Upregulation of COX-2 during cardiac allograft rejection

Circulation

Volumn 101, Issue 4, 2000, Pages 430-438

  Yang, Xiaochun ^a   Ma, Ninsheng ^d   Szabolcs, Matthias J ^a   Zhong, Jing ^d   Athan, Eleni ^a   Sciacca, Robert R ^a   Michler, Robert E ^a   Anderson, Gary D ^b   Wiese, Joseph F ^b   Leahy, Kathleen M ^b   Gregory, Susan ^b   Cannon, Paul J ^a,c  

^a Columbia Univ Coll Phys Surgs ^*  (United States)

^b PFIZER INC   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d NONE

Author keywords

Nitric oxide; Prostaglandins; Rejection

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; CYCLOOXYGENASE 2; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GRAFT REJECTION; HEART GRAFT; HEART TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN BLOOD LEVEL; PROSTAGLANDIN SYNTHESIS; RAT; RECEPTOR UPREGULATION;

EID: 0034141997     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.101.4.430     Document Type: Article

References (51)

1. Smith WL. Prostanoid biosynthesis and mechanisms of action. Am J Physiol. 1992;263(2 pt 2):F181-F191.
2. Mitchell JA, Larkin S, Williams TJ. Cyclooxygenase-2: regulation and relevance in inflammation. Biochem Pharmacol. 1995;50:1535-1542.
3. Wu KK. Inducible cyclooxygenase and nitric oxide synthase. Adv Pharmacol. 1995;33:179-207.
4. Masferrer JL, Zweifel BS, Manning PT, Hauser SD, Leahy KM, Smith WG, Isakson PC, Siebert K. Selective inhibition of inducible cyclooxygenase-2 in vivo is anti-inflammatory and nonulcerogenic. Proc Natl Acad Sci U S A. 1994;91:3228-3232.
5. Wu, KK. Cyclooxygenase-2 induction in congestive heart failure Friend or Foe Circulation. 1998;98:95-96. Editorial.
6. Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P. Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci U S A. 1993;90:7240-7244.
7. 2 negatively modulates induction of nitric oxide synthase by interleukin 1. Proc Natl Acad Sci U S A. 1994;91: 12168-12172.
8. Wu KK. Injury-coupled induction of endothelial eNOS and COX-2 genes: a paradigm for thrombo resistant gene therapy. Proc Assoc Am Physicians. 1998;110:163-170.
9. Yang X, Chowdhury N, Cai B, Brett J, Marboe C, Sciacca RR, Michler RE, Cannon PJ. Induction of myocardial nitric oxide synthase by cardiac allograft rejection. J Clin Invest. 1994;94:714-721.
10. Worrall NK, Lazenby WD, Misco TP, Lin T-S, Rodi CP, Manning PT, Gilton RG, Williamson JR, Ferguson TB Jr. Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase. J Exp Med. 1995;181:63-70.
11. Russell ME, Wallace AF, Wyner LR, Newell JB, Karnovsky MJ. Upregulation and modulation of inducible nitric oxide synthase in rat cardiac allografts with chronic rejection and transplant arteriosclerosis. Circulation. 1995;92:457-464.
12. Akyurek LM, Fellstrom BC, Van Z, Hansson GK, Funa K, Larsson E. Inducible and endothelial nitric oxide synthase expression during development of transplant arteriosclerosis in rat aortic allografts. Am J Pathol. 1996;149:1981-1990.
13. Lewis NP, Tsao PS, Rickenbacher PR, Xue C, Johns RA, Haywood GA, von der Leyen H, Trindade PT, Cooke JP, Hunt SA, Billingham ME, Valantine HA, Fowler MB. Induction of nitric oxide synthase in the human cardiac allograft is associated with contractile dysfunction of the left ventricle. Circulation. 1996;93:720-729.
14. Worrall NK, Pyo RT, Botney MD, Misko TP, Sullivan PM, Alexander DG, Lazenby WD, Fergusen TB Jr. Inflammatory cell-derived NO modulates cardiac allograft contractile and electrophysiological function. Am J Physiol. 1997;(1 pt 2):H28-H36.
