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Volumn 53, Issue 3, 2000, Pages 310-315

Metabolism of the ethanolamine-type antihistamine diphenhydramine (Benadryl)(TM) by the fungus Cunninghamella elegans

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; ANTIHISTAMINIC AGENT; DIPHENHYDRAMINE; DRUG METABOLITE; ETHANOLAMINE DERIVATIVE;

EID: 0034111490     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002530050026     Document Type: Article
Times cited : (13)

References (15)
  • 1
    • 0030974918 scopus 로고    scopus 로고
    • Biphasic kinetics of quaternary ammonium glucuronide formation from amitriptyline and diphenhydramine in human liver microsomes
    • Breyer-Pfaff U, Fischer D, Winne D (1996). Biphasic kinetics of quaternary ammonium glucuronide formation from amitriptyline and diphenhydramine in human liver microsomes. Drug Metabol Dispos 25: 340-345
    • (1996) Drug Metabol Dispos , vol.25 , pp. 340-345
    • Breyer-Pfaff, U.1    Fischer, D.2    Winne, D.3
  • 2
    • 0023848551 scopus 로고
    • Fungal transformations of antihistamines: Metabolism of methapyrilene, thenyldiamine, and tripelennamine to N-oxide and N-demethylated derivatives
    • Cerniglia CE, Hansen EB Jr, Lambert KL, Korfmacher WA, Miller DW (1988) Fungal transformations of antihistamines: metabolism of methapyrilene, thenyldiamine, and tripelennamine to N-oxide and N-demethylated derivatives. Xenobiotica 18: 301-312
    • (1988) Xenobiotica , vol.18 , pp. 301-312
    • Cerniglia, C.E.1    Hansen E.B., Jr.2    Lambert, K.L.3    Korfmacher, W.A.4    Miller, D.W.5
  • 5
    • 0000371588 scopus 로고
    • Labile hydrogen counting in biomolecules using deuterated reagents in desorption chemical ionization and fast atom bombardment mass spectrometry
    • Guarini A, Guglielmetti G, Andriollo N, Vincenti M (1992) Labile hydrogen counting in biomolecules using deuterated reagents in desorption chemical ionization and fast atom bombardment mass spectrometry. Anal Chem 64: 204-210
    • (1992) Anal Chem , vol.64 , pp. 204-210
    • Guarini, A.1    Guglielmetti, G.2    Andriollo, N.3    Vincenti, M.4
  • 6
    • 0023102415 scopus 로고
    • Microbial transformation of the antihistamine pyrilamine maleate. Formation of potential mammalian metabolites
    • Hansen EB Jr, Cerniglia CE, Korfmacher WA, Miller DW, Heflich RH (1987) Microbial transformation of the antihistamine pyrilamine maleate. Formation of potential mammalian metabolites. Drug Metab Dispos 15: 97-106
    • (1987) Drug Metab Dispos , vol.15 , pp. 97-106
    • Hansen E.B., Jr.1    Cerniglia, C.E.2    Korfmacher, W.A.3    Miller, D.W.4    Heflich, R.H.5
  • 7
    • 0028860838 scopus 로고
    • Fungal transformations of antihistamines: Metabolism of brompheniramine, chlorpheniramine, and pheniramine to N-oxide and N-demethylated metabolites by the fungus Cunninghamella elegans
    • Hansen EB Jr, Cho BP, Korfmacher WA, Cerniglia CE (1995) Fungal transformations of antihistamines: metabolism of brompheniramine, chlorpheniramine, and pheniramine to N-oxide and N-demethylated metabolites by the fungus Cunninghamella elegans. Xenobiotica 25: 1081-1092
    • (1995) Xenobiotica , vol.25 , pp. 1081-1092
    • Hansen E.B., Jr.1    Cho, B.P.2    Korfmacher, W.A.3    Cerniglia, C.E.4
  • 9
    • 0024566912 scopus 로고
    • Characterization of the antihistamines tripelennamine, methapyrilene, and thenyldiamine and their N-oxides by thermospray mass spectrometry
    • Korfmacher WA, Freeman JP, Hansen EB Jr, Holder CL, Getek TA (1989) Characterization of the antihistamines tripelennamine, methapyrilene, and thenyldiamine and their N-oxides by thermospray mass spectrometry. J Anal Toxicol 13: 94-96
    • (1989) J Anal Toxicol , vol.13 , pp. 94-96
    • Korfmacher, W.A.1    Freeman, J.P.2    Hansen E.B., Jr.3    Holder, C.L.4    Getek, T.A.5
  • 10
    • 0018336876 scopus 로고
    • Active hydrogen by chemical ionization mass spectrometry
    • Lin YY, Smith LL (1979) Active hydrogen by chemical ionization mass spectrometry. Biomed Mass Spectrom 6: 15-18
    • (1979) Biomed Mass Spectrom , vol.6 , pp. 15-18
    • Lin, Y.Y.1    Smith, L.L.2
  • 11
    • 0023936714 scopus 로고
    • Screening procedure for the detection of alkanolamine antihistamines and their metabolites in urine using computerized gas chromatography-mass spectrometry
    • Maurer H, Pfleger K (1988) Screening procedure for the detection of alkanolamine antihistamines and their metabolites in urine using computerized gas chromatography-mass spectrometry. J Chromatogr 428: 43-60
    • (1988) J Chromatogr , vol.428 , pp. 43-60
    • Maurer, H.1    Pfleger, K.2
  • 12
    • 0030918796 scopus 로고    scopus 로고
    • Microbial models of mammalian metabolism. Biotransformations of HP 749 (Besipirdine) using Cunninghamella elegans
    • Rao GP, Davis PJ (1997) Microbial models of mammalian metabolism. Biotransformations of HP 749 (Besipirdine) using Cunninghamella elegans. Drug Metab Dispos 25: 709-715
    • (1997) Drug Metab Dispos , vol.25 , pp. 709-715
    • Rao, G.P.1    Davis, P.J.2
  • 13
  • 14
    • 0003104917 scopus 로고
    • Microbial transformations as a means of preparing mammalian drug metabolites
    • Rosazza JE, (ed) CRC Press, Boca Raton, pp
    • Smith RV, Rosazza JP (1982) Microbial transformations as a means of preparing mammalian drug metabolites. In: Rosazza JE, (ed) Microbial transformations of bioactive compounds, CRC Press, Boca Raton, pp 1-42
    • (1982) Microbial Transformations of Bioactive Compounds , pp. 1-42
    • Smith, R.V.1    Rosazza, J.P.2
  • 15
    • 84994946327 scopus 로고
    • Ammonia chemical ionization mass spectrometry
    • Westmore JB, Alauddin MM (1986) Ammonia chemical ionization mass spectrometry. Mass Spectrom Rev 5: 381-465
    • (1986) Mass Spectrom Rev , vol.5 , pp. 381-465
    • Westmore, J.B.1    Alauddin, M.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.