메뉴 건너뛰기




Volumn 31, Issue 1, 2000, Pages 60-66

Experimental models of Parkinson's disease;Modelos experimentales de enfermedad de Parkinson

Author keywords

1 methy 4 phenyl 1,2,3,6, tetrahydropyridine; 6 hydroxydopamine; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DOPAMINE; MONOAMINE OXIDASE INHIBITOR; NEUROTOXIN; OXIDOPAMINE;

EID: 0034218813     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.3101.99654     Document Type: Article
Times cited : (9)

References (64)
  • 1
    • 0030824103 scopus 로고    scopus 로고
    • Sistema dopaminérgico y muerte neuronal
    • Luquin MR, Saldise L. Sistema dopaminérgico y muerte neuronal. Rev Neurol 1997; 25: S129-40.
    • (1997) Rev Neurol , vol.25
    • Luquin, M.R.1    Saldise, L.2
  • 2
    • 0014740618 scopus 로고
    • Effects of 6-hydroxydopamine on the uptake and storage of noradrenaline in sympathetic adrenergic neurons
    • Jonsson G, Sachs Ch. Effects of 6-hydroxydopamine on the uptake and storage of noradrenaline in sympathetic adrenergic neurons. Eur J Pharmacol 1970; 9: 141-55.
    • (1970) Eur J Pharmacol , vol.9 , pp. 141-155
    • Jonsson, G.1    Sachs, Ch.2
  • 3
    • 0014376793 scopus 로고
    • 6-Hydroxydopamine induced degeneration of central monoamine neurons
    • Ungerstedt U. 6-Hydroxydopamine induced degeneration of central monoamine neurons. Eur J Pharmacol 1968; 5: 107-10.
    • (1968) Eur J Pharmacol , vol.5 , pp. 107-110
    • Ungerstedt, U.1
  • 5
    • 0017053586 scopus 로고
    • Studies on the mechanisms of 6-hydroxydopamine cytotoxicity
    • Jonsson G. Studies on the mechanisms of 6-hydroxydopamine cytotoxicity. Med Bil 1976; 54: 406-20.
    • (1976) Med Bil , vol.54 , pp. 406-420
    • Jonsson, G.1
  • 6
    • 0024500857 scopus 로고
    • Vitamin e attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: Behavioural and bichemical evidence
    • Cadet JL, Katz M, Kackson-Lewis V, Fahn S. Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: behavioural and bichemical evidence. Brain Res 1991; 476: 10-5.
    • (1991) Brain Res , vol.476 , pp. 10-15
    • Cadet, J.L.1    Katz, M.2    Kackson-Lewis, V.3    Fahn, S.4
  • 7
    • 24344507655 scopus 로고    scopus 로고
    • N-acethylcysteine preduces dopaminergic neuronal death induced by 6-OHDA
    • Luquin MR, Domínguez JJ, Del Rio L, Zbarsky V, Guillén J. N-acethylcysteine preduces dopaminergic neuronal death induced by 6-OHDA. Mov Disord 1996; 11 (Suppl 1): 144.
    • (1996) Mov Disord , vol.11 , Issue.1 SUPPL. , pp. 144
    • Luquin, M.R.1    Domínguez, J.J.2    Del Rio, L.3    Zbarsky, V.4    Guillén, J.5
  • 8
    • 0025980955 scopus 로고
    • The iron chelator desferoxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons
    • Ben-Shachar D, Eshel G, Finberg JP, Youdim MB. The iron chelator desferoxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons. J Neurochem 1991; 56: 1441-4.
    • (1991) J Neurochem , vol.56 , pp. 1441-1444
    • Ben-Shachar, D.1    Eshel, G.2    Finberg, J.P.3    Youdim, M.B.4
  • 9
    • 0015184103 scopus 로고
    • Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of nigrostriatal dopamine system
    • Ungersted U. Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of nigrostriatal dopamine system. Acta Physiol Scand Suppl 1971; 367: 69-93
    • (1971) Acta Physiol Scand Suppl , vol.367 , pp. 69-93
    • Ungersted, U.1
  • 10
    • 0026039075 scopus 로고
    • Effects of 6-OHDA lesions of the nigrostriatal pathway on striatal serotonin innervation in adults rats
    • Takeuchi Y, Sawada T, Blunt S, Jenner P, Marsden CD. Effects of 6-OHDA lesions of the nigrostriatal pathway on striatal serotonin innervation in adults rats. Brain Res 1991; 562: 301-5.