15. Pinsky DJ, Cai B, Yang X, Rodriguez C, Sciacca RR, Cannon PJ. The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor β. J Clin Invest. 1995;95:677-685.
16. Ono K, Lindsay ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg. 1969;7:225-229.
17. Billingham ME, Cary NRB, Hamond ME, Kemnitz J, Marboe C, McAllister HA, Snovar DC, Winters GL, Zerbe A. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. J Heart Lung Transplant. 1990;71:219-225.
18. Szabolcs M, Michler RE, Yang X, Aji W, Roy D, Athan E, Sciacca RR, Minanov OP, Cannon PJ. Apoptosis of cardiac myocytes during cardiac allograft rejection. Relation to induction of nitric oxide synthase. Circulation. 1996;94:1665-1673.
19. Gorczyca W, Gong J, Darzynkiewicz Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl and nick translation assays. Cancer Res. 1993;53:1945-1954.
20. Kaufmann WE, Worley PJ, Pegg J, Bremer M, Isakson P. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc Natl Acad Sci U S A. 1996;93:2317-2321.
21. Anderson GD, Hauser SC, McGarity KL, Bremer ME, Isakson PC, Gregory SA, Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. J Clin Invest. 1996;97:2672-2679.
22. Salvemini D, Seibert K, Masferrer JL, Misko TP, Currie MG, Needleman P. Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. J Clin Invest. 1994;93:1940-1947.
23. Tomlinson A, Appleton I, Moore AR, Gilroy DW, Willis D, Mitchell JA, Willoughby DA. Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy. Br J Pharmacol. 1994;113:693-698.
24. Appleton I, Tomlinson A, Colville-Nash PR, Willoughby DA. Temporal and spatial immunolocalization of cytokines in murine chronic granulomatous tissue. Implications for their role in tissue development and repair processes. Lab Invest. 1993;69:405-414.
25. Vane JR, Mitchell JA, Appleton I, Tomlinson A, Bishop-Bailey D, Croxtall J, Willoughby DA. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc Natl Acad Sci U S A. 1994; 91:2046-2050.
26. Amin AR, Attur M, Patel RN, Thakker GD, Marshall PJ, Rediske J, Stuchin SA, Patel IR, Abramson SB. Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage: influence of nitric oxide. J Clin Invest. 1997;99:1231-1237.
27. Liu SF, Newton R, Evans TW, Barnes PJ. Differential regulation of cyclo-oxygenase-1 and cyclo-oxygenase-2 gene expression by lipopolysaccharide treatment in the rat. Clin Sci (Colch). 1996;90:301-306.
28. 2 production by vascular smooth muscle cells. Biochem Biophys Res Commun. 1993;194:420-424.
29. Rimarachin JA, Jacobson JA, Szabo P, Maclouf J, Creminon C. Weksler BB. Regulation of cyclooxygenase-2 expression in aortic smooth muscle cells. Arterioscler Thromb. 1994;14:1021-1031.
30. Lee SH, Soyoola E, Chanmugam P, Hart S, Sun W, Zhong H, Liou S, Simmons D, Hwang D. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem. 1992;267:25934-25938.
31. Corbett JA, Kwon G, Turk J, McDaniel ML. IL-1 beta induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide. Biochemistry. 1993;32:13767-13770.
32. Mitchell JA, Swierkosc T, Warner TD, Gross S, Thiemermann C, Vane JR. Regulation of prostaglandin synthesis by the release of endogenous nitric oxide in response to bacterial lipopolysaccharide. Br J Pharmacol. 1993;109:4P. Abstract.
33. Stadler J, Stefanovic-Racic M, Billiar TR, Curren RD, McIntyre LA, Geogescu H, Simmons RL, Evans CH. Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol. 1991;147:3915-3920.
