Human herpesvirus-6 and -7 infections in children: Agents of roseola and other syndromes

Current Opinion in Pediatrics

Volumn 12, Issue 3, 2000, Pages 269-274

  Leach, Charles T ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOSCARNET; GANCICLOVIR;

ANTIBIOTIC THERAPY; ARTICLE; CLINICAL FEATURE; DISEASE ASSOCIATION; EXANTHEMA SUBITUM; FEVER; HUMAN HERPESVIRUS 6; HUMAN HERPESVIRUS 7; IMMUNE DEFICIENCY; PRIORITY JOURNAL; SEROPREVALENCE; VIRUS DIAGNOSIS; VIRUS ENCEPHALITIS; VIRUS LATENCY; VIRUS SHEDDING;

ANTIVIRAL AGENTS; CHILD; DIAGNOSIS, DIFFERENTIAL; EXANTHEMA SUBITUM; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 6, HUMAN; HERPESVIRUS 7, HUMAN; HUMANS;

EID: 0034127160     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008480-200006000-00017     Document Type: Article

References (72)

1. 1 Biberfeld P, Petren AL, Eklund A, Lindemalm C, Barkhem T, Ekman M, et al.: Human herpesvirus-6 (HHV-6, HBLV) in sarcoidosis and lymphoproliferative disorders. J Virol Methods 1988, 21:49-59.
2. 2 Wyatt LS, Rodriguez WJ, Balachandran N, Frenkel N: Human herpesvirus 7: antigenic properties and prevalence in children and adults. J Virol 1991, 65:6260-6265.
3. 3 Braun DK, Dominguez G, Pellett PE: Human herpesvirus 6. Clin Microbiol Rev 1997, 10:521-567.
4. 4 Sada E, Yasukawa M, Ito C, Takeda A, Shiosaka T, Tanioka H, Fujita S: Detection of human herpesvirus 6 and human herpesvirus 7 in the submandibular gland, parotid gland, and lip salivary gland by PCR. J Clin Microbiol 1996, 34:2320-2321.
5. 5 Berneman ZN, Ablashi DV, Li G, Eger-Fletcher M, Reitz MS Jr, Hung CL, et al.: Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus. Proc Natl Acad Sci U S A 1992, 89:10552-10556.
6. 6 Lusso P, Secchiero P, Crowley RW, Garrino-Demo A, Berneman ZN, Gallo RC: CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus. Proc Natl Acad Sci U S A 1994, 91:3872-3876.
7. 7 Santoro F, Kennedy PE, Locatelli G, Malnati MS, Berger EA, Lusso P: CD46 is a cellular receptor for human herpesvirus 6. Cell 1999, 99:817-827. This excellent paper describes several experiments that conclusively demonstrate that CD46 is a key cellular receptor for both subtypes of HHV-6.
8. 8 Horvat RT, Parmely MJ, Chandran B: Human herpesvirus 6 inhibits the proliferative responses of human peripheral blood mononuclear cells. J Infect Dis 1993, 167:1274-1280.
9. 9 Atedzoe BN, Ahmad A, Menezes J: Enhancement of natural killer cell cytotoxicity by the human herpesvirus-7 via IL-15 induction. J Immunol 1997, 159:4966-4972.
10. 10 Ablashi DV, Balachandran N, Josephs SF, Hung CL, Krueger GR, Kramarsky B, et al.: Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates. Virology 1991, 184:545-552.
11. 11 Dewhurst S, McIntyre K, Schnabel K, Hall CB: Human herpesvirus 6 (HHV-6) variant B accounts for the majority of symptomatic primary HHV-6 infections in a population of U.S. infants. J Clin Microbiol 1993, 31:416-418.
12. 12 Yamamoto T, Mukai T, Kondo K, Yamanishi K: Variation of DNA sequence in immediate-early gene of human herpesvirus 6 and variant identification by PCR. J Clin Microbiol 1994, 32:473-476.
13. 13 Kasolo FC, Mpabalwani E, Compels DA: Infection with AIDS-related herpesviruses in human immunodeficiency virus-negative infants and endemic childhood Kaposi's sarcoma in Africa. J Gen Virol 1997, 78:847-855.
14. 14 Asano Y, Yoshikawa T, Suga S, Yazaki T, Hata T, Nagai T, et al.: Viremia and neutralizing antibody response in infants with exanthem subitum. J Pediatr 1989, 114:535-539.
15. 15 Asano Y, Suga S, Yoshikawa T, Yazaki T, Uchikawa T: Clinical features and viral excretion in an infant with primary human herpesvirus 7 infection. Pediatrics 1995, 95:187-190.
16. 16 Caserta MT, Hall CB, Schnabel K, McIntyre K, Long C, Costanzo M, et al.: Neuroinvasion and persistence of human herpesvirus 6 in children. J Infect Dis 1994, 170:1586-1589.