    • (1991) Brain Res , vol.562 , pp. 301-305
    • Takeuchi, Y.1    Sawada, T.2    Blunt, S.3    Jenner, P.4    Marsden, C.D.5
  • 11
    • 0026698939 scopus 로고
    • Effects of unilateral 6-hydroxydopamine lesion and prolonged 1-3,4-hydroxyphenylalanine treatment on peptidergig systems in the rat basal ganglia
    • Taylor MD, De Ceballos ML, Rose S, Jenner P, Marsden CD. Effects of unilateral 6-hydroxydopamine lesion and prolonged 1-3,4-hydroxyphenylalanine treatment on peptidergig systems in the rat basal ganglia. Eur J Pharmacol 1992; 219: 183-92.
    • (1992) Eur J Pharmacol , vol.219 , pp. 183-192
    • Taylor, M.D.1    De Ceballos, M.L.2    Rose, S.3    Jenner, P.4    Marsden, C.D.5
  • 13
    • 0024327090 scopus 로고
    • Compensatory responses to nigrostriatal bundle injury: Studies with 6-hydroxydopamine in an animal model of parkinsonism
    • Zigmond MJ, Berger TW, Grace AA, Stricker EM. Compensatory responses to nigrostriatal bundle injury: studies with 6-hydroxydopamine in an animal model of parkinsonism. Mol Chem Neuropathol 1989; 10: 185-200.
    • (1989) Mol Chem Neuropathol , vol.10 , pp. 185-200
    • Zigmond, M.J.1    Berger, T.W.2    Grace, A.A.3    Stricker, E.M.4
  • 14
    • 0018854896 scopus 로고
    • Compensatory increase in tyrosine hydroxylase activity in rat brain after intraventricual injection of 6-hydroxydopamine
    • Acheson Al, Zigmond MJ, Stricker EM. Compensatory increase in tyrosine hydroxylase activity in rat brain after intraventricual injection of 6-hydroxydopamine. Science 1980; 207: 537-40.
    • (1980) Science , vol.207 , pp. 537-540
    • Al, A.1    Zigmond, M.J.2    Stricker, E.M.3
  • 15
    • 0017651245 scopus 로고
    • Dopamine receptor binding enhancement accompanies lesion-induced behavioural supersensitivity
    • Creese Y, Burt DR, Snyder SH. Dopamine receptor binding enhancement accompanies lesion-induced behavioural supersensitivity. Science 1977; 197: 596-8.
    • (1977) Science , vol.197 , pp. 596-598
    • Creese, Y.1    Burt, D.R.2    Snyder, S.H.3
  • 16
    • 0028610569 scopus 로고
    • Biochemical and immunocytochemical changes induced by intrastriatal 6-hydroxydopamine injectionin the rat nigrostriatal dopamine neuron system: Evidence for cell death in the substantia nigra
    • Ichitani Y, Okamura H, Nakahara D, Nagatsu Y, Ibata Y. Biochemical and immunocytochemical changes induced by intrastriatal 6-hydroxydopamine injectionin the rat nigrostriatal dopamine neuron system: evidence for cell death in the substantia nigra. Exp Neurol 1994; 130: 269-78.
    • (1994) Exp Neurol , vol.130 , pp. 269-278
    • Ichitani, Y.1    Okamura, H.2    Nakahara, D.3    Nagatsu, Y.4    Ibata, Y.5
  • 17
    • 0014954436 scopus 로고
    • Quantitative recording of rotational behaviour in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system
    • Ungersted U, Arbuthnott G. Quantitative recording of rotational behaviour in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system. Brain Res 1970; 24: 485-93.
    • (1970) Brain Res , vol.24 , pp. 485-493
    • Ungersted, U.1    Arbuthnott, G.2
  • 18
    • 0025077453 scopus 로고
    • The effects of dopamine-depleting brain lesions on the electrophyological activity of rat substantia nigra dopamine neurons
    • Hollerman RJ, Grace AA. The effects of dopamine-depleting brain lesions on the electrophyological activity of rat substantia nigra dopamine neurons. Brain Res 1990; 533: 203-12.
