Membrane attack complex formation on yeast as trigger of selective release of terminal complement proteins from human polymorphonuclear leukocytes

FEMS Immunology and Medical Microbiology

Volumn 28, Issue 1, 2000, Pages 15-23

  Lukasser Vogl, Elisabeth ^a   Gruber, Andreas ^a   Lass Flörl, Cornelia ^a   Eder, Andrea ^a   Høgåsen, Anne Kirsti M ^b   Morgan, B Paul ^c   Dierich, Manfred P ^a   Würzner, Reinhard ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Complement; Innate immunity; Membrane attack complex; Polymorphonuclear leukocyte

Indexed keywords

COMPLEMEMT COMPONENT C7; COMPLEMENT; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C6; COMPLEMENT COMPONENT C8; COMPLEMENT COMPONENT C9; COMPLEMENT MEMBRANE ATTACK COMPLEX; UNCLASSIFIED DRUG;

ARTICLE; CANDIDA ALBICANS; CELL MEMBRANE; COCULTURE; COMPLEMENT SYSTEM; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOFLUORESCENCE; INFLAMMATION; NEUTROPHIL; NONHUMAN; OPSONIZATION; PRIORITY JOURNAL; PROTEIN SECRETION; SERUM; SUPERNATANT; YEAST;

CANDIDA; CANDIDA ALBICANS; CELL SURVIVAL; CELLS, CULTURED; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPLEMENT SYSTEM PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; NEUTROPHILS; OPSONIN PROTEINS; SACCHAROMYCES CEREVISIAE; YEASTS;

EID: 0034109407     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(99)00195-9     Document Type: Article

References (33)

