The kinetics of tiazofurin uptake by the isolated perfused choroid plexus of the sheep

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 22, Issue 3, 2000, Pages 149-154

  Redzic, Z B ^a   Segal, M B ^b   Gasic, J M ^c   Markovic, I D ^a   Isakovic, A ^a   Rakic, L M ^d  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c Faculty of Biology   (Serbia)

^d Valeant Pharmaceuticals International   (United States)

Author keywords

Adenosine; Blood brain barrier; Blood CSF barrier; Choroid plexus uptake; Nucleoside carriers; Tiazofurin

Indexed keywords

ADENOSINE; MANNITOL; SODIUM; TIAZOFURIN;

ACTIVE TRANSPORT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD CEREBROSPINAL FLUID BARRIER; CHOROID PLEXUS; DRUG UPTAKE; INDICATOR DILUTION CURVE; ISOLATED ORGAN; ISOTOPE LABELING; NONHUMAN; SHEEP; TRANSPORT KINETICS;

EID: 0034130545     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Ghersi-Egea, J.F., Leininger-Muler, B., Cecchelli, R., Fenstermacher, J.D. Blood-brain interfaces: relevance to cerebral drug metabolism. Toxicol Lett 1995, 82/83: 645-53.
2. Pech, I.V., Peterson K., Cairncross, J.G. Chemotherapy for brain tumors. Oncology 1998, 12(4): 537-43.
3. Kroll, R.A., Neuwelt, E.A. Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. Neurosurgery 1998, 42(5): 1083-99.
4. Qin, D., Ma, J., Xiao, J., Tang, Z. Effect of brain irradiation blood-CSF barrier permeability of chemotherapeutic agents. Am J Clin Oncol 1997, 20(3): 263-5.
5. Elliot, P.J., Hayward, N.J., Dean, R.L., Bartus, R.T. Dissociation of blood-brain barrier permeability and hypotensive effect of the bradykinin B2 agonist, RMP-7. Immunopharmacol 1996, 33(1-3): 205-8.
6. Sugita, M., Black, K.L. Cyclic GMP-specific phosphodiesterase inhibition and intracarotid bradykinin infusion enhances permeability into brain tumors. Cancer Res 1998, 58(5): 914-20.
7. Davson, H., Segal, M.B. Physiology of the CSF and Blood-Brain Barriers. CRC Press Inc.: Boca Raton 1996, 93-190.
8. Begley, D., Lechardeur, D., Chen, Z-D. et al. Functional expression of P-glycoprotein in an immortalised cell line of rat brain endothelial cells, RBE4. J Neurochem 1996, 67: 988-95.
9. Vistica, D. Cellular pharmacokinetics of the phaeylalanine mustards. Pharmacol Ther 1983, 22: 379-406.
10. 3 H] tiazofurin into guinea-pig brain by a saturable mechanism. Methods Find Exp Clin Pharmacol 1995, 17(6): 407-14.
11. Green, R.M., Stewart, D.J., Maroun, J.A. Clinical pharmacology of tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide, NSC 286193). Invest New Drugs 1986, 4: 387-94.
12. Rippe, D.J., Edwards, M.K., Schrodt, J.F., Bognanno, J.R., Amour, P.G., Boyko, O.B. Reversible cerebral lesions associated with tiazofurin usage: MR demonstration. J Comput Assist Tomogr 1988, 12(6): 1078-81.
13. Look, K.Y., Sutton, G.P., Natsumeda, Y. et al. Inhibition by tiazofurin of inosine 5′-phosphate dehydrogenase (IMP DH) activity in extracts of ovarian carcinomas. Gynecol Oncol 1992, 47: 66-70.
14. Szekeres, T., Fritzer, M., Pillwein, K., Felzmann, T., Chiba, P. Cell cycle dependent regulation of IMP dehydrogenase activity and effect of tiazofurin. Life Sci 1992, 51(16): 1309-15.
