Clinical characteristic of the febrile convulsions during primary HHV-6 infection

Archives of Disease in Childhood

Volumn 82, Issue 1, 2000, Pages 62-66

  Suga, Sadao ^a   Suzuki, Kyoko ^a   Ihira, Masaru ^a   Yoshikawa, Tetsushi ^a   Kajita, Yuji ^b   Ozaki, Takao ^b   Iida, Keiji ^c   Saito, Yumiko ^c   Asano, Yoshizo ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JA Aichi Showa Hospital   (Japan)

^c SRL INC   (Japan)

Author keywords

Epilepsy; Exanthem subitum; Febrile convulsion; Human herpesvirus 6; Risk factors

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; VIRUS ANTIBODY;

ANTIBODY TITER; ARTICLE; CHILD; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; ELECTROENCEPHALOGRAPHY; FEBRILE CONVULSION; FEMALE; HUMAN; HUMAN HERPESVIRUS 6; IMMUNOFLUORESCENCE; INFANT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; VIRUS CULTURE; VIRUS INFECTION; AGE DISTRIBUTION; HERPES VIRUS INFECTION; PRESCHOOL CHILD; RISK FACTOR; VIROLOGY;

AGE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; FEMALE; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 6, HUMAN; HUMANS; INFANT; MALE; RISK FACTORS; SEIZURES, FEBRILE;

EID: 0033621548     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/adc.82.1.62     Document Type: Article

References (39)