    • (1990) Brain Res , vol.533 , pp. 203-212
    • Hollerman, R.J.1    Grace, A.A.2
  • 19
    • 0029981267 scopus 로고    scopus 로고
    • Dopaminergic neuronal degeneration and motor impairment following axon terminal lesion by intrastriatal 6-hydroxydopamine in the rat
    • Lee CS, Sauer H, Björklund A. Dopaminergic neuronal degeneration and motor impairment following axon terminal lesion by intrastriatal 6-hydroxydopamine in the rat. Neuroscience 1996; 72: 641-53.
    • (1996) Neuroscience , vol.72 , pp. 641-653
    • Lee, C.S.1    Sauer, H.2    Björklund, A.3
  • 20
    • 0028220834 scopus 로고
    • Progressive degeneration of nigrostriatal dopamine neurons following intrastrital terminal lesion with 6-hudroxydopamine a combined retrograde tracing and immunocytochemical study in the rat
    • Sauer H, Oertel WH. Progressive degeneration of nigrostriatal dopamine neurons following intrastrital terminal lesion with 6-hudroxydopamine a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience 1994; 59: 401-15.
    • (1994) Neuroscience , vol.59 , pp. 401-415
    • Sauer, H.1    Oertel, W.H.2
  • 21
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston JW, Ballard PA, Tetrud JW, Irwin I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983; 219: 979-80.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.A.2    Tetrud, J.W.3    Irwin, I.4
  • 22
    • 0025330367 scopus 로고
    • Evaluation of a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated C57 black mouse model for parkinsonism
    • Arai N, Migusi K, Goshima Y, Misu Y. Evaluation of a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated C57 black mouse model for parkinsonism. Brain Res 1990; 515: 57-63.
    • (1990) Brain Res , vol.515 , pp. 57-63
    • Arai, N.1    Migusi, K.2    Goshima, Y.3    Misu, Y.4
  • 23
    • 0001496694 scopus 로고
    • A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6 tetrahydropyridine
    • Burns RS, Chiueh CC, Markey SP, Ebert MH, Jacobowitz DM, Kopin IJ. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6 tetrahydropyridine. Proc Nat Acad Sci USA 1983; 80: 4546-50.
    • (1983) Proc Nat Acad Sci USA , vol.80 , pp. 4546-4550
    • Burns, R.S.1    Chiueh, C.C.2    Markey, S.P.3    Ebert, M.H.4    Jacobowitz, D.M.5    Kopin, I.J.6
  • 24
    • 0021273328 scopus 로고
    • 1-Methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced parkinsonism in the common marmoset
    • Jenner P, Rupinak NMJ, Rose S, Kelly E, Kilpatrick G, Lees A, et al. 1-Methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced parkinsonism in the common marmoset. Neurosci Lett 1984; 50: 85-90.
    • (1984) Neurosci Lett , vol.50 , pp. 85-90
    • Jenner, P.1    Rupinak, N.M.J.2    Rose, S.3    Kelly, E.4    Kilpatrick, G.5    Lees, A.6
  • 25
    • 0021893796 scopus 로고
    • Differences in the metabolims of MPTP in the rodent and primate parallel diferences in sensitivity to its neurotoxic effects
    • Johannessen JN, Chiueh CC, Burns RS, Markey SP. Differences in the metabolims of MPTP in the rodent and primate parallel diferences in sensitivity to its neurotoxic effects. Life Sci 1985; 36: 219-24.
    • (1985) Life Sci , vol.36 , pp. 219-224
    • Johannessen, J.N.1    Chiueh, C.C.2    Burns, R.S.3    Markey, S.P.4
  • 27
    • 0023404733 scopus 로고
    • Blood-brain barrier monoamine oxidase: Enzyme characterization in cerebral microvessels and other tissue from mammalian species, including human
    • Kalaria NR, Harik SI. Blood-brain barrier monoamine oxidase: enzyme characterization in cerebral microvessels and other tissue from mammalian species, including human. J Neurochem 1987; 49: 856-64.
