Evaluation of the potential promoting effect of 60 Hz magnetic fields on N-Ethyl-N-Nitrosourea induced neurogenic Tumors in female F344 rats

Bioelectromagnetics

Volumn 21, Issue 2, 2000, Pages 84-93

  Mandeville, Rosemonde ^a   Franco, Eduardo ^c   Sidrac Ghali, Salwa ^b   Paris Nadon, Louise ^b   Rocheleau, Normand ^b   Mercier, Ginette ^b   Désy, Marie ^b   Devaux, Céline ^d   Gaboury, Louis ^d  

^a Biophage Pharma Inc   (Canada)

^b INRS INSTITUT ARMAND FRAPPIER   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Brain tumors; ENU model; Female F344 rats; Magnetic fields; TPA; Tumor promotion

Indexed keywords

BRAIN; DAMS; MAGNETIC FIELDS; TUMORS;

BRAIN TUMORS; FEMALE F344 RAT; GROUP III; MAGNETIC-FIELD; N-ETHYL-N-NITROSOUREA-MODEL; NEUROGENIC TUMORS; NITROSOUREAS; PROMOTING EFFECT; TPA; TUMOR PROMOTION;

RATS;

ETHYLNITROSOUREA; PHORBOL 13 ACETATE 12 MYRISTATE;

ANIMAL; ARTICLE; BODY WEIGHT; BRAIN TUMOR; CENTRAL NERVOUS SYSTEM TUMOR; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ELECTROMAGNETIC FIELD; FEMALE; FISCHER 344 RAT; GLIOMA; NEURILEMOMA; PATHOLOGY; PERIPHERAL NERVE TUMOR; PREGNANCY; PRENATAL EXPOSURE; RADIATION EXPOSURE; RAT; SPINAL CORD TUMOR;

ANIMALS; BODY WEIGHT; BRAIN NEOPLASMS; CENTRAL NERVOUS SYSTEM NEOPLASMS; ELECTROMAGNETIC FIELDS; ETHYLNITROSOUREA; FEMALE; GLIOMA; NEURILEMMOMA; PERIPHERAL NERVOUS SYSTEM NEOPLASMS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, INBRED F344; SPINAL CORD NEOPLASMS; TETRADECANOYLPHORBOL ACETATE;

EID: 0034132003     PISSN: 01978462     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-186x(200002)21:2<84::aid-bem2>3.0.co;2-b     Document Type: Article

References (39)

