Effects of propylthiouracil (PTU) administration on the synthesis and secretion of thyroglobulin in the rat thyroid gland: A quantitative immunoelectron microscopic study using immunogold technique

Endocrine Pathology

Volumn 8, Issue 4, 1997, Pages 315-325

  Yi, Xue ^a   Yamamoto, Koichi ^a   Shu, Lu ^a   Katoh, Ryohei ^a   Kawaoi, Akira ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Image analysis; Immuno electron microscopy; Propylthiouracil; Thyroglobulin; Thyroid gland

Indexed keywords

EID: 0008009519     PISSN: 10463976     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02739934     Document Type: Article

References (37)

1. Fujita H. Functional morphology of the thyroid. Int Rev Cytol 113:145-185, 1988.
2. Kostrouch Z, Munari-Silem Y, Rajas F, Bernier-Valentin F, Rousset B. Thyroglobulin internalized by thyrocytes passes through early and late endosomes. Endocrinology 129: 2202-2211, 1991.
3. Bernier-Valentin F, Kostrouch Z, Rarbilloud R, Rousset B. Analysis of the thyroglobulin internalization process using in vitro reconstituted thyroid follicles: evidence for a coated vesicle-dependent endocytic pathway. Endocrinology 129:2194-2201, 1991.
4. Scheel G, Herzog V. Mannose 6-phosphate receptor in porcine thyroid follicle cells: localization and possible implications for the intracellular transport of thyroglobulin. Eur J Cell Biol 49:140-148, 1989.
5. Kostrouch Z, Bernier-Valentin F, Munari-Silem Y, Rajas F, Rabilloud R, Rousset B. Thyroglobulin molecules internalized by thyrocyte are sorted in early endosomes and partially recycled back to the follicular lumen. Endocrinology 132:2645-2653, 1993.
6. Herzog V. Pathways of endocytosis in thyroid follicle cells. Inter Rev Cytol 91:107-139, 1984.
7. Kim PS, Arvan P. Hormonal regulation of thyroglobulin export from the endoplasmic reticulum of cultured thyrocytes. J Biol Chem 268:4873-4879, 1993.
8. Leer LM, Cammenga M, De Vijlder JJM. Methimazole and propylthiouracil increased thyroglobulin gene expression in FRTL-5 cells. Mol Cell Endocrinol 82:R25-R30, 1991.
9. Black KG, Sheppard MC, Hoffenberg R. Control of thyroglobulin secretion from the rat thyroid gland. J Endocr 101:107-111, 1984.
10. Scherberg NH. Isolation of thyroglobulin messenger RNA from rats: increased yield in propylthiouracil-induced hyperplasia. Biochem Biophys Res Comm 85:1415-1423, 1978.
11. Monaco F, Santolamazza C, DeRos I, Andreoli A. Effects of propylthiouracil and methylmercaptoimidazole on thyroglobulin synthesis. Acta Endocrinol 93:32-36, 1980.
12. Moura KG, Pazos-Moura CC, Dorris ML, Taurog A. Lack of effect of propylthiouracil and methylmercaptoimidazole on thyroglobulin biosynthesis. PSEBM 194:48-53, 1990.
13. Tachiwaki O, Wollman SH. Comparison of a special class of epithelial cells in hyperplastic hyroids undergoing involution and in thyroids in hypophysectomized rats. Am J Anat 189:57-61, 1990.
14. Tachiwaki O, Zeligs J D, Wollman SH. Ultrastructural changes in thyroid epithelium during involution of the hyperplastic thyroid gland. Am J Anat 189:45-56, 1990.
15. Wollman SH, Herveg JP, Tachiwaki O. Histologic changes in tissue components of the hyperplastic thyroid gland during its involution in the rat. Am J Anat 189:35-44, 1990.
16. Yamamoto K, Xue Y, Katoh R, Kawaoi A. Differential immunolocalization of thyroglobulin (Tg) in the follicular epithelium of rat thyroid glands and its kinetics under thyrotropin (TSH) stimulation: a quantitative immunoelectron microscopic analysis using post-embedding immunogold technique. Acta Histochem Cytochem 30:147-155, 1997.
17. Kawaoi A, Tsuneda M. Functional development and maturation of the rat thyroid gland in the foetal and newborn periods: an immunohistochemical study. Acta Endocrinol 108:518-524, 1985.