17. 17 Leach CT, Newton ER, McParlin S, Jenson HB: Human herpesvirus 6 infection of the female genital tract. J Infect Dis 1994, 169:1281-1283.
18. 18 Okuno T, Oishi H, Hayashi K, Nonogaki M, Tanaka K, Yamanishi K: Human herpesviruses 6 and 7 in cervixes of pregnant women. J Clin Microbiol 1995, 33:1968-1970.
19. 19 Huang LM, Lee CY, Liu MY, Lee PI: Primary infections of human herpesvirus-7 and herpesvirus-6: a comparative, longitudinal study up to 6 years of age. Acta Paediatr 1997, 86:604-608.
20. 20 Kempe CH, Shaw EB, Jackson JR, Silver HK: Studies on the etiology of exanthema subitum (roseola infantum). J Pediatr 1950, 37:561-568.
21. 21 Mukai T, Yamamoto T, Kondo T, Kondo K, Okuno T, Kosuge H, Yamanishi K: Molecular epidemiological studies of human herpesvirus 6 in families. J Med Virol 1994, 42:224-227.
22. 22 van Loon NM, Gummuluru S, Sherwood DJ, Marentes R, Hall CB, Dewhurst S: Direct sequence analysis of human herpesvirus 6 (HHV-6) sequences from infants and comparison of HHV-6 sequences from mother/infant pairs. Clin Infect Dis 1995, 21:1017-1019.
23. 23 Takahashi Y, Yamada M, Nakamura J, Tsukazaki T, Padilla J, Kitamura T, et al.: Transmission of human herpesvirus 7 through multigenerational families in the same household. Pediatr Infect Dis J 1997, 16:975-978.
24. 24 Aubin JT, Poirel L, Agut H, Huraux JM, Bignozzi C, Brossard Y, et al.: Intrauterine transmission of human herpesvirus 6 [letter]. Lancet 1992, 340:482-483.
25. 25 Dahl H, Fjaertoft G, Norsted T, Wang FZ, Mousavi-Jazi M, Linde A: Reactivation of human herpesvirus 6 during pregnancy. J Infect Dis 1999, 180:2035-2038. This article focuses on reactivation of HHV-6 during pregnancy, suggested by higher rates of HHV-6 DNA in blood compared between women at delivery and nonpregnant women; 1% of cord bloods contained HHV-6 DNA.
26. 26 Adams O, Krempe C, Kogler G, Wernet P, Scheid A: Congenital infections with human herpesvirus 6. J Infect Dis 1998, 178:544-546.
27. 27 Daibata M, Miyoshi I: Presence of human herpesvirus 6 DNA in cord blood cells. J Infect Dis 1999, 179:1046-1047.
28. 28 Ward KN, Gray JJ, Efstathiou S: Brief report: primary human herpesvirus 6 infection in a patient following liver transplantation from a seropositive donor. J Med Virol 1989, 28:69-72.
29. 29 Lau YL, Peiris M, Chan GC, Chan AC, Chiu D, Ha SY: Primary human herpes virus 6 infection transmitted from donor to recipient through bone marrow infusion. Bone Marrow Transplant 1998, 21:1063-1066.
30. 30 Suga S, Yoshikawa T, Asano Y, Nakashima T, Yazaki T, Fukuda M, et al.: IgM neutralizing antibody responses to human herpesvirus-6 in patients with exanthem subitum or organ transplantation. Microbiol Immunol 1992, 36:495-506.
31. 31 Ward KN, Gray JJ, Fotheringham MW, Sheldon MJ: IgG antibodies to human herpesvirus-6 in young children: changes in avidity of antibody correlate with time after infection. J Med Virol 1993, 39:131-138.
32. 32 Singh N, Carrigan DR: Human herpesvirus-6 in transplantation: an emerging pathogen. Ann Intern Med 1996, 124:1065-1071.
33. 33 Cone RW, Hackman RC, Huang ML, Bowden RA, Meyers JD, Metcalf M, et al.: Human herpesvirus 6 in lung tissue from patients with pneumonitis after bone marrow transplantation. N Engl J Med 1993, 329:156-161.
34. 34 Chiu SS, Cheung CY, Tse CY, Peiris M: Early diagnosis of primary human herpesvirus 6 infection in childhood: serology, polymerase chain reaction, and virus load J Infect Dis 1998, 178:1250-1256.
35. 35 Clark DA, Kidd IM, Collingham KE, Tarlow M, Ayeni T, Riordan A, et al.: Diagnosis of primary human herpesvirus 6 and 7 infections in febrile infants by polymerase chain reaction. Arch Dis Child 1997, 77:42-45.
36. 36 Drobyski WR, Knox KK, Majewski D, Carrigan DR: Brief report: fatal encephalitis due to variant B human herpesvirus-6 infection in a bone marrow-transplant recipient. N Engl J Med 1994, 330:1356-1360.