1. Aldrich TE, Laborde D, Griffith J, Easterly C. 1992. A metaanalysis of the epidemiological evidence regarding human health risk associated with exposure to electromagnetic fields. ElectroMagnetibiol 11:127-143.
2. Bates MN. 1991. Extremely low frequency electromagnetic fields and cancer: The epidemiologic evidence. Environ Health Perspect 95:147-156.
3. Boorman GA, Montgomery CA Jr., Eustis SL, Wolfe MJ, McConnell EE, Hardisty JF. 1985. Quality assurance in pathology for rodent carcinogenicity studies. In Milman HA and Weisburger EK, editors. "Handbook of Carcinogen Testing". Noyes Publ, pp 345-357.
4. Boorman AG, McCormick DL, Findlay JC, Hailey JR, Gauger JR, Johnson TR, Kovatch RM, Haseman JK. 1999. Chronic toxicity/oncogenicity evaluaton of 60 Hz (power frequency) magnetic fields in F334/N rats. Toxicol Pathol (in press).
5. Druckrey H, Ivankovic S, Preussmann R. 1966. Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant rats. Nature 210:1378-1379.
6. 3H)-phorbol 12-myristate 13-acetate to mouse brain. Cancer Res 40:3635-3641.
7. 3H)-phorbol 12,13-dibutyrate binding by mouse brain. Cancer Res 41:2640-2647.
8. Haseman A, Eustis SL. 1990. Tumor incidences in Fischer 344 rats: NTP Historical data. In Boorman et al., editors. "Pathology of the Fischer rat". Academic Press, pp 555-564.
9. Feldman DB, Seely JC, editors. 1988. "Necropsy guide: Rodents and the rabbit", CRC Press Inc., New York.
10. Fleiss H, editor. 1981. "Statistical methods for rates and proportions", Weily Press, pp 275.
11. Hendee WR, Boteler JC. 1994. The question of health effects from exposure to electromagnetic fields. Health Phys 66: 127-136.
12. Kalter H, Mandybur TI, Ormsby I, Warkany J. 1980. Dose-related reduction by prenatal X-irradiation of the transplacental neurocarcinogenicity of ethylnitrosourea in rats. Cancer Res 40:3973-3976.
13. Kalter H, Ormsby I, Warakany J. 1982. Congenital malformations of the central nervous system and transplacental carcinogenesis: Modification of ethylnitrosourea-induced brain tumors in rats by pretreatment with methyazoxymethanol. Biol Res Pregnancy 3:93-98.
14. Kaplan E, Meier P. 1958. Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481.
15. Kheifets LI, Abdelmonem AA, Buffler PA, Zhang ZW. 1995. Occupational electric and magnetic field exposure and brain cancer: A meta-analysis. J Occupational Environ Medicine 37:1327-1341.
16. Kokunai T, Tamaki N, Matsumoto S. 1987. Promoting effect of 12-O-tetra-decanoyl-phorbol-13-acetate on neurogenic microtumors initiated by transplacental exposure to N-ethyl-N-nitrosourea. Jpn J Cancer Res 78:534-536.
17. Kokunai T, Korosue K, Tamaki N, Matsumoto S. 1986. Promoting effect of 12-O-tetra-decanoylphorbol-13-acetate on the in vitro malignant transformation of fetal brain cells exposed in utero to Ethylnitrosourea. Cancer Res 46:1377-1381.
18. Lewis PD. 1968. Mitotic activity in the primate subependymal layer and the genesis of gliomas. Nature 217:974-975.
19. Löscher W, Mevissen M, Lehmacher W, Stamm A. 1993. Tumor promotion in a breast cancer model by exposure to a weak alternating magnetic field. Cancer Lett 71:75-81.
20. Löscher W, Mevissen M, Häubler M. 1996. Exposure of rats to 50 Hz, 100 μT magnetic field increases the development and growth of mammary tumors in a DMBA-model of breast cancer: Replication study. Annu Rev Res Biol Effects Electric Magnetic Fields, p 7 (abstract).
21. McCann T, Kavet R, Raferty C. 1997. Testing EMF for potential carcinogenic activity: A critical review of animal models. Environ Health Perspect 105:81-103, Suppl 1.
22. McCormick DL, Boorman AG, Findlay JC, Hailey JR, Johnson TR, Gauger JR, Pelcher JM, Sills RC, Haseman JK. 1999. Chronic toxicity/oncogenicity evaluaton of 60 Hz (power frequency) magnetic fields in B6C3F1 mice. Toxicol Pathol (in press).
23. Mandeville R, Mercier G, Oth D, Descôteaux J-P, Lis M. Franco E, Houde M, Tremblay L. 1993. IAF chronic carcinogenicity evaluation of 60-Hz sinusoidal continuous wave magnetic fields in rats: Protocol outline and quality assurance program development. In Blank M, editor. "Electricity and Magnetism in Biology and Medicine". San Francisco Press Inc, pp 419-422.
24. Mandeville R, Franco E, Sidrac-Ghali S, Rocheleau N, Mercier G, Désy M, Gaboury L. 1997. Evaluation of the potential carcinogenicity of 60 Hz linear sinusoidal continuous-wave magnetic fields in Fischer F344 rats. FASEB J 11: 1127-1136.
25. Mantel N. 1966. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50:163-170.
26. Maruvada PS, Harvey S, Jutras P, Goulet D, Mandeville R: A magnetic field exposure facility for evaluation of animal carcinogenicity. Bielectromagnetics (submitted).
27. Moulder JE, Foster KR. 1995. Biological effects of power-frequency fields as they relate to carcinogenesis. Proc Soc Exptl Biol Medicine 209:309-324.
28. 3H)-phorbol 12,13-dibutyrate binding to brain. Cancer Res 41:89-93.
29. National Research Council Report. 1996. Possible health effects of exposure to residential electric and magnetic fields. National Academy Press, Washington.
30. Purves D, Dayan A. 1992. A preliminary investigation of promotion of brain tumors by hexachlorophane in Sprague-Dawley rats transplacentally exposed to N-ethylnitrosourea. Neuropathol Applied Neurobiol 18:259-264.
31. Savitz DA. 1988. Case-control study of childhood cancer and exposure to 60 Hz magnetic fields. Am J Epidemiol 128: 21-38.
32. Sotelo J, Palencia G, Rosas N, Perez R. 1989. Effect of chronic stress on ENU-induced tumors. Biol Psychiatry 26: 690-694.
33. Swenberg JA. 1976. Chemical induction of brain tumors. In Thompson RA, Green JR, editors. "Neoplasia in the Central Nervous System". Raven Press, New York, pp 85-99.
34. Tomenius LL. 1986. 60-Hz electromagnetic environment and the incidence of childhood tumours in Stockholm County. Bioelectromagnetics 7:191-207.
35. Tremblay L, Houde M, Mercier G, Mandeville R. 1996. Differential modulation of natural and adaptive immunity in rats exposed in vivo to 60 Hz magnetic fields. Bioelectromagnetics 17:373-382.
36. Walker VE, Swenberg JA. 1989. Phenobarbital lacks promoting activity for neurogenic tumors in F344 rats transplacentally exposed to Ethylnitrosourea. J Neuropathol Exptl Neurol 48:263-269.
37. Wertheimer N, Leeper E. 1979. Electrical wiring configurations and childhood cancer. Am J Epidemiol 109: 273-284.
38. Yasui M, Kikuchi T, Ogawa M, Otaka Y, Tsuchitani M, Iwata H. 1997. Carcinogenicity test of 50 Hz sinusoidal magnetic fields in rats. Bioelectromagnetics 18:531-540.
39. Zulch KJ, editor. 1979. "Histopathological typing of tumors of the central nervous system. International Histological classification of tumors". World Health Organization: No 21, Geneva.