    • (1987) J Neurochem , vol.49 , pp. 856-864
    • Kalaria, N.R.1    Harik, S.I.2
  • 28
    • 0001134185 scopus 로고
    • Mechanism of MPTP toxicity: More answers more questions
    • Langston JW. Mechanism of MPTP toxicity: more answers more questions. Trends Pharmacol Sci 1985; 6: 375-81.
    • (1985) Trends Pharmacol Sci , vol.6 , pp. 375-381
    • Langston, J.W.1
  • 31
    • 0022466381 scopus 로고
    • Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys
    • Forno LS, Langston JW, DeLanney LE, Irwin I, Ricaurte A. Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys. Ann Neurol 1986; 20: 249-55.
    • (1986) Ann Neurol , vol.20 , pp. 249-255
    • Forno, L.S.1    Langston, J.W.2    DeLanney, L.E.3    Irwin, I.4    Ricaurte, A.5
  • 32
    • 0023924828 scopus 로고
    • An electron microscopic study of MPTP-induced inclusion bodies an old monkey
    • Forno LS, Langston JW, DeLanney LE, Irwin I. An electron microscopic study of MPTP-induced inclusion bodies an old monkey. Brain Res 1988; 448: 150-7
    • (1988) Brain Res , vol.448 , pp. 150-157
    • Forno, L.S.1    Langston, J.W.2    DeLanney, L.E.3    Irwin, I.4
  • 33
    • 0023830780 scopus 로고
    • 1-Methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced parkinsonian syndrome in Macaca Fascicularis: Which mid-brain dopaminergic neurons are lost?
    • German DC, Dubach M, Askari S, Speciale SG, Bowden DM. 1-Methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced parkinsonian syndrome in Macaca Fascicularis: which mid-brain dopaminergic neurons are lost? Neuroscience 1988; 24: 161-74
    • (1988) Neuroscience , vol.24 , pp. 161-174
    • German, D.C.1    Dubach, M.2    Askari, S.3    Speciale, S.G.4    Bowden, D.M.5
  • 34
    • 0026713088 scopus 로고
    • Chronic MPTP treatment reduces substance P and met-enkephalin content in the basal ganglia of the marmoset
    • Perez-Otaño Y, Herrero MT, Luquin MR, Obeso JA, Del Rio J. Chronic MPTP treatment reduces substance P and met-enkephalin content in the basal ganglia of the marmoset. Brain Res 1992; 585: 156-60.
    • (1992) Brain Res , vol.585 , pp. 156-160
    • Perez-Otaño, Y.1    Herrero, M.T.2    Luquin, M.R.3    Obeso, J.A.4    Del Rio, J.5
  • 35
    • 0028304256 scopus 로고
    • MPTP-induced parkinsonism in primates: Pattern of striatal dopamine loss following acute and chronic administration
    • Perez-Otaño Y, Oset C, Herrero MT, Luquin MR, Obeso JA, Del Rio J. MPTP-induced parkinsonism in primates: pattern of striatal dopamine loss following acute and chronic administration. Neurosci Lett 1994; 175: 121-5.
    • (1994) Neurosci Lett , vol.175 , pp. 121-125
    • Perez-Otaño, Y.1    Oset, C.2    Herrero, M.T.3    Luquin, M.R.4    Obeso, J.A.5    Del Rio, J.6
  • 36
    • 24344446437 scopus 로고
    • Extrastriatal dopamine in sympomatic rhesus monkeys treated with 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)
    • Pifl C, Bertel O, Schingnitz G, Hornykiewicz O. Extrastriatal dopamine in sympomatic rhesus monkeys treated with 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP). Neurochem Int 1992; (Suppl): 295S-7S.
    • (1992) Neurochem Int , Issue.SUPPL.
    • Pifl, C.1    Bertel, O.2    Schingnitz, G.3    Hornykiewicz, O.4
  • 37
    • 0021276089 scopus 로고
    • Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase
    • Chiba K, Trevor A, Castaglione Jr N. Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Bochem Biophys Res Commu 1984; 120: 574-8.
    • (1984) Bochem Biophys Res Commu , vol.120 , pp. 574-578
    • Chiba, K.1    Trevor, A.2    Castaglione Jr., N.3
  • 38
    • 24344438846 scopus 로고
    • Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) in monkeys
    • Cohen G, Pasik P, Cohen B, Leist A, Mytilineou C, Yahr MD. Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) in monkeys. Eur J Pharmacol 1984; 100: 189-94.
