Modelling of two enzyme reactions in a linked cofactor recycle system for chiral lactone synthesis

Chemical Engineering Science

Volumn 55, Issue 11, 2000, Pages 2001-2008

  Hogan, Matthew C ^a   Woodley, John M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Biocatalysis; Cyclohexanone monooxygenase; Enzyme; Mathematical modelling; NADPH; Reaction engineering

Indexed keywords

BIOSYNTHESIS; CATALYSIS; KETONES; MATHEMATICAL MODELS; NUMERICAL METHODS; OPTIMIZATION; PH EFFECTS; RATE CONSTANTS;

BIOCATALYSIS; CYCLOHEXANONE MONOOXYGENASE;

ENZYMES;

CHEMICAL REACTION; ENZYME; MATHEMATICAL MODELING; STIRRED TANK;

EID: 0034108772     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2509(99)00478-9     Document Type: Article

References (24)

1. Chenault H.K., Whitesides G.M. Regeneration of nicotinamide cofactors for use in organic synthesis. Applied Biochemistry and Biotechnology. 14:1987;148-197.
2. Chenault H.K., Simon E.S., Whitesides G.M. Cofactor regeneration for enzyme catalysed synthesis. Biotechnology and Genetic Engineering Review. 6:1988;221-251.
3. Fogler H.S. Elements of Chemical Reaction Engineering. 1992;Prentice Hall, Englewood Cliffs, NJ.
4. Ford J.B., Askins K.J., Taylor K.B. Kinetic models for synthesis by a thermophilic alcohol dehydrogenase. Biotechnology and Bioengineering. 42:1993;367-375.
5. Hogan, M.C., Woodley, J.M., & Lilly, M.D. (1998). Biocatalytic Baeyer-Villiger characterisation leading to reactor design. Proceedings of the 1998 IChemE Research Event, IChemE, Rugby, UK, pp. 466-514.
6. Ikemi M., Koizumi N., Ishimatsu Y. Sorbitol production in charged membrane bioreactor with coenzyme regeneration system. 2. Theoretical analysis of a continuous reaction with retained and regenerated NADPH Biotechnology and Bioengineering. 36:1990;155-165.
7. Keinan E., Hafeli E.K., Seth K.K., Lamed R. Thermostable enzymes in organic synthesis. Asymmetric reduction of ketones with alcohol dehydrogenase from Thermoanaerobium brockii. Journal of the American Chemical Society. 108:1986;162-169.
8. Kragl U., Vasic-Racki D., Wandrey C. Continuous production of L-tert-leucine in series of two enzyme membrane reactors, modelling and computer simulation. Bioprocess Engineering. 14:1996;291-297.
9. Lamed R.J., Zeikus J.G. Novel NADP linked alcohol-aldehyde/ketone oxidoreductase in thermophilic ethanologenic bacteria. Biochemical Journal. 195:1981;183-190.
10. Levenspiel O. Chemical Reaction Engineering. 1999;Wiley, New York. 3rd Edition.
11. Lowry O.H., Passonneau J.V., Rock M.K. The stability of pyridine nucleotides. Journal of Biological Chemistry. 236(10):1961;2756-2759.
12. Meyer H.P., Kiener A., Imwinkelried R., Shaw N. Biotransformations for fine chemical production. Chimia. 51:1997;287-289.
13. Oestreicher E.O., Pereira D.A., Pinto G.F. Steady state kinetic mechanism of Thermoanaerobium brockii alcohol dehydrogenase. a study of discrimination between alternative kinetic models Journal of Biotechnology. 46:1996;23-31.
14. Pereira D.A., Pinto G.F., Oestreicher E.O. Kinetic mechanism of the oxidation of 2-propanol catalysed by Thermoanaerobium brockii alcohol dehydrogenase. Journal of Biotechnology. 34:1994;43-50.
15. Ryerson C.C., Ballou D.P., Walsh C. Mechanistic studies on cyclohexanone monooxygenase. Biochemistry. 21:1982;2644-2655.
16. Tachner M.J., Black D.J. The enzymatic Baeyer-Villiger oxidation. enantioselective synthesis of lactones from mesomeric cyclohexanones Journal of the American Chemical Society. 110:1988;6892-6893.
17. Trudgill P.W. Cyclohexanone 1,2-Monooxygenase from acinetobacter NCIMB 9871. Methods in Enzymology. 188:1990;70-77.
18. Walsh T., Chen Y.C. Enzymic Baeyer-Villiger oxidations by flavin-dependant monooxygenases. Angew Chemistry International. 27:1988;333-343.
19. Willetts A. Structural studies and synthetic application of Baeyer-Villiger monooxygenases. Trends in Biotechnology. 15:1997;55-62.
20. Wong C., Whitesides G. Enzyme catalysed organic synthesis. NAD(P)H cofactor regeneration by using glucose-6-phosphate and the glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides Journal of the American Chemical Society. 103:1981;4890-4899.
21. Woodley J.M., Lilly M.D. Biotransformation reactor selection and design. Cabral J.M.S., Best D., Boros L., Tramper J. Applied Biocatalysis. 1994;371-393 Harwood Academic, Chur.
22. Woodley J.M., Lilly M.D. Select and design. The Chemical Engineer. 16:1996;28-30.
23. Woodley J.M., Titchener-Hooker N. The use of windows of operation as a bioprocess design tool. Bioprocess Engineering. 14:1996;263-268.
24. Zubay G.L., Parson W.W., Vance D.E. Principles of Biochemistry. 1995;WCB, Oxford, England.