Murine bone marrow transplantation as a novel approach to studying the role of macrophages in lipoprotein metabolism and atherogenesis

Trends in Cardiovascular Medicine

Volumn 6, Issue 2, 1996, Pages 58-65

  Fazio, Sergio ^a   Linton, MacRae F ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ATHEROGENESIS; BONE MARROW TRANSPLANTATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DYSLIPIDEMIA; GENE THERAPY; HYPERLIPIDEMIA; HYPERLIPOPROTEINEMIA TYPE 3; LIPID METABOLISM; LIPOPROTEIN METABOLISM; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0029876310     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/1050-1738(96)00007-2     Document Type: Short Survey

References (62)

1. Babaev VR, Dergunov AD, Chenchik AA, et al.: 1990. Localization of apolipoprotein E in normal and atherosclerotic human aorta. Atherosclerosis 85:239-247.
2. Basu SK, Brown MS, Ho YK, Havel RJ, Goldstein JL: 1981. Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E. Proc Natl Acad Sci USA 78: 7545-7549.
3. Basu SK, Ho YK, Brown MS, Bilheimer DW, Anderson RGW, Goldstein JL: 1982. Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes. J Biol Chem 257:9788-9795.
4. Basu SK, Goldstein JL, Brown MS: 1983. Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages. Science 219:871-873.
5. Bellosta S, Mahley RW, Senan DA, Murate J, Newland DL, Taylor JM, Pitas RE: 1995. Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic E-null mice. J Clin Invest 96:2170-2179.
6. Blue M-L, Williams DL, Zucker S, Khan SA, Blum CB: 1983. Apolipoprotein E synthesis in human kidney, adrenal gland, and liver. Proc Natl Acad Sci USA 80:283-287.
7. Boisvert WA, Spangerberg J, Curtiss LK: 1995. Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation. J Clin Invest 96:1118-1124.
8. Brown MS, Goldstein JL: 1983. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem 52:223-261.
9. Brown MS, Herz J, Kowal RC, Goldstein JL: 1991. The low-density lipoprotein receptor-related protein: double agent or decoy? Curr Opin Lipid 2:65-72.
10. Curtiss LK: 1992. Cholesterol, apolipoprotein E, and immune cell function. In Cunningham-Rundels S, ed. Nutrient Modulation of the Immune Response. New York, Marcel Dekker, pp 169-1181.
11. Ellsworth JL, Kraemer FB, Cooper AD: 1987. Transport of b-very low density lipoproteins and chylomicron remnants by macrophages is mediated by the low density lipoprotein receptor pathway. J Biol Chem 262:2316-2325.
12. Elshourbagy NA, Liao WS, Mahley RW, Taylor JM: 1985. Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets. Proc Natl Acad Sci USA 82:203-207.
13. Fazio S: 1993. Recent insights into the pathogenesis of type III hyperlipoproteinemia. Trends Cardiovasc Med 3:191-195.
14. Friedrich G, Soriano P: 1991. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 5:1513-1523.
15. Getz GS, Mazzone T, Soltys P, Bates SR: 1988. Atherosclerosis and apoprotein E: an enigmatic relationship. Arch Pathol Lab Med 112:1048-1055.
16. Ghiselli G, Schaefer EJ, Gascon P, Brewer HB Jr: 1981. Type III hyperlipoproteinemia associated with apolipoprotein E deficiency. Science 214:1239-1241.
17. Goldstein JL, Ho YK, Basu SK, Brown MS: 1979. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci USA 76:333-337.
18. Gordon V, Innerarity TL, Mahley RW: 1983. Formation of cholesterol-and apoprotein E-enriched high density lipoproteins in vitro. J Biol Chem 258:6202-6212.
19. Hara H, Yokoyama S: 1991. Interaction of free apolipoproteins with macrophages. J Biol Chem 266:3080-3086.
20. Hayek T, Oiknine J, Brook JG, Aviram M: 1994. Role of apolipoprotein E in cellular cholesterol efflux: studies in apoE knock-out transgenic mice. Biochem Biophys Res Commun 205:1072-1078.
21. Innerarity TL: 1990. Low density lipoprotein receptor-ligand interactions. Atheroscler Rev 20:91-101.
22. Innerarity TL, Arnold KS, Weisgraber KH, Mahley RW: 1986. Apolipoprotein E is the determinant that mediates the receptor uptake of β-very low density lipoproteins by mouse macrophages. Arteriosclerosis 6: 114-122.
23. Ishibashi S, Yamada N, Shimano H, et al.: 1990. Apolipoprotein E and lipoprotein lipase secreted from human monocyte-derived macrophages modulate very low density lipoprotein uptake. J Biol Chem 265: 3040-3047.
24. Ishibashi S, Herz J, Maeda N, Goldstein JL, Brown MS: 1994. The two-receptor model of lipoprotein clearance: Tests of the hypothesis in "knock-out" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proc Natl Acad Sci USA 91:4431-4435.
25. Ji Z-S, Brecht WJ, Miranda RD, Hussain MM, Innerarity TL, Mahley RW: 1993. Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells. J Biol Chem 268:10,160-10,167.
26. Ji Z-S, Fazio S, Lee Y-L, Mahley RW: 1994. Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans. J Biol Chem 269:2764-2772.
27. Kashyap VK, Santamarina-Fojo S, Brown DR, et al.: 1995. Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors. J Clin Invest 96:1612-1620.
28. Koo C, Innerarity TL, Mahley RW: 1985. Obligatory role of cholesterol and apolipoprotein E in the formation of large cholesterol-enriched and receptor-active high density lipoproteins. J Biol Chem 260:11,934-11,943.
29. Kowal RC, Herz J, Goldstein JL, Esser V, Brown MS: 1989. Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins. Proc Natl Acad Sci USA 86:5810-5814.
