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Volumn 298, Issue 3, 1996, Pages 247-256

Effects of MCI-154, a new cardiotonic Ca2+ sensitizer, on ventricular arrhythmias and membrane ionic currents

Author keywords

Ca2+; Current; Heart failure; MCI 154 (6 4 (4 pyridylamino)phenyl 4,5 dihydro 3 (2H) pyridazinone); Ventricular arrhythmia

Indexed keywords

4,5 DIHYDRO 6 [4 (4 PYRIDYLAMINO)PHENYL] 3(2H) PYRIDAZINONE; ADRENALIN; CALCIUM SENSITIZER; CARDIOTONIC AGENT; DIGITALIS; INOTROPIC AGENT; OUABAIN; PIMOBENDAN;

EID: 0029993348     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00776-8     Document Type: Article
Times cited : (8)

References (44)
  • 1
    • 0026020863 scopus 로고
    • Improvement of postischemic contractile dysfunction of dog heart by MCI-154, a novel cardiotonic agent
    • Abe, Y., Y. Kitada, A. Narimatsu and A. Tobe, 1991, Improvement of postischemic contractile dysfunction of dog heart by MCI-154, a novel cardiotonic agent, Eur. J. Pharmacol. 192, 279.
    • (1991) Eur. J. Pharmacol. , vol.192 , pp. 279
    • Abe, Y.1    Kitada, Y.2    Narimatsu, A.3    Tobe, A.4
  • 2
    • 0026741050 scopus 로고
    • Beneficial effects of MCI-154, a cardiotonic agent, on ischemic contractile failure and myocardial acidosis of dog hearts: Comparison with dobutamine, milrinone and pimobendan
    • Abe, Y., Y. Kitada and A. Narimatsu, 1992, Beneficial effects of MCI-154, a cardiotonic agent, on ischemic contractile failure and myocardial acidosis of dog hearts: comparison with dobutamine, milrinone and pimobendan, J. Pharmacol. Exp. Ther. 261, 1087.
    • (1992) J. Pharmacol. Exp. Ther. , vol.261 , pp. 1087
    • Abe, Y.1    Kitada, Y.2    Narimatsu, A.3
  • 3
    • 0027363689 scopus 로고
    • Effect of MCI-154, a cardiotonic agent, on regional contractile function and myocardial oxygen consumption in the presence and absence of coronary artery stenosis in dogs
    • Abe, Y., Y. Kitada and A. Narimatsu, 1993, Effect of MCI-154, a cardiotonic agent, on regional contractile function and myocardial oxygen consumption in the presence and absence of coronary artery stenosis in dogs, J. Pharmacol. Exp. Ther. 265, 819.
    • (1993) J. Pharmacol. Exp. Ther. , vol.265 , pp. 819
    • Abe, Y.1    Kitada, Y.2    Narimatsu, A.3
  • 4
    • 0030077546 scopus 로고    scopus 로고
    • Calcium sensitization in perfused beating guinea pig heart by a positive inotropic agent MCI-154
    • in press
    • Abe, Y., R. Ishisu, K. Onishi, K. Sekioka, A. Narimatsu and T. Nakano, 1996, Calcium sensitization in perfused beating guinea pig heart by a positive inotropic agent MCI-154, J. Pharmacol. Exp. Ther. (in press).
    • (1996) J. Pharmacol. Exp. Ther.
    • Abe, Y.1    Ishisu, R.2    Onishi, K.3    Sekioka, K.4    Narimatsu, A.5    Nakano, T.6
  • 5
    • 0025345251 scopus 로고
    • Inotropic and chonotropic profile of MCI-154: Comparisoprenalinen with isoprenalineprenaline and imazodan in guinea pig cardiac preparations
    • Allert, J.A. and H.R. Adams, 1990, Inotropic and chonotropic profile of MCI-154: comparisoprenalinen with isoprenalineprenaline and imazodan in guinea pig cardiac preparations, J. Cardiovasc. Pharmacol. 16, 59.
