Apoptotic depletion of infiltrating mucosal lymphocytes associated with Fas ligand expression by Helicobactor pylori-infected gastric mucosal epithelium: Human glandular stomach as a site of immune privilege

Digestive Diseases and Sciences

Volumn 45, Issue 4, 2000, Pages 773-780

  Koyama, Shohei ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Apoptosis; Chronic gastritis; Fas ligand; Fas receptor; Helicobacter pylori; Immune privilege

Indexed keywords

FAS ANTIGEN;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL INFILTRATION; CHRONIC GASTRITIS; GASTRITIS; GRAM NEGATIVE INFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE SYSTEM; MAJOR CLINICAL STUDY; PATHOGENESIS; PEPTIC ULCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; ULCEROGENESIS;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, CD95; ANTIGENS, SURFACE; APOPTOSIS; EPITHELIUM; FAS LIGAND PROTEIN; FEMALE; FLOW CYTOMETRY; GASTRIC MUCOSA; GASTRITIS; GENE EXPRESSION REGULATION, BACTERIAL; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IN SITU NICK-END LABELING; LYMPHOCYTES; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; UP-REGULATION;

EID: 0034126435     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005408113467     Document Type: Article

References (28)

1. 1. Blaser MJ: Hypothesis on the pathogenesis and natural history of Helicobactor pylori-induced inflammation. Gastroenterology 102:720-727, 1992
2. 2. Wagner S, Beil W, Westermann J, Logan RPR, Bock CT, Trautwein C, Bleck JS, Manns MP: Regulation of gastric epithelial cell growth by Helicobacter pylori: Evidence for a major role of apoptosis. Gastroenterology 113:1836-1847, 1997
3. 3. Dunn BE, Campbell GP, Perez-Perez GI, Blaser MJ: Purification and characterization of Helicobacter pylori urease. J Biol Chem 265:9464-9469, 1990
4. 4. Crabtree JE, Covacci A, Farmery SM, Xiang Z, Tompkins DS, Perry S, Lindley IJD, Rappuoli R: Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype. J Clin Pathol 48:41-45, 1995
5. 5. Leunk RD, Johnson PT, David BC, Kraft WG, Morgan DR: Cytotoxic activity in broth culture filtrates of Campylobacter pylori. J Med Microbiol 26:93-99, 1988
6. 6. Covacci A, Censini S, Bugnoli M, Petracca R, Burroni D, Macchia G, Massone A, Papini E, Xiang ZY, Figura N, Rappuoli R: Molecular characteristics at the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci USA 90:5791-5795, 1993
7. 7. D'Elios MM, Manghetti M, De Carli M, Costa F, Baldari CT, Burroni D, Telford JL, Romagnani S, Del Prete G: T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. J Immnnol 158:962-967, 1997
8. 8. D'Elios MM, Manghetti M, Almerigogna F, Amedei A, Costa F, Burroni CT, Baldari C, Romagnani S, Telford JL, Del Prete G: Different cytokine profile and antigen-specificity repertoire in Helicobacter pylori-specific T cell clones from the antrum of chronic gastritis patients with or without peptic ulcer. Eur J Immunol 27:1751-1755, 1997
9. 9. Rudi J, Kuck D, Strand S, von Herbay A, Mariani SM, Krammer PH, Galle PR, Stremmel W: Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J Clin Invest 102:1506-1514, 1998
10. 10. Houghton J, Korah RM, Condon MR, Kim KH: Apoptosis in Helicobacter pylori-associated gastric and duodenal ulcer disease is mediated via the Fas antigen pathway. Dig Dis Sci 44:465-478, 1999
11. 11. Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA: Fas ligand-induced apoplosis as a mechanism of immune privilege. Science 270:1189-1192, 1995
12. 12. Bellgrau D, Gold D, Selawry H, Moore J, Franzusoff A, Duke RC: A role for CD95 ligand in preventing graft rejection. Nature 377:630-632, 1995
13. 13. O'Connell J, Bennett MW, O'Sullivan GC, Collins JK, Shanahan F: The Fas counterattack: Cancer as a site of immune privilege. Immunol Today 20:46-52, 1999
14. 14. Fan X, Long A, Goggins, Fan X, Keeling PWN, Kelleher D: Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonization. Gut 38:507-512, 1996
15. 15. Koyama S, Maruyama T, Adachi S, Nozue M: Expression of costimulatory molecules, B7-1 and B7-2 on human gastric carcinoma. J Cancer Res Clin Oncol 124:383-388, 1998
16. 16. Koyama S, Maruyama T, Adachi S: Expression of epidermal growth factor receptor and CD44 splicing variants sharing exons 6 and 9 on gastric and esophageal carcinomas: a two-color flow-cytometric analysis. J Cancer Res Clin Oncol 125:47-54, 1999
17. 17. Koyama S: Augmented human-tumor-cytolytic activity of peripheral blood lymphocytes and cells from a mixed lymphocyte/ tumor culture activated by interleukin-12 plus interleukin-2, and the phenotypic characterization of the cells in patients with advanced carcinoma. J Cancer Res Clin Oncol 123:478-484, 1997
18. 18. Satoh K, Kimura K, Taniguchi Y, Kihira K, Takimoto T, Saifuku K, Kawata H, Tokumara K, Kojima T, Seki M, Ido K, Fujioka T: Biopsy sites suitable for the diagnosis of Helicobacter pylori infection and assessment of the extent of atrophic gastritis. Am J Gastroenterol 93:569-573, 1998
19. 19. Koyagaki N, Kawasaki A, Ebata T, Ohmoto H, Ikeda S, Inoue S, Yoshino K, Okumura K, Yagita H: Metalloproteinase-mediated release of human Fas ligand. J Exp Med 182:1777-1783, 1995
20. 20. Yonehara S, Ishii A, Yonehara M: A cell-killing monoclonal antibody (ant-Fas) to a cell surface antigen co-downregulated with receptor of tumor necrosis factor. J Exp Med 169:1747-1756, 1989
21. 21. Kägi D, Vignaux F, Ledermann B, Bürki K, Depraetere V, Nagata S, Hengartner H, Golstein P: Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 265:528-530, 1994
22. 22. Lowin B, Hahne M, Mattmann C, Tschopp J: Cytolytic T-cell cytotoxicity is mediated through perform and Fas lytic pathways. Nature 370:650-652, 1994
23. 23. Nagata S, Golstein P: The Fas death factor. Science 267:1449-1456, 1995
24. 24. Nagata S: Apoptosis by death factor. Cell 88:355-365, 1997
25. 25. Ungefroren H, Voss M, Jansen M, Roeder C, Henne-Bruns D, Kremer B, Kalthoff H: Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas-mediated apoptosis. Cancer Res 58:1741-1749, 1998
26. 26. Kontny HU, Lehrnbecher TM, Chanock SJ, Mackall CL: Simultaneous expression of Fas and nonfunctional Fas ligand in Ewing's sarcoma. Cancer Res 58:5842-5849, 1998
27. 27. Bernslorff W, Spanjaard RA, Chan AK, Lockhart DC, Sadanaga N, Wood I, Peiper M, Goedegebuure PS, Eberlein TJ: Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas (Apo-1/CD95) receptors and aberrant expression of functional Fas ligand. Surgery 125:73-84, 1999
28. 28. Koyama S: Increased expression of membrane-bound (m) and cytoplasmic (c) Fas ligand during the development of invasion and/or metastasis of human gastric carcinoma. Proc 90th Ann Meeting Am Assoc Cancer Res 40:171, 1999