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Volumn 9, Issue 5, 2000, Pages 1002-1010

Characterization of an anti-Borrelia burgdorferi OspA conformational epitope by limited proteolysis of monoclonal antibody-bound antigen and mass spectrometric peptide mapping

Author keywords

Borrelia burgdorferi; Discontinuous epitope; Lyme disease; Mass spectrometry; Monoclonal antibody

Indexed keywords

BACTERIAL PROTEIN; OUTER SURFACE PROTEIN A; UNCLASSIFIED DRUG;

EID: 0034129705     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.9.5.1002     Document Type: Article
Times cited : (24)

References (49)
  • 1
    • 0021835890 scopus 로고
    • Heterogeneity of major proteins in Lyme disease borreliae: A molecular analysis of North American and European isolates
    • Barbour AG, Heiland RA, Howe TR. 1985. Heterogeneity of major proteins in Lyme disease borreliae: A molecular analysis of North American and European isolates. J Infect Dis 152:478-484.
    • (1985) J Infect Dis , vol.152 , pp. 478-484
    • Barbour, A.G.1    Heiland, R.A.2    Howe, T.R.3
  • 2
    • 0025264283 scopus 로고
    • Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins
    • Brandt ME, Riley BS, Radolf JD, Norgard MV. 1990. Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins. Infect Immun 58:983-991.
    • (1990) Infect Immun , vol.58 , pp. 983-991
    • Brandt, M.E.1    Riley, B.S.2    Radolf, J.D.3    Norgard, M.V.4
  • 6
    • 0025509132 scopus 로고
    • Outer surface protein A (OspA) from the Lyme disease spirochete, Borrelia burgdorferi: High level expression and purification of a soluble recombinant form of OspA
    • Dunn JJ, Lade BN, Barbour AG. 1990. Outer surface protein A (OspA) from the Lyme disease spirochete, Borrelia burgdorferi: High level expression and purification of a soluble recombinant form of OspA. Protein Expr Purif 1:15-168.
    • (1990) Protein Expr Purif , vol.1 , pp. 15-168
    • Dunn, J.J.1    Lade, B.N.2    Barbour, A.G.3
  • 7
    • 0032032551 scopus 로고    scopus 로고
    • Molecular characterization of a conformational epitope of hen egg white lysozyme by differential chemical modification of immune complexes and mass spectrometric peptide mapping
    • Fiedler W, Borchers C, Macht M, Deininger SO, Przybylski M. 1998. Molecular characterization of a conformational epitope of hen egg white lysozyme by differential chemical modification of immune complexes and mass spectrometric peptide mapping. Bioconjug Chem 9:236-241.
    • (1998) Bioconjug Chem , vol.9 , pp. 236-241
    • Fiedler, W.1    Borchers, C.2    Macht, M.3    Deininger, S.O.4    Przybylski, M.5
  • 8
    • 0025202254 scopus 로고
    • Protection of mice against the Lyme disease agent by immunizing with recombinant OspA
    • Fikrig E, Bartold SW, Kantor FS, Flavell RA. 1990. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science 250:553-556.
    • (1990) Science , vol.250 , pp. 553-556
    • Fikrig, E.1    Bartold, S.W.2    Kantor, F.S.3    Flavell, R.A.4
  • 9
    • 0027362985 scopus 로고
    • Evidence for an alpha-helical epitope on outer surface protein A from the Lyme disease spirochete, Borrelia burgdorferi: An application of steady-state and time-resolved fluorescence quenching techniques
    • France LL, Kieleczawa J, Dunn JJ, Luft BJ, Hind G, Sutherland JC. 1993. Evidence for an alpha-helical epitope on outer surface protein A from the Lyme disease spirochete, Borrelia burgdorferi: An application of steady-state and time-resolved fluorescence quenching techniques. Biochim Biophys Acta 1202:287-296.
    • (1993) Biochim Biophys Acta , vol.1202 , pp. 287-296
    • France, L.L.1    Kieleczawa, J.2    Dunn, J.J.3    Luft, B.J.4    Hind, G.5    Sutherland, J.C.6
  • 10
    • 0003980818 scopus 로고
    • Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein
    • Geysen HM, Barteling SJ, Meloen RH. 1985. Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein. Proc Natl Acad Sci USA 82:178-182.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 178-182
    • Geysen, H.M.1    Barteling, S.J.2    Meloen, R.H.3
  • 12
    • 0023846102 scopus 로고