    • (1990) J. Cardiovasc. Pharmacol. , vol.16 , pp. 59
    • Allert, J.A.1    Adams, H.R.2
  • 6
  • 7
    • 0024333650 scopus 로고
    • Relation of positive inotropic and chonotropic effects ofpimobendan, UD-CG 212 Cl, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea pig hearts
    • Brunkhorst, D., H. Van der Leyen, W. Meyer, R. Nigbur, C. Schmidt-Schumacher and H. Scholz, 1989, Relation of positive inotropic and chonotropic effects ofpimobendan, UD-CG 212 Cl, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea pig hearts, Naunyn-Schmied. Arch. Pharmacol. 339, 575.
    • (1989) Naunyn-schmied. Arch. Pharmacol. , vol.339 , pp. 575
    • Brunkhorst, D.1    Van Leyen, H.D.2    Meyer, W.3    Nigbur, R.4    Schmidt-Schumacher, C.5    Scholz, H.6
  • 8
    • 0028226531 scopus 로고
    • Effects of a novel cardiotonic agent (±)-6-[3-(3,4-dimethoxybenzylamono)-2-hydroxypropoxy]-2(1H)-quinolinone (OPC-18790) on contractile force, cyclic AMP level, and aequorin light transients in dog ventricular myocardium
    • Endoh, M., Y. Kawabata, Y. Katano and I. Norota, 1994, Effects of a novel cardiotonic agent (±)-6-[3-(3,4-dimethoxybenzylamono)-2-hydroxypropoxy]-2(1H)-quinolinone (OPC-18790) on contractile force, cyclic AMP level, and aequorin light transients in dog ventricular myocardium, J. Cardiovasc. Pharmacol. 23, 723.
    • (1994) J. Cardiovasc. Pharmacol. , vol.23 , pp. 723
    • Endoh, M.1    Kawabata, Y.2    Katano, Y.3    Norota, I.4
  • 10
    • 0019441262 scopus 로고
    • Improved patch-clamp tequniques for high-resolution current recording from cells and cell-free membrane patches
    • Hamil, O.P., A. Marty, E. Neher, B. Sakkmann and F.J. Sigworth, 1981, Improved patch-clamp tequniques for high-resolution current recording from cells and cell-free membrane patches, Pflüg. Arch. 391, 85.
    • (1981) Pflüg. Arch. , vol.391 , pp. 85
    • Hamil, O.P.1    Marty, A.2    Neher, E.3    Sakkmann, B.4    Sigworth, F.J.5
  • 11
    • 0022492587 scopus 로고
    • Effects of OPC-8212, a new positive inotropic agent, on canine ventricular arrhythmias
    • Hashimoto, K. and H. Mitsuhashi, 1986, Effects of OPC-8212, a new positive inotropic agent, on canine ventricular arrhythmias, Br. J. Pharmacol. 88, 915.
    • (1986) Br. J. Pharmacol. , vol.88 , pp. 915
    • Hashimoto, K.1    Mitsuhashi, H.2
  • 12
    • 0020434960 scopus 로고
    • Canine-effective plasma concentrations of antiarrhythmic drugs on the two stage coronary ligation arrhythmia
    • Hashimoto, K., H. Satoh, T. Shibata and S. Imai, 1982, Canine-effective plasma concentrations of antiarrhythmic drugs on the two stage coronary ligation arrhythmia, J. Pharmacol. Exp. Ther. 223, 801.
    • (1982) J. Pharmacol. Exp. Ther. , vol.223 , pp. 801
    • Hashimoto, K.1    Satoh, H.2    Shibata, T.3    Imai, S.4
  • 13
    • 0021855145 scopus 로고
    • Canine digitalis arrhythmia as a model for detecting Na-channel blocking antiarrhythmic drugs: Comparative study using other canine arrhythmic models and the new antiarrhythmic drugs, profafenone, tocainide anf SUN-1165
    • Hashimoto, K., M. Ishii, S. Komori and H. Mitsuhashi, 1985, Canine digitalis arrhythmia as a model for detecting Na-channel blocking antiarrhythmic drugs: comparative study using other canine arrhythmic models and the new antiarrhythmic drugs, profafenone, tocainide anf SUN-1165, Heart Vessels 1, 29.
