Acute-phase response and circadian expression of connexin26 are not altered in connexin32-deficient mouse liver

Cell and Tissue Research

Volumn 300, Issue 1, 2000, Pages 111-117

  Temme, Achim ^a   Ott, Thomas ^a   Haberberger, Thomas ^a   Traub, Otto ^a   Willecke, Klaus ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Circadian rhythm; Cx32 deficient mice; Experimental inflammation; Liver gap junctions; Mouse (BALB c; C57BL 6)

Indexed keywords

ACTIN; CONNEXIN 26; CONNEXIN 32; ENDOTOXIN; FIBRINOGEN; LIPOPOLYSACCHARIDE; RECOMBINANT INTERLEUKIN 1; RECOMBINANT INTERLEUKIN 6; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DOWN REGULATION; GAP JUNCTION; GENE LOSS; GENETIC TRANSCRIPTION; HEPATITIS; IMMUNOBLOTTING; LIVER CELL; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION;

ACTINS; ACUTE-PHASE REACTION; ALBUMINS; ANIMALS; BLOTTING, NORTHERN; CIRCADIAN RHYTHM; CONNEXINS; FIBRINOGEN; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GAP JUNCTIONS; GENE EXPRESSION; LIVER; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RNA, MESSENGER; RNA, RIBOSOMAL, 18S;

ANIMALIA;

EID: 0034128948     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410050052     Document Type: Article

References (24)

1. Benavides A, Siches M, Llobera M (1998) Circadian rhythms of lipoprotein lipase and hepatic lipase activities in intermediate metabolism of adult rat. Am J Physiol 275:R811-R817
2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72:248-254
3. Chomczynski P, Sacchi N (1987) Single step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
4. Feinberg AP, Vogelstein BA (1983) A technique for radiolabeling restriction endonuclease fragments to high specific activity. Anal Biochem 137:266-267
5. Fey GH, Hocke GM, Wilson DR, Ripperger JA, Todd SC-J, Cui M-Z, Darlington GJ (1994) Cytokines and the acute phase response of the liver. In: Arias IM, Boyer JL, Fausto N, Jakoby WB, Schachter DA, Shafritz DA (eds) The liver: biology and pathobiology, 3rd edn. Raven Press, New York, pp 113-143
6. Fort PC, Marty M, Piecharczyk M, ElSabrouty S, Dani C, Janteur P Blanchard JM (1985) Various rat adult tissues express only one major RNA species from the glyceraldehyde-3-phosphate dehydrogenase. Nucleic Acid Res 13:1431-1442
7. Gingalewski C, Wang K, DeMaio A, Clemens MG (1994) Disruption of hepatic gap junctional communication during acute inflammation. Int Care Med 20:95
8. Gingalewski C, Wang K, Clemens MG, DeMaio A (1996) Posttranscriptional regulation of connexin32 expression in liver during acute inflammation. J Cell Physiol 166:461-467
9. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-686
10. Morrow JF, Steaman RS, Peltzman CG, Potter DA (1981) Induction of serum amyloid A protein and actin. Proc Natl Acad Sci U S A 78:4718-4722
11. Nelles E, Bützler C, Jung D, Temme A, Gabriel HD, Dahl U, Traub O, Stümpel F, Jungermann K, Zielasek J, Toyka K, Dermietzel R, Willecke K (1996) Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice. Proc Natl Acad Sci USA 93: 9565-9570
12. Pasqualetti P, Festuccia V, Acitelli P, Natali L, Collacciani A, Casale R (1997) Circadian rhythms of fibrinogen, antithrombin III and plasminogen in chronic liver diseases of increasing severity. Haemostasis 27:140-148
13. Schibler U, Lavery DJ (1999) Circadian timing in animals. In: Russo E, Edgar L, Cove D, Jaenisch R, Salamini F (eds) Development genetics, epigenetics, and environmental regulation. Springer, Berlin Heidelberg New York, pp 487-505
14. Schreiber G, Howlett G, Nagashima M, Millership A, Martin H, Urban J, Kotler L (1982) The acute phase response of plasma protein synthesis during experimental inflammation. J Biol Chem 257:10271-10277
15. Shinohara ML, Loros JJ, Dunlap JC (1998) Glyceraldehyde-3-phosphate dehydrogenase is regulated on a daily basis by the circadian clock. J Biol Chem 273:446-452
16. Skalli O, Ropraz P, Trzeciak A, Benzonana G, Gillessen D, Gabbiani GA (1986) Monoclonal antibody against α-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 103:2787-2796
17. Spray DC, Saez JC, Hertzberg EL, Dermietzel R (1994) Gap junctions in the liver. Composition, function, and regulation. In: Arias IM, Boyer JL, Fausto N, Jakoby WB, Schachter DA, Shafritz DA (eds) The liver: biology and pathobiology, 3rd edn. Raven Press, New York, pp 951-967
18. Stümpel F, Ott T, Willecke K, Jungermann K (1998) Connexin 32 gap junctions enhance stimulation of glucose output by glucagon and noradrenaline in mouse liver. Hepatology 28:1-5
19. Stutenkemper R, Geisse S, Schwarz H-J, Look J, Traub O, Nicholson BJ, Willecke K (1992) The hepatocyte specific phenotype of murine liver cells correlates with high expression of connexin32 and connexin26 but very low expression of connexin43. Exp Cell Res 201:43-54
20. Temme A, Buchmann A, Gabriel HD, Nelles E, Schwarz M, Willecke K (1997) High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32. Curr Biol 7:713-716
21. Temme A, Traub O, Willecke K (1998) Downregulation of connexin32 protein and gap-junctional intercellular communication by cytokine-mediated acute-phase response in immortalized mouse hepatocytes. Cell Tissue Res 294:345-350
22. Temme A, Ott T, Dombrowski F, Willecke K (2000) The extent of synchronous initiation and termination of DNA synthesis in regenerating mouse liver is dependent on connexin32 expressing gap junctions. J Hepatol (in press)
23. Traub O, Look J, Dermietzel R, Brümmer F, Hülser D, Willecke K (1989) Comparative characterization of the 21kD and 26kD gap junction proteins in murine liver and cultured hepatocytes. Eur J Cell Biol 43:48-54
24. Wang K, Deutschman C, Clemens MG, DeMaio A (1995) Reciprocal expression of phosphoenolpyruvate carboxykinase and acute phase genes during acute inflammation. Shock 3:204-209