Human serum reactivity to porcine endothelial cells after antisense- mediated down-regulation of GpIIIa expression

Transplantation

Volumn 63, Issue 4, 1997, Pages 588-593

  Kearns Jonker, Mary K ^a   Cramer, Donald V ^a   Dane, Leila A ^a   Swensson, Joyce M ^a   Makowka, Leonard ^a  

^a ST VINCENT MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GLYCOPROTEIN IIIA; IMMUNOGLOBULIN M;

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTERY ENDOTHELIUM; ARTICLE; COMPLEMENT DEPENDENT CYTOTOXICITY; DOWN REGULATION; ENDOTHELIUM CELL; GRAFT REJECTION; HUMAN; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SWINE; XENOTRANSPLANTATION;

ANIMALS; ANTISENSE ELEMENTS (GENETICS); CELLS, CULTURED; CLONING, MOLECULAR; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; RABBITS; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0031048858     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199702270-00018     Document Type: Article

References (32)

1. Cramer DV. Natural antibodies. In: Tilney NL, Strom TB, Paul LC, eds. Transplantation biology: cellular and molecular aspects. New York: Raven, 1995.
2. Platt JL, Lindman BJ, Geller RL, et al. The role of natural antibodies in the activation of xenogeneic endothelial cells. Transplantation 1991; 52: 1036.
3. Cramer DV, Sher L, Makowka L. Liver xenotransplantation: clinical experience and future considerations. In: Cooper DKC, Kemp E, Reemtsma K, White DJG, eds. Xenotransplantation. The transplantation of organs and tissues between species. Berlin: Springer-Verlag, 1991: 559.
4. Boyden SV. Natural antibodies and the immune response. Adv Immunol 1966; 5: 1.
5. Auchincloss H Jr. Xenogeneic transplantation: a review. Transplantation 1988; 46: 1.
6. Hammer C. Isohemagglutinins and preformed natural antibodies in xenogeneic organ transplantation. Transplant Proc 1987; 19: 4443.
7. Vanhove B, Bach FH. Human xenoreactive natural antibodies-avidity and targets on porcine endothelial cells. Transplantation 1993; 56: 1251.
8. Maroun J, Reilly CF, Rosenberg RD. Heparan sulfate species and blood vessel wall function. In: Wight TM, Mecham RP, eds. Biology of proteoglycans. Orlando, FL: Academic Press, 1987: 301.
9. Saadi S, Platt JL. Transient perturbation of endothelial integrity induced by natural antibodies and complement. J Exp Med 1995; 181: 21.
10. Platt JL, Vercellotti GM, Lindman BJ, Oegema TR, Bach FH, Dalmasso AP. Release of heparan sulfate from endothelium: implications for pathogenesis of hyperacute rejection. J Exp Med 1990; 171: 1363.
11. Tuso PJ, Cramer DV, Middleton YD, et al. Pig aortic endothelial cell antigens recognized by human IgM natural antibodies. Transplantation 1993; 56: 651.
12. Parker W, Bruno D, Holzknecht ZE, Platt JL. Characterization and affinity isolation of xenoreactive human natural antibodies. J Immunol 1994; 153: 3791.
13. Vaughan HA, McKenzie IFC, Sandrin MS. Biochemical studies of pig xenoantigens detected by naturally occurring human antibodies and the galactose α(1-3)galactose reactive lectin. Transplantation 1995; 59: 102.
14. Holzknecht ZE, Platt JL. Identification of porcine endothelial cell membrane antigens recognized by human xenoreactive natural antibodies. J Immunol 1995; 154: 4565.
15. Zimrin AB, Eisman R, Vilaire G, Schwartz E, Bennett JS, Poncz M. Structure of platelet glycoprotein IIIa. J Clin Invest 1988; 81: 1470.
16. Fitzgerald LA, Steiner B, Rail SC Jr, Lo S, Phillips DR. Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. J Biol Chem 1987; 262: 3936.
17. Rosa JP, Bray PF, Gayet O, et al. Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17. Blood 1988; 72: 593.
18. Tuso PJ, Cramer DV, Cosenza CA, et al. Characterization of human antibodies that are cytotoxic to pig aortic endothelial cells. Transplant Proc 1993; 25: 392.
19. Wetzsteon PJ, Head MA, Fletcher LM, Lye WC, Norman DJ. Cytotoxic flow-cytometric crossmatches (flowtox): a comparison with conventional cytotoxicity crossmatch techniques. Hum Immunol 1992; 35: 93.
20. Gubler U, Hoffman BJ. Simple and very efficient method for generating cDNA libraries. Gene 1983; 25: 263.
21. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning, a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
22. Ausubel FM, Brent R, Kingston RE, et al. Current protocols in molecular biology. New York: John Wiley & Sons, 1992.
23. Pepin MC, Pothier F, Barden N. Impaired type II glucocorticoid receptor function in mice bearing antisense RNA transgene. Nature 1992; 355: 725.
24. Hambor JE, Hauer CA, Shu HK, Groger RK, Kaplan DR, Tykocinski ML. Use of an Epstein-Barr virus episomal replicon for anti-sense RNA-mediated gene inhibition in a human cytotoxic T-cell clone. Proc Natl Acad Sci USA 1988; 85: 4010.
25. Marcantonio EE, Hynes RO. Antibodies to the conserved cytoplasmic domain of the intergrin β-1 subunit react with proteins in vertebrates, invertebrates, and fungi. J Cell Biol 1988; 106: 1765.
26. Dewerchin M, Lijnen HR, Stassen JM, et al. Effect of chemical conjugation of recombinant single-chain urokinase-type plasminogen activator with monoclonal antiplatelet antibodies on platelet aggregation and on plasma clot lysis in vitro and in vivo. Blood 1991; 78: 1005.
27. Alvarado CG, Cotterell AH, McCurry KR, et al. Variation in the level of xenoantigen expression in porcine organs. Transplantation 1995; 59: 1589.
28. Platt JL, Holzknecht ZE. Porcine platelet antigens recognized by human xenoreactive natural antibodies. Transplantation 1994; 57: 327.
29. Elliot EA, Sandrin MS, Flavell RA, Matis LA, McKenzie IFC. A model for inhibiting hyperacute rejection: α-1,3-galactosyl-transferase "knockout" mice [Abstract]. Third International Congress for Xenotransplantation, 1996.
30. Strahan KM, Preecc AF, Xu Y, Gustafsson K. Antisense inhibition of α1,3 galactosyltransferase as a means to reduce human antibody-mediated cytotoxicity to pig cells [Abstract]. Third International Congress for Xenotransplantation, 1996.
31. Tange MJ, Katerelos M, Crawford RJ, et al. Analysis of α1,3 galactosyltransferase knockout mice [Abstract]. Third International Congress for Xenotransplantation, 1996.
32. Tearle RG, Lonie AJ, Zannettino ZL, et al. Production and characterisation of mice that do not express the gal-α1,3-gal epitope [Abstract]. Third International Congress for Xenotransplantation, 1996.