Tumor necrosis factor alpha and interleukin-6 have differential effects on food intake and gastric emptying in fasted rats

Research in Nursing and Health

Volumn 23, Issue 3, 2000, Pages 222-228

  McCarthy, Donna O ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Anorexia; Gastric motility; Interleukin 6; Rats; Tumor necrosis factor

Indexed keywords

IBUPROFEN; INTERLEUKIN 6; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ANOREXIA; ARTICLE; BIOSYNTHESIS; COMMUNICABLE DISEASE; DRUG EFFECT; FEEDING BEHAVIOR; IMMUNOLOGY; MALE; PATHOPHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; STOMACH EMPTYING;

ANIMALS; ANOREXIA; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; COMMUNICABLE DISEASES; FEEDING BEHAVIOR; GASTRIC EMPTYING; IBUPROFEN; INTERLEUKIN-6; MALE; PROSTAGLANDIN ANTAGONISTS; PROSTAGLANDINS; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034200980     PISSN: 01606891     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-240X(200006)23:3<222::AID-NUR6>3.0.CO;2-3     Document Type: Article

References (41)

1. Chang, H.R., & Bistrian, B. (1998). The role of cytokines in the catabolic consequences of infection and injury. JPEN: Journal of Parenteral & Enteral Nutrition, 22, 156-166.
2. Daun, J.M., & McCarthy, D.O. (1993). The role of cholecystokinin in interleukin-1-induced anorexia. Physiology & Behavior, 54, 237-241.
3. Fantuzzi, G., Zheng, H., Faggioni, R., Benigni, F., Ghezzi, P., Sipe, J.D., Shaw, A.R., & Dinarello, C.A. (1996). Effect of endotoxin in IL-1 beta-deficient mice. Journal of Immunology, 157, 291-296.
4. Fattori, E., Cappelletti, M., Costa, P., Sellitto, C., Cantoni, L., Carelli, M., Faggioni, R., Fantuzzi, G., Ghezzi, P., & Poli, V. (1994). Defective inflammatory response in interleukin 6-deficient mice. Journal of Experimental Medicine, 180, 1243-1250.
5. Foster, K.D., Conn, C.A., & Kluger, M.J. (1992). Fever, tumor necrosis factor, and interleukin-6 in young, mature, and aged Fisher 344 rats. American Journal of Physiology, 262, R11-R215.
6. Gabay, C., & Kushner, I. (1999). Acute-phase proteins and other systemic responses to inflammation. The New England Journal of Medicine, 340, 448-454.
7. Giner, M., Laviano, A., Meguid, M.M., & Gleason, J.R. (1996). In 1995 a correlation between malnutrition and poor outcome in critically ill patients still exists. Nutrition, 12, 23-29.
8. Hart, B.L. (1988). Biological basis of the behavior of sick animals. Neuroscience and Biobehavioral Reviews, 12, 123-137.
9. Haslett, P.A. (1998). Anticytokine approaches to the treatment of anorexia and cachexia. Seminars in Oncology, 25(2 Suppl. 6), 53-57.
10. Hunt, J.N. (1980). A possible relation between the regulation of gastric emptying and food intake. American Journal of Physiology, 239, G1-G4.
11. Langhans, W. (1997). The anorectic effect of bacterial cell wall compounds-mechanisms and clinical implications. Appetite, 29, 105.
12. Langhans, W., Savoldelli, D., & Weingarten, S. (1993). Comparison of the feeding responses to bacterial lipopolysaccharide and interleukin-1β. Physiology & Behavior, 53, 643-649.
13. Long, N.C. (1996). Evolution of infectious disease: How evolutionary forces shape physiological responses to pathogens. News in Physiological Sciences, 11, 83-90.
14. Maier, S.F., Goehler, L.E., Fleshner, M., & Watkins, L.R. (1998). The role of the vagus nerve in cytokine-to-brain communication. Annals of the New York Academy of Sciences, 840, 289-300.
15. McCarthy, D.O., & Daun, J.M. (1992). The role of prostaglandins in interleukin-1 induced gastroparesis. Physiology & Behavior, 52, 351-353.
16. McCarthy, D.O., Kluger, M.J., & Vander, A.J. (1984). The role of fever in appetite suppression after endotoxin administration. The American Journal of Clinical Nutrition, 40, 310-316.
17. Montuschi, P., Preziosi, P., & Navarra, P. (1993). Interleukin-1α and tumour necrosis factor inhibit rat gastric fundus motility in vitro. European Journal of Pharmacology, 233, 303-304.
18. Murray, M.J., & Murray, A.B. (1979). Anorexia of infection as a mechanism of host defense. American Journal of Clinical Nutrition, 32, 593-596.
19. Patton, J.S., Peters, P.M., McCabe, J., Crase, D., Hansen, S., Chen, A.B., & Liggitt, D. (1987). Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-α in rodents. Journal of Clinical Investigation, 80, 1587-1596.
