-
1
-
-
0038523512
-
A randomized phase II trial of recombinant human interleukin-12 (IL-12) versus interferon alpha-2a (IFN) in advanced renal cell carcinoma (RCC)
-
Berg, W.J., Bukowski, R., Thompson, J.A., Nemunaitis, J., Murphy, B., Ellerhorst, J. and Motzer, R.J. 1998. A randomized phase II trial of recombinant human interleukin-12 (IL-12) versus interferon alpha-2a (IFN) in advanced renal cell carcinoma (RCC). Proc. ASCO. 17: 318a.
-
(1998)
Proc. ASCO
, vol.17
-
-
Berg, W.J.1
Bukowski, R.2
Thompson, J.A.3
Nemunaitis, J.4
Murphy, B.5
Ellerhorst, J.6
Motzer, R.J.7
-
2
-
-
0027239503
-
Antitumor and antimetastatic activity of Interleukine12 against murine tumors
-
Brunda, M.J., Luistro, L., Warrier, R.R., Wright, R.B., Hubbard, B.R., Murphy, M., Wolf, S.F. and Gately, M.K. 1993. Antitumor and antimetastatic activity of Interleukine12 against murine tumors. J. Exp. Med. 178: 1223-1230.
-
(1993)
J. Exp. Med.
, vol.178
, pp. 1223-1230
-
-
Brunda, M.J.1
Luistro, L.2
Warrier, R.R.3
Wright, R.B.4
Hubbard, B.R.5
Murphy, M.6
Wolf, S.F.7
Gately, M.K.8
-
3
-
-
0029848051
-
Direct intratumoral injection of an adenovirus expressing interlukin-12 induces regression and long-lasting immunity: That is associated with highly localized expression of Interleukin-12
-
Bramson, J.L., Hitt, M., Addison, C.L., Muller, W.J., Gauldie, J. and Graham, F.L. 1996. Direct intratumoral injection of an adenovirus expressing interlukin-12 induces regression and long-lasting immunity: That is associated with highly localized expression of Interleukin-12. Hum. Gene Ther. 7: 1995-2002.
-
(1996)
Hum. Gene Ther.
, vol.7
, pp. 1995-2002
-
-
Bramson, J.L.1
Hitt, M.2
Addison, C.L.3
Muller, W.J.4
Gauldie, J.5
Graham, F.L.6
-
4
-
-
0028824039
-
IL-12 deaths: Explanation and puzzle
-
Coen, J. 1995. IL-12 deaths: explanation and puzzle. Science 270: 908.
-
(1995)
Science
, vol.270
, pp. 908
-
-
Coen, J.1
-
5
-
-
0027538181
-
Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long lasting anti-tumor immunity
-
Dranoff, G., Jaffee, E., Lazenby A., Golumbek, P., Levisky H., Brose, K., Jackson, V., Hamada, H., Pardoll, D. and Mulligan, R. 1993. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long lasting anti-tumor immunity. Proc. Natl. Acad. Sci. USA. 90: 3539-3543.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 3539-3543
-
-
Dranoff, G.1
Jaffee, E.2
Lazenby, A.3
Golumbek, P.4
Levisky, H.5
Brose, K.6
Jackson, V.7
Hamada, H.8
Pardoll, D.9
Mulligan, R.10
-
6
-
-
0028096083
-
Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocytes activity and induces production of IFN-γ in vivo
-
Gately, M.K., Warrier, R.R., Honasoge, S., Carvajal, D.M., Sarmiento, U., Hubbard, B.R. and Murphy, M. 1994. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocytes activity and induces production of IFN-γ in vivo. Int. Immunol. 6: 157-167.
-
(1994)
Int. Immunol.
, vol.6
, pp. 157-167
-
-
Gately, M.K.1
Warrier, R.R.2
Honasoge, S.3
Carvajal, D.M.4
Sarmiento, U.5
Hubbard, B.R.6
Murphy, M.7
-
7
-
-
0025808629
-
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
-
Gubler, U., Chua, A.O., Schoenhaut, D.S., Dwyer, C.M., McComa, W., Motyka, R., Nabavi, N., Wolitzky, A.G., Quinn, P.M., Familletti, P.C. and Gately, M.K. 1991. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA. 88: 4143-4147.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 4143-4147
-
-
Gubler, U.1
Chua, A.O.2
Schoenhaut, D.S.3
Dwyer, C.M.4
McComa, W.5
Motyka, R.6
Nabavi, N.7
Wolitzky, A.G.8
Quinn, P.M.9
Familletti, P.C.10
Gately, M.K.11
-
8
-
-
0027309489
-
High efficacy gene transfer into primary human tumor explants without cell selection
-
Jaffe, E.M., Dranoff, G., Cohen, L.K., Hauda, M.K., Clift, S., Marshall, F.F., Mulligan, R.C. and Pardell, D.M. 1993. High efficacy gene transfer into primary human tumor explants without cell selection. Cancer Res. 53: 2221-2226.
-
(1993)
Cancer Res.