    • Measurement of antibodies to the Borrelia burgdorferi flagellum improves serodiagnosis in Lyme disease
    • Hansen K, Hindersson P, Pedersen NS. 1988. Measurement of antibodies to the Borrelia burgdorferi flagellum improves serodiagnosis in Lyme disease. J Clinical Microbiol 26:338-346.
    • (1988) J Clinical Microbiol , vol.26 , pp. 338-346
    • Hansen, K.1    Hindersson, P.2    Pedersen, N.S.3
  • 13
    • 0343867950 scopus 로고    scopus 로고
    • Characterization of the fine structure of a conformational epitope by epitope excision and differential chemical modification
    • June 13-17, 1999. Dallas, Texas. WPH276
    • Hochleitner EO, Borchers C, Bienstock R, Tomer K. 1999. Characterization of the fine structure of a conformational epitope by epitope excision and differential chemical modification. Proceedings of the 47th ASMS conference, June 13-17, 1999. Dallas, Texas. WPH276.
    • (1999) Proceedings of the 47th ASMS Conference
    • Hochleitner, E.O.1    Borchers, C.2    Bienstock, R.3    Tomer, K.4
  • 14
    • 0032493678 scopus 로고    scopus 로고
    • NMR identification of epitopes of Lyme disease antigen OspA to monoclonal antibodies
    • Huang X, Yang X, Luft BJ, Koide S. 1998. NMR identification of epitopes of Lyme disease antigen OspA to monoclonal antibodies. J Mol Biol 281:61-67.
    • (1998) J Mol Biol , vol.281 , pp. 61-67
    • Huang, X.1    Yang, X.2    Luft, B.J.3    Koide, S.4
  • 15
    • 0032231990 scopus 로고    scopus 로고
    • Matrix-assisted laser desorption ionization mass spectrometry mapping of human immunodeficiency virus-gp120 epitopes recognized by a limited polyclonal antibody
    • Jeyarajah S, Parker CE, Summer MT, Tomer KB. 1998. Matrix-assisted laser desorption ionization mass spectrometry mapping of human immunodeficiency virus-gp120 epitopes recognized by a limited polyclonal antibody. J Am Soc Mass Spectrom 9:157-165.
    • (1998) J Am Soc Mass Spectrom , vol.9 , pp. 157-165
    • Jeyarajah, S.1    Parker, C.E.2    Summer, M.T.3    Tomer, K.B.4
  • 16
  • 18
    • 0026751258 scopus 로고
    • Heterogeneity of outer proteins in Borrelia burgdorferi: Comparison of osp operons of three isolates of different geographic origins
    • Jonsson M, Noppa L, Barbour AG, Bergström S. 1992. Heterogeneity of outer proteins in Borrelia burgdorferi: Comparison of osp operons of three isolates of different geographic origins. Infect Immun 60:1845-1853.
    • (1992) Infect Immun , vol.60 , pp. 1845-1853
    • Jonsson, M.1    Noppa, L.2    Barbour, A.G.3    Bergström, S.4
  • 19
    • 0029024957 scopus 로고
    • Early and late antibody responses to full-length and truncated constructs of outer surface protein A of Borrelia burgdorferi in Lyme disease
    • Kalish RA, Leong JM, Steere A. 1995. Early and late antibody responses to full-length and truncated constructs of outer surface protein A of Borrelia burgdorferi in Lyme disease. Infect Immun 63:2228-2235.
    • (1995) Infect Immun , vol.63 , pp. 2228-2235
    • Kalish, R.A.1    Leong, J.M.2    Steere, A.3
  • 20
    • 0033135224 scopus 로고    scopus 로고
    • Direct identification of protein epitopes by mass spectrometry without immobilization of antibody and isolation of antibody-peptide complexes
    • Kiselar JG, Downard KM. 1999. Direct identification of protein epitopes by mass spectrometry without immobilization of antibody and isolation of antibody-peptide complexes. Anal Chem 71:1792-1801.
    • (1999) Anal Chem , vol.71 , pp. 1792-1801
    • Kiselar, J.G.1    Downard, K.M.2
  • 21
    • 0016756272 scopus 로고
    • Continuous culture of fused cells secreting antibody of predefined specificity
    • Köhler G, Milstein C. 1975. Continuous culture of fused cells secreting antibody of predefined specificity. Nature 256:495-497.
    • (1975) Nature , vol.256 , pp. 495-497
    • Köhler, G.1    Milstein, C.2
  • 22
    • 0017135663 scopus 로고
    • Derivation of specific antibody producing tissue, culture and tumor lines by cells fusion
    • Köhler G, Milstein C. 1976. Derivation of specific antibody producing tissue, culture and tumor lines by cells fusion. Eur J Immunol 6:511-519.
