In vivo antileishmanial action of Ir-(COD)-pentamidine tetraphenylborate on Leishmania donovani and Leishmania major mouse models

Parasite

Volumn 7, Issue 2, 2000, Pages 103-108

  Loiseau, P M ^a   Mbongo, N ^a   Bories, C ^a   Boulard, Y ^b   Craciunescu, D G ^c  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Electron microscopy; Iridium pentamidine complex; Leishmania; Mechanism of action; Pentamidine

Indexed keywords

GADUS MORHUA; LEISHMANIA DONOVANI; LEISHMANIA MAJOR;

ANTITRYPANOSOMAL AGENT; DRUG DERIVATIVE; IRIDIUM; IRIDIUM (CYCLOOCTADIENE) PENTAMIDINE TETRAPHENYLBORATE; ORGANOMETALLIC COMPOUND; TETRAPHENYLBORON;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; DISEASE MODEL; DRUG EFFECT; ELECTRON MICROSCOPY; FEMALE; LEISHMANIA DONOVANI; LEISHMANIA MAJOR; LIVER; MACROPHAGE; MOUSE; PARASITOLOGY; SKIN LEISHMANIASIS; ULTRASTRUCTURE; VISCERAL LEISHMANIASIS;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; IRIDIUM; LEISHMANIA DONOVANI; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LEISHMANIASIS, VISCERAL; LIVER; MACROPHAGES; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON; ORGANOMETALLIC COMPOUNDS; TETRAPHENYLBORATE; TRYPANOCIDAL AGENTS;

EID: 0034204194     PISSN: 1252607X     EISSN: None     Source Type: Journal    
DOI: 10.1051/parasite/2000072103     Document Type: Article

References (22)

1. BASSELIN M., LAWRENCE F. & ROBERT-GERO M. Pentamidine uptake in Leishmania donovani and Leishmania amazonensis promastigotes and axenic amastigotes. Biochemical Journal, 1996, 315, 631-634.
2. BELL C.A., HALL J.E., KYLE D.E., GROGL M., OHEMENG K.A., ALLEN M.A. & TIDWELL R.R. Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis. Antimicrobial Agents and Chemotherapy, 1990, 34, 1381-1386.
3. CROFT S.L. & BRAZIL R.P. Effect of pentamidine isethionate on the ultrastructure and morphology of Leishmania mexicana amazonensis in vitro. Annals of Tropical Medicine and Parasitology, 1982, 76, 37-43.
4. CROFT S.L., NEAL R.A., CRACIUNESCU D.G. & CERTAD-FOMBONA G. The activity of platinum, iridium and rhodium drug complexes against Leishmania donovani. Tropical Medicine and Parasitology, 1992, 43, 24-28.
5. DREYFUSS G., GAYRAL P., DUBOST G., NICOLAS J.A. & CRACIUNESCU D.G. Activité antiparasitaire du cis-Pt(II)-pentamidine dans la trypanosomose expérimentale du mouton à Trypanosoma brucei brucei. Bulletin de la Société de Pathologie Exotique et de ses Filiales, 1988, 81, 561-570.
6. DREYFUSS G., PÉNICAUT B., NICOLAS J.A., CRACIUNESCU D.G. & LOISEAU P.M. Trypanocidal activity and platinum plasma kinetics of cis-Pt pentamidine iodide in Trypanosoma brucei sheep model. Tropical Medicine and Parasitology, 1993, 44, 95-98.
7. DREYFUSS G., LOISEAU P.M., LACHATRE G., PÉNICAUT B., NICOLAS J.A. & CRACIUNESCU D.G. Trypanosoma brucei brucei: anti-trypanosomal evaluation of stilbamidinium hexachloroiridiate on the murine CNS model and iridium serum kinetics in infected sheep. Tropical Medicine and Parasitology, 1995, 46, 41-44.
8. DURAND R., PAUL M., RIVOLLET D., FESSI H., HOUIN R., ASTIER A. & DENIAU M. Activity of pentamidine-loaded poly(D,L-lactide) nanoparticles against Leishmania infantum in a murine model. Parasite, 1997, 4, 331-336.
9. FARRELL N.P., WILLIAMSON J. & MCLAREN D.J.M. Trypanocidal and antitumor activity of platinum metal and platinum-metal-drug dual function complexes. Biochemical Pharmacology, 1984, 33, 961-971.
10. FUSAI T., BOULARD Y., DURAND R., PAUL M., BORIES C., RIVOLLET D., ASTIER A., HOUIN R. & DENIAU M. Ultrastructural changes in parasites induced by nanoparticle-bound pentamidine in a Leishmania major/mouse model. Parasite, 1997, 2, 133-139.
11. KINNAMON K.E., STECK E.A. & RANE D.S. Activity of antitumor drugs against African trypanosomes. Antimicrobial Agents and Chemotherapy, 1979, 15, 157-160.
12. LOISEAU P.M., CRACIUNESCU D.G., DOADRIO-VILLAREJO J.C., CERTADFOMBONA G. & GAYRAL P. Pharmacomodulations on new organometallic complexes of Ir, Pt, Rh, Pd, Os: in vitro and in vivo trypanocidal study against Trypanosoma brucei brucei. Tropical Medicine and Parasitology, 1992, 43, 110-114.
13. LOISEAU P.M., DREYFUSS G., DAULOUEDE S., LACHÂTRE G., VINCENDEAU P. & CRACIUNESCU D.G. Trypanocidal effect of Ir-(COD)-pentamidine tetraphenylborate on T. b. brucei and T. b. gambiense rodent models and serum kinetics in the sheep. Tropical Medicine and International Health, 1997, 2, 19-27.
14. MBONGO N., LOISEAU P.M., LAWRENCE F., BORIES C., CRACIUNESCU D.G. & ROBERT-GERO M. In vitro sensitivity of Leishmania donovani to organometallic derivatives of pentamidine. Parasitology Research, 1997, 83, 515-517.
15. MBONGO N., LOISEAU P.M., LAWRENCE F., CRACIUNESCU D.G. & ROBERT-GERO M. Uptake into Leishmania donovani promastigotes and antileishmanial action of an organometallic complex derived from pentamidine. Arzneimittel Forschung Drug Research, 1998, 48, 850-855.
16. MESA-VALLE C.M., CRACIUNESCU D.G., PARRONDO-IGLESIAS E. & OSUNA A. In vitro action of Platinum (II) and Platinum (IV) complexes on Trypanosoma cruzi and Leishmania donovani. Arzneimittel Forschung/Drug Research, 1989, 39, 838-842.
17. MESA-VALLE C.M., MORALEDA-LINDEZ V. & CRACIUNESCU D. In vitro action of new organometallic compounds against Trypanosomatidae protozoa. Arzneimittel Forschung/Drug Research, 1993, 43, 1010-1013.
18. MODABBER F. Leishmaniasis. in: WHO Tropical Disease Research, Progress 1991-1992, Eleventh Program Report., 1992, pp. 77-81.
19. MOSSMAN T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 1983, 65, 55-63.
20. NEAL R.A. & CROFT S.L. An in vitro system for determining the activity of compounds against the intracellular amastigote form of Leishmania donovani. Journal of Antimicrobial Chemotherapy, 1984, 14, 463-475.
21. SANDS M., KRON M. & BROWN R.B. Pentamidine: a review. Review of Infectious Diseases, 1985, 7, 625-634.
22. SOTO J., BUFFET P., GROGL M. & BERMAN J. Successful treatment of colombian cutaneous leishmaniasis with four injections of pentamidine. American Journal of Tropical Medicine and Hygiene, 1994, 50, 107-111.