34. Stadler J, Harbrecht BG, DiSilvio M, Curran RD, Jordan ML, Simmons RL, Billier TR. Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells. J Leukoc Biol. 1993;53:165-172.
35. Akarasereenont P, Mitchel JA, Appleton I, Thiemermann C, Vane JR. Involvement of protein tyrosine phosphorylation in the induction of cyclooxygenase and nitric oxide synthase by endotoxin in cultured cells. Br J Pharmacol. 1994;113:1522-1528.
36. Russell ME, Wallace AF, Hancock WW, Sayegh MH, Adams DH, Siginga NES, Wyner LR, Karnovsky MJ. Upregulation of cytokines associated with macrophage activation in the Lewis to F344 rat chronic cardiac rejection model. Transplantation. 1995;59:572-578.
37. Buston M, Coffman TM, Saadi S, Platt JL. Modulation of eicosanoid metabolism in endothelial cells in a xenograft model: role of cyclooxygenase-2. J Clin Invest. 1997;100:1150-1158.
38. 2 metabolites regulate inducible nitric oxide synthase in myocytes. Hypertension. 1998;31(1 pt 2):218-224.
39. Doni MG, Writtle BJR, Palmer RMJ, Moncada S. Actions of nitric oxide on the release of prostacyclin from bovine aortic endothelial cells in culture. Eur J Pharamcol. 1988;151:19-25.
40. Davidge ST, Baker PN, MacLaughlin MK, Roberts JM. Nitric oxide produced by endothelial cells increases production of eicosanoids through activation of prostaglandin H synthase. Circ Res. 1995;47:274-283.
41. Hajjar DP, Lander HM, Pearce FS, Upmacis RK, Pomerantz KB. Nitric oxide enhances prostaglandin-H synthase activity by a heme-independent mechanism: evidence implicating nitrosothiols. J Am Chem Soc. 1995; 117:3340-3346.
42. Kroncke K-D, Fehsel K, Kolb-Bachofen V. Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activities. Biol Chem Hoppe Seyler. 1995;376:327-343. Review.
43. Tetsuka T, Daphna-Iken D, Miller BW, Guan Z, Baier LD, Morrison AR. Nitric oxide amplifies interleukin 1-induced cyclooxygenase-2 expression in rat mesangial cells. J Clin Invest. 1996;97:2051-2056.
44. Worrall NK, Misko TP, Sullivan PM, Hui Jia-J, Ferguson TB Jr. Inhibition of inducible nitric oxide synthase attenuates established acute cardiac allograft rejection. Ann Thorac Surg. 1996;62:378-385.
45. Dinchuk JE, Car BD, Focht RJ, Johnson JJ, Jaffee BD, Covington MB, Contel NR, Eng VM, Collins RJ, Czerniak PM, Gorry SA, Trzaskos JM. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature. 1995;378:406-409.
46. Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of nonsteroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1994; 90:11693-11697.
47. Koglin J, Glysing-Jensen T, Mudgett JS, Russell ME. NOS-2 mediates opposing effects in models of acute and chronic rejection-Insights from NOS2 knockout mice. Am J Pathol. 1998;153:1371-1376.
48. Szabolcs MJ, Ravalli S, Minanov O, Sciacca RR, Michler RE, Cannon PJ. Apoptosis and increased expression of inducible nitric oxide synthase in human allograft rejection. Transplantation. 1998;65:804-812.
49. Pinsky DJ, AJi W, Szabolcs M, Athan ES, Liu Y, Yang, Y-M, Kline, RP, Olson KE, Cannon PJ. Nitric oxide triggers programmed cell death (apoptosis) of adult rat ventricular myocytes in culture. Am J Physiol. 1999;277:H1189-HI199.
50. Ing DJ, Zang J, Dzau VJ, Webster KA, Bishopric NH. Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, bak, and bcl-x. Circ Res. 1999;84:21-23.
51. Von Knethen A, Brune B. Cyclooxygenase-2: an essential regulator of NO-mediated apoptosis. FASEB J. 1997;11:887-895.