New pathophysiological findings on acute pancreatitis;Neue pathophysiologische Kenntnisse der akuten Pankreatitis

Chirurg

Volumn 71, Issue 3, 2000, Pages 253-264

  Klar, E ^a,b   Werner, J ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Acute pancreatitis; Etiology; Pathophysiology; Therapy

Indexed keywords

PROTEINASE; REACTIVE OXYGEN METABOLITE; TRYPSINOGEN;

ACUTE DISEASE; ENZYME ACTIVATION; HUMAN; METABOLISM; PANCREAS; PANCREATITIS; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ACUTE DISEASE; ENDOPEPTIDASES; ENZYME ACTIVATION; HUMANS; PANCREAS; PANCREATITIS; REACTIVE OXYGEN SPECIES; TRYPSINOGEN;

EID: 0034154257     PISSN: 00094722     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001040050043     Document Type: Article

References (70)

1. Acosta JL, Ledesma CL (1974) Gallstone migration as a cause for acute pancreatitis. N Engl J Med 290: 484
2. Ammann RW, Bühler H, Brühlmann W, Kehl O, et al (1986) Acute alcoholic pancreatitis: prospective longitudinal study of 144 patients with recurrent alcoholic pancreatitis. Pancreas 1: 195
3. Baas J, Senninger N, Elser H, Herfarth Ch (1995) Dynamic liver scintigraphy: a new way of measuring the function of the reticuloendothelial system of the liver. Eur Surg Res 27: 137
4. Brandt-Nedelev B, Lerch MM, Deussing J, Reinheckel T, et al (1999) Trypsinogenaktivierung im Pankreas Cathepsin B-defizienter Mäuse. Z Gastroenterol 37: 870
5. Büchler M, Malfertheiner P, Uhl W, Schölmerich J, Stöckmann F (1993) Gabexate mesilate in acute pancreatitis. Gastroenterology 104: 1165
6. Cavallini G, Tittobello A, Frulloni L, Castello J, et al (1997) Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gastroenterology 112: 1415
7. Comfort M, Steinberg A (1952) Pedigree of a family with hereditary chronic relapsing pancreatitis. Gastroenterology 21: 54
8. Denham W, Yang J, Fink G, Denham D, et al (1997) Gene targeting demonstrates additive detrimental effects of interleukin-1 and tumor necrosis factor during pancreatitis. Gastroenterology 113: 1741
9. Dickson AP, O,Neill RB, Imrie CW (1984) Hyperlipidemia, alcohol abuse and acute pancreatitis. Br J Surg 71: 685
10. Drivas G, James O, Wardle N (1976) Study of reticuloendothelial capacity in patients with cholestasis. Br Med J 1: 1568
11. Fernandez-del Castillo C, Harringer W, Warshaw AL, Vlahakes GJ, et al (1991) Risk factors for pancreatic cellular injury after cardiopulmonary bypass. N Engl J Med 325: 382
12. Fernandez-del Castillo C, Schmidt J, Warshaw AL, Rattner DW (1993) Interstitial protease activation is the central event in progression to necrotizing pancreatitis. Surgery 116: 497
13. Foitzik T, Faulhaber J, Hotz HG, Kirchengast M, Buhr HJ (1997) Endothelin-1 triggert die Ausbildung der schweren akuten Pankreatitis. Langenbecks Arch Chir 1: 749
14. Foitzik T, Fernandez-del Castillo C, Rattner DW, Klar E, Warshaw AL (1995) Alcohol selectively impairs oxygenation of the pancreas. Arch Surg 130: 357
15. Forman HJ, Thomas MJ (1986) Oxidant production and bactericidal activity of phagocytes. Annu Rev Physiol 48: 669
16. Gorelick FS, Matovick LM (1995) Lysosomal enzymes and pancreatitis. Gastroenterology 109: 620
17. Gorry MC, Gabbaizadeh D, Furey W (1997) Multiple mutations in the cationic trypsinogen gene are associated with hereditary pancreatitis. Gastroenterology 113: 1063
18. Grady T, Otani T, Mah'moud M, Rhee S, et al (1998) Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury. Am J Physiol 275: G1010
19. Greenberger NJ (1973) Pancreatitis and hyperlipemia. N Engl J Med 83: 586
20. Gress TM, Micha AE, Lacher U, Adler G (1998) Diagnosis of a hereditary pancreatitis by the detection of a mutation in the cationic trypsinogen gene. Dtsch Med Wochenschr 123: 453
21. Gross V, Leser HG, Heinisch A Schölmerich J (1993) Inflammatory mediators and cytokines-new aspects of the pathophysiology and assessment of severity of acute pancreatitis. Hepatogastroenterology 40: 522
22. Guy O, Robles-Diaz G, Adrich Z, Sahel J, Sarles H (1983) Protein content of precipitates present in pancreatic juice of alcoholic subjects and patients with chronic calcifying pancreatitis. Gastroenterology 84: 102
