The Chinese herbal medicine Chai-Hu-Long-Ku-Mu-Li-Tan (TW-001) exerts anticonvulsant effects against different experimental models of seizure in rats

Japanese Journal of Pharmacology

Volumn 82, Issue 3, 2000, Pages 247-260

  Wu, Hung Ming ^a   Huang, Chiung Chun ^a   Li, Li Hsin ^a   Tsai, Jing Jane ^a   Hsu, Kuei Sen ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Calcium channel; Chai Hu Long Ku Mu Li Tan (TW 001); Epileptiform activity; Paired pulse facilitation; Sodium channel

Indexed keywords

CALCIUM CHANNEL; CHAI HULONG KU MULITAN; GLUTAMIC ACID; LAMOTRIGINE; PENTETRAZOLE; PHENYTOIN; SODIUM CHANNEL; TW 001; UNCLASSIFIED DRUG; VALPROATE CALCIUM;

ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CALCIUM CURRENT; CHINESE HERB; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG MECHANISM; EPILEPTIC DISCHARGE; EXCITABLE MEMBRANE; GRAND MAL SEIZURE; MALE; NONHUMAN; POSTSYNAPTIC POTENTIAL; PYRAMIDAL NERVE CELL; RAT; SEIZURE THRESHOLD; SODIUM CURRENT;

EID: 0034115390     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.82.247     Document Type: Article

References (36)