    • (1976) Eur J Immunol , vol.6 , pp. 511-519
    • Köhler, G.1    Milstein, C.2
  • 23
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 24
    • 0030932886 scopus 로고    scopus 로고
    • Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab
    • Li H, Dunn JJ, Luft BJ, Lawson CL. 1997. Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab. Proc Natl Acad Sci USA 94:3584-3589.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3584-3589
    • Li, H.1    Dunn, J.J.2    Luft, B.J.3    Lawson, C.L.4
  • 25
    • 0029731189 scopus 로고    scopus 로고
    • Mass spectrometric mapping of protein epitope structures of myocardial infarct markers myoglobin and troponin T
    • Macht M, Fiedler W, Kurzinger K, Przybylski M. 1996. Mass spectrometric mapping of protein epitope structures of myocardial infarct markers myoglobin and troponin T. Biochemistry 35:15633-15639.
    • (1996) Biochemistry , vol.35 , pp. 15633-15639
    • Macht, M.1    Fiedler, W.2    Kurzinger, K.3    Przybylski, M.4
  • 26
    • 0018798006 scopus 로고
    • High-yield cleavage of tryptophanyl peptide bonds by o-iodosobenzoic acid
    • Mahoney WC, Hermodson MA. 1979. High-yield cleavage of tryptophanyl peptide bonds by o-iodosobenzoic acid. Biochemistry 18:3810-3814.
    • (1979) Biochemistry , vol.18 , pp. 3810-3814
    • Mahoney, W.C.1    Hermodson, M.A.2
  • 27
    • 0028930316 scopus 로고
    • Identification of an immunologically important hypervariable domain of major outer surface protein A of Borrelia burgdorferi
    • McGrath BC, Dunn JJ, Gorgone G, Luft BJ, Guttman D, Dykhuizen D. 1995. Identification of an immunologically important hypervariable domain of major outer surface protein A of Borrelia burgdorferi. Infect Immun 63: 1356-1361.
    • (1995) Infect Immun , vol.63 , pp. 1356-1361
    • McGrath, B.C.1    Dunn, J.J.2    Gorgone, G.3    Luft, B.J.4    Guttman, D.5    Dykhuizen, D.6
  • 28
    • 0030059010 scopus 로고    scopus 로고
    • Recombinant outer-surface protein A(desCysl-OspA) from the Lyme disease spirochete Borrelia burgdorferi: High production levels in Saccharomyces cerevisiae yeast cultures
    • Mendoza-Vega O, Keppi E, Bouchon B, Nguyen M, Achstetter T. 1996. Recombinant outer-surface protein A(desCysl-OspA) from the Lyme disease spirochete Borrelia burgdorferi: High production levels in Saccharomyces cerevisiae yeast cultures. Appl Microbiol Biotechnol 44:624-628.
    • (1996) Appl Microbiol Biotechnol , vol.44 , pp. 624-628
    • Mendoza-Vega, O.1    Keppi, E.2    Bouchon, B.3    Nguyen, M.4    Achstetter, T.5
  • 31
    • 0028004403 scopus 로고
    • Epitope mapping of the gastrin-releasing peptide anti-bombesin monoclonal antibody complex by proteolysis followed by matrix-assisted laser desorption ionization mass spectrometry
    • Papac DI, Hoyes J, Tomer KB. 1994. Epitope mapping of the gastrin-releasing peptide anti-bombesin monoclonal antibody complex by proteolysis followed by matrix-assisted laser desorption ionization mass spectrometry. Protein Sci 3:1485-492.
    • (1994) Protein Sci , vol.3 , pp. 1485-1492
    • Papac, D.I.1    Hoyes, J.2    Tomer, K.B.3
  • 33
    • 0025333897 scopus 로고
    • Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficient (scid) mice
    • Schaible UE, Kramer MD, Eichmann K, Modolell M, Museteanu C, Simon MM. 1990. Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficient (scid) mice. Proc Natl Acad Sci USA 87:3768-3772.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3768-3772
    • Schaible, U.E.1    Kramer, M.D.2    Eichmann, K.3    Modolell, M.4    Museteanu, C.5    Simon, M.M.6
  • 34
    • 0025878181 scopus 로고
    • Mapping antibody-binding domains of the major outer surface membrane protein (OspA) of Borrelia burgdorferi
    • Schubach WH, Mudri S, Dattwyler RJ, Luft BJ. 1991. Mapping antibody-binding domains of the major outer surface membrane protein (OspA) of Borrelia burgdorferi. Infect Immun 59:1911-1915.
    • (1991) Infect Immun , vol.59 , pp. 1911-1915
    • Schubach, W.H.1    Mudri, S.2    Dattwyler, R.J.3    Luft, B.J.4
  • 35
    • 0025112794 scopus 로고