18. Kawaoi A, Tsuneda M. Effects of thyroidectomy and administration of propylthiouracil (PTU) or thyrotropin (TSH) to pregnant rats on the functional development of the fetal thyroid gland: an immunohistochemical study. Endocrinol Japon 33:835-841, 1986.
19. 3) in fetal rat thyroid: an immunoelectron microscopic study. J Histochem Cytochem 35:1137-1142, 1987.
20. 3) in nontoxic thyroid tumors by the immunoperoxidase method.Am J Pathol 108:39-49, 1982.
21. Ring PKM, Johanson V. Immunoelectron microscopic demonstration of thyroglobulin and thyroid hormones in rat thyroid gland. J Histochem Cytochem 35:1095-1104, 1987.
22. Iwano T, Akayama M, Yamamoto A, Omori K, Kumazawa T, Tashiro Y. Quantitative immuno-electron microscopic localization of (Na+, K+) ATPase in rat parotid gland. J Histochem Cytochem 35:871-879, 1987.
23. Fukui Y, Yamamoto A, Masaki R, Miyauchi K, Tashiro Y. Quantitative immunocytochemical analysis of tibe induction of cytochrome 450IIB in rat hepatocytes. J Histochem Cytochem 40:73-82, 1992.
24. Okami T, Yamamoto A, Omori K, Akayama M, Uyama M, Tashiro Y. Quantitative immunocytochemical localization of (Na+, K+) ATPase in rat ciliary epithelial cells. J Histochem Cytochem 37:1353-1361, 1989.
25. Posthuma G, Slot JW, Geuze HJ. Immunocytochemical assays of amylase and chymotrypsinogen in rat pancreas secretory granules: efficacy of using immunogold-labeled ultrathin cryosections to estimate relative protein concentrations. J Histochem Cytochem 32:1028-1034, 1984.
26. Posthuma G, Slot JW, Geuze HJ. Usefulness of the immunogold technique in quantitation of a soluble protein in ultra-thin sections. J Histochem Cytochem 35:405-410, 1987.
27. Gu J, D'andrea M. Comparison of detecting sensitivities of different sizes of gold particles with electron-microscopic immunogold staining using atrial natriuretic peptide in rat atria as a model. Am J Anat 185:264-270, 1989.
28. Yokota S. Effect of particle size on labeling density for catalase in protein A-gold immunocytochemistry. J Histochem Cytochem 36:107-109, 1988.
29. Cooper DS. Antithyroid drugs. New Engl J Med 311:1353-1362, 1984.
30. Shiroozu A, Taurog A, Engler H, Dorris ML. Mechanism of action of thioureylene antithyroid drugs in the rat: possible inactivation of thyroid peroxidase by propylthiouracil. Endocrinology 113:362-370, 1983.
31. Taurog A, Dorris ML. A reexamination of the proposed inactivation of thyroid peroxidase in the rat thyroid by propylthiouracil. Endocrinology 124:3038-3042, 1989.
32. Cooper DS, Kleffer JD, Halpern R, Saxe VC, Mover H, Maloof F, Ridgway EC. Propylthiouracil (PTU) pharmacology in the rat. II. Effects of PTU on thyroid function. Endocrinology 113:921-928, 1983.
33. Cooper DS, Saxe VC, Meskell M, Maloof G, Ridgway EC. Acute effects of propylthiouracil (PTU) on thyroidal iodide organification and peripheral iodothyronine deiodination: correlation with serum PTU levels measured by radioimmunoassay. J Clin Endocrin Metab 54:101-107, 1982.
34. 4 metabolism and thyroid gland function in rats. Toxicol Appl Pharmacol 111:263-278, 1991.
35. Stubner D, Gartner R, Greil W, Gropper K, Brabant C, Perrnanetter W, Horn K, Pickardt CR. Hypertrophy and hyperplasia during goitre growth and involution in rats separate bioeffects of TSH and iodine. Acta Endocriol (Copenh) 116:537-548, 1987.
36. Ikekubo K. Kishihara M, Sanders J, Jutton J, Schneider AB. Differences between circulating and tissue thyroglobulin in rats. Endocrinology 109:427-432, 1981.
37. Berg G. Bjorkman U, Ekhom R. The structure of newly synthesized intracellular thyroglobulin molecules. Mol Cell Endocrinol 20:87-95, 1980.