20. Plata-Salaman, C.R. (1995). Strategies for potential manipulation of anorexia during acute and chronic disease. Nutrition, 11(5 Suppl.), 702-704.
21. Plata-Salaman, C.R. (1998a). Cytokines and anorexia: A brief overview. Seminars in Oncology, 25(1 Suppl.), 64-72.
22. Plata-Salaman, C.R. (1998b). Cytokines and feeding. News in Physiological Sciences, 13, 298-304.
23. Plata-Salaman, C.R., Sonti, G., Borkoski, J.P., Wilson, C.D., & French-Mullen, J.M. (1996). Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations. Physiology & Behavior, 60, 867-875.
24. Porter, M.H., Arnold, M., & Langhans, W. (1998). TNF-α tolerance blocks LPS-induced hypophagia but LPS tolerance fails to prevent TNF-α-induced hypophagia. American Journal of Physiology, 274(3 Pt 2), R741-R745.
25. 2 synthesis by the stomach, and retards gastric emptying. Life Sciences, 48, 123-134.
26. Souba, W.W. (1994). Cytokine control of nutrition and metabolism in critical illness. Current Problems in Surgery, 31, 577-643.
27. Strassmann, G., Fong, M., Windsor, S., & Neta, R. (1993). The role of interleukin-6 in lipopolysaccharide-induced weight loss, hypoglycemia and fibrinogen production, in vivo. Cytokine, 5, 285-290.
28. Sütö, G., Király, A., Plourde, V., & Taché, Y. (1996). Intravenous interleukin-1-beta-induced inhibition of gastric emptying: Involvement of central corticotrophin-releasing factor and prostaglandin pathways in rats. Digestion, 57, 135-140.
29. Sütö, G., Király, A., & Taché, Y. (1994). Interleukin 1β inhibits gastric emptying in rats: Mediation through prostaglandin and corticotropin-releasing factor. Gastroenterology, 106, 1568-1575.
30. Swiergiel, A.H., Smagin, G.N., Johnson, L.J., & Dunn, A.J. (1997). The role of cytokines in the behavioral responses to endotoxin and influenza virus infection in mice: Effects of acute and chronic administration of the interleukin-1 receptor antagonist (IL-1ra). Brain Research, 776, 96-104.
31. U.S. Department of Health, Education, and Welfare, 1986. Guide for the care and use of laboratory animals (NIH publication No. 86-23). Washington, DC: U.S. Government Printing Office.
32. Uehara, A., Ishikawa, Y., Okumura, T., Okamura, K., Sekiya, C., Takasugi, Y., & Namiki, M. (1989). Indomethacin blocks the anorexic action of interleukin-1. European Journal of Pharmacology, 170, 257-260.
33. van der Meer, M.J., Sweep, F., Pesman, G.J., Borm, G.F., & Hermus, A.R. (1995). Synergism between IL-1β and TNF-α on the activity of the pituitary-adrenal axis and on food intake of rats. American Journal of Physiology, 268 (Endorcrinol. Metab. 31), E551-E557.
34. van Miert, A.S., Kaya, F., & van Duin, C.T. (1992). Changes in food intake and forestomach motility of dwarf goats by recombinant bovine cytokines (IL-1β, IL-2) and IFN-γ. Physiology & Behavior, 52, 859-864.
35. van Miert, A.S., van Duin, C.T., & Wensing, T. (1992). Fever and acute phase response induced in dwarf goats by endotoxin and bovine and human recombinant tumour necrosis factor alpha. Journal of Veterinary Pharmacology & Therapeutics, 15, 332-342.
36. van Miert, A.S., van Duin, C.T., & Wensing, T. (1994). Effects of flurbiprofen on recombinant human IL-1 alpha-induced fever and associated clinical haematological and blood biochemical changes in the dwarf goat. Veterinary Quarterly, 16, 1-6.
37. van Miert, A.S., van Duin, C.T., & Wensing, T. (1997). Effects of pentoxifylline and polymyxin B on the acute-phase-response to Escherichia coli endotoxin in dwarf goats. Journal of Veterinary Pharmacology & Therapeutics, 20, 61-68.
38. van Miert, A.S.J.P.A.M., & van Duin, C.T.M. (1998). Pharmacological and pathophysiological modulation of food intake and forestomach motility in small ruminants. Journal of Veterinary Pharmacological Therapy, 21, 1-17.
39. Verity, S. (1996). Nutrition and its importance to intensive care patients. Intensive and Critical Care Nursing, 12, 71-78.
40. Wing, E.J., & Young, J.B. (1990). Acute starvation protects mice against Listeria monocytogenes. Infection and Immunity, 28, 771-776.
41. Yang, Z.-J., Koseki, M., Meguid, M.M., Gleason, J.R., & Debonis, D. (1994). Synergistic effect of rhTNFα and rhIL-1α in inducing anorexia in rats. American Journal of Physiology, 267, R1056-R1064.