, vol.53
, pp. 2221-2226
-
-
Jaffe, E.M.1
Dranoff, G.2
Cohen, L.K.3
Hauda, M.K.4
Clift, S.5
Marshall, F.F.6
Mulligan, R.C.7
Pardell, D.M.8
-
9
-
-
0024467154
-
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
-
Kobayashi, M., Fitz, L., Ryan, M., Hewick, R.M., Clark, S.C., Chang, S., Loudon, R., Scherman, F., Perussia, B. and Trinchieri, G. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170: 827-845.
-
(1989)
J. Exp. Med.
, vol.170
, pp. 827-845
-
-
Kobayashi, M.1
Fitz, L.2
Ryan, M.3
Hewick, R.M.4
Clark, S.C.5
Chang, S.6
Loudon, R.7
Scherman, F.8
Perussia, B.9
Trinchieri, G.10
-
10
-
-
0031924595
-
Phase I trial of subcutaneous recombinant human Interleukin-12 in patients with advanced renal cell carcinoma
-
Motzer, R.J., Rakhit, A., Schwartz, L.H., Olencki, T., Malone, T.M., Sandstrom, K., Nadeau, R., Parmar, H. and Bukowski, R. 1998. Phase I trial of subcutaneous recombinant human Interleukin-12 in patients with advanced renal cell carcinoma. Clinical Cancer Res. 4: 1183-1191.
-
(1998)
Clinical Cancer Res.
, vol.4
, pp. 1183-1191
-
-
Motzer, R.J.1
Rakhit, A.2
Schwartz, L.H.3
Olencki, T.4
Malone, T.M.5
Sandstrom, K.6
Nadeau, R.7
Parmar, H.8
Bukowski, R.9
-
11
-
-
0030695173
-
Renal cell carcinoma: Recent progress and future directions
-
Mulders, P., Figlin, R., deKernion, B.J., Wiltrout, R., Linehan, M., Parkinson, D., deWolf, W. and Belidegrum, A. 1997. Renal cell carcinoma: recent progress and future directions. Cancer Res. 57: 5189-5195.
-
(1997)
Cancer Res.
, vol.57
, pp. 5189-5195
-
-
Mulders, P.1
Figlin, R.2
DeKernion, B.J.3
Wiltrout, R.4
Linehan, M.5
Parkinson, D.6
DeWolf, W.7
Belidegrum, A.8
-
13
-
-
0025109422
-
Surgical treatment of renal cell carcinoma I.: Results of curative nephrectomy for renal cell carcinoma without distant metastases
-
Nakamoto, T., Mitani, S., Usui, A., Ikemoto, H., Usui, T. and Nakano, H. 1990. Surgical treatment of renal cell carcinoma I.: Results of curative nephrectomy for renal cell carcinoma without distant metastases. Nishinihon J. Urol. 52: 701-704.
-
(1990)
Nishinihon J. Urol.
, vol.52
, pp. 701-704
-
-
Nakamoto, T.1
Mitani, S.2
Usui, A.3
Ikemoto, H.4
Usui, T.5
Nakano, H.6
-
14
-
-
0024996542
-
Surgical treatment of renal cell carcinoma II.: Results of adjunctive nephrectomy for renal cell carcinoma with distant metastases
-
Nakamoto, T., Mitani, S., Usui, A., Ikemoto, H., Usui, T. and Nakano, H. 1990. Surgical treatment of renal cell carcinoma II.: Results of adjunctive nephrectomy for renal cell carcinoma with distant metastases. Nishinihon J. Urol. 52: 705-708.
-
(1990)
Nishinihon J. Urol.
, vol.52
, pp. 705-708
-
-
Nakamoto, T.1
Mitani, S.2
Usui, A.3
Ikemoto, H.4
Usui, T.5
Nakano, H.6
-
15
-
-
0027963161
-
Recombinant IL-12 administration induces tumor regression in association with IFN-γ
-
Nastala, C.L., Edington, H., Storkus, W., Mckinney, T.G., Brunda, M., Gately, M.K., Wolf, S.F., Schreiber, R. and Lotze, M.T. 1994. Recombinant IL-12 administration induces tumor regression in association with IFN-γ. J. Immunol. 153: 1697-1706.
-
(1994)
J. Immunol.
, vol.153
, pp. 1697-1706
-
-
Nastala, C.L.1
Edington, H.2
Storkus, W.3
McKinney, T.G.4
Brunda, M.5
Gately, M.K.6
Wolf, S.F.7
Schreiber, R.8
Lotze, M.T.9
-
16
-
-
0002325617
-
Interleukin-12: Basic biology and potential application in cancer treatment
-
Robertson, M.J. and Ritz, J. 1996 Interleukin-12: Basic biology and potential application in cancer treatment. The Oncologist. 1: 93-102.
-
(1996)
The Oncologist
, vol.1
, pp. 93-102
-
-
Robertson, M.J.1
Ritz, J.2
-
17
-
-
0028603492
-
Biologic effects of recombinant human interleukin-12 in squirrel monkeys (Sciureus saimiri)
-
Sarmiento, U.M., Riley, J.H., Knaack, P.A., Lipman, J.M., Becker, J.M., Gately, M.K., Chizzonite, R. and Anderson, T.D. 1994. Biologic effects of recombinant human interleukin-12 in squirrel monkeys (Sciureus saimiri). Lab. Invest. 71: 862-873.
