Serotonin and aggression in children

Current psychiatry reports

Volumn 2, Issue 2, 2000, Pages 95-101

  Mitsis, Effie M ^a   Halperin, Jeffrey M ^a,b   Newcorn, Jeffrey H ^b  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; AMINE OXIDASE (FLAVIN CONTAINING);

ADOLESCENT; AGGRESSION; ATTENTION DEFICIT DISORDER; BEHAVIOR DISORDER; CEREBROSPINAL FLUID; CHILD; ENVIRONMENT; FAMILY; GENETICS; HUMAN; PSYCHOLOGICAL ASPECT; REVIEW; SOCIAL BEHAVIOR;

ADOLESCENT; AGGRESSION; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CHILD BEHAVIOR DISORDERS; ENVIRONMENT; FAMILY; HUMANS; HYDROXYINDOLEACETIC ACID; MONOAMINE OXIDASE; SOCIAL BEHAVIOR;

EID: 0034172575     PISSN: 15233812     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11920-000-0052-0     Document Type: Review

References (72)

1. 1. RJ Cadoret MS Cain 1981 Environmental and genetic factors in predicting adolescent antisocial behavior in adoptees Psychiatric Journal of the University of Ottowa 6 220 225 Cadoret RJ, Cain MS: Environmental and genetic factors in predicting adolescent antisocial behavior in adoptees. Psychiatric Journal of the University of Ottowa 1981, 6:220–225.
2. 2. I Kolvin FJW Miller M Fleeting PA Kolvin 1988 Social and parenting factors affecting criminal-offense rates: findings from the Newcastle thousand family study (1947-1980) Br J Psychiatry 152 80 90 3167316 1:STN:280:DyaL1M%2FgtFKguw%3D%3D 10.1192/bjp.152.1.80 Kolvin I, Miller FJW, Fleeting M, Kolvin PA: Social and parenting factors affecting criminal-offense rates: findings from the Newcastle thousand family study (1947-1980). Br J Psychiatry 1988, 152:80–90.
3. 3. R Loeber P Wung K Keenan 1993 Developmental pathways in disruptive child behavior Dev Psychopathol 5 103 133 Loeber R, Wung P, Keenan K, et al.: Developmental pathways in disruptive child behavior. Dev Psychopathol 1993, 5:103–133.
4. 4. D Olweus 1979 Stability of aggressive reaction patterns in males: a review Psychol Bull 86 852 857 482487 10.1037/0033-2909.86.4.852 1:STN:280:DyaL3c%2FhtlKitA%3D%3D Olweus D: Stability of aggressive reaction patterns in males: a review. Psychol Bull 1979, 86:852–857.
5. 5. MB Botchin JR Kaplan SB Manuck JJ Mann 1993 Low versus high prolactin responders to fenfluramine challenge: marker of behavioral differences in adult male cynomolgus macaques Neuropsychopharmacology 9 93 99 8216698 1:CAS:528:DyaK2cXps1KgtQ%3D%3D Botchin MB, Kaplan JR, Manuck SB, Mann JJ: Low versus high prolactin responders to fenfluramine challenge: marker of behavioral differences in adult male cynomolgus macaques. Neuropsychopharmacology 1993, 9:93–99.
6. 6. JD Higley PT Mehlman DM Taub 1992 Cerebrospinal fluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys Arch Gen Psychiatry 49 436 441 1376105 1:CAS:528:DyaK38XmtVGls7w%3D Higley JD, Mehlman PT, Taub DM, et al.: Cerebrospinal fluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys. Arch Gen Psychiatry 1992, 49:436–441.
7. 7. MJ Raleigh MT McGuire 1986 Animal analogues of ostracism: biological mechanisms and social consequences Ethol Sociobiol 7 53 66 Raleigh MJ, McGuire MT: Animal analogues of ostracism: biological mechanisms and social consequences. Ethol Sociobiol 1986, 7:53–66.
8. 8. P Soubrie 1986 Reconciling the role of central serotonin neurons in human and animal behavior Behav Brain Sci 9 319 364 10.1017/S0140525X00022871 Soubrie P: Reconciling the role of central serotonin neurons in human and animal behavior. Behav Brain Sci 1986, 9:319–364.