23. Halliwel B (1991) Reactive oxygen species in living systems: source, biochemistry and role in human disease. Am J Med 91: 14
24. Hartwig W, Jiminez RE, Werner J, Lewandrowski KB, et al (1999) Interstitial trypsinogen release and its relevance to the transformation of mild into necrotizing pancreatitis in rats. Gastroenterology 117: 717
25. Hartwig W, Werner J, Ryschich E, Mayer H, et al (in press) Cigarette smoke enhances ethanol-induced pancreatic injury. Pancreas
26. Hofbauer B, Friess H, Weber A, Baczako K, et al (1996) Hyperlipemia intensifies the course of acute oedematous and acute necrotising pancreatitis in the rat. Gut 38: 753
27. Jungermann J, Lerch MM, Weidenbach H, Lutz MP, Adler G (1995) Disasembly of rat pancreatic acinar cell cytoskeleton during secretagogue stimulation. Am J Physiol 268: G328
28. Katz M, Carangelo R, Miller LJ, Gorelick F (1996) Effect of ethanol on cholecystokinin-stimulated zymogen conversion in pancreatic acinar cells. Am J Physiol 270: G171
29. Keck T, Werner J, Schneider L, Gebhard MM, et al (im Druck) Charakterisierung des Reperfusionsschadens nach Pankreastransplantation und Reduktion durch die Applikation von monoklonalen ICAM-1 Antikörpern. Langenbecks Arch Surg
30. Kemppainen EA, Hedstrom JI, Puolakkainen PA, Lundstrom EA, et al. (1997) Rapid measurements of urinary trypsinogen-2 as a screening test for acute pancreatitis. N Engl J Med 336: 1788
31. Kerner T, Vollmar B, Menger MD, Waldner H, Messmer K (1996) Determinants of pancreatic microcirculation in acute pancreatitis in rats. J Surg Res 62: 85
32. Klar E, Endrich B, Messmer K (1990) Microcirculation of the pancreas. A quantitative study of physiology and changes in pancreatitis. Int J Microcirc Clin Exp 9: 85
33. Klar E, Foitzik T, Buhr H, Messmer K, Herfarth Ch (1993) Isovolemic hemodilution with dextran 60 as treatment of pancreatic ischemia in acute pancreatitis. Ann Surg 217: 369
34. Klar E, Herfarth Ch, Messmer K (1990) Therapeutic effect of isovolemic hemodilution with dextran 60 on the impairment of pancreatic microcirculation in acute biliary pancreatitis. Ann Surg 211: 346
35. Klar E, Messmer K, Warshaw AL, Herfarth Ch (1990) Pancreatic ischaemia in experimental acute pancreatitis: mechanism, significance and therapy. Br J Surg 77: 1205
36. Klar E, Rattner DW, Compton C, Stanford G, Chernow B, Warshaw AL (1991) Adverse effect of therapeutic vasoconstrictors in experimental acute pancreatitis. Ann Surg 214: 168
37. Klar E, Schratt W, Foitzik T, Buhr H, et al (1994) Impact of microcirculatory flow pattern changes on the development of acute edematous and necrotizing pancreatitis in rabbit pancreas. Dig Dis Sci 39: 2639
38. Klöppel G, Dreyer T, Willemer S, Kern HF, Adler G (1986) Human acute pancreatitis: its pathogenesis in the light of immunocytochemical and ultrastructural findings in acinar cells. Virchows Arch A Pathol Anat Histopathol 409: 791
39. Kusterer K, Poschmann T, Friedemann A, Enghofer M, et al (1993) Arterial constriction, ischemia-reperfusion, and leukocyte adherence in acute pancreatitis. Am J Physiol 265: G165
40. Leach SD, Modlin IM, Scheele GA, Gorelick FS (1991) Intracellular activation of digestive zymogens in rat pancreatic acini. Stimulation by high doses of cholecystokinin. J Clin Invest 87: 362
41. Lerch M, Baas J, Senninger N (1999) The role of bile in acute pancreatitis. In: Büchler MW, Uhl W, Friess H, Malfertheiner P (eds) Acute pancreatitis. Blackwell Science, Berlin Wien, p 89
42. Luethen R, Niederau C, Niederau M, Ferrell LD, Grendell JH (1995) Influence of ductal pressure and infusates on activity and subcellular distribution of lysosomal enzymes in the rat pancreas. Gastroenterology 109: 573
43. Mayer H, Thies JC, Schmidt J, Gebhard MM, et al (1999) Characterization and reduction of ischemia/reperfusion-injury after experimental pancreas transplantation. J Gastrointest Surg 3: 162
44. Menger MD, Bonkohoff H, Vollmar B (1996) Ischemia-reperfusion-induced pancreatic microvascular injury. An intravital fluorescence microscopic study. Dig Dis Sci 41: 823