    • (1985) Heart Vessels , vol.1 , pp. 29
    • Hashimoto, K.1    Ishii, M.2    Komori, S.3    Mitsuhashi, H.4
  • 14
    • 0006518644 scopus 로고
    • Effects of milrinone on canine experimental arrhythmias
    • Hashimoto, K., A. Haruno and A. Hirasawa, 1990, Effects of milrinone on canine experimental arrhythmias, Coronary 7, 445.
    • (1990) Coronary , vol.7 , pp. 445
    • Hashimoto, K.1    Haruno, A.2    Hirasawa, A.3
  • 15
    • 0025746309 scopus 로고
    • Effects of antiarrhythmic drugs against sustained halothane-adrenaline arrhythmia models: Which electrophysiological characteristics of drugs are related to their effectiveness?
    • Hashimoto, K., A. Haruno, T. Matsuzaki, A. Sugiyama and K. Akiyama, 1991, Effects of antiarrhythmic drugs against sustained halothane-adrenaline arrhythmia models: which electrophysiological characteristics of drugs are related to their effectiveness?, Cardiovasc. Drugs Ther. 5, 805.
    • (1991) Cardiovasc. Drugs Ther. , vol.5 , pp. 805
    • Hashimoto, K.1    Haruno, A.2    Matsuzaki, T.3    Sugiyama, A.4    Akiyama, K.5
  • 17
    • 0027380163 scopus 로고
    • Effects of a new folskolin derivative, NKH477, on canine ventricular arrhythmia models
    • Hirasawa, A., T. Awaji, M. Hosono, A. Haruno and K. Hashimoto, 1993, Effects of a new folskolin derivative, NKH477, on canine ventricular arrhythmia models, J. Cardiovasc. Pharmacol. 22, 847.
    • (1993) J. Cardiovasc. Pharmacol. , vol.22 , pp. 847
    • Hirasawa, A.1    Awaji, T.2    Hosono, M.3    Haruno, A.4    Hashimoto, K.5
  • 19
    • 0023622768 scopus 로고
    • Cardiac and coronary vasodilator effects of the novel cardiotonic agent, MCI-154, assessed in isoprenalinelated, blood-perfused dog heart preparations
    • Hosono, M. and N. Taira, 1987, Cardiac and coronary vasodilator effects of the novel cardiotonic agent, MCI-154, assessed in isoprenalinelated, blood-perfused dog heart preparations, J. Cardiovasc. Pharmacol. 10, 692.
    • (1987) J. Cardiovasc. Pharmacol. , vol.10 , pp. 692
    • Hosono, M.1    Taira, N.2
  • 20
    • 34547383713 scopus 로고
    • Preparation of iodine-131 labelled human growth hormone of high specific activity
    • Hunter, W.M. and F.C. Greenwood, 1962, Preparation of iodine-131 labelled human growth hormone of high specific activity, Nature 194, 495.
    • (1962) Nature , vol.194 , pp. 495
    • Hunter, W.M.1    Greenwood, F.C.2
  • 21
    • 0023101566 scopus 로고
    • Membrane current changes responsible for the positive inotropic effect of OPC-8212, a new positive inotropic agent, in single ventricular cells of the guinea pig heart
    • Iijima, T. and N. Taira, 1987, Membrane current changes responsible for the positive inotropic effect of OPC-8212, a new positive inotropic agent, in single ventricular cells of the guinea pig heart, J. Pharmacol. Exp. Ther. 240, 657.
    • (1987) J. Pharmacol. Exp. Ther. , vol.240 , pp. 657
    • Iijima, T.1    Taira, N.2
  • 22
    • 0026714944 scopus 로고
    • Preparation of the enantiomers of the novel Ca-sensitizer EMD 53998
    • Jonas, R., M. Klockow and I. Lues, 1992, Preparation of the enantiomers of the novel Ca-sensitizer EMD 53998, Bioorg. Med. Chem. Lett. 2, 589.