1. Yamanishi K, Okuno T, Shiraki K, et al. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1988;i: 1065-7.
2. Asano Y, Yoshikawa T, Suga S, et al. Viremia and neutralizing antibody response in infants with exanthem subitum. J Pediatr 1989;114:535-9.
3. Krugman S, Katz SL, Gershon AA, Wilfert CM. Exanthem subitum (roseola infantum). In: Krugman S, Katz SL, Gershon AA, Wilfert CM, eds. Infectious diseases of children, 9th ed. St Louis: CV Mosby, 1992:377-80.
4. Rosenblum J. Roseola infantum (exanthem subitum) complicated by hemiplegia. Am J Dis Child 1945;69:234-6.
5. Posson D. Exanthem subitum (roseola infantum) complicated by prolonged convulsions and hemiplegia. J Pediatr 1949;35:235-6.
6. Friedman JH, Golomb J, Aronson L. Hemiplegia associated with roseola infantum (exanthem subitum). N Y State J Med 1950;50:1749-50.
7. Holliday PB. Pre-eruptive neurological complications of the common contagious diseases-rubella, rubeola, roseola, and varicella. J Pediatr 1950;36:185-98.
8. Burnstine RC, Kingston N, Paine RS. Residual encephalopathy following roseola infantum. Am J Dis Child 1959;98:144-52.
9. Ishiguro N, Yamada S, Takahashi T, et al. Meningoencephalitis associated with HHV-6 related exanthem subitum. Acta Paediatr Scand 1990;79:987-9.
10. Yoshikawa T, Nakashima T, Suga S, et al. Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis. Pediatrics 1992;89:888-90.
11. Asano Y, Yoshikawa T, Kajita Y, et al. Fatal encephalitis/ encephalopathy in the primary human herpesvirus-6 infection. Arch Dis Child 1992;67:1484-5.
12. Suga S, Yoshikawa T, Asano Y, et al. Clinical and virological analyses of 21 infants with exanthem subitum (roseola infantum) and central nervous system complications. Ann Neurol 1993;33:597-603.
13. Yamanishi K, Kondo K, Mukai T, et al. Human herpesvirus-6 (HHV-6) in the central nervous system. Acta Paediatr Jpn 1992;34:337-43.
14. Yoshikawa T, Suga S, Asano Y, et al. Distribution of antibodies to a causative agent of exanthem subitum (human herpesvirus-6) in healthy individuals. Pediatrics 1989;84:675-7.
15. Fukuyama Y, Seki T, Ohtsuka C, Miura H, Hara M. Practical guidelines for physicians in the management of febrile seizures. Brain Dev 1996;18:479-84.
16. Haslam RHA. Febrile seizures. In: Behrman RE, Kliegman RM, Arvin AM, eds. Nelson textbook of pediatrics, 15th ed. Philadelphia: WB Saunders, 1996:1691-2.
17. Yoshikawa T, Suga S, Asano Y, Yazaki T, Ozaki T. Neutralizing antibodies to human herpesvirus-6 in healthy individuals. Pediatr Infect Dis J 1990;9:589-90.
18. Asano Y, Yoshikawa T, Suga S, et al. Enzyme-linked immunosorbent assay for detection of IgG antibody to human herpesvirus 6. J Med Virol 1990;32:119-23.
19. Hall CB, Long CE, Schnabel KC, et al. Human herpesvirus-6 infection in children: a prospective study of complications and reactivation. N Engl J Med 1994;331: 432-8.
20. Segondy M, Astruc J, Atoui N, et al. Herpesvirus 6 infection in young children. N Engl J Med 1992;327:1099-100.
21. Barone SR, Kaplan MH, Krilov LR. Human herpesvirus-6 infection in children with first febrile seizures. J Pediatr 1995;127:95-7.
22. Bertolani MF, Portolani M, Marotti F, et al. A study of childhood febrile convulsions with particular reference to HHV-6 infection: pathogenic considerations. Childs Nerv Syst 1996;12:534-9.
23. Jee SH, Long CE, Schnabel KC, et al. Risk of recurrent seizures after primary human herpesvirus 6-induced febrile seizure. Pediatr Infect Dis J 1998;17:43-8.
24. He J, McCarthy M, Zhou Y, Chandran B, Wood C. Infection of primary human fetal astrocytes by human herpesvirus 6. J Virol 1996;70:1296-300.
25. Asano Y, Nakashima T, Yoshikawa T, Suga S, Yazaki T. Severity of human herpesvirus-6 viremia and clinical findings in infants with exanthem subitum. J Pediatr 1991;118: 891-5.
26. Kondo K, Nagafuji H, Hata A, Tomomori C, Yamanishi K. Association of herpesvirus 6 infection of the central nervous system with recurrence of febrile convulsions. J Infect Dis 1993;167:1197-200.
27. Caserta MT, Hall CB, Schnabel K, et al. Neuroinvasion and persistence of human herpesvirus 6 in children. J Infect Dis 1994;170:1586-9.
28. Asano Y, Yoshikawa T, Suga S, et al. Fatal fulminant hepatitis in an infant with human herpesvirus-6 infection. Lancet 1990;335:862-3.
29. Ueda T, Miyake Y, Imoto K, et al. Distribution of human herpesvirus 6 and varicella-zoster virus in organs of a fatal case with exanthem subitum and varicella. Acta Paediatr Jpn 1996;38:590-5.
30. Gloning H, Stettner-Gloning R, Pontz BF, Emmrich P. Exanthema subitum, encephalopathy and hepatitis by human herpesvirus-6 (HHV-6) in a 10 month old baby. Monatsschr Kinderheilkd 1991;139:297-300.
31. Yanagihara K, Tanaka-Taya K, Itagaki Y, et al. Human herpesvirus 6 meningoencephalitis with sequelae. Pediatr Infect Dis J 1995;14:240-2.
32. Oki J, Yoshida H, Tokumitsu S, et al. Serial neuroimages of acute necrotizing encephalopathy associated with human herpesvirus 6 infection. Brain Dev. 1995;17:356-9.
33. Luppi M, Barozzi P, Maiorana A, Marasca R, Torelli G. Human herpesvirus 6 infection in normal human brain tissue. J Infect Dis 1994;169:943-4.
34. Luppi M, Barozzi P, Maiorana A, et al. Human herpesvirus-6: a survey of presence and distribution of genomic sequences in normal brain and neuroglial tumors. J Med Virol 1995;47:105-11.
35. Saito Y, Sharer LR, Dewhurst S, et al. Cellular localization of human herpesvirus-6 in the brain of children with AIDS encephalopathy. J Neurovirol 1995;1:30-9.
36. Knox KK, Carrigan DR. Active human herpesvirus (HHV-6) infection of the central nervous system in patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol 1995;9:69-73.
37. Knox KK, Harrington DP, Carrigan DR. Fulminant human herpesvirus six encephalitis in a human immunodeficiency virus-infected infant. J Med Virol 1995;45:288 92.
38. Liedtke W, Trubner K, Schwechheimer K. On the role of human herpesvirus 6 in viral latency in nervous tissue and in cerebral lymphoma. J Neurol Sci 1995;134:184-8.
39. Challoner PB, Smith KT, Parker JD, et al. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci USA 1995;92:7440-4.