15. Pillwein, K., Chiba, P., Knoflach, A. et al. Purine metabolism of human glioblastoma in vivo. Cancer Res 1990; 50: 1575-9.
16. Pillwein, K., Schuchter, K., Ressmann, G. et al. Cytotoxicity, differentiating activity and metabolism of tiazofurin in human neuroblastoma cells. Int J Cancer 1993, 55: 92-5.
17. Vitale, M., Zamai, L., Falcieri, E. et al. IMP dehydrogenase inhibitor, tiazofurin, induces apoptosis in K562 human erythroleukemia cells. Cytometry 1997, 30: 61-6.
18. Piperski, V., Vracar, M., Jokanovic, M., Stukalov, P., Rakic, Lj. Detection of apoptosis and phagocytosis in vitro in C6 rat glioma cells, treated with tiazofurin. Apoptosis 1998, 3: 345-52.
19. Stewart, D., Eisenhauer E., Macdonald, D.R., Caincross, J.G., Langleben, A. Phase II study of tiazofurin in gliomas in adults: A National Cancer Institute of Canada study. J Neurooncol 1993, 15: 175-9.
20. 3 H] tiazofurin blood to brain transport in the guinea pig. Methods Find Exp Clin Pharmacol 1996, 18: 413-8.
21. Wu, D., Clement, J.G., Pardridge, W.M. Low blood-brain barrier permeability to azidothymidine, 3TC and thymidine in rat. Brain Res 1998, 791(1-2): 313-6.
22. Keep R.F., Jones H.C. A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat. Dev Brain Res 1990, 56: 47-53.
23. Deane, R., Segal, M.B. The transport of sugars across the perfused choroid plexus of the sheep. J Physiol 1985, 63: 245-60.
24. Preston, J.E., Segal, M.B. The steady-state amino acid fluxes across the perfused choroid plexus of the sheep. Brain Res 1990, 525: 275-9.
25. Segal, M.B., Preston, J.E., Collis, C.S., Zlokovic, B.V. Kinetics and Na independence of amino acid uptake by blood side of perfused sheep choroid plexus. Am J Physiol 1990, 258: F1288-F1294.
26. Yudilevich, D.L., DeRose, N., Sepulveda, F.V. Facilitated transport of amino acids through the blood-brain barrier of the dog studied in a single capillary circulation. Brain Res 1972, 44: 569-78.
27. Saunders, P.P., Spindler, C.D., Mei-Tao, T., Alverez, E., Robins, R.K. Tiazofurin phosphorylated by three enzymes from Chinese hamster ovary cells. Cancer Res 1990, 50: 5269-74.
28. Redzic, Z.B., Segal, M.B., Markovic, I.D., Gasic, J.M., Vidovic, V., Rakic, Lj.M. The characteristics of basolateral nucleoside transport in the perfused sheep choroid plexus and the effect of NO inhibition on these processes. Brain Res 1997, 767: 26-33.
29. Grygiel, J.J., Balis, F.M., Collins, J.M., Lester, C.M., Poplack, D.G. Pharmacokinetics of tiazofurin in plasma and CSF of rhesus monkeys. Cancer Res 1985, 45: 2037-9.
30. Wu, H., Yuan, G., Brett, C.M., Hui, A.C., Giacomini, K.M. Sodium dependent nucleoside transport in choroid plexus from rabbit. J Biol Chem 1992, 267: 8813-8.
31. Linden, J. Purinergic systems. In: Siegel, G.J., Agranoff, B.W., Albers, R.W., Molinoff, P.B. (Eds.). Basic Neurochemistry. Raven Press: New York 1994, 401-16.
32. Grem, J.L., Rubinstein, L., King, S.A., Cheson, D.B., Hawkins, M.J., Shoemaker, D.D. Clinical toxicity associated with tiazofurin. Invest New Drugs 1990, 8: 227-38.
33. Ghersi-Egea, J.F., Finnegan, W., Chen, J.L., Fenstermacher, J.D. Rapid distribution of intraventricularly administered sucrose into cerebrospinal fluid cisterns via subarachnoid velae in rat. Neuroscience 1996, 75(4): 1271-88.