-
1
-
-
0001523208
-
Structure-activity relationships of alkyl-and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: Potent and systemically active antagonists for the glycine site of the NMDA receptor
-
Cai, S. X., Kher, S. M., Zhou, Z.L., Ilyin, V., Espitia, S. A., Tran, M., Hawkinson, S. E., Woodward, R. M., Weber, E., and Keana, J. F., Structure-activity relationships of alkyl-and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: Potent and systemically active antagonists for the glycine site of the NMDA receptor, J. Med. Chem., 40, 730-738 (1997).
-
(1997)
J. Med. Chem.
, vol.40
, pp. 730-738
-
-
Cai, S.X.1
Kher, S.M.2
Zhou, Z.L.3
Ilyin, V.4
Espitia, S.A.5
Tran, M.6
Hawkinson, S.E.7
Woodward, R.M.8
Weber, E.9
Keana, J.F.10
-
2
-
-
0027396632
-
Anticonvulsant activity of glycine site NMDA antagonists. 2. .trans-2 Carboxy-4-substituted tetrahydroquinolines
-
Carling, R. W., Leeson, P. D., Moseley, A. M., Smith, J. D., Saywell, K., Triclebank, M. D., Kemp, J. A., Marshall, G. R., Foster, A. G., and Grimwood, S., Anticonvulsant activity of glycine site NMDA antagonists. 2. .trans-2 Carboxy-4-substituted tetrahydroquinolines. Bioorg. Med. Chem. Lett., 3, 65-70 (1993).
-
(1993)
Bioorg. Med. Chem. Lett.
, vol.3
, pp. 65-70
-
-
Carling, R.W.1
Leeson, P.D.2
Moseley, A.M.3
Smith, J.D.4
Saywell, K.5
Triclebank, M.D.6
Kemp, J.A.7
Marshall, G.R.8
Foster, A.G.9
Grimwood, S.10
-
3
-
-
0019399306
-
An overview of glutamate as a neurotransmitter
-
Cotman, C. W., Foster, A. C., and Lanthorn, T. H., An overview of glutamate as a neurotransmitter. Adv. Biochem. Biopharmacol., 27, 1-27 (1981).
-
(1981)
Adv. Biochem. Biopharmacol.
, vol.27
, pp. 1-27
-
-
Cotman, C.W.1
Foster, A.C.2
Lanthorn, T.H.3
-
4
-
-
0027770735
-
Synthesis and excitatory aminoacid pharmacology of some novel quinoxalinediones
-
Epperson, J. R., Hewawasam, P., Meanwell, N. A., Boissard, C. G., Gribkoff, V. K. and Postmunson, D., Synthesis and excitatory aminoacid pharmacology of some novel quinoxalinediones. Biomed. Chem. Lett., 3, 2801-2804 (1993).
-
(1993)
Biomed. Chem. Lett.
, vol.3
, pp. 2801-2804
-
-
Epperson, J.R.1
Hewawasam, P.2
Meanwell, N.A.3
Boissard, C.G.4
Gribkoff, V.K.5
Postmunson, D.6
-
5
-
-
0009482135
-
Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site
-
Fabio, R. D., Capelli, A. M., Conti, N., Cugola, A., Donati, D. Feriani, A., Gastaldi, P. and Gaviraghi, G., Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site. J. Med. Chem., 40, 841-850 (1997).
-
(1997)
J. Med. Chem.
, vol.40
, pp. 841-850
-
-
Fabio, R.D.1
Capelli, A.M.2
Conti, N.3
Cugola, A.4
Donati, D.5
Feriani, A.6
Gastaldi, P.7
Gaviraghi, G.8
-
6
-
-
0023767546
-
Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists
-
Honore, T., Davies, S. N., Drejer, J., Fletcher, E. J., Jacobsen, P., Lodge, D. and Nielsen, F. E., Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists. Science, 241, 701-703 (1988).
-
(1988)
Science
, vol.241
, pp. 701-703
-
-
Honore, T.1
Davies, S.N.2
Drejer, J.3
Fletcher, E.J.4
Jacobsen, P.5
Lodge, D.6
Nielsen, F.E.7
-
7
-
-
0002864470
-
Noncompetitive NMDA antagonists as drugs
-
Collingridge, G. L., Watkins, J. C.(Eds.), IRL press, Oxford, England
-
nd ed., Collingridge, G. L., Watkins, J. C.(Eds.), IRL press, Oxford, England, pp 469-486, 1994.
