Engulfment of prions in the germinal centre

Immunology Today

Volumn 21, Issue 2, 2000, Pages 66-67

  Raeber, Alex J ^a,b   Aguzzi, Adriano ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b CYTOS BIOTECHNOLOGY AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

B LYMPHOCYTE; BRAIN SPONGIOSIS; CONFERENCE PAPER; DENDRITIC CELL; GERMINAL CENTER; HUMAN; IMMUNOPATHOGENESIS; NONHUMAN; ORGAN DISTRIBUTION; PRION; PRION DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS PATHOGENESIS; VIRUS REPLICATION;

ANIMALS; B-LYMPHOCYTES; CENTRAL NERVOUS SYSTEM; GERMINAL CENTER; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PRION DISEASES; PRPSC PROTEINS; SPLEEN; T-LYMPHOCYTES;

EID: 0034141683     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(99)01562-5     Document Type: Conference Paper

References (8)

1. 1 Kitamoto, T. et al. (1991) Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease. J. Virol. 65, 6292-6295
2. 2 Klein, M.A. et al. (1997) A crucial role for B cells in neuroinvasive scrapie. Nature 390, 687-690
3. 3 Raeber, A.J. et al. (1999) PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice. EMBO J. 18, 2702-2706
4. 4 Raeber, A.J. et al. (1999) Ectopic expression of PrP in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication. Proc. Natl. Acad. Sci. U. S. A. 96, 3987-3992
5. 5 Hill, A.F. et al. (1999) Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples. Lancet 353, 183-189
6. 6 Klein, M.A. et al. (1998) PrP expression in B lymphocytes is not required for prion neuroinvasion. Nat. Med. 4, 1429-1433
7. 7 Brown, K.L. et al. (1999) Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells. Nat. Med. 5, 1308-1312
8. 8 Blättler, T. et al. (1997) PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature 389, 69-73