Prostatic neoplasia in transgenic mice with prostate-directed overexpression of the c-myc oncoprotein

Prostate

Volumn 43, Issue 4, 2000, Pages 278-285

  Zhang, Xuejun ^a   Lee, Chung ^b   Ng, Po Ying ^a   Rubin, Mark ^c   Shabsigh, Ahmad ^a   Buttyan, Ralph ^a,d  

^a Coll Phys Surgs of Columbia Univ ^*  (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

C myc; Neoplasia; Prostatic intraepithelial neoplasia; Transgenic mice

Indexed keywords

MYC PROTEIN; PROBASIN; RECOMBINANT DNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DNA DETERMINATION; GENE OVEREXPRESSION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE EPITHELIUM; PROSTATE TUMOR; PROTEIN EXPRESSION; RAT;

EID: 0034214052     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0045(20000601)43:4<278::AID-PROS7>3.0.CO;2-4     Document Type: Article

References (17)

1. Pollard M. Lobund-Wistar rat model of prostate cancer in man. Prostate 1998;37:1-4.
2. Buttyan R, Slawin K. Rodent models for targeted oncogenesis of the prostate gland. Cancer Metastasis Rev 1993;12:11-19.
3. Shibata MA, Jorcyk CL, Liu ML, Yoshidome K, Gold LG, Green JE. The C3(1)/SV40 T antigen transgenic mouse model of prostate and mammary cancer. Toxicol Pathol 1998;26:177-182.
4. Greenberg NM, DeMayo FJ, Sheppard PC, Barrios R, Lebovitz R, Finegold M, Angelopoulou R, Dodd JG, Duckworth ML, Rosen JM, Matusik RJ. The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice. Mol Endocrinol 1994;8:230-239.
5. Gingrich JR, Greenberg NM. A transgenic mouse prostate cancer model. Toxicol Pathol 1996;24:502-504.
6. Kasper S, Sheppard PC, Van Y, Pettigrew N, Borowsky AD, Prins GS, Dodd JG, Duckworth ML, Matusik RJ. Development, progression and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: a model for prostate cancer. Lab Invest 1998;78:1-15.
7. Zhang X, Chen M-W, Ng A, Ng P-Y, Lee C, Rubin M, Olsson CA, Buttyan R. Abnormal prostate development in C3(1)-bcl-2 transgenic mice. Prostate 1997;32:16-26.
8. McDonnell TJ, Troncosco P, Brisbay SM, Logothetis C, Chung LW, Hsieh JT, Tu SM, Campbell ML. Expression of the protooncogene bcl-2 in the prostate and its association with the emergence of androgen-independent prostate cancer. Cancer Res 1992;52:6940-6944.
9. Colombel M, Symmans F, Gil S, O'Toole KM, Chopin D, Benson M, Olsson CA, Korsmeyer S, Buttyan R. Detection of the apoptosis-suppressing oncoprotein bcl-2 in hormone-refractory human prostate cancers. Am J Pathol 1993;143:390-400.
10. Krajewska M, Krajewski S, Epstein JI, Shabaik A, Sauvageot J, Song K, Kitada S, Reed JC. Immunohistochemical analysis of bcl-2, bax, bcl-X and mcl-1 expression in prostate cancers. Am J Pathol 1996;148:1567-1576.
11. Buttyan R, Sawczuk IS, Benson MC, Siegal JD, Olsson CA. Enhanced expression of the c-myc protooncogene in high-grade human prostate cancers. Prostate 1987;11:327-337.
12. Fleming WH, Hamel A, MacDonald R, Ramsey E, Pettigrew NM, Johnston B, Dodd JG, Matusik RJ. Expression of the c-myc protooncogene in human prostatic carcinoma and benign prostatic hyperplasia. Cancer Res 1986;46:1535-1538.
13. Jenkins RB, Qian J, Lieber MM, Bostwick DG. Detection of c-myc oncogene amplification and chromosomal anomalies in metastatic prostatic cancer by fluorescence in situ analysis. Cancer Res 1997;57:524-531.
14. Haggman MJ, Macoska JA, Wojno KJ, Oesterling JE. The relationship between prostatic intrapepithelial neoplasia and prostate cancer: critical issues. J Urol 1997;158:12-22.
15. Nesbit CE, Tersak JM, Prochownik EV. Myc oncogenes and human neoplastic disease. Oncogene 1999;18:3004-3016.
16. Schmidt EV. The role of c-myc in cellular growth control. Oncogene 1999;18:2988-2896.
17. Yan Y, Sheppard PC, Kasper S, Lin L, Hoare S, Kapoor A, Dodd JG, Duckworth ML, Matusik RJ. Large fragment of the probasin promoter targets high levels of transgene expression to the prostate of transgenic mice. Prostate 1997;32:129-139.