37. 37 Mirandola P, Menegazzi P, Merighi S, Ravaioli T, Cassai E, Di Luca D: Temporal mapping of transcripts in herpesvirus 6 variants. J Virol 1998, 72:3837-3844.
38. 38 Marsh S, Kaplan M, Asano Y, Hoekzema D, Komaroff AL, Whitman JE Jr, Ablashi DV: Development and application of HHV-6 antigen capture assay for the detection of HHV-6 infections. J Virol Methods 1996, 61:103-112.
39. 39 Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, Kurata T: Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1988, i:1065-1067.
40. 40 Kusuhara K, Ueda K, Miyazaki C, Okada K, Tokugawa K: Attack rate of exanthem subitum in Japan [letter]. Lancet 1992, 340:482.
41. 41 Pruksananonda P, Hall CB, Insel RA, McIntyre K, Pellett PE, Long CE, et al.: Primary human herpesvirus 6 infection in young children. N Engl J Med 1992, 326:1445-1450.
42. 42 Hall CB, Long CE, Schnabel KG, Caserta MT, McIntyre KM, Costanzo MA, et al.: Human herpesvirus-6 infection in children: a prospective study of complications and reactivation. N Engl J Med 1994, 331:432-438.
43. 43 Barone SR, Kaplan MH, Krilov LR: Human herpesvirus-6 infection in children with first febrile seizures. J Pediatr 1995, 127:95-97.
44. 44 Suga S, Suzuki K, Ihira M, Yoshikawa T, Kajita Y, Ozaki T, et al.: Clinical characteristics of febrile convulsions during primary HHV-6 infection. Arch Dis Child 2000, 82:62-66. This article presents a comparison of Japanese infants with febrile seizures who did versus those who did not have primary HHV-6 infection. Patients with HHV-6-associated seizures were younger, more likely to have atypical seizures, and perhaps at higher risk for recurrent seizures than those who did not have HHV-6.
45. 45 Hukin J, Farrell K, MacWilliam LM, Colbourne M, Waida E, Tan R, et al.: Case-control study of primary human herpesvirus 6 infection in children with febrile seizures. Pediatrics 1998, 101:e3. Available at http://www.pediatrics.org/cgi/content/full/101/5/e3. Accessed April 11, 2000.
46. 46 Kondo K, Nagafuji H, Hata A, Tomomori C, Yamanishi K: Association of human herpesvirus 6 infection of the central nervous system with recurrence of febrile convulsions. J Infect Dis 1993, 167:1197-1200.
47. 47 Jee SH, Long CE, Schnabel KC, Sehgal N, Epstein LG, Hall CB: Risk of recurrent seizures after a primary human herpesvirus 6-induced febrile seizure. Pediatr Infect Dis J 1998, 17:43-48.
48. 48 Liedtke W, Trubner K, Schwechheimer K: On the role of human herpesvirus 6 in viral latency in nervous tissue and in cerebral lymphoma. J Neurol Sci 1995, 134:184-188.
49. 49 Knox KK, Harrington DP, Carrigan DR: Fulminant human herpesvirus six encephalitis in a human immunodeficiency virus-infected infant. J Med Virol 1995, 45:288-292.
50. 50 McCullers JA, Lakeman FD, Whitley RJ: Human herpesvirus 6 is associated with focal encephalitis. Clin Infect Dis 1995, 21:571-576.
51. 51 Tang YW, Espy MJ, Persing DH, Smith TF: Molecular evidence and clinical significance of herpesvirus coinfection in the central nervous system. J Clin Microbiol 1997, 35:2869-2872.
52. 52 Kolski H, Ford-Jones EL, Richardson S, Petric M, Nelson S, Jamieson F, et al.: Etiology of acute childhood encephalitis at The Hospital for Sick Children, Toronto, 1994-1995. Clin Infect Dis 1998, 26:398-409.
53. 53 Asano Y, Yoshikawa T, Kajita Y, Ogura R, Suga S, Yazaki T, et al.: Fatal encephalitis/encephalopathy in primary human herpesvirus-6 infection. Arch Dis Child 1992, 67:1484-1485.
54. 54 Peiris M: Human herpesvirus-6 (HHV-6) and HHV-7 infections in bone marrow transplant recipients. Crit Rev Oncol Hematol 1999, 32:187-196. This is a well-written, comprehensive review of HHV-6 and -7 infections in bone marrow transplant patients.
55. 55 Jacobson S: Association of human herpesvirus-6 and multiple sclerosis: here we go again? J Neurovirol 1998, 4:471-473.
