Identification and characterization of a Kunitz-type protease inhibitor in ascites fluid from patients with ovarian carcinoma

International Journal of Cancer

Volumn 87, Issue 1, 2000, Pages 44-54

  Kobayashi, Hiroshi ^a   Hirashima, Yasuyuki ^a   Sun, Gun W ^a   Ohi, Hidekazu ^a   Fujie, Michio ^a   Terao, Toshihiko ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

SERINE PROTEINASE INHIBITOR;

ARTICLE; ASCITES FLUID; BLOOD SAMPLING; CANCER INVASION; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; EXTRAVASATION; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; OVARY CARCINOMA; PERITONEAL CAVITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN;

ADENOCARCINOMA, CLEAR CELL; ADENOCARCINOMA, MUCINOUS; ANIMALS; ASCITIC FLUID; BIOTINYLATION; BLOTTING, WESTERN; CARCINOMA, ENDOMETRIOID; CYSTADENOCARCINOMA, SEROUS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOTHELIAL GROWTH FACTORS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOKINES; MICE; MICE, INBRED BALB C; MICE, NUDE; OVARIAN NEOPLASMS; PEPTIDES; PLANT PROTEINS; PRECIPITIN TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TRYPSIN INHIBITORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0034119486     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20000701)87:1<44::AID-IJC7>3.0.CO;2-Q     Document Type: Article

References (32)