1. Malech H.L., Gallin J.I. Current concepts: immunology. Neutrophils in human diseases. N. Engl. J. Med. 317:1987;687-694.
2. Jones J., Morgan B.P. Apoptosis is associated with reduced expression of complement regulatory molecules, adhesion molecules and other receptors on polymorpho-nuclear leucocytes: functional relevance and role in inflammation. Immunology. 86:1995;651-660.
3. Ruthe R.C., Andersen B.R., Cunningham B.L., Epstein R.B. Efficacy of granulocyte transfusions in the control of systemic candidiasis in the leukopenic host. Blood. 52:1978;493-498.
4. Hurtel B., Lagrande P.H., Michel J.C. Systemic candidiasis in mice. Ann. Immunol. 131:1980;105-118.
5. Szabo I., Guan L., Rogers T.J. Modulation of macrophage phagocytic activity by cell wall components of Candida albicans. Cell. Immunol. 164:1995;182-188.
6. Morgan B.P. Complement membrane attack on nucleated cells: resistance, recovery and non-lethal effects. Biochem. J. 264:1989;1-14.
7. Morgan B.P., Gasque P. Expression of complement in the brain: role in health and disease. Immunol. Today. 17:1996;461-466.
8. Esser A.F., Sodetz J.M. Membrane attack complex proteins C5b-6, C7, C8, and C9 of human complement. Methods Enzymol. 162:1988;551-578.
9. Kozel T.R. Activation of the complement system by pathogenic fungi. Clin. Microbiol. Rev. 9:1996;34-46.
10. Alper C.A., Johnson A.M., Birtch A.G., Moore F.D. Human C3: evidence for the liver as the primary site of synthesis. Science. 163:1969;286-288.
11. Hobart M.J., Lachmann P.J., Calne R.Y. C6: synthesis by the liver in vivo. J. Exp. Med. 146:1977;629-649.
12. Alper C.A., Raum D., Awdeh Z.L., Petersen B.H., Taylor P.D., Starzl T.E. Studies of hepatic synthesis in vivo of plasma proteins, including orosomucoid, transferrin, α 1-antitrypsin, C8, and factor B. Clin. Immunol. Immunopathol. 16:1980;84-89.
13. Würzner R., Joysey V.C., Lachmann P.J. Complement component C7. Assessment of in vivo synthesis after liver transplantation reveals that hepatocytes do not synthesize the majority of human C7. J. Immunol. 152:1994;4624-4629.
14. Høgåsen A.K.M., Würzner R., Abrahamsen T.G., Dierich M.P. Human polymorphonuclear leukocytes store large amounts of terminal complement components C7 and C6, which may be released on stimulation. J. Immunol. 154:1995;4734-4740.
15. Naughton M.A., Walport M.J., Würzner R., Carter M.J., Alexander G.J.M., Goldman J.M., Botto M. Organ-specific contribution to circulating C7 levels by the bone marrow and liver in humans. Eur. J. Immunol. 26:1996;2108-2112.
16. Jack R.M., Fearon D.T. Selective synthesis of mRNA and proteins by human peripheral blood neutrophils. J. Immunol. 140:1988;4286-4293.
17. Botto M., Lissandrini D., Sorio C., Walport M.J. Biosynthesis and secretion of complement component (C3) by activated human polymorphonuclear leukocytes. J. Immunol. 149:1992;1348-1355.
18. Okuda T., Suzuki H. Immunocytochemical demonstration of C3 in mouse neutrophils and eosinophils. Acta Histochem. Cytochem. 29:1996;181-184.
19. Pereira H.A., Hosking C.S. The role of complement and antibody in opsonization and intracellular killing of Candida albicans. Clin. Exp. Immunol. 57:1984;307-314.
20. Ashman R.B., Papadimitriou J.M. Production and function of cytokines in natural and aquired immunity to Candida albicans infection. Microbiol. Rev. 59:1995;646-672.
21. Würzner R., Orren A., Potter P., Morgan B.P., Ponard D., Späth P., Brai M., Schulze M., Happe L., Götze O. Functionally active complement proteins C6 and C7 detected in C6-and C7-deficient individuals. Clin. Exp. Immunol. 83:1991;430-437.
22. Abraha A., Morgan B.P., Luzio J.P. The preparation and characterization of monoclonal antibodies to human complement component C8 and their use in purification of C8 and C8 subunits. Biochem. J. 251:1988;285-292.
23. Morgan B.P., Daw R.A., Siddle K., Luzio J.P., Campbell A.K. Immunoaffinity purification of human complement component C9 using monoclonal antibodies. J. Immunol. Methods. 64:1983;269-281.
24. Würzner R., Schulze M., Happe L., Franzke A., Bieber F.A., Oppermann M., Götze O. Inhibition of terminal complement complex formation and cell lysis by monoclonal antibodies. Complement Inflamm. 8:1991;328-340.
25. Würzner R., Xu H., Franzke A., Schulze M., Peters J.H., Götze O. Blood dendritic cells carry terminal complement complexes on their cell surface as detected by newly developed neoepitope-specific monoclonal antibodies. Immunology. 74:1991;132-138.
26. Kaminishi H., Miyaguchi H., Tamaki T., Suenaga N., Hisamatsu M., Mihashi I., Matsumoto H., Maeda H., Hagihara Y. Degradation of humoral host defense by Candida albicans proteinase. Infect. Immun. 63:1995;984-988.
27. Kinoshita T. Biology of complement: the overture. Immunol. Today. 12:1991;291-295.
28. Würzner R., Mewar D., Fernie B.A., Hobart M.J., Lachmann P.J. Importance of the third thrombospondin repeat of C6 for terminal complement complex assembly. Immunology. 85:1995;214-219.
29. Borg-von Zepelin M., Beggah S., Boggian K., Sanglard D., Monod M. The expression of the secreted aspartyl proteinases SAP4 to SAP6 from Candida albicans in murine macrophages. Mol. Microbiol. 28:1998;543-554.
30. Wagner T., Borg-von Zepelin M., Rüchel R. pH-dependent denaturation of extracellular aspartic proteinases from Candida species. J. Med. Vet. Mycol. 33:1995;275-278.
31. Orren A., Würzner R., Potter P.C., Fernie B.A., Coetzee S., Morgan B.P., Lachmann P.J. Properties of a low molecular weight complement component C6 found in human subjects with subtotal C6 deficiency. Immunology. 75:1992;10-16.
32. Würzner R., Hobart M.J., Orren A., Tokunaga K., Nitze R., Götze O., Lachmann P.J. A novel protein polymorphism of human complement C7 detected by a monoclonal antibody. Immunogenetics. 35:1992;398-402.
33. Würzner R. Evasion of pathogens by avoiding recognition or eradication by complement, in part via molecular mimicry. Mol. Immunol. 36:1999;249-260.