-
(1994)
nd Ed.
, pp. 469-486
-
-
Iversen, L.L.1
Kemp, J.A.2
-
8
-
-
0027469106
-
The glycine site of the NMDA receptor-Five years on
-
Kemp, J. A. and Leeson, P. D., The glycine site of the NMDA receptor-Five years on. Trends Pharmacol. Sci., 14, 20-25 (1993).
-
(1993)
Trends Pharmacol. Sci.
, vol.14
, pp. 20-25
-
-
Kemp, J.A.1
Leeson, P.D.2
-
9
-
-
0028240929
-
3-Arylmethyl-and 3-(Aryloxy)-3 phenyl-4-hydroxyquinolin-2(1H)-ones: Orally Active Antagonists of the Glycine site on the NMDA Receptor
-
Kulagowski, J. J., Baker, R., Curtis, N. R., Leeson, P. D., Mawer, I. M., Moseley, A. M., Ridgill, M. P., Rowley, M., Stansfield, I., Foster, A. C., Grimwood, S., Hill, R. G., Kenp, J. A., Marshall, G. R., Saywell, K. L. and Tricklebank, M. D., 3-(Arylmethyl-and 3-(Aryloxy)-3 phenyl-4-hydroxyquinolin-2(1H)-ones: Orally Active Antagonists of the Glycine site on the NMDA Receptor. J. Med. Chem., 37, 1402-1405 (1994).
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1402-1405
-
-
Kulagowski, J.J.1
Baker, R.2
Curtis, N.R.3
Leeson, P.D.4
Mawer, I.M.5
Moseley, A.M.6
Ridgill, M.P.7
Rowley, M.8
Stansfield, I.9
Foster, A.C.10
Grimwood, S.11
Hill, R.G.12
Kenp, J.A.13
Marshall, G.R.14
Saywell, K.L.15
Tricklebank, M.D.16
-
10
-
-
0024345567
-
Quinoxaline Derivatives are High affinity Antagonists of the NMDA Receptor-associated Glycine Sites
-
Kessler, M., Baudry, M. and Lynch, G., Quinoxaline Derivatives are High affinity Antagonists of the NMDA Receptor-associated Glycine Sites. Brain Res., 489, 377-382 (1989).
-
(1989)
Brain Res.
, vol.489
, pp. 377-382
-
-
Kessler, M.1
Baudry, M.2
Lynch, G.3
-
11
-
-
0025740632
-
Kynurenic acid derivatives, Structure-activity relationships for excitatory aminoacid antagonism and identification of potent and selective antagonists at the glycine site on the NMDA receptor
-
Leeson, P. D., Baker, R., Carling, R. W., Curtis, N. R., Moore, K. W., William, B. J., Foster, A. C., Donald, A. E., Kemp, J. A. and Marshall, G. R., Kynurenic acid derivatives, Structure-activity relationships for excitatory aminoacid antagonism and identification of potent and selective antagonists at the glycine site on the NMDA receptor, J. Med. Chem., 34, 1243-1252 (1991).
-
(1991)
J. Med. Chem.
, vol.34
, pp. 1243-1252
-
-
Leeson, P.D.1
Baker, R.2
Carling, R.W.3
Curtis, N.R.4
Moore, K.W.5
William, B.J.6
Foster, A.C.7
Donald, A.E.8
Kemp, J.A.9
Marshall, G.R.10
-
12
-
-
0026766273
-
4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor
-
Leeson, P. D., Carling, R. W., Moore, K. W., Moseley, A. M., Smith, G. D., Stevenson, G., Chan, T., Baker, R., Foster, A. C., Grimwood, S., Kemp, G. A., Marshall, G. R. and Hoogsteen, K., 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor, J. Med. Chem., 35, 1954-1968 (1992).
-
(1992)
J. Med. Chem.
, vol.35
, pp. 1954-1968
-
-
Leeson, P.D.1
Carling, R.W.2
Moore, K.W.3
Moseley, A.M.4
Smith, G.D.5
Stevenson, G.6
Chan, T.7
Baker, R.8
Foster, A.C.9
Grimwood, S.10
Kemp, G.A.11
Marshall, G.R.12
Hoogsteen, K.13
-
13
-
-
0027988561
-
The glycine site on the NMDA receptor: Structure-activity relationship and therapeutic potential
-
Leeson, P. D. and Iversen, L. L., The glycine site on the NMDA receptor: Structure-activity relationship and therapeutic potential, J. Med. Chem., 37, 4053-4067 (1994).