1. APPELLA, E., ROBINSON, E.A., ULLRICH, S.J., STOPPELI, M.P., CORTI, A., CASSANI, G. and BLASI, F., The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases. J. biol. Chem., 262, 4437-4440 (1987).
2. CHOMICZYNSKI, P. and SACCHI, N., Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159 (1987).
3. DANO, K., ANDREASEN, P.A., GRONDAHL-HANSEN, J., KRISTENSEN, P., NIELSEN, L.S. and SKRIVER, L. Plasminogen activators, tissue degradation, and cancer. Adv. Cancer Res., 44, 139-266 (1985).
4. FUJII, T., MAEDA, M. and TERAO, T., Basic and clinical study of anticancer effect of etoposide on choriocarcinoma. Acta Obstet. Gynecol. Jpn., 40, 593-600 (1988).
5. FUKUYAMA, M., HAYASHI, Y., KOIKE, M., OGAWA, M. and KOSAKI, G., Immunohistochemical localization of pancreatic secretory trypsin inhibitor in fetal and adult pancreatic and extrapancreatic tissues. J. Histochem. Cytochem., 34, 227-235 (1986).
6. GUESDON, J.L., Immunoenzymatic techniques applied to the specific detection of nucleic acid. A review. J. Immunol. Methods, 150, 33-49 (1992).
7. HALILA, H., LEHTOVIRTA, P. and STENMAN, U.H., Tumour-associated trypsin inhibitor (TATI) in ovarian cancer. Brit. J. Cancer, 57, 304-307 (1988).
8. HAYAKAWA, O., TSUMURA, N. and KOIZUMI, M., Establishment and characterization of cell line derived from mucinous cystadenocarcinoma of human ovary. Sapporo-Isi., 55, 153-160 (1986).
9. HIRAHARA, F., MIYAGI, Y., MIYAGI, E., YASUMITSU, H., KOSHIKAWA, N., NAGASHIMA, Y., KITAMURA, H., MINAGUCHI, H., UMEDA, M. and MIYAZAKI, K., Trypsinogen expression in human ovarian carcinomas. Int. J. Cancer, 63, 176-181 (1995).
10. IMAI, S., MAEDA, H., KIYOZUKA, Y., NODA, T., MORIYAMA, I. and ICHIJO, M., Characterization of the CA125 antigen secreted from a newly established human ovarian cancer cell line (SHIN-3). Acta Pathol. Jpn., 39, 43-49 (1989).
11. KIKUCHI, Y., HIRATA, J. and KITA, T., Enhancement of antiproliferative effect of cis-diamminedichloroplatinum (II) by clomiphene and tamoxifen in human ovarian cancer cells. Gynecol. Oncol., 49, 365-372 (1993).
12. KIKUCHI, Y., IWANO, I. and KITA, K., Effects of calmodulin antagonists on human ovarian cancer cell proliferation in vitro. Biochem. biophys. Res. Comm., 123, 385-392 (1984).
13. KIKUCHI, Y., KIZAWA, I., OOMORI, K., MIYAUCHI, M., KITA, T., SUGITA, M., TENJIN, Y. and KATO, K., Establishment of a human ovarian cancer cell line capable of forming ascites in nude mice and effects of tranexamic acid on cell proliferation and ascites formation. Cancer Res., 47, 592-596 (1987).
14. KOBAYASHI, H., FUJIE, M., SHINOHARA, H., OHI, H., SUGIMURA, M. and TERAO, T., Effects of urinary trypsin inhibitor on the invasion of reconstituted basement membranes by ovarian cancer cells. Int. J Cancer, 57, 378-384 (1994a).
15. KOBAYASHI, H., GOTOH, J., FUJIE, M. and TERAO, T., Characterization of the cellular binding site for the urinary trypsin inhibitor. J. biol. Chem., 269, 20642-20647 (1994b).
16. KOBAYASHI, H., GOTOH, J., HIRASHIMA, Y., FUJIE, M., SUGINO, D. and TERAO, T., Inhibitory effect of a conjugate between human urokinase and urinary trypsin inhibitor on tumor cell invasion in vitro. J. biol. Chem., 270, 8361-8366 (1995a).
17. KOBAYASHI, H., GOTOH, J., HIRASHIMA, Y. and TERAO, T., Expression of urokinase and urinary trypsin inhibitor in metastatic and non-metastatic murine Lewis lung carcinoma cells. Int. J. Oncol., 8, 757-763 (1996a).
18. KOBAYASHI, H., GOTOH, J., HIRASHIMA, Y. and TERAO, T., Inter-α-trypsin inhibitor bound to tumor cells is cleaved into the heavy chains and the light chain on the cell surface. J. biol. Chem., 271, 11362-11367 (1996b).
19. KOBAYASHI, H., GOTOH, J., KANAYAMA, N., HIRASHIMA, Y., TERAO, T. and SUGINO, D., Inhibition of tumor cell invasion through matrigel by a peptide derived from the domain II region in urinary trypsin inhibition. Cancer Res., 55, 1847-1852 (1995b).
20. KOBAYASHI, H., GOTOH, J. and TERAO, T., Urinary trypsin inhibitor efficiently inhibits urokinase production in tumor necrosis factor-stimulated cells. Europ. J. Cell Biol., 71, 380-386 (1996c).
21. KOBAYASHI, H., HIRASHIMA, Y., SUN, G.W., FUJIE, M., SHIBATA, K., TAMOTSU, S., MIURA, K., SUGINO, D., TANAKA, Y., KONDO, S. and TERAO, T., Identification and characterization of the cell-associated binding protein for urinary trypsin inhibitor. Biochim. biophys. Acta, 1383, 253-268 (1998).
22. KOBAYASHI, H., SHINOHARA, H., GOTOH, J., FUJIE, M., FUJISHIRO, S. and TERAO, T., Anti-metastatic therapy by urinary trypsin inhibitor in combination with an anti-cancer agent. Brit. J. Cancer, 72, 1131-1137 (1995c).
23. KOBAYASHI, H., SHINOHARA, H., OHI, H., SUGIMURA, M., TERAO, T. and FUJIE, M., Urinary trypsin inhibitor (UTI) and fragments derived from UTI by limited proteolysis efficiently inhibit tumor cell invasion. Clin. Exp. Metast., 12, 117-128 (1994c).
24. KOBAYASHI, H., SHINOHARA, H., TAKEUCHI, K., ITOH, M., FUJIE, M., SAITOH, M. and TERAO, T., Inhibition of the soluble and the tumor cell receptor-bound plasmin by urinary trypsin inhibitor and subsequent effects on tumor cell invasion and metastasis. Cancer Res., 54, 844-849 (1994d).
25. KOHLER, G. and MILSTEIN, C., Continuous cultures of fused cells secreting antibody of predefined specificity. Nature (Lond.), 256, 495-497 (1975).
26. MIYAGI, Y., KOSHIKAWA, N., YASUMITSU, MIYAGI, E., HIRAHARA, F., AOKI, I., MISUGI, K., UMEDA, M. and MIYAZAKI, K., cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2. J. Biochem., 116, 939-942 (1994).
27. MIZUSHIMA, S., NII, A., KATO, K. and UEMURA, A., Gene expression of the two heavy chains and one light chain forming the inter-alpha-trypsin inhibitor in human tissues. Biol. Pharm. Bull., 21, 167-169 (1998).
28. REISINGER, P., HOCHSTRASSER, K., ALBRECHT, G.J., LEMPART, K. and SALIER, J.-P., Human inter-alpha-trypsin inhibitor: localization of the Kunitz-type domains in the N-terminal part of the molecule and their release by trypsin-like proteinases. Biol. Chem. Hoppe-Seyler, 366, 479-483 (1985).
29. SALIER, J.P., ROUET, P., RAGUENEZ, G. and DAVEAU, M., The inter-alpha-inhibitor family: from structure to regulation. Biochem. J., 315, 1-9 (1996).
30. THOMAS, G.J., YUNG, S. and DAVIES, M., Bikunin present in human peritoneal fluid is in part derived from the interaction of serum with peritoneal mesothelial cells. Amer. J. Pathol., 153, 1267-1276 (1998).
31. YOSHIDA, M., KIYOZUKA, Y. and NODA, T., Establishment and characterization of human cell line derived from mucinous cystadenocarcinoma of ovary. J. Jpn. Soc. Clin. Cytol., 32, 1-8 (1993).
32. YUDOH, K., MATSUI, H. and TSUJI, H., Nitric oxide induced by tumor cells activates tumor cell adhesion to endothelial cells and permeability of the endothelium in vitro. Clin. Exp. Metast., 15, 557-567 (1997).