Accelerated atherosclerosis in C57B1/6 mice transplanted with ApoE-deficient bone marrow

Atherosclerosis

Volumn 150, Issue 1, 2000, Pages 71-80

  Van Eck, Miranda ^a   Herijgers, Nicole ^a   Vidgeon Hart, Martin ^b   Pearce, Nigel J ^b   Hoogerbrugge, Peter M ^c   Groot, Pieter H E ^b   Van Berkel, Theo J C ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b GLAXOSMITHKLINE   (United Kingdom)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apolipoprotein E; Atherosclerosis; Bone marrow transplantation; Lipoproteins; Macrophages

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; CHOLESTEROL ESTER; TRIACYLGLYCEROL;

ANIMAL; AORTA; ARTERIOSCLEROSIS; ARTICLE; BLOOD; BONE MARROW TRANSPLANTATION; C57BL MOUSE; CHOLESTEROL INTAKE; FEMALE; HISTOCOMPATIBILITY; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; METABOLISM; MOUSE; PATHOLOGY;

ANIMALS; AORTA; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; BONE MARROW TRANSPLANTATION; CHOLESTEROL; CHOLESTEROL ESTERS; CHOLESTEROL, DIETARY; FEMALE; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; TRANSPLANTATION CHIMERA; TRIGLYCERIDES;

EID: 0034181351     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(99)00372-X     Document Type: Article

References (45)