45. Menger MD, Vollmar B (1996) In vivo documentation of an arteriovenous shunt in rat pancreatic acinar tissue Pancreas 13: 125
46. Mithöfer K, Fernandez-del Castillo C, Frick TW, Foitzik T, et al (1995) Increased intrapancreatic trypsinogen activation in ischemia-induced experimentall pancreatitis. Ann Surg 21: 364
47. Mithöfer K, Fernandez-del Castillo C, Frick T, Lewandrowski KB, et al (1995) Acute hypercalcemia causes acute pancreatitis and ectopic trypsinogen activation in the rat. Gastroenterology 109: 239
48. Niederau C, Niederau M, Borchard F, Ude K, et al (1992) Effects of antioxidants and free radical scavengers in three different models of acute pancreatitis. Pancreas 4: 486
49. Pezizilli R, Billi P, Miniero R, Barakat B (1997) Serum interleukin-10 in human acute pancreatitis. Dig Dis Sci 42: 1469
50. Pirola RC, Davis AE (1968) Effects of ethyl alcohol on sphincteric resistance at the choledochol-duodenal junction in man. Gut 9: 557
51. Rinderknecht H (1988) Fatal pancreatitis, a consequence of excessive leukocyte stimulation? Int J Pancreatol 3: 105
52. Rinderknecht H, Adham NF, Renner IG, Carmack C (1988) A possible zymogen self-destruct mechanism preventing pancreatic autodigestion. Int J Pancreatol 3: 33
53. Schölmerich J (1996) Interleukins in acute pancreatitis. Scand J Gastroenterol 31: 37
54. Schönberg MH, Büchler M, Beger HG (1994) Oxygen radicals in experimental acute pancreatitis. Hepatogastroenterol 41: 313
55. Senninger N, Moody FG, Coelho JC, Buren DH van (1986) The role of biliary obstruction in the pathogenesis of acute pancreatitis in the opossum. Surgery 99: 688
56. Singh M, Simsek H (1990) Ethanol and the pancreas. Gastroenterology 98: 1051
57. Springer T (1990) Adhesion receptors of the immune system. Nature 345: 425
58. nd edn. Raven Press, New York, p 581
59. Steinle A, Weidenbach H, Adler G, Schmidt RM (1999) NFאB/ REL activation prevents higher degree of damage in cerulein pancreatitis. Gastroenterology 116: A1165
60. Telek G, Ducroc R, Maire F, Chariot J, Feldmann G (1999) The genese of cellular adhesion molecules are activated early during the course of experimental acute pancreatitis. Possible role of oxidative stress and NFאB. Gastroenterology 116: A1168
61. Vollmar B, Preissler G, Menger MD (1994) Hemorrhage induces arteriolar vasomotion and intermittent capillary perfusion in rat pancreas. Am J Physiol 267: H1936
62. Ward JB, Petersen OH, Jenkins SA, Sutton R (1995) Is an elevated concentration of acinar cytosolic free ionised calcium the trigger for acute pancreatitis. Lancet 346: 1016
63. Warshaw AL, O'Hara PJ (1978) Susceptibility of the pancreas to ischemic injury in shock. Ann Surg 188: 197
64. Werner J, Dragotakes SC, Fernandez-del Castillo C, Rivera JA, et al (1998) Technetium-99m-labeled white blood cells - a new method to define the local and systemic role of leukocytes in acute experimental pancreatitis. Ann Surg 227: 86
65. Werner J, Klar E (1999) Therapeutische Beeinflussung des Schweregrades der akuten Pankreatitis. Chir Gastroenterol 15: 328
66. Werner J, Laposata M, Fernandez-del Castillo C, Saghir M, et al (1997) Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol. Gastroenterology 113: 286
67. Werner J, Rivera J, Fernandez-del Castillo C, Warshaw AL (1997) Differing roles of nitric oxide in the pathogenesis of acute edematous versus necrotizing pancreatitis. Surgery 121: 23
68. Werner J, Schmidt J, Gebhard MM, Herfarth Ch, Klar E (1996) Überlegenheit von Dextran gegenüber HAES und Kristalloiden in der Hemmung der Leukocyten-Endothel-Interaktion bei experimenteller nekrotisierender Pankreatitis. Langenbecks Arch Chir Forum 24 [Suppl II]: 467
69. Werner J, Z'graggen K, Fernandez-del Castillo C, Lewandrowski KB, et al (1999) Specific therapy for local and systemic complications of acute pancreatitis with monoclonal antibodies against ICAM-1. Ann Surg 229: 834
70. Whitcomb DC, Gorry MC, Preston RA (1996) Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 14: 141