Local morphine withdrawal increases c-fos gene, fos protein, and oxytocin gene expression in hypothalamic magnocellular neurosecretory cells

Journal of Neuroscience

Volumn 20, Issue 3, 2000, Pages 1272-1280

  Johnstone, Louise E ^a   Brown, Colin H ^a   Meeren, Hanneke K M ^a   Vuijst, Chrétienne L ^a   Brooks, Philip J ^b   Leng, Gareth ^a   Russell, John A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Adrenoreceptors; Benoxathian; Dependence; Hypothalamic paraventricular nucleus; Microdialysis; Naloxone; Opioid; Supraoptic nucleus

Indexed keywords

BENOXATHIAN; MESSENGER RNA; MORPHINE; NALOXONE; OXYTOCIN; PENTOBARBITAL; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG WITHDRAWAL; FEMALE; GENE EXPRESSION; MAGNOCELLULAR NUCLEUS; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SUPRAOPTIC NUCLEUS; THALAMUS MIDLINE NUCLEUS;

EID: 0034143428     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-03-01272.2000     Document Type: Article

References (47)

1. Aghajanian GK (1978) Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine. Nature 276:186-188.
2. Baraban SC, Stornetta RL, Guyenet PG (1945) Effects of morphine and morphine withdrawal on adrenergic neurons of the rat rostral ventrolateral medulla. Brain Res 676:245-257.
3. Bicknell RJ (1988) Optimizing release from peptide hormone secretory nerve terminals. J Exp Biol 139:51-65.
4. Bicknell RJ, Leng G, Lincoln DW, Russell JA (1998) Naloxone excites oxytocin neurones in the supraoptic nucleus of lactating rats after chronic morphine treatment. J Physiol (Lond) 396:297-317.
5. Brooks PJ, Kaplitt MG, Kleopoulos SP, Funabashi T, Mobbs CV, Pfaff DW (1993) Detection of messenger RNA and low-abundance heteronuclear RNA with single-stranded DNA probes produced by amplified primer extension labeling. J Histochem Cytochem 41:1761-1766.
6. Brown CH, Munro G, Murphy NP, Leng G, Russell JA (1996) Activation of oxytocin neurones by systemic cholecystokinin is unchanged by morphine dependence or withdrawal excitation in the rat. J Physiol (Lond) 496:787-794.
7. Brown CH, Munro G, Johnstone LE, Robson AC, Landgraf R, Russell JA (1997) Oxytocin neurone autoexcitation during morphine withdrawal in anaesthetized rats. NeuroReport 8:951-955.
8. Brown CH, Murphy NP, Munro G, Ludwig M, Bull PM, Leng G, Russell JA (1998) Interruption of central noradrenergic pathways and morphine withdrawal excitation of oxytocin neurones in the rat. J Physiol (Lond) 507:831-842.
9. Burbach JP, Lopes da Silva S, Cox JJ, Adan RA, Cooney AJ, Tsai MJ, Tsai SY (1994) Repression of estrogen-dependent stimulation of the oxytocin gene by chicken ovalbumin upstream promoter transcription factor I. J Biol Chem 269:15046-15053.
10. Cunningham HTJ, Sawechenko PE (1988) Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus. J Comp Neurol 274:60-76.
11. Curran TC, Gordon MB, Rubino KL, Sambucetti LC (1987) Isolation and characterization of the c-fos (rat) cDNA and analysis of post-translational modification in vitro. Oncogene 2:79-84.
12. Douglas AJ, Meeren HK, Johnstone LE, Pfaff DW, Russell JA, Brooks PJ (1998) Stimulation of expression of the oxytocin gene in rat supraoptic neurons at parturition. Brain Res 782:167-174.
13. Hamamura M, Leng G, Emson PC, Kiyama H (1991) Electrical activation and c-fos mRNA expression in rat neurosecretory neurones alter systemic administration of cholecystokinin. J Physiol (Lond) 444:51-63.
14. Harbuz M, Russell JA, Sumner BE, Kawata M, Lightman SL (1991) Rapid changes in the content of proenkephalin A and corticotrophin releasing hormone mRNAs in the paraventricular nucleus during morphine withdrawal in urethane-anaesthetized rats. Mol Brain Res 9:285-291.
15. Hatton GI (1990) Emerging concepts of structure-function dynamics in adult brain: the hypothahimo-neurohypophysial system. Prog Neurobiol 34:437-504.
16. Higuchi T, Honda K, Fukuoka T, Negoro H, Wakahayashi K (1985) Release of oxytocin during suckling and parturition in the rat. J Endocrinol 105:339-346.
17. Hoffman GE, Smith MS, Verbalis JG (1993) c-fos and related immediate early gene products as markers of activity in neuroendocrine systems. Front Neuroendocrinol 14:173-213.
18. Ivell R, Richter D (1984) Structure and comparison of the oxytocin and vasopressin genes from rat. Proc Natl Acad Sci USA 81:2006-2010.
19. Jhamandas JH, Harris KH, Petrov T, Jhamandas KH (1996) Activation of nitric oxide-synthesizing neurones during precipitated morphine withdrawal. NeuroReport 7:2843-2846.
20. Kovacs KJ, Sawchenko PE (1996) Sequence of stress-induced alterations in indices of synaptic and transcriptional activation in parvocellular neurosecretory neurons. J Neurosci 16:262-273.
