The accelerated occurrence of age-related changes of organism in Chernobyl workers: A radiation-induced progeroid syndrome?

Experimental Gerontology

Volumn 35, Issue 1, 2000, Pages 105-115

  Polyukhov, A M ^a   Kobsar, I V ^a   Grebelnik, V I ^a   Voitenko, V P ^a  

^a INSTITUTE OF GERONTOLOGY   (Ukraine)

Author keywords

Accelerated aging; Biological age; Biomarkers of aging; Chernobyl; Ionizing radiation

Indexed keywords

BIOLOGICAL MARKER;

ADULT; AGING; ARTICLE; CHERNOBYL ACCIDENT; DOSIMETRY; FEMALE; HUMAN; IONIZING RADIATION; MAJOR CLINICAL STUDY; MALE; PREMATURE AGING; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; SYNDROME; WORKER;

ABNORMALITIES, RADIATION-INDUCED; ACCIDENTS, RADIATION; ADULT; FEMALE; HUMANS; MALE; MIDDLE AGED; PROGERIA; RADIATION DOSAGE; SYNDROME; UKRAINE;

EID: 0034142280     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(99)00081-9     Document Type: Article

References (50)

1. Abdulkadyrov, K. M., Samuskevich, I. G., Gritsaev, S. V., Balashova, V. A., Pavlova, I. E., Rosanova, O. E., & Bubnova, L. N. The results of a hematological examination of the population living in an area of intense radiological control in Bryansk Province (1998). Lik Sprava (Ukraine) 2, 24-27.
2. Akhaladze N.G., Tokar A.V., Botyakova N.V. Cardiopulmonary and integral biological age of Chernobyl power station explosion liquidators. Probl Aging Longevity (Ukraine). 3:1993;345-351.
3. Beckman K.B., Ames B.N. The free radical theory of aging matures. Physiol Rev. 78:1998;547-581.
4. Bigbee W.L., Jensen R.H., Veidebaum T., Tekkel M., Rahu M., Stengrevics A., Auvinen A., Hakulinen T., Servomaa K., Rytomaa T., Obrams G.I., Boice J.D. Biodosimetry of Chernobyl cleanup workers from Estonia and Latvia using the glycophorin A in vivo somatic cell mutation assay. Radiat Res. 147:1997;215-224.
5. Bolognesi C., Abbondandolo A., Barale R., Casalone R., Bonassi S. Age-related increase of baseline frequencies of sister chromatid exchanges, chromosome aberrations, and micronuclei in human lymphocytes. Cancer Epidemiol Biomarkers Prev. 6:1997;249-256.
6. Burkart W. Radioepidemiology in the aftermath of the nuclear program of the former Soviet Union unique lessons to be learnt . Radiat Environ Biophys. 35:1996;65-73.
7. Caratero A., Courtade M., Bonnet L., Planel H., Caratero C. Effect of a continuous gamma irradiation at a very low dose on the life span of mice. Gerontology. 44:1998;272-276.
8. Chang, W. P., Hwang, B. F., Wang, D., & Wang J. D. (1997). Cytogenetic effect of chronic low-dose, low-dose-rate gamma-radiation in residents of irradiated buildings. Lancet 350, 330-333.
9. Davidov B.I., Ushakov I.B. The brain lesions caused by ionising radiation. 1991;Energoatomizdat, Moscow.
10. Fenech M. Chromosomal damage rate, aging and diet. Ann NY Acad Sci. 854:1998;23-26.
11. Gadhia P.K. Possible age-dependent adaptive response to a low dose of X-rays in human lymphocytes. Mutagenesis. 13:1998;151-152.
12. Goldman M. The Russian radiation legacy its integrated impact and lessons . Environ Health Perspect. 105 (suppl. 6:1997;1385-1391.
13. Goldsmith J.R., Merkin L., Quastel M.R., Poljak S., Kordysh E.A., Wishkerman V., Emerit I. Evaluation of the radiation exposures of Chernobyl "liquidators" exploratory studies of a sample of immigrants to Israel . Int J Occup Environ Health. 3:1997;51-59.
14. Havenaar, J., Rumyantzeva, G., Kasyanenko, A., Kaasjager K., Westermann, A., van den Brink, W., van den Bout, J., & Savelkoul, J. (1997a). Health effects of the Chernobyl disaster: Illness or illness behaviour? A comparative general health survey in two former Soviet regions. Environ Health Perspect, 105(suppl. 6), 1533-1537.
