IL-2 signaling in human monocytes involves the phosphorylation and activation of p59(hck)

Journal of Immunology

Volumn 164, Issue 9, 2000, Pages 4575-4585

  Bosco, Maria C ^a   Curiel, Rafael E ^b   Zea, Arnold H ^b   Malabarba, Maria G ^c   Ortaldo, John R ^c   Espinoza Delgado, Igor ^b  

^a G GASLINI INSTITUTE   (Italy)

^b LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HERBIMYCIN A; INTERLEUKIN 2; PROTEIN TYROSINE KINASE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; MONOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0034192105     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.9.4575     Document Type: Article

References (61)

1. Miyazaki, T., Z. J. Liu, A. Kawahara, Y. Minami, K. Yamada, Y. Tsujimoto, E. L .Barsoumian, R. M. Permutter, and T. Taniguchi. 1995. Three distinct IL-2 signaling pathways mediated by Bcl-2, c-Myc, and Lck cooperate in hematopoietic cell proliferation. Cell 81:223.
2. Minami, Y., and T. Taniguchi. 1995. IL-2 signaling: recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor. Curr. Opin. Cell Biol. 7:156.
3. Johnston, J. A., C. M. Bacon, M. C. Riedy, and J. J. O'Shea. 1996. Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency. J. Leukocyte Biol. 60:441.
4. Kirken, R. A., M. G. Malabarba, J. Xu, L. DaSilva, R. A. Erwin, Liu, L. Hennighausen, H. Rui, and W. L. Farrar. 1997. Two discrete regions of interleukin-2 (IL2) receptor β independently mediate IL2 activation of a PD98059/ rapamycin/wortmannin-insensitive Stat5a/b serine kinase. J. Biol. Chem. 272: 15459.
5. lck: identification of novel intermolecular association. Science 252:1523.
6. lck. Proc. Natl. Acad. Sci. USA 88:1996.
7. Minami, Y., Y. Nakagawa, A. Kawahara, T. Miyazaki, K. Sada, H. Yamamura, and T. Taniguchi. 1995. Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myr induction pathway. Immunity 2:89.
8. Miyazaki, T., A. Kawahara, H. Fujii, Y. Nakagawa, Y. Minami, Z. Liu, I. Oishi, O. Silvennoinen, B. Witthuhn, J. Ihle, et al. 1994. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 266:1045.
9. Witthuhn, B., O. Silvennoinen, O. Miura, K. Lai, C. Cwik, E. Liu, and J. Ihle. 1994. Involvement of the Jak3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153.
10. Johnston, J., M. Kawamura, T. Kirken, Y. Chen, T. Blake, K. Shibuta, J. Ortaldo, D. McVicar, and J. O'Shea. 1994. Phosphorylation and activation of the Jak3 Janus kinase in response to interleukin 2. Nature 370:151.
11. c chains with JAK1 and JAK3: implications for XSCID and XCID. Science 266:1042.
12. lck. EMBO J. 12:759.
13. Waldmann, T. A., C. K. Goldman, R. J. Robb, J. M. Depper, W. J. Leonard, S. O. Sharrow, K. F. Bongiovanni, S. J. Korsmeyer, and W. C. Greene. 1984. Expression of interleukin 2 receptors on activated human B cells. J. Exp. Med. 160:1450.
14. Longo, D. L., E. P. Gelmann, J. Cossman, R. A. Young, R. C. Gallo, S. J. O'Brien, and L. A. Matis. 1984. Isolation of HTLV-transformed B-lymphocyte clone from a patient with HTLV-associated adult T-cell leukaemia. Nature 310: 505.
15. Muraguchi, A., J. H. Kehrl, D. L. Longo, D. J. Volkman, K. A. Smith, and A. S. Fauci. 1985. Interleukin 2 receptors on human B cells: implications for the role of interleukin 2 in human B cell function. J. Exp. Med 161:181.
16. Wei, S., D. K. Blanchard, J. H. Liu, W. J. Leonard, and J. Y. Djeu. 1993. Activation of tumor necrosis factor-α production from human neutrophils by IL-2 via IL-2-Rβ. J. Immunol. 150:1979.
17. Rand, T. H., D. S. Silberstein, H. Kornfeld, and P. F. Weller. 1991. Human eosinophils express functional interleukin 2 receptors. J. Clin. Invest. 88:825.
18. Ohashi, Y., T. Takeshita, K. Nagata, S. Mori, and K. Sugamura. 1989. Differential expression of the 1L-2 receptor subunits, p55 and p75 on various populations of primary peripheral blood mononuclear cells. J. Immunol. 143:3548.
19. Espinoza-Delgado, I., J. R. Ortaldo, R. Winkler-Pickett, K. Sugamura. L. Varesio, and D.L. Longo. 1990. Expression and role of p75 interleukin 2 receptor on human monocytes. J. Exp. Med. 171:1821.
20. Wahl, S. M., N. McCartney-Francis, D. A. Hunt, P. D. Smith, L. M. Wahl, and I. M. Katona. 1987. Monocyte interleukin 2 receptor gene expression and interleukin 2 augmentation of microbicidal activity. J. Immunol. 139:1342.