    • Searching for peptides with an epitope library
    • Scott JK, Smith GP. 1990. Searching for peptides with an epitope library. Science 249:386-390.
    • (1990) Science , vol.249 , pp. 386-390
    • Scott, J.K.1    Smith, G.P.2
  • 37
    • 0026565206 scopus 로고
    • Epitopes on the outer surface protein A of Borrelia burgdorferi recognized by antibodies and T cells of patients with Lyme disease
    • Shanafelt MC, Anzola J, Soderberg C, Yssel H, Turck CW, Peltz G. 1992. Epitopes on the outer surface protein A of Borrelia burgdorferi recognized by antibodies and T cells of patients with Lyme disease. J Immunol 148:218-224.
    • (1992) J Immunol , vol.148 , pp. 218-224
    • Shanafelt, M.C.1    Anzola, J.2    Soderberg, C.3    Yssel, H.4    Turck, C.W.5    Peltz, G.6
  • 38
    • 0032813306 scopus 로고    scopus 로고
    • Lyme disease and the Lyme disease vaccines
    • Sigal LH. 1999. Lyme disease and the Lyme disease vaccines. Bull Rheum Dis 48:1-4.
    • (1999) Bull Rheum Dis , vol.48 , pp. 1-4
    • Sigal, L.H.1
  • 40
    • 0024362494 scopus 로고
    • Lyme disease
    • Steere AC. 1989. Lyme disease. N Engl J Med 321:586-596.
    • (1989) N Engl J Med , vol.321 , pp. 586-596
    • Steere, A.C.1
  • 41
    • 0025630449 scopus 로고
    • Molecular epitope identification by limited proteolysis of an immobilized antigen-antibody complex and mass spectrometric peptide mapping
    • Suckau D, Köhl J, Karwath G, Schneider K, Casaretto M, Bitter-Suermann D, Przybylski M. 1990. Molecular epitope identification by limited proteolysis of an immobilized antigen-antibody complex and mass spectrometric peptide mapping. Proc Natl Acad Sci USA 87:9848-9852.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9848-9852
    • Suckau, D.1    Köhl, J.2    Karwath, G.3    Schneider, K.4    Casaretto, M.5    Bitter-Suermann, D.6    Przybylski, M.7
  • 42
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin H, Staehelin T, Gordon J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 43
    • 0032791759 scopus 로고    scopus 로고
    • Vaccination against Lyme borreliosis
    • Wahlberg P. 1999. Vaccination against Lyme borreliosis. Ann Med 31:233-235.
    • (1999) Ann Med , vol.31 , pp. 233-235
    • Wahlberg, P.1
  • 44
    • 0026712541 scopus 로고
    • Molecular analysis of the outer surface protein A (OspA) of Borrelia burgdorferi for conserved and variable antibody binding domains
    • Wilske B, Luft B, Schubach WH, Zumstein G, Jauris S, Preac-Mursic V, Kramer MD. 1992. Molecular analysis of the outer surface protein A (OspA) of Borrelia burgdorferi for conserved and variable antibody binding domains. Med Microbiol Immunol 181:191-207.
    • (1992) Med Microbiol Immunol , vol.181 , pp. 191-207
    • Wilske, B.1    Luft, B.2    Schubach, W.H.3    Zumstein, G.4    Jauris, S.5    Preac-Mursic, V.6    Kramer, M.D.7
  • 45
    • 0000154075 scopus 로고
    • Immunodominant proteins of Borrelia burgdorferi, the etiologic agent of Lyme borreliosis
    • Wilske B, Preac-Mursic V, Fuchs R, Soutschek E. 1991. Immunodominant proteins of Borrelia burgdorferi, the etiologic agent of Lyme borreliosis. World J Microbiol 7:130-136.
    • (1991) World J Microbiol , vol.7 , pp. 130-136
    • Wilske, B.1    Preac-Mursic, V.2    Fuchs, R.3    Soutschek, E.4
  • 47
    • 0032009787 scopus 로고    scopus 로고
    • Epitope mapping of monoclonal antibodies by mass spectrometry: Identification of protein antigens in complex biological systems
    • Yu L, Gaskell SJ, Brookman JL. 1998. Epitope mapping of monoclonal antibodies by mass spectrometry: identification of protein antigens in complex biological systems. J Am Soc Mass Spectrom 9:208-215.
    • (1998) J Am Soc Mass Spectrom , vol.9 , pp. 208-215
    • Yu, L.1    Gaskell, S.J.2    Brookman, J.L.3
  • 48
    • 0028541590 scopus 로고
    • Protein epitope mapping by mass spectrometry
    • Zhao Y, Chait BT. 1994. Protein epitope mapping by mass spectrometry. Anal Chem 66:3723-3726.
    • (1994) Anal Chem , vol.66 , pp. 3723-3726
    • Zhao, Y.1    Chait, B.T.2


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