal S., Delmolino L., Androphy E. J. Enhanced degradation of p53 protein in HPV-6 and BPV-1 E6-immortalized human mammary epithelial cells. EMBO J. 12:1993;1847-1852.
4. Chen J. J., Reid C. E., Band V., Androphy E. J. Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. Science. 269:1995;529-531.
5. Crook T., Tidy J. A., Vousden K. H. Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation. Cell. 67:1991;547-556.
6. Crook T., Fisher C., Masterson P. J., Vousden K. H. Modulation of transcriptional regulatory properties of p53 by HPV E6. Oncogene. 9:1994;1225-1230.
7. Demers G. W., Foster S. A., Halbert C. L., Galloway D. A. Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7. Proc. Natl. Acad. Sci. USA. 91:1994;4382-4386.
8. Desaintes C., Hallez S., Alphen P. V., Burny A. Transcriptional activation of several heterologous promoters by the E6 protein of human papillomavirus type 16. J. Virol. 66:1992;325-333.
9. Desbarats L., Gaubatz S., Eilers M. Discrimination between different E-box-binding proteins at an endogenous target gene of c-myc. Genes Dev. 10:1996;447-460.
10. Duyao M. P., Kessler D. J., Spicer D. B., Bartholomew C., Cleveland J. L., Siekevitz M., Sonenshein G. E. Transactivation of the c-myc. J. Biol. Chem. 267:1992;16288-16291.
11. Dyson N., Howley P. M., Münger K., Harlow E. The human papillomavirus-16 E7 oncoprotein is able to bind the retinoblastoma gene product. Science. 243:1989;934-936.
12. Eilers M., Schirm S., Bishop J. M. The MYC protein activates transcription of the α-prothymosin gene. EMBO J. 10:1991;133-141.
13. El-Deiry W. S., Kern S. E., Pietenpol J. A., Klinzler K. W., Vogelstein B. Definition of a consensus binding site for p53. Nat. Genet. 1:1992;45-49.
14. El-Deiry W. S., Tokino T., Velculescu V. E., Levy D. B., Parsons R., Trent J. M., Lin D., Mercer W. E., Klinzler K. W., Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell. 19:1993;817-825.
15. Eschenfeldt W. H., Berger S. L. The human prothymosin α is polymorphic and induced upon growth stimulation: Evidence using a cloned cDNA. Proc. Natl. Acad. Sci. USA. 83:1986;9403-9407.
16. Etscheid B. G., Foster S. A., Galloway D. A. The E6 protein of human papillomavirus type 16 functions as a transcriptional repressor in a mechanism independent of the tumor suppressor protein, p53. Virology. 205:1994;583-585.
17. Farmer G., Bargonetti J., Zhu H., Friedman P., Prywes R., Prives C. Wild-type p53 activates transcriptionin vitro. Nature. 358:1992;83-86.
18. Gaubatz S., Meichle A., Eilers M. An E-box element localized in the first intron mediates regulation of the prothymosin α gene by c-myc. Mol. Cell. Biol. 14:1994;3853-3862.
19. Gaubatz S., Imhof A., Dosch R., Werner O., Mitchell P., Buettner R., Eilers M. Transcriptional activation by Myc is under negative control by the transcription factor AP-2. EMBO J. 14:1995;1508-1519.
20. Gómez-Márquez J., Segade F., Dosil M., Pichel J. G., Bustelo X. R., Freire M. The expression of prothymosin α gene in T lymphocytes and leukemic lymphoid cells is tied to lymphocyte proliferation. J. Biol. Chem. 264:1989;8451-8454.
21. Gorman C. M., Moffat L. F., Howard B. H. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1982;1044-1051.
22. Gu Z., Pim D., Labrecque S., Banks L., Matlashewski G. DNA damage induced p53 mediated transcription is inhibited by human papillomavirus type 18 E6. Oncogene. 9:1994;629-633.
