Multiple HLA-class I-specific inhibitory NK receptor expression and IL-4/IL-5 production by CD8+ T-cell clones in HIV-1 infection

Immunology Letters

Volumn 72, Issue 3, 2000, Pages 179-182

  De Maria, Andrea ^a   Mavilio, Domenico ^a   Costa, Paola ^b   Dignetti, Paola ^a   Fogli, Manuela ^b   Mingari, M Cristina ^a,b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

CD8+; HIV 1; IL 4; Inhibitory NK receptors; T lymphocytes

Indexed keywords

CD8 ANTIGEN; CYTOKINE; HLA ANTIGEN CLASS 1; INTERLEUKIN 4; INTERLEUKIN 5; RECEPTOR;

ARTICLE; CASE REPORT; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

ANTIGENS, CD; ANTIGENS, CD94; HISTOCOMPATIBILITY ANTIGENS CLASS I; HIV INFECTIONS; HIV-1; HUMANS; INTERLEUKIN-4; INTERLEUKIN-5; LECTINS, C-TYPE; LEUKOCYTES, MONONUCLEAR; MEMBRANE GLYCOPROTEINS; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0034213541     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2478(00)00186-3     Document Type: Article

References (14)

1. Walker B.D., Flexner C., Paradis T.J., Fuller T.C., Hirsch M.S., Schooley R.T., Moss B. HIV-1 reverse transcriptase is a target for cytotoxic T lymphocytes in infected individuals. Science. 240:1988;64-66.
2. Koenig S., Earl P., Powell D., Pantaleo G., Merli S., Moss B., Fauci A.S. Group-specific, major histocompatibility complex class I-restricted cytotoxic responses to human immunodeficiency virus 1 (HIV-1) envelope proteins by cloned peripheral blood T-cells from an HIV-1-infected individual. Proc. Natl. Acad. Sci. USA. 86:1988;8638-8642.
3. Ogg G.S., Jin X., Bonhoeffer S. et al. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science. 279:1998;2103.
4. Koup R.A., Safrit J.T., Cao Y. et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68:1994;4650-4655.
5. Pantaleo G., De Maria A., Koenig S. et al. CD8+ T lymphocytes of patients with AIDS maintain normal broad cytolytic function despite the loss of human immunodeficiency virus-specific cytotoxicity. Proc. Natl. Acad. Sci. USA. 87:1990;4818-4822.
6. Pantaleo G., Menzo S., Vaccarezza M. et al. Studies in subjects with long-term non-progressive human immunodeficiency virus infection. New Engl. J. Med. 332:1995;209-216.
7. Shearer G.M., Clerici M. Early T-helper cell defects in HIV infection. AIDS. 6:1991;245-253.
8. Price D.A., Goulder P.J.R., Klenerman P. et al. Cytotoxic T lymphocyte escape variants during primary infection. Proc. Natl. Acad. Sci. USA. 94:1997;1890-1894.
9. Pantaleo G., Koenig S., Baseler M., Lane H.C., Fauci A.S. Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. Expansion in vivo of a non-clonogenic CD3+CD8+DR+CD25- T-cell population. J. Immunol. 144:1990;1696-1704.
10. Dalod M., Sinet M., Deschemins J.C., Fiorentino S., Venet A., Guillet J.G. Altered ex vivo balance between CD28+ and CD28- cells within HIV-specific CD8+ T-cells of HIV-seropositive patients. Eur. J. Immunol. 29:1999;38-44.
11. De Maria A., Ferraris A., Guastella M. et al. Expression of HLA class I-specific inhibitory natural killer cell receptors in HIV-specific cytolytic T lymphocytes: impairment of specific cytolytic functions. Proc. Natl. Acad. Sci. USA. 94:1997;10285.
12. Maggi E., Manetti R., Annunziato F. et al. Functional characterization and modulation of cytokine production by CD8+ T-cells from human immunodeficiency virus-infected individuals. Blood. 89:1997;3672-3681.
13. Mingari M.C., Ponte M., Bertone S. et al. HLA class I-specific inhibitory receptors in human T lymphocytes: interleukin 15-induced expression of CD94/NKG2A in superantigen- or alloantigen-activated CD8+ T-cells. Proc. Natl. Acad. Sci. USA. 95:1998;1172-1176.
14. Speiser D.E., Pittet M.J., Valmori D. et al. In vivo expression of natural killer inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. J. Exp. Med. 190:1999;775-782.