    • (1992) Bioorg. Med. Chem. Lett. , vol.2 , pp. 589
    • Jonas, R.1    Klockow, M.2    Lues, I.3
  • 23
    • 0041958499 scopus 로고
    • Effects of pimobendan on contraction and calcium currents in canine single ventricular cells
    • Kanai, K., Y. Momose, K. Ogino and T. Hayashi, 1994, Effects of pimobendan on contraction and calcium currents in canine single ventricular cells, Can. J. Physiol. Pharmacol. 72 (Suppl. 1), 98.
    • (1994) Can. J. Physiol. Pharmacol. , vol.72 , Issue.1 SUPPL. , pp. 98
    • Kanai, K.1    Momose, Y.2    Ogino, K.3    Hayashi, T.4
  • 24
    • 0023202842 scopus 로고
    • Changes in membrane potentials and currents of ventricular cells of the guinea pig heart by a new cardiotonic drug, MCI-154
    • Katayama, S., A. Narimatsu, R. Suzuki, T. lijima and N. Taira, 1987, Changes in membrane potentials and currents of ventricular cells of the guinea pig heart by a new cardiotonic drug, MCI-154, Jpn. J. Pharmacol. 44, 481.
    • (1987) Jpn. J. Pharmacol. , vol.44 , pp. 481
    • Katayama, S.1    Narimatsu, A.2    Suzuki, R.3    Lijima, T.4    Taira, N.5
  • 26
    • 0023145072 scopus 로고
    • Contractile proteins: Possible targets for the cardiotonic action of MCI-154, a novel cardiotonic agent?
    • Kitada, Y., A. Narimatsu, N. Matsumura and M. Endo, 1987a, Contractile proteins: possible targets for the cardiotonic action of MCI-154, a novel cardiotonic agent?, Eur. J. Pharmacol. 134, 229.
    • (1987) Eur. J. Pharmacol. , vol.134 , pp. 229
    • Kitada, Y.1    Narimatsu, A.2    Matsumura, N.3    Endo, M.4
  • 27
    • 0023502557 scopus 로고
    • 2+ sensitivity of the contractile system by MCI-154, a novel cardiotonic agent, in chemically skinned fibers from the guinea pig papillaly muscles
    • 2+ sensitivity of the contractile system by MCI-154, a novel cardiotonic agent, in chemically skinned fibers from the guinea pig papillaly muscles, J. Pharmacol. Exp. Ther. 243, 633.
    • (1987) J. Pharmacol. Exp. Ther. , vol.243 , pp. 633
    • Kitada, Y.1    Narimatsu, A.2    Matsumura, N.3    Endo, M.4
  • 28
    • 0023612740 scopus 로고
    • Dose the positive inotropic action of a novel cardiotonic agent, MCI-154, involve mechanisms other than cyclic AMP?
    • Kitada, Y., A. Narimatsu, R. Suzuki, M. Endoh and N. Taira, 1987c, Dose the positive inotropic action of a novel cardiotonic agent, MCI-154, involve mechanisms other than cyclic AMP?, J. Pharmacol. Exp. Ther. 243, 639.
    • (1987) J. Pharmacol. Exp. Ther. , vol.243 , pp. 639
    • Kitada, Y.1    Narimatsu, A.2    Suzuki, R.3    Endoh, M.4    Taira, N.5
  • 31
    • 4243250280 scopus 로고
    • Positive inotropic agents that augment Ca sensitivity and inhibit phosphodiesterase III
    • Kitada, Y., Y. Abe and A. Narimatsu, 1991, Positive inotropic agents that augment Ca sensitivity and inhibit phosphodiesterase III, Jpn. J. Pharmacol. 55 (Suppl.), 44.
