The direction of microsatellite mutations is dependent upon allele length

Nature Genetics

Volumn 24, Issue 4, 2000, Pages 396-399

  Xu, Xin ^a   Peng, Mei ^a   Fang, Zhian ^b   Xu, Xiping ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSATELLITE DNA;

ALLELE; ARTICLE; FEMALE; GENE FREQUENCY; GENE MAPPING; GENE MUTATION; GENOTYPE; HAPLOTYPE; HUMAN; MALE; MARKER GENE; NUCLEOTIDE REPEAT; PRIORITY JOURNAL;

ALLELES; FEMALE; GENE FREQUENCY; GENETIC MARKERS; HUMANS; HYPERTENSION; MALE; MICROSATELLITE REPEATS; MODELS, GENETIC; MUTATION; SEX FACTORS;

EUKARYOTA; MAMMALIA; PRIMATES;

EID: 0034111151     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/74238     Document Type: Article

References (18)

1. Weber, J.L. & Wong, C. Mutation of human short tandem repeats. Hum. Mol. Genet. 2, 1123-1128 (1993).
2. Garza, J.C., Slatkin, M. & Freimer, N.B. Microsatellite allele frequencies in humans and chimpanzees, with implications for constraints on allele size. Mol. Biol. Evol. 12, 594-603 (1995).
3. Goldstein, D.B. & Pollock, D.D. Launching microsatellites: a review of mutation processes and methods of phylogenetic interference. J. Hered. 88, 335-342 (1997).
4. Wierdl, M., Dominska, M. & Petes, T.D. Microsatellite instability in yeast: dependence on the length of the microsatellite. Genetics 146, 769-779 (1997).
5. Twerdi, C.D., Boyer, J.C. & Farber, R.A Relative rates of insertion and deletion mutations in a microsatellite sequence in cultured cells. Proc. Natl Acad. Sci. USA 96, 2875-2879 (1999).
6. Brinkmann, B., Klintschar, M., Neuhuber, F., Huhne, J. & Rolf, B. Mutation rate in human microsatellites: influence of the structure and length of the tandem repeat. Am. J. Hum. Genet. 62, 1408-1415 (1998).
7. Primmer, C.R., Saino, N., Moller, A.P. & Ellegren, H. Directional evolution in germline microsatellite mutations. Nature Genet. 13, 391-393 (1996); erratum: 14, 133 (1996).
8. Primmer, C.R., Saino, N., Moller, A.P. & Ellegren, H. Directional evolution in germline microsatellite mutations. Nature Genet. 13, 391-393 (1996); erratum: 14, 133 (1996).
9. Amos, W., Sawcer, S.J., Feakes, R.W. & Rubinsztein, D.C. Microsatellites show mutational bias and heterozygote instability. Nature Genet. 13, 390-391 (1996).
10. Xu, X. et al. An extreme-sib-pair genome scan for genes regulating blood pressure. Am. J. Hum. Genet. 54, 1694-1701 (1999).
11. Di Rienzo, A. et al. Mutational processes of simple-sequence repeat loci in human populations. Proc. Natl Acad. Sci. USA 91, 3166-3170 (1994).
12. Kimmel, M. & Chakraborty, R. Measures of variation at DNA repeat loci under a general stepwise mutation model. Theor. Popul. Biol. 50, 345-367 (1996).
13. Valdes, A.M., Slatkin, M. & Freimer, N.B Allele frequencies at microsatellite loci: the stepwise mutation model revisited. Genetics 133, 737-749 (1993).
14. Zhivotovsky, L.A. & Feldman, M.W. Microsatellite variability and genetic distances. Proc. Natl Acad. Sci. USA 91, 11549-11552 (1995).
15. Levinson, G. & Gutman, G.A. Slipped-strand mispairing: a major mechanism for DNA sequence evolution. Mol. Biol. Evol. 4, 203-221 (1987).
16. Sia, E.A., Kokoska, R.J., Dominska, M., Greenwell, P. & Petes, T.D. Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes. Mol. Cell. Biol. 17, 2851-2858 (1997).
17. Horvath, S. & Laird, N.M. A discordant-sibship test for disequilibrium and linkage: no need for parental data. Am. J. Hum. Genet. 63, 1886-1897 (1998).
18. Kruglyak, L., Daly, M.J., Reeve-Daly, M.P. & Lander, E.S. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am. J. Hum. Genet. 58, 1347-1363 (1996).