15. Havenaar, J., Rumyantzeva, G., van den Brink, W., van den Bout, J., van Engeland H., Koeter, M. W. (1997). Long-term mental health effects of the Chernobyl disaster: An epidemiologic survey in two former Soviet regions. Am J Psychiatry, 154(11), 1605-1607.
16. Jaworowski Z. Beneficial effects of radiation and regulatory policy. Australas Phys Eng Sci Med. 20:1997;125-138.
17. Juckett D.A., Rosenberg B. Tine series analysis supporting the hypothesis that enhanced cosmic radiation during germ cell formation can increase breast cancer mortality in germ cell cohorts. Int J Biometeorol. 40:1997;206-221.
18. Il'in L.A., Kriuchkov V.P., Osanov D.P., Pavlov D.A. The irradiation levels of the participants in the cleanup of the aftermath of the Chernobyl accident in 1986-1987 and the verification of the dosimetric data. Radiats Biol Radioecol. 35:1995;803-828.
19. Knight J.A. The process and theories of aging. Ann Clin Lab Sci. 25:1995;1-12.
20. Kotko D. N. & Plachinda Yu. I. (1992). Assessment of functional age of blood circulation system. Probl Aging Longevity (Ukraine) 2, 393-396.
21. Kutkov V.A., Gusev I.A., Dementiev S.I. Internal exposure of the staff involved in the cleanup after the accident at the Chernobyl nuclear power plant in 1986. World Health Stat Q. 49:1996;62-66.
22. Lakosina N.D., Sergeev I.I., Woskresenskyi B.A. Clinical characteristics of psychic disturbances in persons living in radiation contaminated zone. Zh Nevropatol Psikhiatr Im S S Korsakova. 92:1992;69-72.
23. Lee M.S., Tanaka K., Nakagaichi M., Nakamodo F.M., Watanabe K., Takeshima N., Niyama T., Chodzko-Zaiko W. The relative utility of health-related fitness tests and skilled motor performance tests as measure of biological age in Japanese men. Appl Human Sci. 15:1996;97-104.
24. Levytsky, E. L. Gubsky, Iu. L. (1994). Free radical damage of the nuclear genetic apparatus of cells. Ukr Biokhim Zh 66, 18-30.
25. Likhtarev I.A., Kovgan L.N., Repin V.S., Los' I.P., Chumak V.V., Novak D.N., Sobolev B.G., Kairo I.A., Chepurnoy N.I., Perevosnikov O.N., Litvinets L.A. Dosimetric support of the International Programme on the Health Effects of the Chernobyl Accident (IPHECA) pilot project main results and problems . World Health Stat Q. 49:1996;40-51.
26. Littlefield L.G., McFee A.F., Salomaa S., Tucker J.D., Inskip P.D., Sayer A.M., Lindholm C., Makinen S., Ustonen R., Sorensen K., Tekkel M., Veidebaum T., Auvinen A., Boice J.D. Do recorded doses overestimate true doses received by Chernobyl cleanup workers? Results of cytogenetic analyses of Estonian workers by fluorescence in situ hybridization. Radiat Res. 150:1998;237-249.
27. Mankovsky N.B., Polyukhov A.M., Karaban I.N., Musienko G.V. Biological age of patients with Parkinson's disease depending on their calendar age and duration of disease. Probl Aging Longevity (Ukraine). 7:1998;26-30.
28. McClearn G.E. Biomarkers of age and ageing. Exp Gerontol. 32:1997;87-94.
29. McClearn, G. E. Biogerontological theories. (1997b). Exp Gerontol 32, 3-10.
30. Milkovic-Krauk S., Restek-Samarzija N., Samarzija M., Kraus O. Individual variation in response to lead exposure a dilemma for the occupational health physician . Am J Ind Med. 31:1997;631-635.
31. Mine M., Okumura Y., Ichimaru M., Nakamura T., Kondo S. Apparently beneficial effect of low to intermediate doses of A-bomb radiation on human lifespan. Int J Radiat Biol. 58:1990;1035-1043.
32. Moore D.H. II, Tucker J.D., Jones I.M., Langlois R.G., Pleshanov P., Vorobtsova I., Jenser R. A study of the effects of exposure on cleanup workers at the Chernobyl nuclear reactor accident using multiple end points. Radiat Res. 148:1997;463-475.