9. 9. EF Coccaro LJ Siever HM Klar 1989 Serotonergic studies in patients with affective and personality disorders Arch Gen Psychiatry 46 587 599 2735812 1:CAS:528:DyaK3MXksVOitLo%3D Coccaro EF, Siever LJ, Klar HM, et al.: Serotonergic studies in patients with affective and personality disorders. Arch Gen Psychiatry 1989, 46:587–599.
10. 10. M Linnoila M Virkkunen M Dvhrinin 1983 Low cerbrospinalfluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior Life Sci 33 2609 2614 6198573 10.1016/0024-3205(83)90344-2 1:CAS:528:DyaL2cXjtVWjtg%3D%3D Linnoila M, Virkkunen M, Dvhrinin M, et al.: Low cerbrospinalfluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci 1983, 33:2609–2614.
11. 11. V O’Keane E Moloney H O’Neil 1992 Blunted prolactin responses to d-fenfluramine in sociopathy: evidence for subsensitivity of central serotonergic function Br J Psychiatry 160 643 646 1591573 1:STN:280:By2B2svhtlE%3D O’Keane V, Moloney E, O’Neil H, et al.: Blunted prolactin responses to d-fenfluramine in sociopathy: evidence for subsensitivity of central serotonergic function. Br J Psychiatry 1992, 160:643–646.
12. 12. M Virkkunen D Goldman DA Nielsen M Linnoila 1995 Low brain serotonin turnover rate (low CSF 5-HIAA) and impulsive violence J Psychiatry Neurosci 20 271 275 7544158 1:STN:280:DyaK2MznsFSjsw%3D%3D Virkkunen M, Goldman D, Nielsen DA, Linnoila M: Low brain serotonin turnover rate (low CSF 5-HIAA) and impulsive violence. J Psychiatry Neurosci 1995, 20:271–275.
13. 13. DH Fishbein D Lozovsky JH Jaffe 1989 Impulsivity, aggression, and neuroendocrine responses to serotonergic stimulation in substance abusers Biol Psychiatry 25 1049 1066 2720017 10.1016/0006-3223(89)90293-X 1:STN:280:DyaL1M3kslKisw%3D%3D Fishbein DH, Lozovsky D, Jaffe JH: Impulsivity, aggression, and neuroendocrine responses to serotonergic stimulation in substance abusers. Biol Psychiatry 1989, 25:1049–1066.
14. 14. SB Manuck JD Flory RE Ferrell 1998 Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample Neuropsychopharmacology 19 287 299 9718592 10.1016/S0893-133X(98)00015-3 1:STN:280:DyaK1czosVOjtg%3D%3D Manuck SB, Flory JD, Ferrell RE, et al.: Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample. Neuropsychopharmacology 1998, 19:287–299.
15. 15. SB Manuck JD Flory RE Ferrell 1999 Aggression and angerrelated traits associated with a polymorphism of the tryptophan hydroxylase gene Biol Psychiatry 45 603 614 10088047 10.1016/S0006-3223(98)00375-8 1:STN:280:DyaK1M7ovVSguw%3D%3D Manuck SB, Flory JD, Ferrell RE, et al.: Aggression and angerrelated traits associated with a polymorphism of the tryptophan hydroxylase gene. Biol Psychiatry 1999, 45:603–614.
16. 16. AS New J Gelernter Y Yovell 1998 Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study Am J Med Genet (Neuropsychiatric Genet) 81 13 17 10.1002/(SICI)1096-8628(19980207)81:1<13::AID-AJMG3>3.0.CO;2-O 1:STN:280:DyaK1c7ntlGitQ%3D%3D New AS, Gelernter J, Yovell Y, et al.: Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study. Am J Med Genet (Neuropsychiatric Genet) 1998, 81:13–17.
17. 17. GL Brown MH Ebert PF Goyer 1982 Aggression, suicide, and serotonin: relationships to CSF amine metabolites Am J Psychiatry 139 741 746 6177256 1:CAS:528:DyaL38Xktlerurc%3D Brown GL, Ebert MH, Goyer PF, et al.: Aggression, suicide, and serotonin: relationships to CSF amine metabolites. Am J Psychiatry 1982, 139:741–746.