23. Hamel P. A., Gill R. M., Phillips R. A., Gallie B. L. Transcriptional repression of the E2-containing promoters EIIaE, c-myc, Mol. Cell. Biol. 12:1992;3431-3438.
24. Haritos A. A., Goodall G. J., Horecker B. L. Prothymosin α: Isolation and properties of the major immunoreactive form of thymosin α1 in rat thymus. Proc. Natl. Acad. Sci. USA. 81:1984;1008-1011.
25. Harper J. W., Adami G. R., Wei N., Keyomarsi K., Elledge J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:1993;805-816.
26. Hiebert S. W., Lipp M., Nevins J. R. E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor. Proc. Natl. Acad. Sci. USA. 86:1989;3594-3598.
27. Hoppe-Seyler F., Butz K. Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53. J. Virol. 67:1993;3111-3117.
28. Hubbert N. L., Sedman S. A., Schiller J. T. Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes. J. Virol. 66:1992;6237-6241.
29. Kakkis E., Riggs K. J., Gillespie W., Calame K. A transcriptional repressor of c-myc. Nature. 339:1989;718-721.
30. Keen N., Elston R., Crawford L. Interaction of the E6 protein of human papillomavirus with cellular proteins. Oncogene. 9:1994;1493-1499.
31. Kinoshita T., Shirasawa H., Shino Y., Shimizu K., Moriya H., Simizu B. Human papillomavirus type 16 E6 protein up-regulates the expression of the high mobility group protein HMG-I(Y) gene in mouse 10T1/2 cells. Virus Res. 42:1996;119-125.
32. Klingelhutz A. J., Foster S. A., McDougall J. K. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature. 380:1996;79-82.
33. Lechner M. S., Mack D. H., Finicle A. B., Crook T., Vousden K. H., Laimins L. A. Human papillomavirus E6 proteins bind p53in vivo. EMBO J. 11:1992;3045-3052.
34. Lehn H., Krieg P., Sauer G. Papillomavirus genomes in human cervical tumors: Analysis of their transcriptional activity. Proc. Natl. Acad. Sci. USA. 82:1985;5540-5544.
35. Li X., Coffino P. High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation. J. Virol. 70:1996;4509-4516.
36. Lorincz A. T., Richard R., Jenson A. B., Greenberg M. D., Lancaster W., Kurman R. J. Human papillomavirus infection of the cervix: Relative risk associations of 15 common anogenital types. Obstet. Gynecol. 79:1992;328-337.
37. Mack D. H., Vartikar J., Pipas J. M., Laimins L. A. Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53. Nature. 363:1993;281-283.
38. Mallon R. G., Wojciechowicz D., Defendi V. DNA-binding activity of papillomavirus proteins. J. Virol. 61:1987;1655-1660.
39. Manrow R. E., Sburlati A. R., Hanover J. A., Berger S. L. Nuclear targeting of prothymosin α J. Biol. Chem. 266:1991;3916-3924.
40. Marcu K. B., Bossone S. A., Patel A. J. Myc function and regulation. Annu. Rev. Biochem. 61:1992;809-860.
41. Matsunaga T., Shirasawa H., Tanabe M., Ohnuma N., Takahashi H., Simizu B. Expression of alternatively splicedsrc. Cancer Res. 53:1993;3179-3185.
42. Mietz J. A., Unger T., Huibregtse J. M., Howley P. M. The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein. EMBO J. 11:1992;5013-5020.
43. Mori M., Barnard G. F., Staniunas R. J., Jessup J. M., Steele G. D. Jr., Chen L. B. Prothymosin-α mRNA expression correlates with that of c-myc. Oncogene. 8:1993;2821-2826.
44. Morosov A., Phelps W. C., Raychaudhuri P. Activation of the c-fos. J. Biol. Chem. 269:1994;18434-18440.
45. Papamarcaki T., Tsolas O. Prothymosin α binds to histone H1in vitro. FEBS Lett. 345:1994;71-75.
46. Pim D., Storey A., Thomas M., Massimi P., Banks L. Mutational analysis of HPV-18 E6 identifies domains required for p53 degradationin vitro,in vivo. Oncogene. 9:1994;1869-1876.
