-
1
-
-
0343635579
-
-
note
-
Often in this context the word "prevent" is used. Strictly speaking "prevent" means "to stop from happening." In this review, this definition will be adhered to if there are data to support the use of prevent. If the effects are reduced or minimized, these terms will be used.
-
-
-
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2
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Shedding light on sunscreens
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Rcelandts R. Shedding light on sunscreens. Clin Exp Dermatol 23:147-157 (1998).
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Roy, C.R.1
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4
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Tyrrell RM. Ultraviolet radiation and free radical damage to skin. Biochem Soc Symp 61:47-53 (1995)
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Tyrrell, R.M.1
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5
-
-
0342765359
-
-
note
-
There are differences in these definitions in the United States and Europe. In the United States it is common to define UVA as 320-400 nm, whereas in Europe, the UVA range is defined as 315-400 nm. In this paper we will adhere to the former.
-
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6
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10
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Erythema and sunburn are not the same thing Erythema is a perceptible reddening of the skin. Severe erythema caused by an exposure to multiple MEDs results in a sunburn. In the latter case the skin undergoes a series of distinct biochemical physiologic changes
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Coblentz WW, Stair R, Hogue JM. The spectral erythemic reaction of the human skin to ultra-violet radiation. Proc Natl Acad Sci USA 17:401-405 (1931). Erythema and sunburn are not the same thing Erythema is a perceptible reddening of the skin. Severe erythema caused by an exposure to multiple MEDs results in a sunburn. In the latter case the skin undergoes a series of distinct biochemical physiologic changes.
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Kocheva, I.E.1
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-
The wavelength dependence for lipid damage in cultured human skin fibroblasts shows that the effectiveness of UVB compared to that of UVA is 10-100 times greater. This is one or two orders of magnitude lower than the effectiveness for the relative effects of UVB and UVA at inducing DNA damage
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Morliere P, Moysan A, Tirache I. Action spectrum tor UV-induced lipid peroxidation in cultured human skin fibroblasts. Free Radic Biol Med 19:365-371 (1995). The wavelength dependence for lipid damage in cultured human skin fibroblasts shows that the effectiveness of UVB compared to that of UVA is 10-100 times greater. This is one or two orders of magnitude lower than the effectiveness for the relative effects of UVB and UVA at inducing DNA damage.
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Direct comparison of DNA damage, isomerization of urocan c acid and edema in the mouse produced by three commonly used artificial UV light sources
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Yarosh DB, Kibitel J, Ullrich SE, Kim TH, Ananthaswamy HN, Krien P, Fourtanier A, Kripke ML. Direct comparison of DNA damage, isomerization of urocan c acid and edema in the mouse produced by three commonly used artificial UV light sources. Photochem Photobiol 69:571-574 (1999).
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0342765356
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note
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The lack of BCC and MM in animal models may reflect a fault in the experimental design. Most of these studies have been conducted using primarily UVB sources. This is an historic idiosyncrasy because for many years it was assumed that the highly energetic UVB photons were the sole culprits for human skin malignancies. More recent studies have implicated the longer portion of the solar spectrum, however, few studies have included these wavelengths in their attempts to induce BCC and MM.
-
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UVB induces atypical melanocytic lesions and melanoma in human skin
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24
-
-
0342765355
-
-
note
-
This study has been cited often since its publication as evedence that UVB is a cause of melanoma in humans!
-
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25
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Transgenic mouse model of malignant skin melanoma
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0342765352
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note
-
This model illustrates the power of acton spectra studies and their application to human skin photobiology. However, to put this in perspective, it is important to note that SCC are the least common skin malignancies in humans.
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note
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There are two common examples: UVB phototherapy for psoriasis and UVA tanning salons
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This leads to a major quandary of the "catch-22" variety - we don't know enough to select a marker right now. and new information may prove any selection incorrect. The solution is not to rely on a biologic end point but rather to gauge the raw screening ability of any potential product.
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An example of a scare tactic is to use the word epidemic in conjunction with skin cancer and specifically MM. It is important to put the incidence of skin cancer in perspective. Although increasing in incidence, skin cancer afflicts a small percentage of the population. As mentioned earlier, the least common forms are SCC and MM. For the most part, MM is the most serious threat to life, yet even considering this, one may question the use of the word epidemic in any context for skin cancer. Early detection has become much more common and hence these lesions are much more responsive to therapy or surgical excision.
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These kind of studies that re-evaluate ong-standing hypotheses are essential as we attempt to unravel puzzling aspects of epidemiologic studies that appear to be in conflict.
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It has often been claimed that sunscreen users do not spend more time in the sun (none published). Therefore, in epidemiology studies showing that an increased incidence of skin cancer correlates with sunscreen use attributing the effects to underapplying sunscreens needs to be reconsidered as a possible explanation for unexpected correlations.
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Although some have been impatient with the lag between the FDA temporary monograph issued in 1979 and final monograph in 1999, it should be noted that much has been learned about skin photobiology in these two decades. It also appears prudent that the FDA las chosen not to rush the publication of UVA guidelines, as there is still much to be learned in this area.
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Once assigned oxymoron status, several reports have documented the existence of sunscreen photochemistry However, other than the potential impact on product efficacy (SPF), no deleterious effect in human skin has been attributed to such a phenomenon
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