21. Leng G, Mansfield S, Bicknell RJ, Blackburn RE, Brown D, Chapman C, Dyer RG, Hollingsworth S, Shihuki K, Yates JO, et al (1988) Endogenous opioid actions and effects of environmental disturbance on parturition and oxytocin secretion in rats. J Reprod Fertil 84:345-356.
22. Leng G, Russell JA, Grossmann R (1989) Sensitivity of magnocellular oxytocin neurones to opioid antagonists in rats treated chronically with intracerebroventricular (i.c.v.) morphine. Brain Res 484:290-296.
23. Lightman SL, Young WS (1987) Vasopressin, oxytocin, dynorphin, enkephalin and corticotrophin-releasing factor mRNA stimulation in the rat. J Physiol (Lond) 394:23-39.
24. Luckman SM, Antonijevic I, Leng G, Dye S, Douglas AJ, Russell JA, Bieknell RJ (1993) The maintenance of normal parturition in the rat requires neurohypophysial oxytocin. J Neuroendocrinol 5:7-12.
25. Luckman SM, Dyball RE, Leng G (1994) Induction of c-fos expression in hypothalamic magnocellular neurons requires synaptic activation and not simply increased spike activity. J Neurosci 14:4825-4830.
26. Luckman SM, Dye S, Cox HJ (1996) Induction of members of the Fos/Jun family of immediate-early genes in identified hypothalamic neurons: in vivo evidence for differential regulation. Neuroscience 73:473-483.
27. Ludwig M, Leng G (1997) Autoinhibition of supraoptic nucleus vasopressin neurons in vivo: a combined retrodialysis/electrophysiological study in rats. Eur J Neurosci 9:2532-2540.
28. Ludwig M, Brown CH, Russell JA, Leng G (1997a) Local opioid inhibition and morphine dependence of supraoptie nucleus oxytocin neurones in the rat in vivo. J Physiol (Lond) 505:145-152.
29. Ludwig M, Johnstone LE, Neumann I, Landgraf R, Russell JA (1997b) Direct hypertonic stimulation of the rat supraoptic nucleus increases c-fos expression in glial cells rather than magnocellular neurones. Cell Tissue Res 287:79-90.
30. Melchiorre C, Brasili L, Giardina D, Pigini M, Strappaghetti G (1984) 2-[[[2-(2,6-Dimethoxyphenoxy)ethyl|amino]-methyl]-1,4-benzoxathian: a new antagonist with high potency and selectivity toward alpha 1-adrenoreceptors. J Med Chem 27:1535-1536.
31. Murphy NP, Onaka T, Brown CH, Leng G (1997) The role of afferent inputs to supraoptic nucleus oxytocin neurons during naloxone-precipitated morphine withdrawal in the rat. Neuroscience 80:567-577.
32. Nye HE, Nestler EJ (1996) Induction of chronic Fos-related antigens in rat brain by chronic morphine administration. Mol Pharmacol 49:636-645.
33. Paxinos G, Watson C (1996) The rat brain in stereotaxic coordinates, Ed 3. London: Academic.
34. Pumford KM, Leng G, Russell JA (1991) Morphine actions on supraoptic oxytocin neurones in anaesthetized rats: tolerance after i.c.v. morphine infusion. J Physiol (Lond) 440:437-454.
35. Rasmussen K, Beitner-Johnson DB, Krystal JH, Aghajanian GK, Nestler EJ (1990) Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. J Neurosci 10:2308-2317.
36. Rayner VC, Robinson IC, Russell JA (1988) Chronic intracerebroventricular morphine and lactation in rats: dependence and tolerance in relation to oxytocin neurones. J Physiol (Lond) 396:319-347.
37. Redmond Jr DE, Krystal JH (1984) Multiple mechanisms of withdrawal from opioid drugs. Annu Rev Neurosci 7:443-478.
38. Russell JA, Pumford KM, Bicknell RJ (1992) Contribution of the region anterior and ventral to the third ventricle to opiate withdrawal excitation of oxytocin secretion. Neuroendocrinology 55:183-192.
39. Russell JA, Coombes JE, Leng G, Bicknell RJ (1993) Morphine tolerance and inhibition of oxytocin secretion by kappa-opioids acting on the rat neurohypophysis. J Physiol (Lond) 469:365-386.
40. Russell JA, Leng G, Bicknell RJ (1995) Opioid tolerance and dependence in the magnocellular oxytocin system: a physiological mechanism? Exp Physiol 80:307-340.
41. Sheng M, Greenberg ME (1990) The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4:477-485.
42. Shu SY, Ju G, Fan LZ (1988) The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system. Neurosci Lett 85:169-171.
43. Stornetta RL, Norton FE, Guyenet PG (1993) Autonomic areas of rat brain exhibit increased Fos-like immunoreactivity during opiate withdrawal in rats. Brain Res 624:19-28.
44. Sumner BE, Coombes JE, Pumford KM, Russell JA (1990) Opioid receptor subtypes in the supraoptic nucleus and posterior pituitary gland of morphine-tolerant rats. Neuroscience 37:635-645.
45. Takayama K, Suzuki T, Miura M (1994) The comparison of effects of various anesthetics on expression of Fos protein in the rat brain. Neurosci Lett 176:59-62.
46. Walther N, Wehrenberg U, Brackmann B, Ivell R (1991) Mapping of the bovine oxytocin gene control region: Identification of binding sites for luteal nuclear proteins in the 5′ non-coding region of the gene. J Neuroendocrinol 3:539-550.
47. Xing Y, Johnson CV, Dobner PR, Lawrence JB (1993) Higher level organization of individual gene transcription and RNA splicing. Science 259:1326-1330.