Identification and gene organization of three novel members of the IL-1 family on human chromosome 2

Genomics

Volumn 66, Issue 2, 2000, Pages 213-216

  Busfield, S J ^a   Comrack, C A ^a   Yu, G ^a   Chickering, T W ^a   Smutko, J S ^a   Zhou, H ^a   Leiby, K R ^a   Holmgren, L M ^a   Gearing, D P ^a   Pan, Y ^a,b  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

ARTICLE; CHROMOSOME 2; DNA SEQUENCE; EPITHELIUM CELL; EXPRESSED SEQUENCE TAG; GENE DUPLICATION; GENE EXPRESSION; GENE ISOLATION; GENETIC ORGANIZATION; HUMAN; HUMAN TISSUE; INFLAMMATION; MOLECULAR EVOLUTION; MULTIGENE FAMILY; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

EID: 0034210283     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2000.6184     Document Type: Article

References (21)

1. Andrei C., Dazzi C., Lotti L., Torrisi M. R., Chimini G., Rubartelli A. The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome-related vesicles. Mol. Biol. Cell. 10:1999;1463-1475.
2. Boland M. P., Foster S. J., O'Neill L. A. Daunorubicin activates NFκB and induces κB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells. J. Biol. Chem. 272:1997;12952-12960.
3. Boraschi D., Bossu P., Macchia G., Ruggiero P., Tagliabue A. Structure-function relationship in the IL-1 family. Front. Biosci. 1:1995;d270-308.
4. Busfield S. J., Michnick D. A., Chickering T. W., Revett T. L., Ma J. Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus. Mol. Cell. Biol. 17:1997;4007-4014.
5. Butcher C., Steinkasserer A., Tejura S., Lennard A. C. Comparison of two promoters controlling expression of secreted or intracellular IL-1 receptor antagonist. J. Immunol. 153:1994;701-711.
6. Carrie A., Jun L., Bienvenu T., Vinet M. C., McDonell N. A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation. Nat. Genet. 23:1999;25-31.
7. Cohen G. M. Caspases: The executioners of apoptosis. Biochem. J. 326:1997;1-16.
8. Dale M., Nicklin M. J. H. Interleukin-1 receptor cluster: Gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. Genomics. 57:1999;177-179.
9. Dinarello C. A. The interleukin-1 family: 10 years of discovery. FASEB J. 8:1994;1314-1325.
10. Eisenberg S. P., Brewer M. T., Verderber E., Heimdal P., Brandhuber B. J., Thompson R. C. Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: Evolution of a cytokine control mechanism. Proc. Natl. Acad. Sci. USA. 15:1991;5232-5236.
11. Greenfield E. M., Horowitz M. C., Lavish S. A. Stimulation by parathyroid hormone of interleukin-6 and leukemia inhibitory factor expression in osteoblasts is an immediate-early gene response induced by cAMP signal transduction. J. Biol. Chem. 271:1996;10984-10989.
12. Gyapay G., Schmitt K., Fizames C., Jones H., Vega-Czarny N. A radiation hybrid map of the human genome. Hum. Mol. Genet. 5:1996;339-346.
13. Hudson T. J., Stein L. D., Gerety S. S., Ma J., Castle A. B. An STS-based map of the human genome. Science. 270:1995;1945-1954.
14. Kleyn P. W., Fan W., Kovats S. G., Lee J. J., Pulido J. C. Identification and characterization of the mouse obesity gene tubby: A member of a novel gene family. Cell. 85:1996;281-290.
15. Kupper T. S., Groves R. W. The interleukin-1 axis and cutaneous inflammation. J. Invest. Dermatol. 105:1995;62S-66S.
16. Manly K. F., Olson J. M. Overview of QTL mapping software and introduction to Map Manager QT. Mamm. Genome. 10:1999;327-334.
17. Mulero J. J., Pace A. M., Nelken S. T., Loeb D. B., Correa T. R., Drmanac R., Ford J. E. ILIHY1: A novel interleukin-1 receptor antagonist gene. Biochem. Biophys. Res. Commun. 263:1999;712-706.
18. Orencole S. F., Dinarello C. A. Characterization of a subclone (D10S) of the D10.G4.1 helper T-cell line which proliferates to attomolar concentrations of interleukin-1 in the absence of mitogens. Cytokine. 1:1989;14-22.
19. Steinkasserer A., Spurr N. K., Cox S., Jeggo P., Sim R. B. The human IL-1 receptor antagonist gene (IL-1RN) maps to chromosome 2q14-q21, in the region of the IL-1α and IL-1β loci. Genomics. 13:1992;654-657.
20. Stewart E. A., McKusick K. B., Aggarwal A., Bajorek E., Brady S. An STS-based radiation hybrid map of the human genome. Genome Res. 7:1997;422-433.
21. Thomassen E., Renshaw B. R., Sims J. E. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Cytokine. 11:1999;389-399.