18. 18. L Lidberg JR Tuck M Asberg 1985 Homicide, suicide and CSF 5-HIAA Acta Psychiatr Scand 71 230 236 2580421 1:CAS:528:DyaL2MXktlalsLo%3D Lidberg L, Tuck JR, Asberg M, et al.: Homicide, suicide and CSF 5-HIAA. Acta Psychiatr Scand, 1985, 71:230–236.
19. 19. AJ Cleare AJ Bond 1997 Does central serotonergic function correlate inversely with aggression? A study using d-fenfluramine in healthy subjects Psychiatry Res 69 89 95 9109176 10.1016/S0165-1781(96)03052-1 1:CAS:528:DyaK2sXivVGlsr8%3D Cleare AJ, Bond AJ: Does central serotonergic function correlate inversely with aggression? A study using d-fenfluramine in healthy subjects. Psychiatry Res 1997, 69:89–95.
20. 20. PT Mehlman JD Higley I Faucher 1994 Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates Am J Psychiatry 151 1485 1491 7522411 1:STN:280:DyaK2cznvFamug%3D%3D Mehlman PT, Higley JD, Faucher I, et al.: Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates. Am J Psychiatry 1994, 151:1485–1491.
21. 21. PT Mehlman JD Higley I Faucher 1995 Correlation of CSF 5-HIAA concentration with sociality and the timing of emigration in free-ranging primates Am J Psychiatry 152 907 913 7538731 1:STN:280:DyaK2M3nsVOmtQ%3D%3D Mehlman PT, Higley JD, Faucher I, et al.: Correlation of CSF 5-HIAA concentration with sociality and the timing of emigration in free-ranging primates. Am J Psychiatry 1995, 152:907–913.
22. 22. JD Higley ST King MF Hasert 1996 Stability of interindividual differences in serotonin function and its relationship to severe aggression and competent social behavior in rhesus macaque females Neuropsychopharmacology 14 67 76 8719031 10.1016/S0893-133X(96)80060-1 1:CAS:528:DyaK28XpvVequw%3D%3D Higley JD, King ST, Hasert MF, et al.: Stability of interindividual differences in serotonin function and its relationship to severe aggression and competent social behavior in rhesus macaque females. Neuropsychopharmacology 1996, 14:67–76.
23. 23. MJP Kruesi JL Rapoport S Hamburger 1990 Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents Arch Gen Psychiatry 47 419 426 1691910 1:CAS:528:DyaK3MXksVOitbw%3D Kruesi MJP, Rapoport JL, Hamburger S, et al.: Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Arch Gen Psychiatry 1990, 47:419–426.
24. 24. MJP Kruesi E Hibbs TP Zahn 1992 A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders Arch Gen Psychiatry 49 429 435 1376104 1:STN:280:DyaK383os12iug%3D%3D Kruesi MJP, Hibbs E, Zahn TP, et al.: A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders. Arch Gen Psychiatry 1992, 49:429–435.
25. 25. FX Castellanos J Elia MJP Kruesi 1994 Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorder Psychiatry Res 52 305 316 7527565 10.1016/0165-1781(94)90076-0 1:STN:280:DyaK2M%2FotlOqtA%3D%3D Castellanos FX, Elia J, Kruesi MJP, et al.: Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorder. Psychiatry Res 1994, 52:305–316.
26. 26. RA Clarke DL Murphy JN Constantino 1999 Serotonin and externalizing behavior in young children Psychiatry Res 86 29 40 10359480 10.1016/S0165-1781(99)00022-0 1:CAS:528:DyaK1MXjvVentLg%3D Found the relationship between central 5-HT and behavioral deviance in infants to be weak, if present at all Clarke RA, Murphy DL, Constantino JN: Serotonin and externalizing behavior in young children. Psychiatry Res 1999, 86:29–40. Found the relationship between central 5-HT and behavioral deviance in infants to be weak, if present at all.
