Oral immunization of mice with a glycoconjugate vaccine containing the O157 antigen of Escherichia coli O157:H7 admixed with cholera toxin fails to elicit protection against subsequent colonization by the pathogen

Canadian Journal of Microbiology

Volumn 46, Issue 3, 2000, Pages 283-290

  Conlan, J Wayne ^a   KuoLee, Rhonda ^a   Webb, Ann ^a   Cox, Andrew D ^a   Perry, Malcolm B ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Escherichia coli O157:H7; Glycoconjugate vaccine; Mice; Mucosal immunity

Indexed keywords

CHOLERA TOXIN; GLYCOCONJUGATE; SERUM ALBUMIN; VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL VIRULENCE; CONTROLLED STUDY; DISEASE TRANSMISSION; ESCHERICHIA COLI; IMMUNE RESPONSE; IMMUNIZATION; INTESTINE FLORA; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; SURVIVAL; VACCINATION;

ANIMALIA; BACTERIA (MICROORGANISMS); BOVINAE; EQUUS CABALLUS; ESCHERICHIA COLI; POSIBACTERIA;

EID: 0034106712     PISSN: 00084166     EISSN: None     Source Type: Journal    
DOI: 10.1139/cjm-46-3-283     Document Type: Article

References (21)

1. Childers, N.K., Michalek, S.M., Pritchard, D.G., and McGhee, J.R. 1990. Mucosal and systemic responses to an oral liposome-Streptococcus mutans carbohydrate vaccine in humans. Reg. Immunol. 3: 289-296.
2. Cohen, A., Madrid-Marina, V., Estrov, Z., Freedman, M.H., Lingwood, C.A., and Dosch, H.M. 1990. Expression of glycolipid receptors to Shiga-like toxin on human B lymphocytes: a mechanism for the failure of long-lived antibody response to dysenteric disease. Int. Immunol. 2: 1-8.
3. Conlan, J.W., and Perry, M.B. 1998. Susceptibility of three strains of conventional adult mice to intestinal colonization by an isolate of Escherichia coli O157:H7. Can. J. Microbiol. 44: 800-805.
4. Conlan, J.W., Cox, A.D., KuoLee, R., Webb, A., and Perry, M.B. 1999a. Parenteral immunization with a glyco-conjugate vaccine containing the O157 antigen of Escherichia coli O157:H7 elicits a systemic humoral immune response in mice, but fails to prevent colonization by the pathogen. Can. J. Microbiol. 45: 279-286.
5. Conlan, J.W., KuoLee, R., Webb, A., and Perry, M.B. 1999b. Salmonella landau as a live vaccine against Escherichia coli O157:H7 investigated in a mouse model of intestinal colonization. Can. J. Microbiol. 45: 723-731.
6. Curtiss, R. 1990. Attenuated Salmonella strains as live vectors for the expression of foreign antigens. In New generation vaccines. Edited by G.C. Woodrow and M.M. Levine. Marcel Dekker, N.Y. pp. 161-188.
7. Hornquist, E., Lycke, N., Czerkinsky, C., and Holmgren, J. 1994. Cholera toxin and Cholera B subunit as oral-mucosal adjuvant and antigen carrier systems. In Novel delivery systems for oral vaccines. Edited by D.T. O'Hagan. CRC Press, Boca Raton, Fla. pp. 157-174.
8. Jackson, R.J., Fujihashi, K., Amano, J.X., Kiyono, H., Elson, C.O., and McGhee, J.R. 1993. Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin B-subunit whole-cell vaccine. In-fect. Immun. 61: 4272-4279.
9. Konadu, E., Robbins, J.B., Shiloach, J., Bryla, D.A., and Szu, S.C. 1994. Preparation, characterization, and immunological properties in mice of Escherichia coli O157 O-specific polysaccharide-protein conjugate vaccines. Infect. Immun. 62: 5048-5054.
10. Konadu, E.Y., Parke, J.C., Tran, H.T., Bryla, D.A., Robbins, J.B., and Szu, S.C. 1998. Investigational vaccine for Escherichia coli O157: Phase 1 study of O157 O-specific polysaccharide - Pseudomonas aeruginosa recombinant exoprotein A (rEPA) conjugates in adults. J. Infect. Dis. 177: 383-387.
11. McGhee, J.R., and Kiyono, H. 1994. Effective mucosal immunity: Current concepts for vaccine delivery and immune response analysis. Int. J. Technol. Assess. Health Care, 10: 93-106.
12. Mestecky, J., Lue., C., and Russell, M.W. 1991. Selective transport of IgA: Cellular and molecular aspects. Gastroenerol. Clin. N. Am. 20: 441-471.
13. Michetti, P., Mahan, M.J., Slauch, J.M., Mekalanos, J.J., and Neutra, M.R. 1992. Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium. Infect. Immun. 60: 1786-1792.
14. Neill, M.A. 1998. Treatment of disease due to shiga toxin-producing Escherichia coli: infectious disease management. In Escherichia coli O157:H7 and other shiga toxin-producing E. coli. Edited by J.B. Kaper, and A.D. O'Brien. American Society for Microbiology, Washington D.C. pp. 357-363.
15. O'Hagan, D.T. 1994. Oral immunization and the common mucosal immune system. In Novel delivery systems for oral vaccines. Edited by D.T. O'Hagan. CRC Press, Boca Raton, Fla. pp. 1-26.
16. Orr, N., Robin, G., Cohen, D., Arnon, R., and Lowell, G.H. 1993. Immunogenicity and efficacy of oral or intranasal Shigella flexneri 2a and Shigella sonnei proteosome-lipopolysaccharide vaccines in animal models. Infect. Immun. 61: 2390-2395.
17. Perry, M.B., Bundle, D.R., Gidney, M.A.J., and Lior, H. 1988. Identification of Escherichia coli serotype O157 strains by using a monoclonal antibody. J. Clin. Microbiol. 26: 2391-2394.
18. Shalaby, W.S.W. 1995. Development of oral vaccines to stimulate mucosal and systemic immunity: barriers and novel strategies. Clin. Immunol. Immunopathol. 74: 127-134.
19. Su, C., and Brandt, L.J. 1995. Escherichia coli O157:H7 infection in humans. Ann. Intern. Med. 123: 698-714.
20. Tauxe, R.V. 1998. Public health perspective on immunoprophylactic strategies for Escherichia coli O157:H7: who or what would we immunize? In Escherichia coli O157:H7 and other shiga toxin-producing E. coli. Edited by J.B. Kaper, and A.D. O'Brien. American Society for Microbiology, Washington D.C. pp. 445-452.
21. Winner, L., Mack, J., Welzin, R., Mekalanos, J.J., Kraehenbuhl, J.-P., and Neutra, M.R. 1991. New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immuno-globulin A from hybridoma tumors protects against Vibrio cholerae infection. Infect. Immun. 59: 977-982.