21. Espinoza-Delgado, I., D. L. Longo, G. L. Gusella, and L. Varesio. 1992. Regulation of IL-2 receptor subunit genes in human monocytes: differential effects of IL-2 and IFN-γ. J. Immunol. 149:2961.
22. Bosco, M. C., S. Rottschafer, L. S. Taylor, J. R. Ortaldo, D. L. Longo, and I. Espinoza-Delgado. 1997. The antineoplastic agent bryostatin-1 induces proinflammatory cytokine production in human monocytes: synergy with interleukin-2 and modulation of interleukin-2Rγ chain expression. Blood 89:3402.
23. Kovacs, E. J., B. Brock, L. Varesio, and H. A. Young. 1989. IL-2 induction of IL-1β mRNA expression in monocytes: regulation by agents that block second messenger pathways. J. Immunol. 143:3532.
24. Strieter, R. M., D. G. Remick, J. P. Lynch, R. N. Spengler, and S. L. Kunkel. 1989. Interleukin-2-induced tumor necrosis factor-α (TNF-α) gene expression in human alveolar macrophages and blood monocytes. Am. Rev. Respir. Dis. 139: 335.
25. Musso, T., I. Espinoza-Delgado, K. Pulkki, G. L. Gusella, D. L. Longo, and L. Varesio. 1992. IL-2 induces IL-6 production in human monocytes. J. Immunol. 148:795.
26. Gusella, G. L., T. Musso, M. C. Bosco, I. Espinoza-Delgado, K. Matsushima, and L. Varesio. 1993. IL-2 up-regulates but IFN-γ suppresses IL-8 expression in human monocytes. J. Immunol. 151:2725.
27. Stankova, J., G. Dupuis, N. Gagnon, M. Thivierge, S. Turcotte, and M. Rola-Pleszczynski. 1993. Priming of human monocytes with leukotriene B4 enhances their sensitivity in IL-2-driven tumor necrosis factor-α production: transcriptional and post-transcriptional up-regulation of IL-2 receptors. J. Immunol. 150:4041.
28. Epling-Burnette, P. K., S. Wei, D. K. Blanchard, E. Spranzi, and J. Y. Djeu. 1993. Coinduction of granulocyte-macrophage colony-stimulating factor release and lymphokine-activated killer cell susceptibility in monocytes by interleukin-2 via interleukin-2 receptor β. Blood 81:3130.
29. Misago, M., J. Tsukada, R. Ogawa, M. Kikuchi, T. Hanamura, S. Chiba, S. Oda, I. Morimoto, and S. Eto. 1993. Enhancing effects of IL-2 on M-CSF production by human peripheral blood monocytes. Int. J. Hematol. 58:43.
30. Brach, M. A., C. Arnold, M. Kiehntopf, H. J. Gruss, and F, Hermann. 1993. Transcriptional activation of the macrophage colony-stimulating factor gene by IL-2 is associated with secretion of bioactive macrophage colony-stimulating factor protein by monocytes and involves activation of the transcription factor NF-κB. J. Immunol. 150:5535.
31. Remick, D. G., J. W. Larrick, D. T. Nguyen, and S. L. Kunkel. 1987. Stimulation of prostaglandin E2 and thromboxane B2 production by human monocytes in response to inlerleukin-2. Biochem. Biophys. Res. Commun. 147:86.
32. Galligioni, E., M. Quaia, A. Spada, D. Favaro, M. Santarosa, R. Talamini, and S. Monfardini. 1993. Activation of cytolytic activity in peripheral blood monocytes of renal cancer patients against non-cultured autologous tumor cells. Int. J. Cancer 55:380.
33. Bosco, M. C., K. Pulkki, T. K. Rowe, A. H. Zea, T. Musso, D. L. Longo, L. Varesio, and I. Espinoza-Delgado. 1995. IL-4 inhibits IL-2-induced tumoricidal activity and secretory functions of human monocytes: modulation of IL-2 binding and IL-2 receptor βγ chain expression. J. Immunol. 155:1411.
34. Bosco, M. C., I. Espinoza-Delgado, M. Schwabe, G. L. Gusella, D. L. Longo, K. Sugamura, and L. Varesio. 1994. Regulation by interleukin-2 (IL-2) and interferon γ of IL-2 receptor y chain gene expression in human monocytes. Blood 83:2995.
35. Bosco, M. C., I. Espinoza-Delgado, M. Schwabe, S. M. Russell, W. J. Leonard, D. L. Longo, and L. Varesio. 1994. The γ subunit of the interleukin-2 receptor is expressed in human monocytes and modulated by interleukin-2. interferon γ, and transforming growth factor β1. Blood 83:3462.
36. Holter, W., R. Grunow, H. Stockinger, and W. Knapp. 1986. Recombinant interferon-γ induces interleukin 2 receptors on human peripheral blood monocytes. J. Immunol. 136:2171.
37. Holter, W., C. K. Goldman, L. Casabo, D. L. Nelson, W. C. Greene, and T. A. Waldmann. 1987. Expression of functional IL 2 receptors by lipopolysaccharide and interferon-γ stimulated human monocytes. J. Immunol. 138 :2917.