-
(1994)
Lab. Invest.
, vol.71
, pp. 862-873
-
-
Sarmiento, U.M.1
Riley, J.H.2
Knaack, P.A.3
Lipman, J.M.4
Becker, J.M.5
Gately, M.K.6
Chizzonite, R.7
Anderson, T.D.8
-
18
-
-
0025028960
-
Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells
-
Stern, A.S., Podlaski, F.J., Hulmes, J.D., Pan, Y.C.E., Quinn, P.M., Wolitzky, A.G., Familletti, P.C., Stremlo, D.L., Truitt, T., Chizzonite, R. and Gately, M.K. 1990. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl. Acad. Sci. USA. 87: 6808-6812.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 6808-6812
-
-
Stern, A.S.1
Podlaski, F.J.2
Hulmes, J.D.3
Pan, Y.C.E.4
Quinn, P.M.5
Wolitzky, A.G.6
Familletti, P.C.7
Stremlo, D.L.8
Truitt, T.9
Chizzonite, R.10
Gately, M.K.11
-
19
-
-
0027953555
-
Fibroblasts genetically engineered to secrete Interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo
-
Tahara, H., Zeh III, H.J., Storkus, W.J., Pap, I., Watkins, S.C., Gubler, U., Wolf, S.F., Robbins, P.D. and Lotze, M.T. 1994. Fibroblasts genetically engineered to secrete Interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo. Cancer Res. 54: 182-189.
-
(1994)
Cancer Res.
, vol.54
, pp. 182-189
-
-
Tahara, H.1
Zeh H.J. III2
Storkus, W.J.3
Pap, I.4
Watkins, S.C.5
Gubler, U.6
Wolf, S.F.7
Robbins, P.D.8
Lotze, M.T.9
-
20
-
-
0029053343
-
Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector
-
Tahara, H., Zitvogel, L., Storkus, W.J., Zeh III, H.J., McKinney, T.G., Schreiber, R.D., Gubler, U., Robbins, P.D. and Lotze, M.T. 1995. Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector. J. Immunol. 154: 6466-6474.
-
(1995)
J. Immunol.
, vol.154
, pp. 6466-6474
-
-
Tahara, H.1
Zitvogel, L.2
Storkus, W.J.3
Zeh H.J. III4
McKinney, T.G.5
Schreiber, R.D.6
Gubler, U.7
Robbins, P.D.8
Lotze, M.T.9
-
21
-
-
0028968497
-
Administration of recombinant interleukin-12 to mice suppresses hematopoiesis in bone marrow but enhances hematopoiesis in the spleen
-
Tare, N.S., Bowen, S., Warrier, R.W., Carvajal, D.M., Benjamin, W.R., Riley, J.H., Anderson, T.D. and Gately, M.K. 1995. Administration of recombinant interleukin-12 to mice suppresses hematopoiesis in bone marrow but enhances hematopoiesis in the spleen. J. Interferon Cytokine Res. 15: 377-383.
-
(1995)
J. Interferon Cytokine Res.
, vol.15
, pp. 377-383
-
-
Tare, N.S.1
Bowen, S.2
Warrier, R.W.3
Carvajal, D.M.4
Benjamin, W.R.5
Riley, J.H.6
Anderson, T.D.7
Gately, M.K.8
-
22
-
-
0028897739
-
Inhibition of angiogenesis in vivo by Interleukin 12
-
Voest, E.E., Kenyan, B., O'Reilly, M.S., Truitt, G., D'Amato, R.J. and Folkman, J. 1995. Inhibition of angiogenesis in vivo by Interleukin 12. J. Natl. Cancer Inst. 87: 581-586.
-
(1995)
J. Natl. Cancer Inst.
, vol.87
, pp. 581-586
-
-
Voest, E.E.1
Kenyan, B.2
O'Reilly, M.S.3
Truitt, G.4
D'Amato, R.J.5
Folkman, J.6
-
23
-
-
0027192081
-
Immunotherapy for metastatic renal cell carcinoma
-
Wirth, M.P. 1993. Immunotherapy for metastatic renal cell carcinoma. Urol. Clin. North Am. 20: 283-295.
-
(1993)
Urol. Clin. North Am.
, vol.20
, pp. 283-295
-
-
Wirth, M.P.1
-
24
-
-
0028625325
-
Construction and characterization of retroviral vectors expressing biologically active human interleukin-12
-
Zitvogel, L., Tahara, H., Cai, Q., Storkus, W.J., Muller, G., Wolf, S.F., Gately M., Robbins, P.D. and Lotze, M.T. 1994. Construction and characterization of retroviral vectors expressing biologically active human interleukin-12. Hum. Gene Ther. 5: 1493-1506.
-
(1994)
Hum. Gene Ther.
, vol.5
, pp. 1493-1506
-
-
Zitvogel, L.1
Tahara, H.2
Cai, Q.3
Storkus, W.J.4
Muller, G.5
Wolf, S.F.6
Gately, M.7
Robbins, P.D.8
Lotze, M.T.9
|