Total syntheses of kurasoins A and B, novel protein farnesyltransferase inhibitors, and absolute structures of kurasoins A and B

Heterocycles

Volumn 53, Issue 4, 2000, Pages 777-784

  Hirose, Tomoyasu ^a   Sunazuka, Toshiaki ^a   Zhi Ming, Tian ^a   Handa, Masaki ^a   Uchida, Ryuji ^a   Shiomi, Kazuro ^a   Harigaya, Yoshihiro ^a   Omura, Satoshi ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

KURASOINS A; KURASOINS B; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CHIRALITY; EPOXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY; STEREOCHEMISTRY; STEREOSPECIFICITY; SYNTHESIS;

EID: 0034175789     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/com-99-8744     Document Type: Article

References (11)

1. F. Tamanoi, Trends Biochem. Soc., 1993, 18, 349
2. R. Uchida, K. Shiomi, J. Inokoshi, R. Masuma, T. Kawakubo, H. Tanaka, Y. Iwai, and S. Ōmura, J. Antibiot., 1996, 49, 932.
3. R. Uchida, K. Shiomi, T. Sunazuka, J. Inokoshi, A. Nishizawa, T. Hirose, H. Tanaka, Y. Iwai, and S. Ōmura, J. Antibiot., 1996, 49, 886.
4. J. R. Parikh and W. V. Doering, J. Am. Chem. Soc., 1967, 89, 5505.
5. Y. Gao, R. M. Hanson, J. M. Klunder, and S. Y. Ko, J. Am. Chem. Soc., 1987, 109, 5765.
6. J. A. Dale, D. L. Dull, and H. S. Mosher, J. Org. Chem., 1970, 35, 3519.
7. Chiralcel OJ i.d. 4.6×250 mm column; mobile phase, n-hexane / 2-propyl alcohol (85:15); Flow rate, 1.0 mL/min; Detection, UV at 275 nm.
8. T. Sunazuka, N. Tabata, T. Nagamitsu, H. Tomoda, and S. Ōmura, Tetrahedron Lett., 1993, 42, 6659.
9. Chiralcel OJ i.d. 4.6×250 mm column; mobile phase, n-hexane / 2-propyl alcohol (75:25); Flow rate, 1.0 mL/min; Detection, UV at 275 nm.
10. N. Tabata, T. Sunazuka, H. Tomoda, T. Nagamitsu, Y. Iwai, and S. Ōmura, J. Antibiot., 1993, 46, 886.
11. T. Sunazuka, N. Tabata, T. Nagamitsu, H. Tomoda, and S. Ōmura, J. Antibiot., 1993, 46, 1178