27. 27. JN Constantino DL Murphy 1996 Monoamine metabolites in ‘leftover’ newborn human cerebrospinal fluid-a potential resource for biobehavioral research Psychiatry Res 65 129 142 9029662 10.1016/S0165-1781(96)02976-9 1:CAS:528:DyaK2sXhsVGlu7g%3D Constantino JN, Murphy DL: Monoamine metabolites in ‘leftover’ newborn human cerebrospinal fluid-a potential resource for biobehavioral research. Psychiatry Res 1996, 65:129–142.
28. 28. JM Halperin V Sharma LJ Siever 1994 Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder Am J Psychiatry 151 243 248 8296897 1:STN:280:DyaK2c7islGrsg%3D%3D Halperin JM, Sharma V, Siever LJ, et al.: Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. Am J Psychiatry 1994, 151:243–248.
29. 29. JM Halperin JH Newcorn ST Schwartz 1997 Age-related changes in the association between serotonergic function and aggression in boys with ADHD Biol Psychiatry 41 682 689 9066992 10.1016/S0006-3223(96)00168-0 1:CAS:528:DyaK2sXit12ksrg%3D Halperin JM, Newcorn JH, Schwartz ST, et al.: Age-related changes in the association between serotonergic function and aggression in boys with ADHD. Biol Psychiatry 1997, 41:682–689.
30. 30. DS Pine JD Coplan GA Wasserman 1997 Neuroendocrine response to fenfluramine challenge in boys. Associations with aggressive behavior and adverse rearing Arch Gen Psych 54 839 846 1:CAS:528:DyaK2sXmtlGqtb0%3D Pine DS, Coplan JD, Wasserman GA, et al.: Neuroendocrine response to fenfluramine challenge in boys. Associations with aggressive behavior and adverse rearing. Arch Gen Psych 1997, 54:839–846.
31. 31. DM Stoff AP Pasatiempo JH Yeung 1992 Neuroendocrine responses to challenge with dl-fenfluramine and aggression in disruptive behavior disorders of children and adolescents Psychiatry Res 43 263 276 1438624 10.1016/0165-1781(92)90059-C 1:STN:280:DyaK3s%2Fms1yisw%3D%3D Stoff DM, Pasatiempo AP, Yeung JH, et al.: Neuroendocrine responses to challenge with dl-fenfluramine and aggression in disruptive behavior disorders of children and adolescents. Psychiatry Res 1992, 43:263–276.
32. 32. RH Grayson JM Halperin V Sharma 1997 Changes in plasma prolactin and catecholamine metabolite levels following acute needle-stick in children Psychiatry Res 69 27 32 9080542 10.1016/S0165-1781(96)03048-X 1:CAS:528:DyaK2sXit1artb4%3D Grayson RH, Halperin JM, Sharma V, et al.: Changes in plasma prolactin and catecholamine metabolite levels following acute needle-stick in children. Psychiatry Res 1997, 69:27–32.
33. 33. B Birmaher M Stanley L Greenhill 1990 Platelet imipramine binding in children and adolescents with impulsive behavior J Am Acad Child Adolesc Psychiatry 29 914 918 2177056 10.1097/00004583-199011000-00013 1:STN:280:DyaK3M7gslGlsg%3D%3D Birmaher B, Stanley M, Greenhill L, et al.: Platelet imipramine binding in children and adolescents with impulsive behavior. J Am Acad Child Adolesc Psychiatry 1990, 29:914–918.
34. 34. DM Stoff L Pollock B Vitiello 1987 Reduction of (3H)-Imipramine binding sites on platelets of conduct-disordered children Neuropsychopharmacology 1 55 62 2855302 10.1016/0893-133X(87)90010-8 1:CAS:528:DyaL1cXktlKjt7Y%3D Stoff DM, Pollock L, Vitiello B, et al.: Reduction of (3H)-Imipramine binding sites on platelets of conduct-disordered children. Neuropsychopharmacology 1987, 1:55–62.
35. 35. A Donovan JM Halperin JH Newcorn V Sharma 1999 Thermal response to serotonergic challenge and aggression in ADHD children J Child Adolesc Psychopharmacology 9 85 91 1:STN:280:DyaK1MzovV2itg%3D%3D 10.1089/cap.1999.9.85 Donovan A, Halperin JM, Newcorn JH, Sharma V: Thermal response to serotonergic challenge and aggression in ADHD children. J Child Adolesc Psychopharmacology 1999, 9:85–91.