30. Kraft HG, Menzel HJ, Hoppichler F, Vogel W, Utermann G: 1989. Changes of genetic apolipoprotein phenotypes caused by liver transplantation: implications for apolipoprotein synthesis. J Clin Invest 83:137-142.
31. Kramer FB: 1992. Role of lipoprotein lipase and apolipoprotein E secretion by macrophages in modulating lipoprotein uptake. Diabetes 41:77-80.
32. Lin CT, Xu Y, Wu J-Y, Chan L: 1986. Immunoreactive apolipoprotein E is a widely distributed cellular protein: immunohistochemical localization of apolipoprotein E in baboon tissues. J Clin Invest 78:947-958.
33. Linton MF, Gish R, Hubl ST, et al.: 1991. Phenotypes of apolipoprotein B and apoli-poprotein E after liver transplantation. J Clin Invest 88:270-281.
34. Linton MF, Atkinson JB, Fazio S: 1995. Prevention of atherosclerosis in apoE deficient mice by bone marrow transplantation. Science 267:1034-1037.
35. Mabuchi H, Itoh H, Takeda M, et al.: 1989. A young type III hyperlipoproteinemic patient associated with apolipoprotein E deficiency. Metabolism 38:115-119.
36. Mahley RW: 1988. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240:622-630.
37. Mahley RW, Rall SC Jr: 1989. Type III hyperlipoproteinemia (dysbetalipoproteinemia): the role of apolipoprotein E in normal and abnormal lipoprotein metabolism. In Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic Basis of Inherited Disease, 6th ed, vol 1. New York, McGraw-Hill, pp 1195-1213.
38. Mahley RW, Weisgraber KH, Hussain MM, et al.: 1989. Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits. J Clin Invest 83: 2125-2130.
39. Mazzone T, Reardon C: 1994. Expression of heterologous human apolipoprotein E by J774 macrophages enhances cholesterol efflux to HDL3. J Lipid Res 35:1345-1353.
40. Mazzone T, Gump H, Diller P, Getz G: 1987. Macrophage free cholesterol content regulates apolipoprotein E synthesis. J Biol Chem 262:11,657-11,662.
41. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R: 1994. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb 14:133-140.
42. Newman TC, Dawson PA, Rudel LL, Williams DL: 1985. Quantitation of apolipoprotein E mRNA in the liver and peripheral tissues of nonhuman primates. J Biol Chem 260: 2452-2457.
43. Nolan GP, Fiering S, Nicolas J-F, Herzenberg LA: 1988. Fluorescence-activated cell analysis and sorting of viable mammalian cells based on β-D-galactosidase activity after transduction of Escherichia coli lacZ. Proc Natl Acad Sci USA 85:2603-2607.
44. Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA: 1987. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis 68:231-240.
45. Parkman R: 1986. The application of bone marrow transplantation to the treatment of genetic diseases. Science 232:1373-1378.
46. Plump AS, Smith JD, Hayek T, et al.: 1992. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71:343-353.
47. Reddick RL, Zhang SH, Maeda N: 1994. Atherosclerosis in mice lacking apoE: evaluation of lesional development and progression. Arterioscler Thromb 14:141-147.
48. Rosenfeld MI, Butler S, Ord VA, et al.: 1993. Abundant expression of apoprotein E by macrophages in human and rabbit atherosclerotic lesions. Arterioscler Thromb 13: 1382-1389.
49. Ross R: 1993. The pathogenesis of atherosclerosis: a perspective for the 1990's. Nature 362:801-809.
50. Ross R: 1995. Cell biology of atherosclerosis. Annu Rev Physiol 57:791-804.
51. Schaefer EJ, Gregg RE, Ghiselli G, et al.: 1986. Familial apolipoprotein E deficiency. J Clin Invest 78:1206-1219.
52. Shimano H, Yamada N, Katsuki M, et al.: 1992. Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia. Proc Natl Acad Sci USA 89:1750-1754.
53. Shimano H, Ohsuga J, Shimada M, et al.: 1995. Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall. J Clin Invest 95:469-476.
54. Simonet WS, Bucay N, Lauer SJ, et al.: 1990. In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic mice. J Biol Chem 265:10,809-10,812.
55. Smith JD, Plump AS, Hayek T, Walsh A, Breslow JL: 1990. Accumulation of human apolipoprotein E in the plasma of transgenic mice. J Biol Chem 265:14709-14712.
56. Stevenson SC, Marshall-Neff J, Teng B, Lee CB, Roy S, McClelland A: 1995. Phenotypic correction of hypercholesterolemia in apoE-deficient mice by adenovirus-mediated in vivo gene transfer. Arterioscler Thromb Vasc Biol 15:479-484.
57. Vollmer E, Roessner A, Bosse A, et al.: 1991. Immunohistochemical double labeling of macrophages, smooth muscle cells, and apolipoprotein E in the atherosclerotic plaque. Pathol Res Pract 187:184-188.
58. Willnow TE, Sheng Z, Ishibashi S, Herz J: 1994. Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Science 264:1471-1474.
59. Yamada N, Shimano H, Mokuno H, et al.: 1989. Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits. Proc Natl Acad Sci USA 86:665-669.
60. Yamada N, Inoue I, Kawamura M, et al.: 1992. Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits. J Clin Invest 89:706-711.
61. Zannis VJ, Cole FS, Jackson CL, Kurnit DM, Karathanasis SK: 1985. Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues. Biochemistry 24:4450-4455.
62. Zhang SH, Reddick RL, Piedrahita JA, Maeda N: 1992. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258:468-471.