33. Moroz B.B., Deshevoi Iu.B. Role of emotional stress in development of somatic injuries in liquidators of the Chernobyl power plant accident irradiated with small doses. Radiats Biol Radioecol. 39:1999;97-105.
34. Nakamura E., Lane M.A., Roth G.S., Ingram D.K. A strategy for identifying biomarkers of aging further evaluation of haematology and blood chemistry data from a caloric restriction study in rhesus monkeys . Exp Gerontol. 33:1998;421-443.
35. Niagu A.I., Loganovskii K.N. Changes in the nervous system during chronic exposure to ionizing radiation. Zh Nevropatol Psikhiatr Im S S Korsakova. 97:1997;62-70.
36. Pitkevitch, V. A., Ivanov, V. K., Tsyb, A. F., Maksyoutov, M. A., Matiash, V. A., & Shchukina, N.V. (1997). Exposure levels for persons involved in recovery operations after the Chernobyl accident. Statistical analysis based on the data of the Russian National Medical and Dosimetric Registry (RNMDR). Radiat Environ Biophys 36, 149-160.
37. Pollykove M. Nonlinearity of radiation health effects. Environ Health Perspect. 106:(suppl. 1):1998;363-368.
38. Polyukhov, A. M. & Grebelnik, V. I. (1991). Diagnosing of psychoemotional status and the level of social integration in elderly people by means of age-dependent psychological scales. In: Gerontology and Geriatrics. Preventive Gerontology and Geriatrics. D. F. Chebotarev (Ed.) Kiev Inst. of Gerontology, Kiev.
39. Polyukhov A.M., Kobsar I.V., Nyagu A.I., Voitenko V.P. Biological age of the persons participated in liquidation of the results of Chernobyl APS accident. Probl Ageing Longevity (Ukraine). 2:1992;300-304.
40. Povoroznjuk V.V., Podrushnjak E.P., Koshtura I.P. Bone-muscular system in persons of various age exposed to small dose ionizing irradiation changes in structure and function and ways to correct them . Probl Aging Longevity (Ukraine). 5:1995;227-238.
41. Schevchenko V.A., Akayeva E.A., Yeliseyeva I.M., Yelisova T.V., Yofa E.L., Nilova I.N., Syomov A.B., Burkart W. Human cytogenetic consequences of the Chernobyl accident. Mutat Res. 361:1996;29-34.
42. Shantyr I.I., Nikiforov A.M., Romanovich I.K., Schwartz V.A., Makarova N.V., Deryapa L.N., Saygina E.B. Estimation of radiation exposures of "liquidators" of the Chernobyl Nuclear Power Station; identification of risk groups. Int J Occup Environ Health. 3:1997;45-50.
43. Tel'nov V.I. Age-related dynamics of the genetic marker distribution in an irradiated population. Haptoglobin genetic system. Genetika. 33:1997;1406-1413.
44. Tel'nov V.I., Zhuntova G.V. Genotype analysis of biochemical status in people irradiated with significant doses of radiation. Vopr Med Khim. 44:1998;479-484.
45. Tokunaga K., Kanno K., Ochi M., Nishimura T., Shishino K., Murase M., Makino H., Tokui S. Lipid peroxide and antioxidants in the elderly. Rinsho Byori. 46:1998;783-789.
46. Torubarov, F. S., Nikolova, M. K., & Drobot M. Lu. (1991). The effect of small doses of ionizing radiation on the development of vascular brain diseases. Zh Nevropatol Psikhiatr Im S S Korsakova 91, 52-55.
47. Uttley M., Crawford M.H. Efficacy of a composite biological age score to predict ten-year survival among Kansas and Nebraska Mennonites. Hum Biol. 66:1994;121-144.
48. Voitenko, V. P., Polyukhov, A. M. & Barbaruk, L. G. (1984). Biological age as a keen problem of gerontology. In: Gerontology and Geriatrics. Biological Age, Heredity and Ageing. D. F. Chebotarev (Ed.) Kiev: Kiev Institute of Gerontology.
49. Voitenko V.P., Polyukhov A.M. The system mechanisms of development and ageing. 1986;Nauka, Leningrad.
50. Zubovskii G.A., Tararukhina O.B. Prevention of atherosclerosis and myocardial infarction in the liquidators of the accident at the Chernobyl Power Plant. Radiats Bio Radioecol. 39:1999;296-298.