36. 36. DS Pine G Wasserman J Coplan 1996 Serotonergic and cardiac correlates of aggression in children Proc NY Acad Sci 794 391 393 10.1111/j.1749-6632.1996.tb32552.x 1:STN:280:DyaK2s%2Fgs1egsw%3D%3D Pine DS, Wasserman G, Coplan J, et al.: Serotonergic and cardiac correlates of aggression in children. Proc NY Acad Sci 1996, 794:391–393.
37. 37. KP Schulz JH Newcorn KE McKay 1998 Central serotonergic function and aggression in boys: effect of ADHD Scientific Proceedings of the Annual Meeting of the American Academy of Child and Adolescent Psychiatry 14 91 91 Schulz KP, Newcorn JH, McKay KE, et al.: Central serotonergic function and aggression in boys: effect of ADHD. Scientific Proceedings of the Annual Meeting of the American Academy of Child and Adolescent Psychiatry. 1998, 14:91.
38. 38. MS Lidlow PS Goldman-Rakic P Rakic 1991 Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex Proc Natl Acad Sci 88 10218 10221 10.1073/pnas.88.22.10218 Lidlow MS, Goldman-Rakic PS, Rakic P: Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex. Proc Natl Acad Sci 1991, 88:10218–10221.
39. 39. JD Higley SJ Suomi M Linnoila 1991 CSF monoamine metabolite concentrations vary according to age, rearing, and sex, and are influenced by the stress or os social separation in rhesus monkeys Psychopharmacology 103 551 556 1712115 10.1007/BF02244258 1:CAS:528:DyaK3MXit1Wqs70%3D Higley JD, Suomi SJ, Linnoila M: CSF monoamine metabolite concentrations vary according to age, rearing, and sex, and are influenced by the stress or os social separation in rhesus monkeys. Psychopharmacology 1991, 103:551–556.
40. 40. PJ Langlais FX Walsh ED Bird HL Levy 1985 Cerebrospinal fluid neurotransmitter metabolites in neurologically normal infants and children Pediatrics 75 580 586 2579365 1:CAS:528:DyaL2MXkt1Sgs7Y%3D Langlais PJ, Walsh FX, Bird ED, Levy HL: Cerebrospinal fluid neurotransmitter metabolites in neurologically normal infants and children. Pediatrics 1985, 75:580–586.
41. 41. FS Silverstein S Donn K Buchanan MV Johnston 1985 Concentrations of homovanillic acid and 5-hydroxyindoleacetic acid in cerebrospinal fluid from human infants in the perinatal period J Neurochem 43 1769 1772 10.1111/j.1471-4159.1984.tb06109.x Silverstein FS, Donn S, Buchanan K, Johnston MV: Concentrations of homovanillic acid and 5-hydroxyindoleacetic acid in cerebrospinal fluid from human infants in the perinatal period. J Neurochem 1985, 43:1769–1772.
42. 42. LH Pick JM Halperin ST Schwartz JH Newcorn 1999 A longitudinal study of neurobiological mechanisms in boys with attention-deficit hyperactivity disorder: preliminary findings Biol Psychiatry 45 373 373 10.1016/S0006-3223(98)00074-2 The only study to examine stability of central 5-HT function in children with DBDs Pick LH, Halperin JM, Schwartz ST, Newcorn JH: A longitudinal study of neurobiological mechanisms in boys with attention-deficit hyperactivity disorder: preliminary findings. Biol Psychiatry 1999, 45:373–373. The only study to examine stability of central 5-HT function in children with DBDs.
43. 43. O Cases I Seif J Grimsby 1995 Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA Science 268 1763 1766 7792602 10.1126/science.7792602 1:CAS:528:DyaK2MXmsFCitrY%3D Cases O, Seif I, Grimsby J, et al.: Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 1995, 268:1763–1766.
44. 44. Loeber R, Stouthamer-Loeber M: Development of juvenile aggression and violence. Am Psychologist 1998, 242–259.
