Developmental stress disrupts habituation but spares prepulse inhibition in young rats

Physiology and Behavior

Volumn 69, Issue 4-5, 2000, Pages 527-530

  Finamore, Terri L ^a   Port, Richard L ^a  

^a SLIPPERY ROCK UNIVERSITY   (United States)

Author keywords

Habituation; Hippocampus; Prepulse inhibition; Schizophrenia; Stress

Indexed keywords

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HABITUATION; MATERNAL DEPRIVATION; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; STARTLE REFLEX; STRESS;

EID: 0034210114     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(00)00205-5     Document Type: Article

References (26)

1. DeKloet E.R. Brain corticosteroid receptor balance and homeostatic control. Front Neuroendocrinol. 12:1991;95-123.
2. DeKloet E.R., Rosenfeld P., van Eekelen J.A., Sutanto W., Levine S. Stress, glucocorticoids and development. Prog Brain Res. 73:1988;101-120.
3. Ellenbroek B.A., Cools A.R. The neurodevelopment hypothesis of schizophrenia. clinical evidence and animal models Neurosci Res Comm. 22:1988;127-136.
4. Geyer M.A. Behavioral studies of hallucinogenic drugs in animals. implications for schizophrenia research Pharmacopsychiatry. 31:1998;73-79.
5. Geyer M.A., Wilkinson L.S., Humby T., Robbins T.W. Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biol Psychiatry. 34:1993;361-372.
6. Heim C., Owens M.J., Plotsky P.M., Nemeroff C.B. Persistent changes in corticotropin-releasing factor systems due to early life stress. relationship to the pathophysiology of major depression and post-traumatic stress disorder Psychopharmacol Bull. 33:1997;185-192.
7. Heresco-Levy U., Javitt D.C. The role of N-Methyl-D-Aspartate (NMDA) receptor-mediated neurotransmission in the pathophysiology and therapeutics of psychiatric syndromes. Eur Neuropsychopharmacol. 8:1998;141-152.
8. Jeste D.V., Lohr J.B. Hippocampal pathologic findings in schizophrenia. a morphometric study Arch Gen Psychiatry. 46:1989;1019-1024.
9. Kehoe P., Shoemaker W.J., Triano L., Callahan M., Rappolt G. Adult rats stressed as neonates show exaggerated behavioral responses to both pharmacological and environmental challenges. Behav Neurosci. 112:1998;116-125.
10. Lupien S.J., de Leon M., de Santi S., Convit A., Tarshish C., Nair N.P.V., Thakur M., McEwen B.S., Hauger R.L., Meaney M.J. Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nat Neurosci. 1:1998;69-73.
11. Lupien S.J., McEwen B.S. The acute effects of corticosteroids on cognition. integration of animal and human model studies Brain Res Rev. 24:1997;1-27.
12. McEwen B.S. Re-examination of the glucocorticoid hypothesis of stress and aging. Prog Brain Res. 93:1992;365-383.
13. McEwen B.S. Corticosteroids and hippocampal plasticity. Ann NY Acad Sci. 746:1994;134-142.
14. McEwen B.S. Stressful experience, brain and emotion. developmental, genetic and hormonal influences Gazzaniga M.S. The Cognitive Neurosciences. 1995;1117-1136 MIT Press, Cambridge, MA.
15. Norman R.M., Malla A.K. Stressful life events and schizophrenia. I. A review of the research Br J. Psychiatry. 162:1993;161-166. a.
16. Olney J.W., Farber N.B. Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry. 52:1995;998-1007.
17. Pfaff D.W., Silva M.T., Weiss J.M. Telemetered recordings of hormonal effects on hippocampal neurons. Science. 172:1971;394-395.
18. Rosenthal D. Genetic Theory and Abnormal Behavior. 1970;McGraw-Hill, New York.
19. Sapolsky R. Stress, the Aging Brain, and the Mechanism of Neuron Death. 1992;MIT Press; Cambridge, MA.
20. Sapolsky R.M., Krey L.C., McEwen B.S. The neuroendocrinology of stress and aging. the glucocorticoid cascade hypothesis Endocr Rev. 7:1986;284-301.
21. Seybold K.S., Finamore T.L., Noble M.M., Port R.L. Hippocampal and NMDA dysfunction as a substrate for disrupted habituation and prepulse inhibition in schizophrenia. Neurosci Abstracts. 25:1999;572.
22. Shors T.J., Servatius R.J. The contribution of stressor intensity, duration, and context to the stress-induced facilitation of associative learning. Neurobiol Learn Mem. 67:1997;92-96.
23. Stanton M.E., Gutierrez Y.R., Levine S. Maternal deprivation potentiates pituitary-adrenal stress responses in infant rats. Behav Neurosci. 102:1988;692-700.
24. Swerdlow N.R., Lipska B.K., Weinberger D.R., Braff D.L., Jaskiw G.E., Geyer M.A. Increased sensitivity to the sensorimotor gating-disruptive effects of apomorphine after lesions of medial prefrontal cortex or ventral hippocampus in adult rats. Psychopharmacology. 122:1995;27-34.
25. Walker E.F., Diforio D. Schizophrenia. a neural diathesis stress model Psychol Rev. 104:1997;667-685.
26. Wilkinson L.S., Killcross S.S., Humby T., Hall F.S., Geyer M.A., Robbins T.W. Social isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition. Neuropsychopharmacology. 10:1994;61-72.