    • (1991) Jpn. J. Pharmacol. , vol.55 , Issue.SUPPL. , pp. 44
    • Kitada, Y.1    Abe, Y.2    Narimatsu, A.3
  • 32
    • 0027931027 scopus 로고
    • 2+-regulated interactions between troponin subunits from bovine heart
    • 2+-regulated interactions between troponin subunits from bovine heart, J. Pharmacol. Exp. Ther. 270, 831.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 831
    • Liao, R.1    Gwathmey, J.K.2
  • 33
    • 0023787111 scopus 로고
    • Effects of pimobendan (UD-CG 115 BS), a new positive inotropic agent, on ventricular tachycardia and ischemic ventricular fibrillation in a conscious canine model of recent myocardial infarction
    • Lynch, J.J., J.M. Kitzen, P.T. Hoff and B.R. Lucchesi, 1988, Effects of pimobendan (UD-CG 115 BS), a new positive inotropic agent, on ventricular tachycardia and ischemic ventricular fibrillation in a conscious canine model of recent myocardial infarction, J. Cardiovasc. Pharmacol. 12, 547.
    • (1988) J. Cardiovasc. Pharmacol. , vol.12 , pp. 547
    • Lynch, J.J.1    Kitzen, J.M.2    Hoff, P.T.3    Lucchesi, B.R.4
  • 34
    • 0024460406 scopus 로고
    • Effects of the positive inotropic agents milrinone and pimobendan on the development of lethal ischemic arrhythmias in conscious dogs with recent myocardial infarction
    • Lynch, J.J., A.C.G. Uprichard, J.W. Frye, E.M. Driscoll, J.M. Kitzen and B.R. Lucchesi, 1989, Effects of the positive inotropic agents milrinone and pimobendan on the development of lethal ischemic arrhythmias in conscious dogs with recent myocardial infarction, J. Cardiovasc. Pharmacol. 14, 585.
    • (1989) J. Cardiovasc. Pharmacol. , vol.14 , pp. 585
    • Lynch, J.J.1    Uprichard, A.C.G.2    Frye, J.W.3    Driscoll, E.M.4    Kitzen, J.M.5    Lucchesi, B.R.6
  • 35
    • 0025008034 scopus 로고
    • Effect of OPC-8490 on the membrane potentials and membrane currents of single guinea-pig myocytes
    • Momose, Y. and S. Sasayama, 1990, Effect of OPC-8490 on the membrane potentials and membrane currents of single guinea-pig myocytes, Cardiovasc. Drugs Ther. 4, 713.
    • (1990) Cardiovasc. Drugs Ther. , vol.4 , pp. 713
    • Momose, Y.1    Sasayama, S.2
  • 36
    • 0023122035 scopus 로고
    • Cardiovascular pharmacology of 6-[4-(4′-pyridil)aminophenyl]-4,5-dihydro-3(2H)-pyridazinone hydrochloride, a novel and potent cardiotonic agent with vasodilator properties
    • Narimatsu, A., Y. Kitada, N. Satoh, R. Suzuki and H. Okushima, 1987, Cardiovascular pharmacology of 6-[4-(4′-pyridil)aminophenyl]-4,5-dihydro-3(2H)-pyridazinone hydrochloride, a novel and potent cardiotonic agent with vasodilator properties, Arzneim.-Forsch./Drug Res. 37, 398.
    • (1987) Arzneim.-Forsch./Drug Res. , vol.37 , pp. 398
    • Narimatsu, A.1    Kitada, Y.2    Satoh, N.3    Suzuki, R.4    Okushima, H.5
  • 38
    • 0021687326 scopus 로고
    • Effect on contractility of skinned fibers from mammalian heart and smooth muscle by a new benzimidazole derivative, 4,5-dihydro-6-[2-(4-methoxy-phenyl)-1H-benzimidazole-5-yl]-5-methyi-3(2H)- pyriclazinone
    • Ruegg, J.C., G. Pfitzer, D. Eubler and C. Zeugner, 1984, Effect on contractility of skinned fibers from mammalian heart and smooth muscle by a new benzimidazole derivative, 4,5-dihydro-6-[2-(4-methoxy-phenyl)-1H-benzimidazole-5-yl]-5-methyi-3(2H)- pyriclazinone, Arzneim.-Forsch./Drug Res. 34, 1736.