1. Delgado-Escueta AV, Ward AA JR, Woodbury DM and Porter RJ: New wave of research in the epilepsies. Adv Neurol 44, 3-55 (1986)
2. Rogawski MA and Porter RJ: Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol Rev 42, 223-286 (1990)
3. Macdonald RL and Kelly K: New antiepileptic drug mechanisms of action. In An Appraisal of Some New Anticonvulsants - A Clinical Perspective, Edited by Trimble M, pp 35-50, Wiley, New York (1994)
4. Juul-Jenson P: Epidemiology of intractable epilepsy. In Intractable Epilepsy: Experimental and Clinical Aspects, Edited by Schmidt D and Morselli PL, pp 5-11, Raven Press, New York (1986)
5. Regesta G and Tanganelli P: Clinical aspects and biological bases of drug-resistant epilepsies. Epilepsy Res 34, 109-122 (1999)
6. Harvey RA and Champe PC: Drugs used to treat epilepsy. In Lippincott's Illustrated Reviews: Pharmacology, Edited by Harvey RA and Champe PC, Vol 1, pp 143-150, JB Lippincott Co, New York (1992)
7. Sugaya E and Sugaya A: Cellular physiology of epileptogenic phenomena and its application to therapy against intractable epilepsy. Comp Biochem Physiol 98, 249-270 (1991)
8. Löscher W and Schmidt D: Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res 2, 145-181 (1988)
9. Dingledine R, Mcbain CJ and McNamara JO: Excitatory amino acid receptors in epilepsy. Trends Pharmacol Sci 11, 334-338 (1990)
10. Löscher W: Basic aspects of epilepsy. Curr Opin Neurol Neurosurg 6, 223-232 (1993)
11. Kimball AW, Burnett WT and Doherty DG: Chemical protection against ionizing radiation. I. Sampling methods for screening compounds in radiation protection studies with mice. Radiation Res 7, 1-12 (1957)
12. Litchfield JT and Wilcoxon F: A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 96, 99-113 (1949)
13. Löscher W and Hönack D: Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats. Eur J Pharmacol 232, 147-158 (1993)
14. Hsu KS and Huang CC: Characterization of the anoxia-induced long-term synaptic potentiation in area CA1 of the rat hippocampus. Br J Pharmacol 122, 671-681 (1997)
15. Huang CC and Hsu KS: Nitric oxide signaling is required for the generation of anoxia-induced long-term potentiation in the hippocampus. Eur J Neurosci 9, 2202-2206 (1997)
16. Hsu KS: Characterization of dopamine receptors mediating inhibition of excitatory synaptic transmission in the rat hippocampal slices. J Neurophysiol 76, 1887-1895 (1996)
17. 2 agonists inhibit high-voltage-activated calcium channels in rat hippocampal CA1 neurons. Am J Physiol 271, C1269-C1277 (1996)
18. Walker MC and Sander JW: Developments in anti-epileptic drug therapy. Curr Opin Neurol 7, 131-139 (1994)
19. Dunwiddie TV and Hass HL: Adenosine increases synaptic facilitation in the in vitro rat hippocampus: Evidence for a presynaptic site of action. J Physiol (Lond) 369, 365-377 (1985)
20. Manabe T, Wyllie DJA, Perkel DJ and Nicoll RA: Modulation of synaptic transmission and long-term potentiation: Effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus. J Neurophysiol 70, 1451-1459 (1993)
21. Schulz PE, Cook EP and Johnston D: Changes in paired-pulse facilitation suggest presynaptic involvement in long-term potentiation. J Neurosci 14, 5325-5337 (1994)
22. Lang DG, Wang CM and Cooper BR: Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells. J Pharmacol Exp Ther 266, 829-835 (1993)
23. Twombly DA, Yoshii M and Narahashi T: Mechanisms of calcium channel block by phenytoin. J Pharmacol Exp Ther 246, 189-195 (1988)
24. Harris EW and Cotman CW: Effects of acidic amino acid antagonists on paired-pulse potentiation at the lateral perforant path. Exp Brain Res 52, 455-460 (1983)
25. Kable JS and Cotman CW: Adenosine, L-AP4, and baclofen modulation of paired-pulse potentiation in the dentate gyrus: Interstimulus interval-dependent pharmacology. Exp Brain Res 94, 97-104(1993)
26. Peacock JH and Walker CR: Development of calcium action potentials in mouse hippocampal cell cultures. Dev Brain Res 8, 39-52 (1983)
27. Mclean MJ and Macdonald RL: Sodium valproate, but not ethosuximide, produces use-and voltage-dependent limitation of high frequency repetitive firing action potentials of mouse central neurons in cell culture. J Pharmacol Exp Ther 237, 1001-1011 (1986)
28. Mclean MJ and Macdonald RL: Carbamazepine and 10,11-epoxy-carbamazepine produce use-and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture. J Pharmacol Exp Ther 238, 727-738 (1986)
29. Willow M, Gonoi T and Catterall WA: Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells. Mol Pharmacol 27, 549-558 (1985)
30. Straub H, Kohling R and Speckmann EJ: Picrotoxin-induced epileptic activity in hippocampal and neocortical slices (guinea pig): suppression by organic calcium channel blockers. Brain Res 658, 119-126 (1994)
31. Lee WL and Hablitz JJ: Involvement of non-NMDA receptors in picrotoxin-induced epileptiform activity in the hippocampus. Neurosci Lett 107, 129-134 (1989)
32. Lee WL and Hablitz JJ: Initiation of epileptiform activity by excitatory amino acid receptors in the disinhibited rat neocortex. J Neurophysiol 65, 87-95 (1991)
33. Thompson SM and Wong RKS: Development of calcium current subtypes in isolated rat hippocampal cells. J Physiol (Lond) 439, 671-689 (1991)
34. Reuther H:Calcium channel modulation by neurotransmitters, enzymes and drugs. Nature 301, 569-574 (1983)
35. Salvati P, Maj R, Caccia C, Cervini MA, Fornaretto MG, Lamberti E, Pevarello P, Skeen GA, White HS, Wolf HH, Faravelli L, Mazzanti M, Mancinelli E, Varasi M and Fariello RG: Biochemical and electrophysiological studies on the mechanism of action of PNU-151774E, a novel antiepileptic compound. J Pharmacol Exp Ther 288, 1151-1159 (1999)
36. Shen D and Chang H: The anticonvulsant and analgesic activities of Tianma (Gastrodia elata B1). Acta Physiol Sin 10, 242-245 (1963)