-
(1994)
J. Med. Chem.
, vol.37
, pp. 4053-4067
-
-
Leeson, P.D.1
Iversen, L.L.2
-
14
-
-
0024308464
-
Interaction of 6-Cyano-7-nitroquinoxaline-2,3-dione with the N-Methyl-D-Aspartate Receptor Associated Glycine Binding Site
-
Lester, R. A. J., Quarum, M. L., Parker, J. D., Weber, E. and Jahr, C. E., Interaction of 6-Cyano-7-nitroquinoxaline-2,3-dione with the N-Methyl-D-Aspartate Receptor Associated Glycine Binding Site. Mol. Pharmacol. 35, 565-570(b) (1989).
-
(1989)
Mol. Pharmacol.
, vol.35
-
-
Lester, R.A.J.1
Quarum, M.L.2
Parker, J.D.3
Weber, E.4
Jahr, C.E.5
-
15
-
-
0026779905
-
3-Phenyl-4-hydroxyquinolin-2(1H)-ones: Potent and Selective Antagonists at the Strychnine-Insensitive Glycine Site on the N-Methyl-D-aspartate Receptor Complex
-
McQuaid, L. A., Smith, E. C. R., Lodge, D., Pralong, E., Wikel, J. H., Calligaro, D. O. and OMalley, P. J., 3-Phenyl-4-hydroxyquinolin-2(1H)-ones: Potent and Selective Antagonists at the Strychnine-Insensitive Glycine Site on the N-Methyl-D-aspartate Receptor Complex. J. Med. Chem., 35, 3423-3425 (1992).
-
(1992)
J. Med. Chem.
, vol.35
, pp. 3423-3425
-
-
McQuaid, L.A.1
Smith, E.C.R.2
Lodge, D.3
Pralong, E.4
Wikel, J.H.5
Calligaro, D.O.6
Omalley, P.J.7
-
16
-
-
0025390880
-
Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission
-
Meldrum, B., Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission. Cerebrovasc. Brain Metab. Rev., 2, 27-57 (1990).
-
(1990)
Cerebrovasc. Brain Metab. Rev.
, vol.2
, pp. 27-57
-
-
Meldrum, B.1
-
17
-
-
0026652403
-
3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site
-
Salituro, F. G., Harrison, B. L., Baron, B., Nyce, P. L., Stewart, K. T., Kehne, J. H., White, H. S. and McDonald, I. A., 3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site. J. Med. Chem., 35, 1791-1799 (1992).
-
(1992)
J. Med. Chem.
, vol.35
, pp. 1791-1799
-
-
Salituro, F.G.1
Harrison, B.L.2
Baron, B.3
Nyce, P.L.4
Stewart, K.T.5
Kehne, J.H.6
White, H.S.7
McDonald, I.A.8
-
18
-
-
0027087308
-
Competitive antagonism of glutamate receptor channels by substituted benzazepines in cultured cortical neurons
-
Swartz, K. J., Koroshetz, W. J., Ress, A. H. and Heuttner, J. E., Competitive antagonism of glutamate receptor channels by substituted benzazepines in cultured cortical neurons. Mol. Pharmacol., 41, 1130-1141 (1992).
-
(1992)
Mol. Pharmacol.
, vol.41
, pp. 1130-1141
-
-
Swartz, K.J.1
Koroshetz, W.J.2
Ress, A.H.3
Heuttner, J.E.4
-
19
-
-
0001414813
-
In vitro Characterisation of ACEA-1021: A Potent NMDA Receptor Glycine Site Antagonist
-
Woodward, R. M., Huettner, J. E., Guastella, J. and Weber, E., In vitro Characterisation of ACEA-1021: A Potent NMDA Receptor Glycine Site Antagonist. Soc. Neurosci. Abstr., 19, 296.14 (1993).
-
(1993)
Soc. Neurosci. Abstr.
, vol.19
, pp. 29614
-
-
Woodward, R.M.1
Huettner, J.E.2
Guastella, J.3
Weber, E.4
|