1. Stary HC, Chandler AB, Glagov S, Guyton JR, Insull W Jr, Rosenfeld ME, et al. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis - a report from the committee on vascular lesions of the council on atherosclerosis, American Heart Association. Circulation 1994;89:2462-78.
2. Rosenfeld ME, Butler S, Ord VA, Lipton BA, Dyer CA, Curtiss LK, et al. Abundant expression of apoprotein E by macrophages in human and rabbit atherosclerotic lesions. Arterioscler Thromb 1993;13:1382-9.
3. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988;240:622-30.
4. Moestrup SK. The α2-macroglobulin receptor and epithelial glycoprotein-330: two giant receptors mediating endocytosis of multiple ligands. Biochim Biophys Acta 1994;1197:197-213.
5. Krieger M, Herz J. Structures and functions of multiligand receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem 1994;62:601-37.
6. Williams DL, Dawson PA, Newman TC, Rudel LL. Synthesis of apolipoprotein E by peripheral tissues. Potential functions in reverse cholesterol transport and cellular cholesterol metabolism. Ann NY Acad Sci 1985;454:222-9.
7. Lin C-T, Xu J-J, Chan L. Immunoreactive apolipoprotein E is a widely distributed cellular protein. Immunolocalisation of apolipoprotein E in baboon tissues. J Clin Invest 1986;78:947-58.
8. Elshourbagy NA, Liao WS, Mahley RW, Taylor JM. Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets. Proc Natl Acad Sci USA 1985;82:203-7.
9. Mazzone T, Gump H, Diller P, Getz GS. Macrophage free cholesterol content regulates apolipoprotein E synthesis. J Biol Chem 1987;262:11657-62.
10. Mazzone T, Basheeruddin K, Poulos C. Regulation of macrophage apolipoprotein E gene expression by cholesterol. J Lipid Res 1989;30:1055-64.
11. Mazzone T, Basheeruddin K. Dissociated regulation of macrophage LDL receptor and apolipoprotein E gene expression by sterol. J Lipid Res 1991;32:507-14.
12. Dory L. Synthesis and secretion of apoE in thioglycolate elicited mouse peritoneal macrophages: effect of cholesterol efflux. J Lipid Res 1989;30:809-16.
13. Dory L. Regulation of apolipoprotein E secretion by high density lipoprotein3 in mouse macrophages. J Lipid Res 1991;32:783-92.
14. Ishibashi S, Yamada N, Shimano H, Mori N, Mokuno H, Gotohda T, et al. Apolipoprotein E and lipoprotein lipase secreted from human monocyte-derived macrophages modulate very low density lipoprotein uptake. J Biol Chem 1990;265:3040-7.
15. Basu SK, Brown MS, Ho YK, Havel RJ, Goldstein JL. Mouse macrophages synthesize and secrete a protein resembling apolipoprotein. E Proc Natl Acad Sci USA 1981;78:7545-9.
16. Basu SK, Ho YK, Brown MS, Bilheimer DW, Anderson RGW, Goldstein JL. Biochemical and genetic studies of apolipoprotein E secreted by mouse peritoneal macrophages and human monocytes. J Biol Chem 1982;257:9788-95.
17. 3. J Lipid Res 1994;35:1345-53.
18. Shimano H, Ohsuga J, Shimada M, Namba Y, Gotoda T, Harada K, et al. Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall. J Clin Invest 1995;95:469-76.
19. Bellosta S, Mahley RW, Sanan DA, Murata J, Newland DL, Taylor JM, et al. Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice. J Clin Invest 1995;96:2170-9.
20. Hayek T, Oiknine J, Brook JG, Aviram M. Role of HDL apolipoprotein E in cellular cholesterol efflux: studies in apo E knockout transgenic mice. Biochem Biophys Res Commun 1994;205:1072-8.
21. Breslow JL. Mouse models of atherosclerosis. Science 1996;272:685-8.
22. Purcell-Huynh DA, Farese RV Jr, Johnson DF, Flynn LM, Pierotti V, Newland DL, et al. Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet. J Clin Invest 1995;95:2246-57.
23. Cohen RD, Castellani LW, Qiao JH, Van Lenten BJ, Lusis AJ, Reue K. Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV. J Clin Invest 1997;99:1906-16.
24. Arai T, Wang N, Bezouevski M, Welch C, Tall AR. Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scavenger receptor BI transgene. J Biol Chem 1999;274:2366-71.
25. Groot PHE, Van Vlijmen BJM, Benson GM, Hofker MH, Schiffelers R, Vidgeon-Hart M, et al. Quantitative assessment of aortic atherosclerosis in ApoE*3 Leiden transgenic mice and its relation to serum cholesterol exposure. Arterioscler Thromb Vasc Biol 1996;16:926-33.
26. Redgrave TG, Roberts DCK, West CE. Separation of plasma lipoproteins by density-gradient ultracentrifugation. Anal Biochem 1975;65:42-9.
27. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193(32):265-75.
28. Basu SK, Goldstein JL, Anderson GW, Brown MS. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc Natl Acad Sci USA 1976;73:3178-82.
29. Blomhoff R, Drevon CA, Eskild W, Helgerud P, Norum KR, Berg T. Clearance of acetyl low density lipoprotein by rat endothelial cells. J Biol Chem 1984;259:8898-903.
30. Zhu Y, Bellosta S, Langer C, Bernini F, Pitas RE, Mahley RW, Assman G, von Eckardstein A. Low-dose expression of a human apolipoprotein E transgene in macrophages restores cholesterol efflux capacity of apolipoprotein E-deficient mouse plasma. Proc Natl Acad Sci USA 1998;95:7585-90.
31. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apoE. Science 1992;258:468-71.
32. Plump AS, Smith JD, Hayek T, Aalto-Setälä K, Walsch A, Verstuyft JG, Rubin EM, et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 1992;71:343-53.
33. Van Ree JH, Van den Broek WJAA, Dahlmans VEH, Groot PHE, Vidgeon-Hart M, Frants RR, et al. Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice. Atherosclerosis 1994;111:25-37.
34. Van Eck M, Herijgers N, Yates J, Pearce NJ, Hoogerbrugge PM, Groot PHE, et al. Bone marrow transplantation in apolipoprotein E-deficient mice - effect of apoE gene dosage on serum lipid concentrations, (β)VLDL catabolism, and atherosclerosis. Arterioscler Thromb Vasc Biol 1997;17:3117-26.
35. Linton MF, Atkinson JB, Fazio S. Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation. Science 1995;267:1034-7.
36. Fazio S, Linton MF. Murine bone marrow transplantation as a novel approach to studying the role of macrophages in lipoprotein metabolism and atherogenesis. Trends Cardiovasc Med 1996;6:58-65.
37. Boisvert WA, Spangenberg J, Curtiss LK. Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation. J Clin Invest 1995;96:1118-24.
38. Fazio S, Babaev VR, Murray AB, Hasty AH, Carter KJ, Gleaves LA, et al. Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages. Proc Natl Acad Sci USA 1997;94:4647-52.
39. Boisvert WA, Curtiss LK. Elimination of macrophage specific apolipoprotein E reduces diet-induced atherosclerosis in C57B1/6 male mice. J Lipid Res 1999;40:806-13.
40. Paigen B, Holmes PA, Mitchell D, Albee D. Comparison of atherosclerotic lesions and HDL-lipid levels in male, female, and testosterone-treated female mice from strains C57BL/6, BALB/c, and C3H. Atherosclerosis 1987;64:215-21.
41. Massimi M, Lear SR, Williams DL, Jones AL, Erickson SK. Differential expression of apolipoprotein E messenger RNA within the rat liver lobule determined by in situ hybridisation. Hepatology 1999;29:1549-55.
42. Ishii I, Ito Y, Morisaki N, Saito Y, Hirose S. Genetic differences of lipid metabolism in macrophages from C57BL/6J and C3H/HeN mice. Arterioscler Thromb Vasc Biol 1995;15:1189-94.
43. Kruth HS, Skarlatos SI, Gaynor PM, Gamble W. Production of cholesterol-enriched nascent very high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux. J Biol Chem 1994;269:24511-8.
44. Zhang WY, Gaynor PM, Kruth HS. Apolipoprotein E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors. J Biol Chem 1996;271:28641-6.
45. Cullen P, Cignarella A, Brennhausen B, Mohr S, Assmann G, von Eckardstein A. Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages. J Clin Invest 1998;101:1670-7.