GTPase mechanism and function: New insights from systematic mutational analysis of the phosphate-binding loop residue Ala30 of Rab5

Biochemical Journal

Volumn 346, Issue 2, 2000, Pages 501-508

  Liang, Zhimin ^a   Mather, Timothy ^b   Li, Guangpu ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Endocytosis; GTP hydrolysis; Rab; Ras

Indexed keywords

ALANINE; ARGININE; GLYCINE; GUANOSINE TRIPHOSPHATASE; MUTANT PROTEIN; PROLINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN BHK; ENDOCYTOSIS; ENZYME MECHANISM; ENZYME STRUCTURE; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ALANINE; ANIMALS; BINDING SITES; CRICETINAE; GTP PHOSPHOHYDROLASES; HYDROLYSIS; MUTAGENESIS; PROTEIN BINDING; RAB5 GTP-BINDING PROTEINS;

ANIMALIA; CRICETINAE;

EID: 0034163510     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3460501     Document Type: Article

References (45)

1. 1 Bourne, H. R., Sanders, D. A. and McCormick, F. (1990) Nature (London) 348, 125-132
2. 2 Moss, J. and Vaughan, M. (1998) J. Biol. Chem. 273, 21431-21434
3. 3 Novick, P. and Zerial, M. (1997) Curr. Opin. Cell Biol. 9, 496-504
4. 4 Pfeffer, S. R. (1994) Curr. Opin. Cell Biol. 6, 522-526
5. 5 Der, C. J., Finkel, T. and Cooper, G. M. (1986) Cell 44, 167-176
6. 6 Krengel, U., Schlichting, L., Scherer, A., Schumann, R., French, M., John, J., Kabsch, W., Pai, E. F. and Wittinghofer, A. (1990) Cell 62, 539-548
7. 7 Maegley, K. A., Admiraal, S. J. and Herschlag, D. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 8160-8166
8. 8 Privé, G. G., Milburn, M. V., Tong, L., de Vos, A. M., Yamaizumi, Z., Nishimura, S. and Kim, S.-H. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 3649-3653
9. 9 Rittinger, K., Walker, P. A., Eccleston, J. F., Smerdon, S. J. and Gamblin, S. J. (1997) Nature (London) 389, 758-762
10. 10 Scheffzek, K., Ahmadian, M. R., Kabsch, W., Wiesmuller, L., Lautwein, A., Schmitz, F. and Wittinghofer, A. (1997) Science 277, 333-338
11. 11 Ahmadian, M. R., Stege, P., Scheffzek, K. and Wittinghofer, A. (1997) Nat. Struct. Biol. 4, 686-689
12. 12 Coleman, D. E., Berghuis, A. M., Lee, E., Linder, M. E., Gilman, A. G. and Sprang, S. R. (1994) Science 265, 1405-1412
13. 13 Sondek, J., Lambright, D. G., Noel, J. P., Hamm, H. E. and Sigler, P. B. (1994) Nature (London) 372, 276-279
14. 14 Seeburg, P. H., Colby, W. W., Capon, D. J., Goedel, D. V. and Levinson, A. D. (1984) Nature (London) 312, 71-75
15. 15 Chung, H.-h., Benson, D. R. and Schultz, P. G. (1993) Science 259, 806-809
16. 16 Lowy, D. R. and Willumsen, B. M. (1993) Annu. Rev. Biochem 62, 851-891
17. 17 Dumas, J. J., Zhu, Z., Connolly, J. L. and Lambright, D. G. (1999) Structure 7, 413-423
18. 18 Ostermeier, C. and Brunger, A. T. (1999) Cell 96, 363-374
19. 19 Pai, E. F., Krengel, U., Petsko, G. A., Goody, R. S., Kabsch, W. and Wittinghofer, A. (1990) EMBO J. 9, 2351-2359
20. 20 Campbell-Burk, S., Papastavros, M. Z., McCormick, F. and Redfield, A. G. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 817-820
21. 21 Miller, A. F., Papastavros, M. Z. and Redfield, A. G. (1992) Biochemistry 31, 10208-10216
22. 22 Redfield, A. G. and Papastavros, M. Z. (1990) Biochemistry 29, 3509-3514
23. 23 Bucci, C., Parton, R. G., Mather, I. M., Stunnenberg, H., Simons, K., Hoflack, B. and Zerial, M. (1992) Cell 70, 715-728
24. 24 Li, G. and Stahl, P. D. (1993) J. Biol. Chem. 268, 24475-24480
25. 25 Liu, K. and Li, G. (1998) J. Biol. Chem. 273, 10087-10090
26. 26 Chen, B. and Przybyla, A. E. (1994) BioTechniques 17, 657-659
27. 27 Bollag, G. and McCormick, F. (1995) Methods Enzymol. 255, 161-170
28. 28 Greer, J. (1990) Proteins Struct. Funct. Genet. 7, 312-334
29. 29 Turk, D. (1992) Ph.D. Thesis, Technische Universitaet, Muenchen, Germany
30. 30 Kabcenell, A. K., Goud, B., Northup, J. and Novick, P. J. (1990) J. Biol. Chem. 265, 9366-9372
31. 31 Hoffenberg, S., Sanford, J. C., Liu, S., Daniel, D. S., Tuvin, M., Knoll, B. J., Wessling-Resnick, M. and Dickey, B. F. (1995) J. Biol. Chem. 270, 5048-5056
32. 32 Shapiro, A. D., Riederer, M. A. and Pfeffer, S. R. (1993) J. Biol. Chem. 268, 6925-6931
33. 33 Freissmuth, M. and Gilman, A. G. (1989) J. Biol. Chem. 264, 21907-21914
34. 34 Landis, C. A., Masters, S. B., Spada, A., Pace, A. M., Bourne, H. R. and Vallar, L. (1989) Nature (London) 340, 692-696
35. 35 Gorvel, J.-P., Chavrier, P., Zerial, M. and Gruenberg, J. (1991) Cell 64, 915-925
36. 36 Li, G., Barbieri, M. A., Colombo, M. I. and Stahl, P. D. (1994) J. Biol. Chem. 269, 14631-14635
37. 37 McLauchlan, H., Newell, J., Morrice, N., Osborne, A., West, M. and Smythe, E. (1998) Curr. Biol. 8, 34-45
38. 38 Gibbs, J. B., Schaber, M. D., Allard, W. J., Sigal, I. S. and Scolnick, E. M. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 5026-5030
39. 39 Trahey, M. and McCormick, F. (1987) Science 238, 542-545
40. 40 Eccleston, J. F., Moore, K. J., Morgan, L., Skinner, R. H. and Lowe, P. N. (1993) J. Biol. Chem. 268, 27012-27019
41. 41 Barbieri, M. A., Li, G., Colombo, M. I. and Stahl, P. D. (1994) J. Biol. Chem. 269, 18720-18722
42. 42 Stenmark, H., Parton, R. G., Steele-Mortimer, O., Lutcke, A., Gruenberg, J. and Zerial, M. (1994) EMBO J. 13, 1287-1296
43. 43 Sanford, J. C., Pan, Y. and Wessling-Resnick, M. (1993) J. Biol. Chem. 268, 23773-23776
44. 44 Seabra, M. C. (1996) J. Biol. Chem. 271, 14398-14404
45. 45 Schimmo̊ller, F., Simon, I. and Pfeffer, S. R. (1998) J. Biol. Chem. 273, 22161-22164