    • (1984) Arzneim.-Forsch./Drug Res. , vol.34 , pp. 1736
    • Ruegg, J.C.1    Pfitzer, G.2    Eubler, D.3    Zeugner, C.4
  • 39
    • 0041457110 scopus 로고
    • Effects of MCI-154, novel cardiotonic agent, on mean circulatory filling pressure in anesthetized dogs
    • Satoh, N., Y. Abe, Y. Kitada, A. Narimatsu and A. Tobe, 1988, Effects of MCI-154, novel cardiotonic agent, on mean circulatory filling pressure in anesthetized dogs, Eur. J. Pharmacol. 47, 189.
    • (1988) Eur. J. Pharmacol. , vol.47 , pp. 189
    • Satoh, N.1    Abe, Y.2    Kitada, Y.3    Narimatsu, A.4    Tobe, A.5
  • 40
    • 0027493823 scopus 로고
    • Positive chonotropic and inotropic responses to novel cardiotonics, NKH 477 and MCI-154 in isoprenalinelated, perfused canine heart preparations
    • Sawaki, S., Y. Furukawa, Y. Inoue, S. Takayama and S. Chiba, 1993, Positive chonotropic and inotropic responses to novel cardiotonics, NKH 477 and MCI-154 in isoprenalinelated, perfused canine heart preparations, Asia Pacific J. Pharmacol. 8, 133.
    • (1993) Asia Pacific J. Pharmacol. , vol.8 , pp. 133
    • Sawaki, S.1    Furukawa, Y.2    Inoue, Y.3    Takayama, S.4    Chiba, S.5
  • 41
    • 0020530852 scopus 로고
    • Effective plasma concentrations of antiarrhythmic drugs against sustained halothane-adrenaline arrhythmia in dog
    • Shibuya, T., K. Hashimoto and S. Imai, 1983, Effective plasma concentrations of antiarrhythmic drugs against sustained halothane-adrenaline arrhythmia in dog, J. Cardiovasc. Pharmacol. 5, 538.
    • (1983) J. Cardiovasc. Pharmacol. , vol.5 , pp. 538
    • Shibuya, T.1    Hashimoto, K.2    Imai, S.3
  • 42
    • 0041958494 scopus 로고
    • OPC-18790, a quinolinone-derivative positive inotropic agent, inhibits potassium currents in guinea-pig ventricular myocytes
    • Takase, H., T. Mori, K. Sekiguchi and T. lijima, 1994, OPC-18790, a quinolinone-derivative positive inotropic agent, inhibits potassium currents in guinea-pig ventricular myocytes, Jpn. J. Pharmacol. 64 (Suppl. 1), 102.
    • (1994) Jpn. J. Pharmacol. , vol.64 , Issue.1 SUPPL. , pp. 102
    • Takase, H.1    Mori, T.2    Sekiguchi, K.3    Lijima, T.4
  • 43
    • 0026515374 scopus 로고
    • Electrophysiological actions of the pimobendan metabolite, UD-CG 212 Cl, in guinea pig myocardium
    • Westfall, M.V., G.M. Wahler, K. Fujino and R.J. Solaro, 1992, Electrophysiological actions of the pimobendan metabolite, UD-CG 212 Cl, in guinea pig myocardium, J. Pharmacol. Exp. Ther. 260, 58.
    • (1992) J. Pharmacol. Exp. Ther. , vol.260 , pp. 58
    • Westfall, M.V.1    Wahler, G.M.2    Fujino, K.3    Solaro, R.J.4
  • 44
    • 0027372246 scopus 로고
    • Effects of OPC-18790, a new positive inotropic agent, on canine ventricular arrhythmias
    • Wu, Z., T. Awaji, H. Abe, S. Motomura and K. Hashimoto, 1993, Effects of OPC-18790, a new positive inotropic agent, on canine ventricular arrhythmias, Jpn. J. Pharmacol. 63, 399.
    • (1993) Jpn. J. Pharmacol. , vol.63 , pp. 399
    • Wu, Z.1    Awaji, T.2    Abe, H.3    Motomura, S.4    Hashimoto, K.5


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