Methodological aspects for in vitro characterization of receptor binding using 11C-labeled receptor ligands: A detailed study with the benzodiazepine receptor antagonist [11C]Ro 15-1788

Nuclear Medicine and Biology

Volumn 24, Issue 8, 1997, Pages 723-731

  Sihver, Wiebke ^b   Sihver, Sven ^b   Bergström, Mats ^a,b   Murata, Tetsuhito ^d   Matsumura, Kiyoshi ^c   Onoe, Hirotaka ^c   Andersson, Yvonne ^a   Bjurling, Peter ^a   Fasth, Karl Johan ^a   Westerberg, Göran ^a   Ögren, Matthias ^a   Jacobsson, Gunilla ^a   Lundqvist, Hans ^a   Oreland, Lars ^b   Watanabe, Yasuyoshi ^b,c   Långström, Bengt ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c OSAKA BIOSCIENCE INSTITUTE   (Japan)

^d Uppsala University PET Centre ^*

Author keywords

11C Ro 15 1788; In vitro receptor binding; Phosphor imaging; Positron emission tomography; Short lived nuclides

Indexed keywords

CARBON 11; FLUMAZENIL;

ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; DRUG RECEPTOR BINDING; ISOTOPE LABELING; ISOTOPE TRACING; LIGAND BINDING; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT;

ANIMALS; CARBON RADIOISOTOPES; FLUMAZENIL; GABA MODULATORS; LIGANDS; MALE; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0030695929     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(97)00113-3     Document Type: Article

References (33)

1. 3H]Ro 15-1788) in the mouse brain: Preferential affinity of zolpidem for the ω1 (BZD1) subtype. J. Pharmacol. Exp. Ther. 245, 1033-1041.
2. Bonetti E. P., Pieri L., Cumin R., Schaffner R., Pieri M., Gamzu E. R., Müller R. K. M. and Haefely W. (1992) Benzodiazepine antagonist Ro 15-1788: Neurological and behavioral effects. Psychopharmacology 78, 8-18.
3. 3H]diazepam. Proc. Natl. Acad. Sci. USA 74, 3805-3809.
4. 3H]Ro 15-1788 binding to membrane-bound rat brain benzodiazepine receptors. J. Neurochem. 42, 918-923.
5. 11C-labeled benzodiazepine analogue. Neurosci. Lett. 85, 304-310.
6. 3H]Ro 15-1788 in mice. Psychopharmacology 92, 8-13.
7. 11C with double-tracer applications. Int. J. Appl. Radiat. Isot. 35, 129-134.
8. 11C]flumazenil, and a single experiment protocol. J. Cereb. Blood Flow Metab. 15, 284-300.
9. 11C)-methionine in the multicellular spheroid system. J. Nucl. Med. 32, 2258-2265.
10. 3H]Ro 15-1788. Life Sci. 37, 345-355.
11. 3H]sarmazenil in post-mortem human brain. Hum. Psychopharmacol. 7, 367-377.
12. Hansen T. D., Warner D. S., Todd M. M., Baker M. T. and Jensen N. F. (1991) The influence of inhalational anesthetics on in vivo and in vitro benzodiazepine receptor binding in the rat cerebral cortex. Anesthesiology 74, 97-104.
13. Hantraye P., Kalhma M., Prenant C., Guibert B., Sastre J., Crouzei M., Naquet R., Comat D. and Maziere M. (1984) Central type benzodiazepine binding sites: A positron emission tomography study in the baboon's brain. Neurosci. Lett. 48, 115-120.
14. Hulme E. C. and Birdsall N. J. M. (1993) Strategy and tactics in receptor binding studies. In Receptor-Ligand Interaction: A Practical Approach (Edited by Hulme E. C.), pp. 63-176. Oxford University Press, Oxford.
15. Johnston R. F., Pickett S. C. and Barker D. L. (1990) Autoradiography using storage phosphor technology. Electrophoresis 11, 355-360.
16. Komiskey H. L. and MacFarlan M. F. (1983) Aging: Effect on neuronal and non-neuronal benzodiazepine binding sites. Neurochem. Res. 8, 1135-1141.
17. Matsumura K., Bergström M, Onoe H., Takechi H., Westerberg G., Antoni G., Bjurling P., Jacobson G. B., Långström B. and Watanabe Y. (1995). In vitro positron emission tomography (PET): Use of positron emission tracers in functional imaging in living brain slices. Neurosci. Res. 22, 219-229.
18. 11C]flunitrazepam, deux coordinats pour l'etude par tomography par positions des sites de liaison des benzodiazepines. C. R. Acad. Sci. 296, 871-876.
19. Möhler H. (1982) Benzodiazepine receptors: Differential interaction of henzodiazepine agonists and antagonists after photoaffinity labeling with flunitrazepam. Eur. J. Pharmacol. 80, 435-436.
20. Möhler H., Burkard W. P., Keller H. H., Richards J. G. and Haefely W. (1981) Benzodiazepine antagonist Ro 15-1788: Binding characteristics and interaction with drug-induced changes in dopamine turnover and cerebellar cGMP levels. J. Neurochem. 37, 714-722.
21. Möhler H. and Okada T. (1977) Benzodiazepine receptor: Demonstration in the central nervous system. Science 198, 849-851.
22. Möhler H. and Richards J. G. (1981) Agonist and antagonist benzodiazepine receptor interaction in vitro. Nature 294, 763-765.
23. 11C-labeled Ro 15-1788 binding to benzodiazepine receptors in the human brain by positron emission tomography. J. Psychiatr. Res. 19, 609-622.
24. Pickett S. (1995). Molecular Dynamics Technical Note 55. Molecular Dynamics, Sunnyvale, CA.
25. 11C]physostigmine. Neuroimage 1, 173-180.
26. Richards J. G., Möhler H. and Haefely W. (1982) Benzodiazepine binding sites: Receptors or acceptors? Trends Pharmacol. Sci. 3, 233-235.
27. Richards J. G. and Möhler H. (1984) Benzodiazepine receptors. Neuropharmacology 23, 233-242.
28. 3H]flumazenil binding in different regions of the rat central nervous system. Psychopharmacology 111, 315-322.
29. Smith P. K., Krohn R. I., Hermanson G. T., Mallia A. K., Gartner F. H., Provenzano M. D., Fujimoto E. K., Goeke N. M., Olson B. J. and Klenk D. C. (1985) Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85.
30. Speth R. C., Johnson R. W., Regan J., Reisine T., Kobayashy R. M., Bresolin N., Roeske W. R. and Yamamura H. I. (1980) The benzodiazepine receptor of mammalian brain. Fed. Proc. 39, 3032-3038.
31. Tallman J. F., Paul S. M., Skolnick P. and Gallager D. W. (1980). Receptors for the age of anxiety: Pharmacology of the benzodiazepines. Science 207, 274-281.
32. Whiting B. R., Owen J. F. and Rubin B. H. (1988). Storage phosphor X-ray diffraction detectors. Nucl. Instr. Meth. Phys. Res. 266, 628-635.
33. 3H-labeled ligands visualized by imaging plates. Neuroreport 3, 961-964.