Direct block of inward rectifier potassium channels by nicotine

Toxicology and Applied Pharmacology

Volumn 164, Issue 1, 2000, Pages 97-101

  Wang, Huizhen ^a   Yang, Baofeng ^c   Zhang, Limin ^a   Xu, Donghui ^d   Wang, Zhiguo ^a,b  

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c HARBIN MEDICAL UNIVERSITY   (China)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

Canine ventricular myocyte; Inward rectifier K+ channel; Nicotine; Two electrode voltage clamp; Whole cell patch clamp; Xenopus oocyte

Indexed keywords

ATROPINE; BETA ADRENERGIC RECEPTOR; MECAMYLAMINE; MUSCARINIC AGENT; NICOTINE; NICOTINIC RECEPTOR BLOCKING AGENT; POTASSIUM; POTASSIUM CHANNEL; PROPRANOLOL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOG; DRUG MECHANISM; HEART ARRHYTHMIA; HEART DEPOLARIZATION; NONHUMAN; POTASSIUM CURRENT; XENOPUS LAEVIS;

ANIMALIA; CANIS FAMILIARIS; NICOTIANA TABACUM; XENOPUS LAEVIS;

EID: 0034177134     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2000.8896     Document Type: Article

References (36)

1. Barry D. M., Nerbonne J. M. Myocardial potassium channels: Electrophysiological and molecular diversity. Annu. Rev. Physiol. 58:1996;363-394.
2. Beaumont J., Michaels D. C., Delmar M., Davidenko J., Jalife J. A model study of changes in excitability of ventricular muscle cells: inhibition, facilitation, and hysteresis. Am. J. Physiol. 268:1995;H1181-H1194.
3. Benowitz N. L., Porchet H., Jacob P. III. Pharmacokinetics, metabolism, and pharmacodynamics of nicotine. Wonnacott S., Russel M. A. H., Stoleman I. P. Nicotine Psychopharmacology: Molecular, Cellular, and Behavioral Aspects. 1990;112-157 Oxford Univ. Press, Oxford.
4. Benowitz N. L. Pharmacological aspects of cigarette smoking and nicotine addiction. N. Engl. J. Med. 319:1988;1318-1330.
5. Benowitz N. L., Gourlay S. G. Cardiovascular toxicity of nicotine: Implications for nicotine replacement therapy. J. Am. Coll. Cardiol. 29:1997;1422-1431.
6. + currents in isolated human ventricular myocytes from patients with terminal failure. Circ. Res. 73:1993;379-385.
7. Boyden P. A., Jeck C. D. Ion channel function in disease. Cardiovasc. Res. 29:1995;312-318.
8. Carryl O. R., Gallardo-Carpentier A., Carpentier R. G. Effects of nicotine and ethanol on rat atrial membrane potentials. Alcohol. 9:1992;87-92.
9. Chevalier H. J., Bandilla B., Dontenwill W., Hanel J. Effect of high doses of nicotine in pig. I. Changes of the electrocardiogram. Basic Res. Cardiol. 71:1976;68-75.
10. 3H]-nicotine in rats. Biomed. Environ. Sci. 6:1993;59-64.
11. Escobedo L. G., Zack M. M. Comparison of sudden and nonsudden coronary deaths in the United States. Circulation. 93:1996;2033-2036.
12. Golod D. A., Kumar R., Joyner R. W. Determinants of action potential initiation in isolated rabbit atrial and ventricular myocytes. Am. J. Physiol. 274:1998;H1902-H1913.
13. Greenspan K., Edmands R. E., Knoebel S. B., Fisch C. Some effects of nicotine on cardiac automaticity, conduction, and inotropy. Arch. Intern. Med. 123:1969;707-712.
14. Jarvik M. E. Beneficial effects of nicotine. Br. J. Addict. 86:1991;571-575.
15. Keeley E. C., Pirwitz M. J., Landau C., Lange R. A., Hillis L. D., Poerster E. H., Conrad K., Willard J. E. Intranasal nicotine spray does not augment the adverse effects of cigarette smoking on myocardial oxygen demand or coronary arterial dimensions. Am. J. Med. 101:1996;357-363.
16. Kloc M., Miller M., Carrasco A. E., Eastman E., Etkin L. The maternal store of the xlgv7 mRNA in full-grown oocytes is not required for normal development in Xenopus. Development. 107:1989;899-907.
17. + channel in human cardiac myocytes: Alterations in channel behavior in myocytes isolated from patients with idiopathic dilated cardiomyopathy. Circulation. 92:1995;164-174.
18. Lakier J. B. Smoking and cardiovascular disease. Am. J. Med. 93:1992;8S-12S.
19. Myerburg R. J., Kessler K. M., Castellanos. A sudden cardiac death: Epidemiology, transient risk, and intervention assessment. Ann. Intern. Med. 119:1993;1187-1197.
20. + channel. J. Mol. Cell. Cardiol. 28:1996;957-965.
21. K1 with antisense oligonucleotides targeted to Kir2.1 mRNA. Am. J. Physiol. 274:1998;H892-H900.
22. Nichols C. G., Makhina E. N., Pearson W. L., Sha Q., Lopatin A. N. Inward rectification and implication for cardiac excitability. Circ. Res. 78:1996;1-7.
23. Nowak R. Was safer cigarette research snuff. Science. 264:1994;766-767.
24. Pappano A. J., Rembish R. A. Nicotine-induced restoration of action potentials to cardiac tissue depolarization by potassium. Life Sci. 9:1970;1381-1388.
25. Russell M. A., Jarvis M., Iyer R., Feyerabend C. Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers. Br. Med. J. 280:1980;972-976.
26. Satoh H. Effects of nicotine on spontaneous activity and underlying ionic currents in rabbit sinoatrial nodal cells. Gen. Pharmacol. 28:1997;39-44.
27. Shi H., Wang H., Wang Z. Identification and characterization of multiple subtypes of muscarinic acetylcholine receptors and their physiological functions in canine hearts. Mol. Pharmacol. 55:1999;497-507.
28. Shimoni Y., Clark R. B., Gilles W. R. Role of an inwardly rectifying potassium current in rabbit ventricular action potential. J. Physiol. 448:1992;709-727.
29. Stewart P. M., Catterall J. R. Chronic nicotine ingestion and atrial fibrillation. Br. Heart J. 54:1985;222-223.
30. + channel currents in vascular smooth muscle cells from rat tail arteries. Eur. J. Pharmacol. 364:1999;247-254.
31. Varanda W. A., Aracava Y., Sherby S. M., VanMeter W. G., Eldefrawi M. E., Albuquerque E. X. The acetylcholine receptor of the neuromuscular junction recognizes mecamylamine as a noncompetitive antagonist. Mol. Pharmacol. 28:1985;128-137.
32. + current. Br. J. Pharmacol. 162:1999;1725-1734.
33. + channel binding and block produced by alternatively spliced Kvβ1 subunits. J. Biol. Chem. 271:1996;28311-28317.
34. West J. W., Guzman S. V., Bellet S. Cardiac effects of intracoronary arterial injection of nicotine. Circ. Res. 6:1958;389-395.
35. Westman E. C. Does smokeless tobacco cause hypertension. South Med. J. 88:1995;716-720.
36. Wilde A. A. M., Aksnes G. Myocardial potassium loss and cell depolarization in ischemia and hypoxia. Cardiovasc. Res. 29:1995;1-15.