    • (1984) Eur J Pharmacol , vol.100 , pp. 189-194
    • Cohen, G.1    Pasik, P.2    Cohen, B.3    Leist, A.4    Mytilineou, C.5    Yahr, M.D.6
  • 39
    • 0021224694 scopus 로고
    • Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine by monoamino oxidase inhibitors
    • Heikkila RE, Manzino L, Cabbat FS, Douvoisin RC. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine by monoamino oxidase inhibitors. Nature 1984; 311: 467-9.
    • (1984) Nature , vol.311 , pp. 467-469
    • Heikkila, R.E.1    Manzino, L.2    Cabbat, F.S.3    Douvoisin, R.C.4
  • 40
    • 0021736752 scopus 로고
    • Oxidation of the neurotoxic amine 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP) by the monoamino oxidises a and Band suicide inactivation of the enzimes by MPTP
    • Salach JI, Singer TP, Castaglione Jr C, Trevor A. Oxidation of the neurotoxic amine 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP) by the monoamino oxidises A and Band suicide inactivation of the enzimes by MPTP. Biochem Biophys Res Commun 1984; 125: 831-5.
    • (1984) Biochem Biophys Res Commun , vol.125 , pp. 831-835
    • Salach, J.I.1    Singer, T.P.2    Castaglione Jr., C.3    Trevor, A.4
  • 41
    • 0024843036 scopus 로고
    • Demonstration of monoamino oxidase-A and B in the human brain-stem by histochemical technique
    • Konradi C, Kornhuber J, Froelich L, Fritze J, Heinsen H, Beckmann H, et al. Demonstration of monoamino oxidase-A and B in the human brain-stem by histochemical technique. Neuroscience 1989; 33: 383-400.
    • (1989) Neuroscience , vol.33 , pp. 383-400
    • Konradi, C.1    Kornhuber, J.2    Froelich, L.3    Fritze, J.4    Heinsen, H.5    Beckmann, H.6
  • 42
    • 0025134212 scopus 로고
    • Astroglial ablation prevents MPTP-induced nigrostriatal neuronal death
    • Takada M, Li ZK, Hattori T. Astroglial ablation prevents MPTP-induced nigrostriatal neuronal death. Brain Res 1990; 509: 55-61.
    • (1990) Brain Res , vol.509 , pp. 55-61
    • Takada, M.1    Li, Z.K.2    Hattori, T.3
  • 43
  • 44
    • 0022394212 scopus 로고
    • Deprenyl protects dopamine neurons from the neurotoxic effect of 1-methyl-4-phenylpyridinium ion (MPP)
    • Mylitineou C, Cohen G. Deprenyl protects dopamine neurons from the neurotoxic effect of 1-methyl-4-phenylpyridinium ion (MPP). J Neurochem 1985; 45: 1951-3.
    • (1985) J Neurochem , vol.45 , pp. 1951-1953
    • Mylitineou, C.1    Cohen, G.2
  • 45
    • 0025278873 scopus 로고
    • Toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinium for rat dopaminergic neurons in culture: Selectivity and irreversibility
    • Michel PP, Dandapani BK, Knusel B, Sánchez-Ramps J, Hefti F. Toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinium for rat dopaminergic neurons in culture: selectivity and irreversibility. J Neurochem 1990; 54: 1102-9.
    • (1990) J Neurochem , vol.54 , pp. 1102-1109
    • Michel, P.P.1    Dandapani, B.K.2    Knusel, B.3    Sánchez-Ramps, J.4    Hefti, F.5
  • 46
    • 0023210581 scopus 로고
    • Toxins and Parkinson's disease: MPTP parkinsonism in humans and animals
    • Kopin IJ. Toxins and Parkinson's disease: MPTP parkinsonism in humans and animals. Avd Neurol 1986; 45: 137-44.
