Hemodynamic effects of sildenafil in men with severe coronary artery disease

New England Journal of Medicine

Volumn 342, Issue 22, 2000, Pages 1622-1626

  Herrmann, Howard C ^a   Chang, Gene ^a   Klugherz, Bruce D ^a   Mahoney, Paul D ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; SILDENAFIL;

ADULT; AGED; ARTICLE; BLOOD FLOW VELOCITY; CIGARETTE SMOKING; CLINICAL ARTICLE; CORONARY ARTERY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DISEASE; CORONARY ARTERY OBSTRUCTION; CORONARY HEMODYNAMICS; DIABETES MELLITUS; DISEASE SEVERITY; ERECTILE DYSFUNCTION; HUMAN; HYPEREMIA; HYPERTENSION; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; VASCULAR RESISTANCE; VOLUMETRY;

CORONARY DISEASE; CORONARY VESSELS; HEMODYNAMIC PROCESSES; HUMANS; MALE; MIDDLE AGED; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES;

EID: 0034213608     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200006013422201     Document Type: Article

References (21)

1. NIH Consensus Development Panel on Impotence. NIH Consensus Conference: impotence. JAMA 1993;270:83-90.
2. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994;151:54-61.
3. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 1998;338:1397-404. [Erratum, N Engl J Med 1998;339:59.]
4. Viagra (sildenafil citrate). New York: Pfizer, June 1999 (package insert, rev.).
5. Zusman RM, Morales A, Glasser DB, Osterloh IH. Overall cardiovascular profile of sildenafil citrate. Am J Cardiol 1999;83:35C-44C.
6. Feenstra J, van Drie-Pierik RJHM, Lacle CF, Stricker BHCH. Acute myocardial infarction associated with sildenafil. Lancet 1998;352:957-8.
7. Wallis RM, Corbin JD, Francis SH, Ellis P. Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. Am J Cardiol 1999;83:3C-12C.
8. Doucette JW, Corl PD, Payne HM, et al. Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity. Circulation 1992;85:1899-911.
9. Jackson G, Benjamin N, Jackson N, Allen MJ. Effects of sildenafil citrate on human hemodynamics. Am J Cardiol 1999;83:13C-20C.
10. Scoblionko DP, Brown BG, Mitten S, et al. A new digital electronic caliper for measurement of coronary arterial stenosis: comparison with visual estimates and computer-assisted measurements. Am J Cardiol 1984;53: 689-93.
11. Theron HD, Lambert CR, Pepine CJ. Videodensitometry versus digital calipers for quantitative coronary angiography. Am J Cardiol 1990;66: 1186-90.
12. Baumgart D, Haude M, Goerge G, et al. Improved assessment of coronary stenosis severity using the relative flow velocity reserve. Circulation 1998;98:40-6.
13. Ballard SA, Gingell CJ, Tang K, Turner LA, Price ME, Naylor AM. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urol 1998;159:2164-71.
14. Matherne GP, Headrick JP, Liang BT. Adenosine receptor subtypes and cardioprotection in cardiac myocyte and transgenic models. In: Burnstock G, Dobson JG Jr, Liang BT, Linden J, eds. Cardiovascular biology of purines. Vol. 209. Dordrecht, the Netherlands: Kluwer Academic, 1998: 86-107.
15. Wilson RF, Wyche K, Christensen BV, Zimmer S, Laxson DD. Effects of adenosine on human coronary arterial circulation. Circulation 1990;82: 1595-606.
16. Traverse JH, Du R, Chen YJ, et al. Sildenafil (Viagra) improves coronary blood flow distal to a coronary stenosis during exercise. Circulation 1999;100:Suppl I:I-489. abstract.
17. Arora RR, Timoney M, Melilli L. Acute myocardial infarction after the use of sildenafil. N Engl J Med 1999;341:700.
18. Muller JE, Mittleman A, Maclure M, Sherwood JB, Tofler GH. Triggering myocardial infarction by sexual activity: low absolute risk and prevention by regular physical exertion. JAMA 1996;275:1045-9.
19. Kloner RA, Jarow JP. Erectile dysfunction and sildenafil citrate and cardiologists. Am J Cardiol 1999;83:576-82.
20. Gould KL, Kirkeeide RL, Buchi M. Coronary flow reserve as a physiologic measure of stenosis severity. J Am Coll Cardiol 1990;15:459-74.
21. Cheitlin MD, Hutter AM Jr, Brindis RG, et al. Use of sildenafil (Viagra) in patients with cardiovascular disease. Circulation 1999;99:168-77. [Erratum, Circulation 1999;100:2389.]