47. Riggs K., Saleque S., Wong K.-K., Merrell K. T., Lee J.-S., Shi Y., Calame K. Yin-Yang 1 activates the c-myc. Mol. Cell. Biol. 13:1993;7487-7495.
48. Rüther U., Wagner E. F., Müller R. Analysis of the differential-promoting potential of inducible c-fos. EMBO J. 4:1985;1775-1781.
49. Sburlati A. R., Manrow R. E., Berger S. L. Prothymosin α antisense oligomers inhibit myeloma cell division. Proc. Natl. Acad. Sci. USA. 88:1991;253-257.
50. Scheffner M., Werness B. A., Huibregtse J. M., Levine A. J., Howley P. M. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell. 63:1990;1129-1136.
51. Scheffner M., Huibregtse J. M., Vierstra R. D., Howley P. M. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell. 75:1993;495-505.
52. Schmidt G., Werner D. Nucleotide sequence of the murine prothymosin α cDNA and its deduced primary and secondary protein structure. Biochim. Biophys. Acta. 1088:1991;442-444.
53. Sedman S. A., Barbosa M. S., Vass W. C., Hubbert N. L., Haas J. A., Lowy D. R., Schiller J. T. The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture. J. Virol. 65:1991;4860-4866.
54. Sedman S. A., Hubbert N. L., Vaas D. R., Lowy J. T., Schiller J. T. Mutant p53 substitutes for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity. J. Virol. 66:1992;4201-4208.
55. Seto E., Usheva A., Zambetti G. P., Momand J., Horikoshi N., Weinmann R., Levine A. J., Shenk T. Wild-type p53 binds to the TATA-binding protein and represses transcription. Proc. Natl. Acad. Sci. USA. 89:1992;12028-12032.
56. Sherman L., Schlegel R. Serum- and calcium-induced differentiation of human keratinocytes is inhibited by the E6 oncoprotein of human papillomavirus type 16. J. Virol. 70:1996;3269-3279.
57. Shimizu K., Shirasawa H., Jin M.-H., Inaba N., Sekiya S., Simizu B. Alternative splicing of human papillomavirus type-16 E6-mRNA in mouse and monkey cell lines. Int. J. Oncol. 4:1994;971-976.
58. Shirasawa H., Tomita Y., Sekiya S., Takamizawa H., Simizu B. Integration and transcription of human papillomavirus type 16 and 18 sequences in cell lines derived from cervical carcinomas. J. Gen. Virol. 68:1987;583-591.
59. Shirasawa H., Tomita Y., Kubota K., Kasai T., Sekiya S., Takamizawa H., Simizu B. Transcriptional differences of the human papillomavirus type 16 genome between precancerous lesions and invasive carcinomas. J. Virol. 62:1988;1022-1027.
60. Shirasawa H., Jin M.-H., Shimizu K., Akutsu N., Shino Y., Simizu B. Transcription-modulatory activity of full-length E6 and E6*I proteins of human papillomavirus type 16. Virology. 203:1994;36-42.
61. Storey A., Massimi P., Dawson K., Banks L. Conditional immortalization of primary cells by human papillomavirus type 18 E6 and EJ-ras. Oncogene. 11:1995;653-661.
62. Tavtigian S. V., Zabludoff S. D., Wold B. J. Cloning of mid-G1 serum response genes and identification of a subset regulated by conditionalmyc. Mol. Biol. Cell. 5:1994;375-388.
63. Thomas M., Massimi P., Jenkins J., Banks L. HPV-18 E6 mediated inhibition of p53 DNA binding activity is independent of E6 induced degradation. Oncogene. 10:1995;261-268.
64. Werness B. A., Levine A. J., Howley P. M. Association of human papillomavirus type 16 and 18 E6 proteins with p53. Science. 248:1990;76-79.