Interaction within clusters of dendritic cells and helper T cells during initial Th1/Th2 commitment

European Journal of Immunology

Volumn 30, Issue 5, 2000, Pages 1255-1262

  Schuhbauer, Diana Maria Sofia ^a   Mitchison, Nicholas Avrion ^b   Mueller, Brigitte ^a  

^a DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cytokine; Dendritic cell; Fluorescence activated cell sorter; T lymphocyte; Th1 Th2

Indexed keywords

CD4 ANTIGEN; CYTOCHROME C; CYTOKINE; EPITOPE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; MONOCLONAL ANTIBODY; OVALBUMIN; PEPTIDE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL INTERACTION; CELL POPULATION; CONTROLLED STUDY; DENDRITIC CELL; HELPER CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PARACRINE SIGNALING; PIGEON; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

EID: 0034109234     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(200005)30:5<1255::AID-IMMU1255>3.0.CO;2-W     Document Type: Article

References (39)

1. Breel, M., Mobius, R. E. and Kraal, G., Dendritic cells of the mouse recognised by two monoclonal antibodies. Eur J. Immunol. 1987. 17: 1555-1559.
2. + T cells. J. Exp. Med. 1997. 185: 2133-2141.
3. Steinman, R. M., The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 1991. 9: 271-296.
4. Mellman, I., Turley, S. J. and Steinman, R. M., Antigen processing for amateurs and professionals. Trends Cell. Biol. 1998. 8: 231-237.
5. Mitchison, N. A., An exact comparison between the efficiency of two- and three-cell-type clusters in mediating helper activity. Eur. J. Immunol. 1990. 20: 699-702.
6. Stuhler, G. and Walden, P., Collaboration of helper and cytotoxic T lymphocytes. Eur J. Immunol. 1993. 23: 2279-2286.
7. Bennett, S. R. M., Carbone, F. R., Karamalis, F., Flavell, R. A., Miller, J. F. A. P. and Heath, W. R., Help for cytotoxic T-cell responses is mediated by CD40 signalling, Nature 1998. 393: 478-480.
8. + T-helper and a T-killer cell. Nature 1998. 393: 474-478.
9. Toes, R. E. M., Schoenberger, S. P., van der Voort, E. I. H., Offringa, R. and Melief, C. J. M., CD40-CD40Ligand interactions and their role in cytotoxic T lymphocyte priming and antitumor immunity. Semin. Immunol. 1998. 10: 443-448.
10. Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzavecchia, A. and Alber, G., Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 1996. 184: 747-752.
11. Abbas, A. K., Murphy, K. M. and Sher, A., Functional diversity of helper T lymphocytes. Nature 1996. 383: 787-793.
12. Mitchison, N. A., Schuhbauer, O. and Muller, B., Natural and induced regulation of Th1/Th2 balance. Springer Seminars in Immunopathology 1999. 21: 199-210.
13. - T cells. Springer Semin. Immunopathol. 1999. 21: 231-248.
14. + T cells, interleukin 4 production is cytokine-autonomous, whereas interferon gamma production is cytokine-dependent. Proc. Natl. Acad. Sci. USA 1997. 94: 3189-3194.
15. Ria, F., Penna, G. and Adorini, L., Th1 cells induce and Th2 inhibit antigen-dependent IL-12 secretion by dendritic cells. Eur. J. Immunol. 1998. 28: 2003-2016.
16. Baumgart, M., Moos, V., Schuhbauer, D. and Muller, B., Differential expression of major histocompatibility complex class II genes on murine macrophages associated with T cell cytokine profile and protective/suppressive effects. Proc. Natl. Acad. Sci. USA 1998. 95: 6936-6940.
17. + T helper cell phenotype development in a T cell receptor-alpha betatransgenic model. J. Exp. Med. 1995. 182: 1579-1584.
18. Knight, S. C., Igball, S., Roberts, M. S., Macatonia, S. and Bedford, P. A., Transfer of antigen between dendritic cells in the stimulation of primary T cell proliferation. Eur. J. Immunol. 1998. 28: 1636-1644.
19. D'Andrea, A., Rengaraju, M., Valiante, N. M. et al., Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 1992. 176: 1387-1398.
20. Kalinski, P., Hilkens, C. M., Snijders, A., Snijdewint, F. G. and Kapsenberg, M. L., IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells. J. Immunol. 1997. 159: 28-35.
21. - subclasses of dendritic cells direct the development of distinct T helper cells in vivo. J. Exp. Med. 1999. 189: 587-592.
22. Pulendran, B., Smith, J. L., Caspary, G., Brasel, K., Ettit, D., Maraskovsky, E. and Maliszewski, C. R., Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc. Natl. Acad. Sci. USA 1999. 96:1036-1041.
23. Syrbe, U., Siveke, J. and Hamann, A., Th1/Th2 subsets: distinct differences in homing and chemokine receptor expression? Springer Semin. Immunopathol. 1999. 21: 263-285.
24. Szabo, S. J., Dighe, A. S., Gubler, U. and Murphy, K. M., Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 1997. 185: 817-824.
25. Guler, M. L., Jacobson, N. G., Gubler, U. and Murphy, K. M., T cell genetic background determines maintenance of IL-12 signaling effects on BALB/c and B10.D2 T helper cell type 1 phenotype development. J. Immunol. 1997. 159: 1767-1774.
26. Chang, J. T., Shevach, E. M. and Segal, B. M., Regulation of inlerleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells. J. Exp. Med. 1999. 189: 969-978.
27. Akbar, S. M., Inaba, K. and Onji, M., Upregulation of MHC class II antigen on dendritic cells from hepatitis B virus transgenic mice by interferon-gamma: abrogation of immune response defect to a T-cell-dependent antigen. Immunology 1996. 87: 519-527.
28. Koch, F., Stanzl, U., Jennewein, P., Janke, K., Heufler, C., Kampgen, E., Romain, N. and Schuler, G., High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 1996. 184: 741-746.
29. + T cell response to protein immunization. Int. Immunol. 1994. 6: 1515-1523.
30. Toellner, K. M., Luther, S. A., Sze, D. M., Choy, R. K., Taylor, D. R., MacLennan, I. C. M. and Acha-Orbea, H., T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching. J. Exp. Med. 1998. 187: 1193-1204.
31. Richter, A., Lohning, M. and Radbruch, A., Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression. J. Exp. Med. 1999. 190: 1439-1450.
32. Luksch, C. R., Winqvist, O., Ozaki, M. E., Karlsson, L., Jackson, M. R., Peterson, P. A. and Webb, S. R., Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells. Proc. Natl. Acad. Sci. USA 1999. 96: 3023-3028.
33. Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I. and Kroczek, R. A., ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 1999. 397: 263-266.
34. Bachmann, M. F., Wong, B. R., Josien, R., Steinman, R. M., Oxenius, A. and Choi, Y., TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation. J. Exp. Med. 1999. 189: 1025-1031.
35. -TCRIo thymocytes in vivo. Science 1990. 250: 1720-1723.
36. + T cells from T cell receptor transgenic mice. J. Exp. Med. 1992. 176: 1091-1098.
37. Haskins, K., Kubo, R., White, J., Pigeon, M., Kappler, J. and Marrack, P., The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody. J. Exp. Med. 1983. 157: 1149-1169.
38. Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S. and Steinman, R. M., Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colonystimulating factor. J. Exp. Med. 1992. 176: 1693-1702.
39. Assenmacher, M., Schmitz, J. and Radbruch, A., Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-gamma and in interleukin-4 expressing cells. Eur. J. Immunol. 1994. 24: 1097-1101.