56. 56 Challoner PB, Smith KT, Parker JD, MacLeod DL, Coulter SN, Rose TM, et al.: Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci U S A 1995, 92:7440-7444.
57. 57 Kositanont U, Wasi C, Wanprapar N, Bowonkiratikachorn P, Chokephaibulkit K, Chearskul S, et al.: Primary infection of human herpesvirus 6 in children with vertical infection of human immunodeficiency virus type 1. J Infect Dis 1999, 180:50-55. This is an epidemiologic and virologic study of HIV-exposed Thai infants. A lower rate of HHV-6 infection was noted in HIV-positive patients, but HHV-6 infection was associated with accelerated progression of HIV disease.
58. 58 Asano Y, Yoshikawa T, Suga S, Yazaki T, Kondo K, Yamanishi K: Fatal fulminant hepatitis in an infant with human herpesvirus-6 infection [letter]. Lancet 1990, 335:862-863.
59. 59 Huang LM, Lee CY, Lin KH, Chuu WM, Lee PI, Chen RL, et al.: Human herpesvirus-6 associated with fatal haemophagocytic syndrome [letter]. Lancet 1990, 336:60-61.
60. 60 Saijo M, Saijo H, Yamamoto M, Takimoto M, Fujiyasu H, Murono K, Fujita K: Thrombocytopenic purpura associated with primary human herpesvirus 6 infection [letter]. Pediatr Infect Dis J 1995, 14:405.
61. 61 Prezioso PJ, Cangiarella J, Lee M, Nuovo GJ, Borkowsky W, Orlow SJ, Greco MA: Fatal disseminated infection with human herpesvirus-6. J Pediatr 1992, 120:921-923.
62. 62 Tanaka K, Kondo T, Torigoe S, Okada S, Mukai T, Yamanishi K: Human herpesvirus 7: another causal agent for roseola (exanthem subitum). J Pediatr 1994, 125:1-5.
63. 63 Hidaka Y, Okada K, Kusuhara K, Miyazaki C, Tokugawa K, Ueda K: Exanthem subitum and human herpesvirus 7 infection [letter]. Pediatr Infect Dis J 1994, 13:1010-1011.
64. 64 Torigoe S, Kumamoto T, Koide W, Taya K, Yamanishi K: Clinical manifestations associated with human herpesvirus 7 infection. Arch Dis Child 1995, 72:518-519.
65. 65 Suga S, Yoshikawa T, Nagai T, Asano Y: Clinical features and virological findings in children with primary human herpesvirus 7 infection. Pediatrics 1997, 99:e4. Available at: http://www.pediatrics.org/cgi/content/full/99/3/e4. Accessed April 11, 2000.
66. 66 Caserta MT, Hall CB, Schnabel K, Long CE, D'Heron N: Primary human herpesvirus 7 infection: a comparison of human herpesvirus 7 and human herpesvirus 6 infections in children. J Pediatr 1998, 133:386-389. From a large sample of infants seen in an emergency department, eight had primary HHV-7 infection and 29 had primary HHV-6 infection. HHV-7-infected patients were slightly older and more likely to have seizures.
67. 67 Drago F, Ranieri E, Malaguti F, Battifoglio ML, Losi E, Rebora A: Human herpesvirus 7 in patients with pityriasis rosea: electron microscopy investigations and polymerase chain reaction in mononuclear cells, plasma and skin. Dermatology 1997, 195:374-378.
68. 68 Kempf W, Adams V, Kleinhans M, Burg G, Panizzon RG, Campadelli-Fiume G, Nestle FOL: Pityriasis rosea is not associated with human herpesvirus 7. Arch Dermatol 1999, 135:1070-1072. In contrast to a previous study, these authors studied 13 cases of pityriasis rosea and 14 controls and found no association with HHV-7 infection.
69. 69 Hashida T, Komura E, Yoshida M, Otsuka T, Hibi S, Imashuku S, et al.: Hepatitis in association with human herpesvirus-7 infection. Pediatrics 1995, 96:783-785.
70. 70 van den Berg JS, van Zeijl JH, Rotteveel JJ, Melchers WJ, Gabreels FJ, Galama JM: Neuroinvasion by human herpesvirus type 7 in a case of exanthem subitum with severe neurologic manifestations. Neurology 1999, 52:1077-1079.
71. 71 Secchiero P, Zella D, Barabitskaja O, Reitz MS, Capitani S, Gallo RC, Zauli G: Progressive and persistent downregulation of surface CXCR4 in CD4(+) T cells infected with human herpesvirus 7. Blood 1998, 92:4521-4528.
72. 72 Romi H, Singer O, Rapaport D, Frenkel N: Tamplicon-7, a novel T-lymphotropic vector derived from human herpesvirus 7. J Virol 1999, 73:7001-7007.