Increased frequency of LOH on chromosome 9 in sporadic primary melanomas is associated with increased patient age at diagnosis

Mutagenesis

Volumn 15, Issue 3, 2000, Pages 257-260

  Smeds, Johanna ^a   Kumar, Rajiv ^a   Rozell, Barbro Lundh ^b   Hemminki, Kari ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADULT; AGE; AGED; ALLELE; ARTICLE; CHROMOSOME 9; CHROMOSOME 9P; CHROMOSOME MARKER; CONTROLLED STUDY; GENE LOSS; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MELANOMA; PATIENT CODING; PRIORITY JOURNAL; STATISTICAL ANALYSIS; TELOMERE; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

EID: 0034107393     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/15.3.257     Document Type: Article

References (22)

1. Clark, W.H.Jr, Elder, D.E., Guerry, D.T., Braitman, L.E., Trock, B.J., Schultz, D., Synnestvedt, M. and Halpern, A.C. (1989) Model predicting survival in stage I melanoma based on tumor progression. J Natl Cancer Inst., 81, 1893-1904.
2. Connor, M. and Ferguson-Smith, M. (1997) Essential Medical Genetics, 1997 Edn. Blackwell Scientific, Oxford, UK, pp. 116-129.
3. Flores, J.F., Walker, G.J., Glendening, J.M., Haluska, F.G., Castresana, J.S., Rubio, M.P., Pastorfide, G.C., Boyer, L.A., Kao, W.H., Bulyk, M.L., Barnhill, R.L., Hayward, N.K., Housman, D.E. and Fountain, J.W. (1996) Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma. Cancer Res., 56, 5023-5032.
4. Grossman, L. (1997) Epidemiology of ultraviolet-DNA repair capacity and human cancer. Environ. Health Perspect., 105 (suppl.), 927-930.
5. Healy, E., Belgaid, C.E., Takata, M., Vahlquist, A., Rehman, I., Rigby, H. and Rees, J.L. (1996) Allelotypes of primary cutaneous melanoma and benign melanocytic nevi. Cancer Res., 56, 589-593.
6. Healy, E., Belgaid, C., Takata, M., Harrison, D., Zhu, N.W., Burd, D.A., Rigby, H.S., Matthews, J.N. and Rees, J.L. (1998) Prognostic significance of allelic losses in primary melanoma. Oncogene, 16, 2213-2218.
7. Jones, I.M., Thomas, C.B., Tucker, B., Thompson, C.L., Pleshanov, P., Vorobtsova, I. and Moore, D.H. (1995) Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans. Mutat. Res., 338, 129-139.
8. Kamb, A., Gruis, N.A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S.V., Stockert, E., Day, R.S., Johnson, B.E. and Skolnick, M.H. (1994) A cell cycle regulator potentially involved in genesis of many tumor types. Science, 264, 436-440.
9. Kumar, R., Lundh Rozell, B., Louhelainen, J. and Hemminki, K. (1998a) Mutations in the CDKN2A (p16INK4a) gene in microdissected sporadic primary melanomas. Int. J. Cancer, 75, 193-198.
10. Kumar, R., Sauroja, I., Punnonen, K., Jansen, C. and Hemminki, K. (1998b) Selective deletion of exon lbetaof the p!9ARFgene in metastatic melanoma cell lines. Genes Chromosom. Cancer, 23, 273-277.
11. Kumar, R., Smeds, J., Lundh Rozell, B. and Hemminki, K. (1999) Loss of heterozygosity at chromosome 9p21 (INK4-p14ARF locus): homozygous deletions and mutations in the p16 and p14ARF genes in sporadic melanomas. Melanoma Res., 9, 138-147.
12. Lengauer, C., Kinzler, K.W. and Vogelstein, B. (1998) Genetic instabilities in human cancers. Nature, 396, 643-649.
13. Ohta, M., Berd, D., Shimizu, M., Nagai, H., Cotticelli, M.G., Mastrangelo, M., Shields, J.A., Shields, C.L., Croce, C.M. and Huebner, K. (1996) Deletion mapping of chromosome region 9p21-p22 surrounding the CDKN2 locus in melanoma. Int. J. Cancer, 65, 762-767.
14. Parris, C.N., Harris, J.D., Griffin, D.K., Cuthbert, A.P., Silver, A.J. and Newbold, R.F. (1999) Functional evidence of novel tumor suppressor genes for cutaneous malignant melanoma. Cancer Res., 59, 516-520.
15. Puig, S., Ruiz, A., Lazaro, C., Castel, T., Lynch, M., Palou, J., Vilalta, A., Weissenbach, J., Mascaro, J.M. and Estivill, X. (1995) Chromosome 9p deletions in cutaneous malignant melanoma tumors: the minimal deleted region involves markers outside the p16 (CDKN2) gene. Am. J. Hum. Genet., 57, 395-402.
16. Ramsey, M.J., Moore, D.H., Briner, J.F., Lee, D.A., Olsen, L., Senft, J.R. and Tucker, J.D. (1995) The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting. Mutat. Res., 338, 95-106.
17. Ruiz, A., Puig, S., Lynch, M., Castel, T. and Estivill, X. (1998) Retention of the CDKN2A locus and low frequency of point mutations in primary and metastatic cutaneous malignant melanoma. Int. J. Cancer, 76, 312-316.
18. van der Velden, P., Sandkuijl, L.A., Bergman, W., Hille, E.T.M., Frants, R.R. and Gruis, N.A. (1999) A locus linked to p16 modifies melanoma risk in dutch familial atypical multiple mole melanoma (FAMMM) syndrome families. Genome Res., 9, 575-580.
19. Waber, P., Dlugosz, S., Cheng, Q.C., Truelson, J. and Nisen, P.D. (1997) Genetic alterations of chromosome band 9p21-22 in head and neck cancer are not restricted to p16INK4a. Oncogene, 15, 1699-1704.
20. Walker, G.J., Flores, J.F., Glendening, J.M., Lin, A.H., Markl, I.D. and Fountain, J.W. (1998) Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets. Genes Chromosom. Cancer, 22, 157-163.
21. Wei, Q. (1998) Effect of aging on DNA repair and skin carcinogenesis: a minireview of population-based studies. J. Invest. Dermatol. Symp. Proc., 3, 19-22.
22. Wiest, J.S., Franklin, W.A., Otstot, J.T., Forbey, K., Varella-Garcia, M., Rao, K., Drabkin, H., Gemmill, R., Ahrent, S., Sidransky, D., Saccomanno, G., Fountain, J.W. and Anderson, M.W. (1997) Identification of a novel region of homozygous deletion on chromosome 9p in squamous cell carcinoma of the lung: the location of a putative tumor suppressor gene. Cancer Res., 57, 1-6.