Connexin 32 Gap junctions enhance stimulation of glucose output by glucagon and noradrenaline in mouse liver

Hepatology

Volumn 28, Issue 6, 1998, Pages 1616-1620

  Stümpel, Frank ^a,c   Ott, Thomas ^b   Willecke, Klaus ^b   Jungermann, Kurt ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c Inst fur Biochem/Molek Zellbiol   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 32; GLUCOSE;

ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; GAP JUNCTION; GLUCONEOGENESIS; HORMONAL REGULATION; LIVER METABOLISM; LIVER PERFUSION; LIVER SINUSOID; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

EID: 0031738009     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510280622     Document Type: Article

References (24)

1. Dermietzel R, Hwang TK, Spray DS. The gap junction family: structure, function and chemistry. Anat Embryol 1990;182:517-528.
2. White TW, Bruzzone R, Paul DL. The connexin family of intercellular channel forming proteins. Kidney Int 1995;48:1148-1157.
3. Saez JC, Connor JA, Spray DC, Bennett MVL. Hepatocyte gap junctions are permeable to a second messenger, inositol 1, 4, 5-triphosphate and to calcium ions. Proc Natl Acad Sci U S A 1989;86:2708-2712.
4. Traub O, Look J, Dermietzel R, Brummer F, Hulser D, Willecke K. Comparative characterisation of the 21-kD and 26-kD gap junction proteins in murine liver and cultured hepatocytes. J Cell Biol 1989;108:1039-1051.
5. Rosenberg E, Spray DC, Reid LM. Transcriptional and posttranscriptional control of connexin mRNAs in periportal and pericentral rat hepatocytes. Eur J Cell Biol 1992;59:21-26.
6. Spray DC, Sáez JC, Hertzberg EL, Dermietzel R: Gap junctions in liver. In: Arias IM, Boyer JL, Fausto N, Jakoby WB, Schachter DA, Shafritz DA, eds. The Liver: Biology and Pathobiology. 3rd ed. New York: Raven, 1994:951-967.
7. Henderson D, Eibl H, Weber K. Structure and biochemistry of mouse hepatic gap junctions. J Mol Biol 1979;132:193-218.
8. Metz W, Forssmann WG. Innervation of the liver in guinea pig and rat. Anat Embryol 1980;160:239-252.
9. Iwai M, Miyashita T, Shimazu T. Inhibition of glucose production during hepatic nerve stimulation in regenerating rat liver perfused in situ. Eur J Biochem 1991;200:69-74.
10. Seseke FG, Gardemann A, Jungermann K. Signal propagation via gap junctions, a key step in the regulation of liver metabolism by the sympathetic hepatic nerves. FEBS Lett 1992;301:265-270.
11. Helles E, Bützler C, Jung D, Temme A, Gabriel HD, Dahl U, Traub O, et al. Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin 32-deficient mice. Proc Natl Acad Sci U S A 1996;93:9565-9570.
12. 2+ signals in multicellular systems of rat hepatocytes. Biochem J 1994;304:585-594.
13. Tordjman T, Berthon B, Claret M, Combettes L. Coordinated intercellular calcium waves induced by noradrenaline in rat hepatocytes: dual control by gap junction permeability and agonist. EMBO J 1997;16:5398-5407.
14. 2+ waves in the intact liver. J Biol Chem 1995;270:8102-8107.
15. Jungermann K, Kietzmann T. Zonation of parenchymal and nonparenchymal metabolism in liver. Annu Rev Nutr 1996;16:179-203.
16. Gardemann A, Jahns U, Jungermann K. Control of glycogenolysis and blood flow by arterial and portal norepinephrine in perfused rat liver. Am J Physiol 1991;260:E762-E771.
17. Jelinek LJ, Lok S, Rosenberg GB, Smith RA, Grant FJ, Biggs S, Bensch PA, Kuijper JL, et al. Expression cloning and signaling properties of the rat glucagon receptor. Science 1993;259:1614-1616.
18. Krones A, Kietzmann T, Jungermann K. Periportal localisation of glucagon mRNA in rat liver and regulation of its expression by glucose and oxygen in hepatocyte cultures. FEBS Lett 1998;421:136-140.
19. Berthoud VM, Iwanij V, Garcia AM, Saez JC. Connexins and glucagon receptors during development of rat hepatic acinus. Am J Physiol 1992;263:G650-G658.
20. Spray DC, Bai S, Burk RD, Saez JC. Regulation and function of liver gap junctions and their genes. Prog Liver Dis 1994;12:1-18.
21. Sáez JC. Intercellular gap junctional communication is required for an optimal metabolic response of the functional units of liver. HEPATOLOGY 1997;25:775-776.
22. Meda P. Gap junction involvement in secretion: the pancreas experience. Clin Exp Pharmacol Physiol 1996;23:1053-1057.
23. Vozzi C, Ullrich S, Charollais A, Philippe J, Orci L, Meda P. Adequate connexin-mediated coupling is required for proper insulin production. J Cell Biol 1995;131:1561-1572.
24. 2+ waves are organized among hepatocytes in the intact organ. Am J Physiol 1995;269:G167-G171.