45. 45. MJ Lyons WT True SA Eisen 1995 Differential heritability of adult and juvenile antisocial traits Arch Gen Psychiatry 52 906 915 7487339 1:STN:280:DyaK28%2Fms12qsQ%3D%3D Lyons MJ, True WT, Eisen SA, et al.: Differential heritability of adult and juvenile antisocial traits. Arch Gen Psychiatry 1995, 52:906–915.
46. 46. J Biederman K Munir D Knee 1987 Conduct and oppositional disorder in clinically referred children with attention deficit disorder: a controlled family study J Am Acad Child Adolesc Psychiat 26 724 727 1:STN:280:DyaL1c%2Fjt1Okug%3D%3D 10.1097/00004583-198709000-00018 Biederman J, Munir K, Knee D: Conduct and oppositional disorder in clinically referred children with attention deficit disorder: a controlled family study. J Am Acad Child Adolesc Psychiat 1987, 26:724–727.
47. 47. PJ Frick BB Lahey R Loeber 1992 Familial risk factors to oppositional defiant disorder and conduct disorder: parental psychopathology and maternal parenting J Consult Clin Psychol 60 49 55 1556285 10.1037/0022-006X.60.1.49 1:STN:280:DyaK383htVyrsg%3D%3D Frick PJ, Lahey BB, Loeber R, et al.: Familial risk factors to oppositional defiant disorder and conduct disorder: parental psychopathology and maternal parenting. J Consult Clin Psychol 1992, 60:49–55.
48. 48. BB Lahey JC Piacentini K McBurnett 1988 Psychopathology in the parents of children with conduct disorder and hyperactivity J Am Acad Child Adolesc Psychiatry 27 163 170 3360717 1:STN:280:DyaL1c7psl2gsA%3D%3D 10.1097/00004583-198803000-00005 Lahey BB, Piacentini JC, McBurnett K, et al.: Psychopathology in the parents of children with conduct disorder and hyperactivity. J Am Acad Child Adolesc Psychiatry 1988, 27:163–170.
49. 49. EF Coccaro JM Silverman HM Klar 1994 Familial correlates of reduced central serotonergic system function in patients with personality disorders Arch Gen Psychiatry 51 318 324 8161292 1:STN:280:DyaK2c3htlGrsg%3D%3D Coccaro EF, Silverman JM, Klar HM, et al.: Familial correlates of reduced central serotonergic system function in patients with personality disorders. Arch Gen Psychiatry 1994, 51:318–324.
50. 50. JN Constantino JA Morris DL Murphy 1997 CSF 5-HIAA and family history of antisocial personality disorder in newborns Am J Psychiatry 154 1771 1773 9396964 1:STN:280:DyaK1c%2FlvFSqtQ%3D%3D Constantino JN, Morris JA, Murphy DL: CSF 5-HIAA and family history of antisocial personality disorder in newborns. Am J Psychiatry 1997, 154:1771–1773.
51. 51. JN Constantino DL Murphy JA Morris 1999 Family psychiatric history, cerebrospinal fluid monoamine metabolites, and temperament in infants Biol Psychiatry 45 626 632 10088050 10.1016/S0006-3223(98)00170-X 1:STN:280:DyaK1M7ovVSnsA%3D%3D Constantino JN, Murphy DL, Morris JA: Family psychiatric history, cerebrospinal fluid monoamine metabolites, and temperament in infants. Biol Psychiatry 1999, 45:626–632.
52. 52. JM Halperin JH Newcorn I Kopstein 1997 Serotonin, aggression, and parental psychopathology in children with attention-deficit hyperactivity disorder J Amer Acad Child Adol Psychiatry 36 1391 1398 1:STN:280:DyaK2svnsV2gsw%3D%3D 10.1097/00004583-199710000-00021 Halperin JM, Newcorn JH, Kopstein I, et al.: Serotonin, aggression, and parental psychopathology in children with attention-deficit hyperactivity disorder. J Amer Acad Child Adol Psychiatry 1997, 36:1391–1398.
53. 53. D Ernouf P Compagnon P Lothion 1993 Platelets in 3H 5HT uptake in descendants from alcoholic patients: a potential risk factor for alcohol dependence Life Science 52 989 995 10.1016/0024-3205(93)90190-E 1:CAS:528:DyaK3sXhs1aqu7c%3D Ernouf D, Compagnon P, Lothion P, et al.: Platelets in 3H 5HT uptake in descendants from alcoholic patients: a potential risk factor for alcohol dependence. Life Science 1993, 52:989–995.