38. Musso, T., L. Varesio, X. Zhang, T. K. Rowe, P. Ferrara, J. R. Ortaldo, J. J. O'Shea, and D. W. McVicar. 1994. IL-4 and IL-13 induce Lsk, a Csk-like tyrosine kinase, in human monocytes. J. Exp. Med. 180:2383.
39. Musso, T., J. A. Johnston, D. Linnekin, L. Varesio, T. K. Rowe, J. J. O'Shea, and D. W. McVicar. 1995. Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7. J. Exp. Med. 181:1425.
40. syk, and paxillin during receptor-mediated phagocytosis in macrophages. J. Biol. Chem. 269:3897.
41. Ghazizadeh, S., and H. Fleit. 1994. Tyrosine phosphorylation provides an obligatory early signal for FcγRII mediated endocytosis in the monocytic cell THP-1. J. Immunol. 152:30.
42. Ziegler, S. F., C. B. Wilson, and R. M. Perlmutter. 1988. Augmented expression of a myeloid-specific protein tyrosine kinase gene (hck) after macrophage activation. J. Exp. Med. 168:1801.
43. Boulet, I., S. Ralph, E. Stanley, P. Lock, A. Dunn, S. Green, and W. Phillips. 1994. Lipopolysaccharide and interferon-γ induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages. Oncogene 7:703.
44. Villa, A., M. Siren, P. Macchi, C. Matteucci, L. D. Notarangelo, P. Vezzoni, and A. Mantuvani. 1996. Monocyte function in a severe combined immunodeficient patient with a donor splice site mutation in the Jak3 gene. Blood 88:817.
45. Stevenson, H. C. 1984. Isolation of human mononuclear leukocyte subsets by countercurrent centrifugal elutriation. Methods Enzymol. 108:242.
46. Sehgal, P. B., L. T. May, I. Tamm, and J. Vilcek. 1987. Human β2 interferon and B-cell differentiation factor BSF-2 are identical Science 235:731.
47. Uehara, Y., and H. Fukazawa. 1991. Use and selectivity of herbimycin A as inhibitor of protein-tyrosine kinases. Methods Enzymol. 201:370.
48. Mustelin, T., K. M. Coggeshall, N. Isakov, and A. Altman. 1990. T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation. Science 247:1584.
49. Espinoza-Delgado, I., M. C. Bosco, T. Musso, G. Gusella, D. L. Longo, and L. Varesio. 1995. Interleukin 2 and human monocyte activation. J. Leukocyte Biol. 57:1995.
50. Bosco, M. C., I. Espinoza-Delgado, T. K. Rowe, M. G. Malabarba, D. L. Longo, and L. Varesio. 1997. Functional role for the myeloid differentiation antigen CD14 in the activation of human monocytes by IL-2. J. Immunol. 159:2922.
51. Gadina, M., L. M. Stancato, C. M. Bacon, A. C. Lamer, and J. J. O'Shea. 1998. Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role. J. Immunol. 160:4657.
52. Eiseman, E., and J. B. Bolen. 1990. src-related tyrosine protein kinases as signaling components in hematopoietic cells [published erratum appears in 1990, Cancer Cells 2:405]. Cancer Cell 2:303.
53. June, C. H., M. C. Fletcher, J. A. Ledbetter, G. L. Schieven, J. N. Siegel, A. F. Phillips, and L. E. Samelson. 1990. Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction. Proc. Natl. Acad. Sci. USA 87:7722.
54. Uehara, Y., H. Fukazawa, Y. Murakami, and S. Mizuno. 1989. Irreversible inhibition of v-src tyrosine kinase activity by herbimycin A and its abrogation by sulfhydryl compounds. Biochem. Biophys. Res. Commun. 163:803.
55. lck. Proc. Natl. Acad. Sci. USA 89:2789.
56. O'Shea, J. J., D, W. McVicar, D. B. Kuhns, and J. R. Ortaldo. 1992. A role for protein tyrosine kinase activity in natural cytotoxicity as well as antibody-dependent cellular cytotoxicity: effects of herbimycin A. J. Immunol. 148:2497.
57. ras. Eur. J. Immunol. 23:131.
58. Shapira, L., S. Takashiba, C. Champagne, S. Amar, D. Van Dyke, and T. E. 1994. Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide-induced TNF-α and IL-1β production by human monocytes. J. Immunol. 153:1818.
59. Saltzman, E. M., R. R. Thom, and J. E. Casnellie. 1988. Activation of a tyrosine protein kinase is an early event in the stimulation of T lymphocytes by interleu-kin-2. J. Biol. Chem. 263:6956.
60. Torigoe, T., H. Saragovi, and J. Reed. 1992. Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line. Proc. Natl. Acad. Sci. USA 89:2674.
61. lyn with the interleukin 2 receptor: implications for redundancy and pleotropism in cytokine signal transduction. Proc. Natl. Acad. Sci. USA 90:4201.