    • (1986) Avd Neurol , vol.45 , pp. 137-144
    • Kopin, I.J.1
  • 47
    • 0025122203 scopus 로고
    • Induction by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of lipid peroxidation in vivo in vitamine e deficient mice
    • Adams JD, Odunze JN, Sevanian A. Induction by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of lipid peroxidation in vivo in vitamine E deficient mice. Biochem Pharmacol 1990; 39: R5
    • (1990) Biochem Pharmacol , vol.39
    • Adams, J.D.1    Odunze, J.N.2    Sevanian, A.3
  • 48
    • 0023521344 scopus 로고
    • 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) accelerates the accumulation of lipofuscin in mouse adrenal gland
    • Hadjiconstantinou M, Tjioe S, Alho H, Miller C, Neft NH. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) accelerates the accumulation of lipofuscin in mouse adrenal gland. Neurosci Lett 1987; 83: 1-6.
    • (1987) Neurosci Lett , vol.83 , pp. 1-6
    • Hadjiconstantinou, M.1    Tjioe, S.2    Alho, H.3    Miller, C.4    Neft, N.H.5
  • 49
    • 24344489418 scopus 로고    scopus 로고
    • Desferoxamine does not protect against MPP+-induced toxicity in rats
    • Luquin MR, Zbarsky V, Del Rio L, Domínguez JJ, Guilén J. Desferoxamine does not protect against MPP+-induced toxicity in rats. Mov Disord 1996; 11 (Suppl 1): 144.
    • (1996) Mov Disord , vol.11 , Issue.1 SUPPL. , pp. 144
    • Luquin, M.R.1    Zbarsky, V.2    Del Rio, L.3    Domínguez, J.J.4    Guilén, J.5
  • 50
    • 0022349344 scopus 로고
    • 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhanced by pretreament with diethyldithiocarbamate
    • Corsini GU, Pintus S, Chiueh CC, Weiss JF, Kopin IJ. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhanced by pretreament with diethyldithiocarbamate. Eur J Pharmacol 1985; 119: 127-8.
    • (1985) Eur J Pharmacol , vol.119 , pp. 127-128
    • Corsini, G.U.1    Pintus, S.2    Chiueh, C.C.3    Weiss, J.F.4    Kopin, I.J.5
  • 51
    • 0029844003 scopus 로고    scopus 로고
    • Inhibibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons
    • Hantraye P, Brouillet E, Ferrante R, Palfi S, Dolan R, Mattews RT. Inhibibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat Med 1996; 2: 965-76.
    • (1996) Nat Med , vol.2 , pp. 965-976
    • Hantraye, P.1    Brouillet, E.2    Ferrante, R.3    Palfi, S.4    Dolan, R.5    Mattews, R.T.6
  • 52
    • 0026760948 scopus 로고
    • A novel neuronal messenger molecule in the brain: The free radical, nitric oxide
    • Dawson TM, Dawson VL, Snyder SH. A novel neuronal messenger molecule in the brain: the free radical, nitric oxide. Ann Neurol 1992; 32: 297-311.
    • (1992) Ann Neurol , vol.32 , pp. 297-311
    • Dawson, T.M.1    Dawson, V.L.2    Snyder, S.H.3
  • 53
    • 0021810979 scopus 로고
    • Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Nicklas WJ, Vyas I, Heikkila RE. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Life Sci 1985; 36: 2503-8.
    • (1985) Life Sci , vol.36 , pp. 2503-2508
    • Nicklas, W.J.1    Vyas, I.2    Heikkila, R.E.3
  • 54
    • 0022447784 scopus 로고
    • Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP
    • Ramsay RR, Dagdar J, Trevor A, Singer TP. Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP. Life Sci 1986; 39: 581-588.
    • (1986) Life Sci , vol.39 , pp. 581-588
    • Ramsay, R.R.1    Dagdar, J.2    Trevor, A.3    Singer, T.P.4
  • 55
    • 0023186383 scopus 로고
    • Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-phenyl-pyridinium ion on activities of the enzymes in the electron transport system in mouse brain
    • Mizuno Y, Sone N, Saitoh T. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-phenyl-pyridinium ion on activities of the enzymes in the electron transport system in mouse brain. J Neurochem 1987; 48: 1787-93.
    • (1987) J Neurochem , vol.48 , pp. 1787-1793
    • Mizuno, Y.1    Sone, N.2    Saitoh, T.3
  • 56
    • 0024997609 scopus 로고
    • 1-Methyl-4-phenylpiridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles
    • Hasegawa E, Takeshige K, Oishi T, Murai Y, Minakami S. 1-Methyl-4-phenylpiridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles. Biochem Biophys Res Commun 1990; 170: 1049-55.