54. 54. RJ Cadoret WR Yates E Troughton 1995 Genetic-environmental interaction in the genesis of aggressivity and conduct disorders Arch Gen Psychiatry 52 916 924 7487340 1:STN:280:DyaK28%2Fms12qtg%3D%3D Cadoret RJ, Yates WR, Troughton E, et al.: Genetic-environmental interaction in the genesis of aggressivity and conduct disorders. Arch Gen Psychiatry 1995, 52:916–924.
55. 55. JD Higley WW Thompson M Champoux 1993 Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (macaca mulatta) Arch Gen Psychiatry 50 615 623 7688210 1:CAS:528:DyaK3sXmtFOqt78%3D Higley JD, Thompson WW, Champoux M, et al.: Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (macaca mulatta). Arch Gen Psychiatry 1993, 50:615–623.
56. 56. AD Seroczynski CS Bergeman EF Coccaro 1999 Etiology of the impulsivity/aggression relationship: genes or environment Psychiatry Research 86 41 57 10359481 10.1016/S0165-1781(99)00013-X 1:STN:280:DyaK1M3os1Snsg%3D%3D Examined the impact of genetic and environmental factors in the development of aggression in adults Seroczynski AD, Bergeman CS, Coccaro EF: Etiology of the impulsivity/aggression relationship: genes or environment. Psychiatry Research 1999, 86:41–57. Examined the impact of genetic and environmental factors in the development of aggression in adults.
57. 57. EF Coccaro CS Bergeman GE McClearn 1993 Heritability of irritable aggressiveness: a study of twins reared together and apart Psychiatry Res 48 229 242 8272445 10.1016/0165-1781(93)90074-Q 1:STN:280:DyaK2c%2FpslyjtQ%3D%3D Coccaro EF, Bergeman CS, McClearn GE: Heritability of irritable aggressiveness: a study of twins reared together and apart. Psychiatry Res 1993, 48:229–242.
58. 58. J Ghodsian-Carpey LA Baker 1987 Genetic and environmental influences on aggression in 4-to 7-year-old twins Aggressive Behav 13 173 186 10.1002/1098-2337(1987)13:4<173::AID-AB2480130402>3.0.CO;2-Y Ghodsian-Carpey J, Baker LA: Genetic and environmental influences on aggression in 4-to 7-year-old twins. Aggressive Behav 1987, 13:173–186.
59. 59. GW Kraemer MH Ebert DE Schmidt WT McKinney 1989 A longitudinal study of the effect of different social rearing conditions on cerebrospinal fluid norepinephrine and biogenic amine metabolites in rhesus monkeys Neuropsychopharmacology 2 175 189 2477005 10.1016/0893-133X(89)90021-3 1:STN:280:DyaK3c%2FgtVanuw%3D%3D Kraemer GW, Ebert MH, Schmidt DE, McKinney WT: A longitudinal study of the effect of different social rearing conditions on cerebrospinal fluid norepinephrine and biogenic amine metabolites in rhesus monkeys. Neuropsychopharmacology 1989, 2:175–189.
60. 60. GW Kraemer S Clarke 1996 Social attachment, brain function, and aggression Ann N Y Acad Sci 794 121 135 8853599 10.1111/j.1749-6632.1996.tb32516.x 1:STN:280:DyaK2s%2Fgs1ejtw%3D%3D Kraemer GW, Clarke S: Social attachment, brain function, and aggression. Ann N Y Acad Sci 1996, 794:121–135.
61. 61. DA Nielsen D Goldman M Virkkunen 1994 Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism Arch Gen Psychiatry 51 34 38 7506517 1:STN:280:DyaK2c7gslSkuw%3D%3D Nielsen DA, Goldman D, Virkkunen M, et al.: Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry 1994, 51:34–38.
62. 62. EF Coccaro RJ Kavoussi TB Cooper RL Hauger 1997 Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects Am J Psychiatry 154 1430 1435 9326827 1:STN:280:DyaK2svmslKiug%3D%3D Coccaro EF, Kavoussi RJ, Cooper TB, Hauger RL: Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects. Am J Psychiatry 1997, 154:1430–1435.
63. 63. RA Glennon M Dukat 1995 Serotonin receptro subtypes FE Ploom DJ Kupfe Psychopharmacology: The Fourth Generation of Progress Raven Press New York 415 429 Glennon RA, Dukat M: Serotonin receptro subtypes. In Psychopharmacology: The Fourth Generation of Progress. Edited by Ploom FE, Kupfe DJ. New York: Raven Press; 1995:415–429.
64. 64. B Olivier J Mos 1994 Serotonin receptor subtypes and aggressive behavior Neuropsychopharmacology 10 944s 944s Olivier B, Mos J: Serotonin receptor subtypes and aggressive behavior. Neuropsychopharmacology 1994, 10:944s.
65. 65. SF Boer de M Lesourd E Mocaer JM Koolhaas 1998 Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: a comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635 J Pharmacol Exp Ther 288 1125 1133 de Boer SF, Lesourd M, Mocaer E, Koolhaas JM: Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: a comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. J Pharmacol Exp Ther 1998, 288:1125–1133.
66. 66. M Virkkunen M Eggert R Rawlings M Linnoila 1996 A prospective follow-up study of alcoholic violent offenders and fire setters Arch Gen Psychiatry 53 523 529 8639035 1:STN:280:DyaK283ktVaisw%3D%3D Virkkunen M, Eggert M, Rawlings R, Linnoila M: A prospective follow-up study of alcoholic violent offenders and fire setters. Arch Gen Psychiatry 1996, 53:523–529.
67. 67. J Lappalainen M Dean L Charbonneau 1995 Mapping of the serotonin 5-HT1D autoreceptor gene on chromosome 6 using a coding region polymorphism Am J Med Genet 60 157 161 7485252 10.1002/ajmg.1320600214 1:STN:280:DyaK28%2FptVagtA%3D%3D Lappalainen J, Dean M, Charbonneau L, et al.: Mapping of the serotonin 5-HT1D autoreceptor gene on chromosome 6 using a coding region polymorphism. Am J Med Genet 1995, 60:157–161.
68. 68. KA Miczek EM Weerts JA Vivian HM Barros 1995 Aggression, anxiety, and vocalizations in animals: GABAA and 5-HT anxiolytics Psychopharmacology 121 38 56 8539340 10.1007/BF02245590 1:CAS:528:DyaK2MXos1Wjsbg%3D Miczek KA, Weerts EM, Vivian JA, Barros HM: Aggression, anxiety, and vocalizations in animals: GABAA and 5-HT anxiolytics. Psychopharmacology 1995, 121:38–56.
69. 69. C Sanchez J Arnt J Hyttel EK Moltzen 1993 The role of serotonergic mechanisms in inhibition of isolation-induced aggression in male mice Psychopharmacology 110 53 59 7870899 10.1007/BF02246950 1:CAS:528:DyaK3sXhvVCjurc%3D Sanchez C, Arnt J, Hyttel J, Moltzen EK: The role of serotonergic mechanisms in inhibition of isolation-induced aggression in male mice. Psychopharmacology 1993, 110:53–59.
70. 70. R Hen F Saudou A Amara 1994 Mice lacking 5-hydroxytryptamine 1B receptors display aggressive behavior Soc Neurosci Abstr 20 1266 1266 Hen R, Saudou F, Amara A, et al.: Mice lacking 5-hydroxytryptamine 1B receptors display aggressive behavior. Soc Neurosci Abstr 1994, 20:1266.
71. 71. F Saudou DA Amara A Dierich 1994 Enhanced aggressive behavior in mice lacking 5-HT1B receptor Science 265 1875 1878 8091214 10.1126/science.8091214 1:CAS:528:DyaK2cXlvFKlt7Y%3D Saudou F, Amara DA, Dierich A, et al.: Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science 1994, 265:1875–1878.
72. 72. TE Moffitt 1993 Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy Psychol Rev 100 674 701 8255953 10.1037/0033-295X.100.4.674 1:STN:280:DyaK2c%2Fnsl2nsA%3D%3D Moffitt TE: Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. Psychol Rev 1993, 100:674–701.