    • (1990) Biochem Biophys Res Commun , vol.170 , pp. 1049-1055
    • Hasegawa, E.1    Takeshige, K.2    Oishi, T.3    Murai, Y.4    Minakami, S.5
  • 57
    • 0026513177 scopus 로고
    • 21 aminosteroids interact with the dopamine transporter to protect against 1-methyl-4-phenylpyridinium-induced neurotoxicity
    • Sánchez-Ramos JR, Song, S, Mash DC, Wiener WJ. 21 aminosteroids interact with the dopamine transporter to protect against 1-methyl-4-phenylpyridinium-induced neurotoxicity. J Neurochem 1992; 58: 328-34.
    • (1992) J Neurochem , vol.58 , pp. 328-334
    • Sánchez-Ramos, J.R.1    Song, S.2    Mash, D.C.3    Wiener, W.J.4
  • 58
    • 0023864237 scopus 로고
    • The mechanism of I-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: Role of intracellular calcium
    • Kass GEN, Wright JM, Nicotera P, Orrenius S. The mechanism of I-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: role of intracellular calcium. Arch Biochem Biophys 1988; 260: 789-97.
    • (1988) Arch Biochem Biophys , vol.260 , pp. 789-797
    • Kass, G.E.N.1    Wright, J.M.2    Nicotera, P.3    Orrenius, S.4
  • 59
    • 0026082060 scopus 로고
    • Protection of substantia nigra neurons from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists
    • Turski L, Bressler K, Retting KJ, Löschmann PA, Wachtel H. Protection of substantia nigra neurons from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists. Nature 1991; 349: 414-8
    • (1991) Nature , vol.349 , pp. 414-418
    • Turski, L.1    Bressler, K.2    Retting, K.J.3    Löschmann, P.A.4    Wachtel, H.5
  • 60
    • 0028897834 scopus 로고
    • Pretreatment with nimodipine prevents MPTP-induced neurotoxcity at the nigral but not at striatal level in mice
    • Kupsch A, Gerlach M, Pupeter SC, et al. Pretreatment with nimodipine prevents MPTP-induced neurotoxcity at the nigral but not at striatal level in mice. Neuroreport 1995; 6: 621-5.
    • (1995) Neuroreport , vol.6 , pp. 621-625
    • Kupsch, A.1    Gerlach, M.2    Pupeter, S.C.3
  • 61
    • 0027945523 scopus 로고
    • Dopamine D1 receptor mutant mice are deficient in striatal expression of Dynorphin and in dopamine-mediated behavioural responses
    • Xu M, Moratalla R, Gold LH, Hiroi N, Koob GF, Graybiel AM, Tonewaga S. Dopamine D1 receptor mutant mice are deficient in striatal expression of Dynorphin and in dopamine-mediated behavioural responses. Cell 1994; 79: 729-42.
    • (1994) Cell , vol.79 , pp. 729-742
    • Xu, M.1    Moratalla, R.2    Gold, L.H.3    Hiroi, N.4    Koob, G.F.5    Graybiel, A.M.6    Tonewaga, S.7
  • 62
    • 0028605680 scopus 로고
    • Elimination of cocaine-induced mediated neurophysiological effects in dopamine receptor mutant mice
    • Xu M, Hu XT, Cooper EXC, Moratalla R, Graybiel AM, White FJ, et al. Elimination of cocaine-induced mediated neurophysiological effects in dopamine receptor mutant mice. Cell 1994; 79: 945-55.
    • (1994) Cell , vol.79 , pp. 945-955
    • Xu, M.1    Hu, X.T.2    Cooper, E.X.C.3    Moratalla, R.4    Graybiel, A.M.5    White, F.J.6
  • 64
    • 0029165456 scopus 로고
    • Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors
    • Baik JH, Picetti R, Salardi A, Thiriet G, Dierich A. Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Nature 1995; 377: 424-8.
    • (1995) Nature , vol.377 , pp. 424-428
    • Baik, J.H.1    Picetti, R.2    Salardi, A.3    Thiriet, G.4    Dierich, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.