Differential effects of interferon-γ on metabolism of lipoprotein immune complexes mediated by specific human macrophage Fcγ receptors

Journal of Lipid Research

Volumn 41, Issue 3, 2000, Pages 405-415

  Morganelli, Peter M ^a   Kennedy, Susan M ^a   Mitchell, Teresa I ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Bispecific antibodies; Cholesterol linoleate; Cholesterol metabolism; Cholesterol trafficking; Fc receptors; Gamma interferon; Human macrophages; Lipoprotein metabolism; Lipoproteins; Scavenger receptors

Indexed keywords

CHOLESTEROL DERIVATIVE; FC RECEPTOR; GAMMA INTERFERON; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MONOCLONAL ANTIBODY; SCAVENGER RECEPTOR;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; CHOLESTEROL ESTERIFICATION; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROLYSIS; LIPOPROTEIN METABOLISM; MACROPHAGE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIGEN-ANTIBODY COMPLEX; CHOLESTEROL ESTERS; HEAT; HUMANS; INTERFERON TYPE II; LIPOPROTEINS; MACROPHAGES; RECEPTORS, IGG;

EID: 0034106365     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Krieger, M., S. Acton, J. Ashkenas, A. Pearson, M. Penman, and D. Resnick. 1993. Molecular flypaper, host defense, and atherosclerosis. Stucture, binding properties, and functions of macrophage scavenger receptors. J. Biol. Chem. 268: 4569-4572.
2. Steinbrecher, U. P. 1999. Receptors for oxidized low density lipoprotein. Biochim Biophys Acta. 1436: 279-298.
3. Brown, M. S., and J. L. Goldstein. 1983. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu. Rev. Biochem. 52: 223-261.
4. Nicholson, A. C., S. Frieda, A. Pearce, and R. L. Silverstein. 1995. Oxidized LDL binds to CD36 on human monocyte-derived macrophages and transfected cell lines. Evidence implicating the lipid moiety of the lipoprotein as the binding site. Arterioscler. Thromb. Vasc. Biol. 15: 269-275.
5. Acton, S. L., P. E. Scherer, H. F. Lodish, and M. Krieger. 1994. Expression cloning of SR-BI, a CD36-related class B scavenger receptor. J. Biol. Chem. 269: 21003-21009.
6. Ottnad, E., S. Parthasarathy, G. R. Sambrano, M. P. Ramprasad, O. Quehenberger, N. Kondratenko, S. Green, and D. Steinberg. 1995. A macrophage receptor for oxidized low density lipoprotein distinct from the receptor for acetyl low density lipoprotein: partial purification and role in recognition of oxidatively damaged cells. Proc. Natl. Acad. Sci. USA. 92: 1391-1395.
7. Ramprasad, M. P., W. Fischer, J. L. Witztum, G. R. Sambrano, O. Quehenberger, and D. Steinberg. 1995. The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosialin, the mouse homologue of human CD68. Proc. Natl. Acad. Sci. USA. 92: 9580-9584.
8. Griffith, R. L., A. Virella, H. C. Stevenson, and M. I. Lopes-Virella. 1988. Low density lipoprotein metabolism by human macrophages activated with low density lipoprotein immune complexes. J. Exp. Med. 168: 10-41-1059.
9. Morganelli, P. M., T. J. Kitzmiller, R. Hemmer, and M. W. Fanger. 1992. Redirected targeting of LDL to human monocyte Fc gamma receptors with bispecific antibodies. Arterioscler. Thromb. 12: 1131-1138.
10. Khoo, J. C., E. Miller, P. McLoughlin, and D. Steinberg. 1988. Enhanced macrophage uptake of low density lipoprotein after self-aggregation. Arteriosclerosis. 8: 348-358.
11. Lopes-Virella, M. F., and G. Virella. 1992. Immune mechanisms of atherosclerosis in diabetes mellitus. Diabetes. 41 Suppl 2: 86-91.
12. Lopes-Virella, M. F., N. Binzafar, S. Rackley, A. Takei, M. La Via, and G. Virella. 1997. The uptake of LDL-IC by human macrophages: predominant involvement of the Fc gamma RI receptor. Atherosclerosis. 135: 161-170.
13. Morganelli, P. M., R. A. Rogers, T. J. Kitzmiller, and A. Bergeron. 1995. Enhanced metabolism of LDL aggregates mediated by specific human monocyte IgG Fc receptors. J. Lipid Res. 36: 714-724.
14. Salonen, J. T., S. Yla-Herttuala, R. Yamamoto, S. Butler, H. Korpela, R. Salonen, K. Nyyssonen, W. Palinski, and J. L. Witztum. 1992. Autoantibody against oxidised LDL and progression of carotid atherosclerosis [see comments]. Lancet. 339: 883-887.
15. Yla-Herttuala, S., W. Palinski, S. W. Butler, S. Picard, D. Steinberg, and J. L. Witztum. 1994. Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL. Arterioscler. Thromb. 14: 32-40.
16. Brown, M. S., Y. K. Ho, and J. L. Goldstein. 1980. The cholesteryl ester cycle in macrophage foam cells. Science. 255: 9344-9352.
17. Chang, T. Y., C. C. Chang, and D. Cheng. 1997. Acyl-coenzyme A:cholesterol acyltransferase. Annu. Rev. Biochem. 66: 613-638.
18. Xu, X. X., and I. Tabas. 1991. Lipoproteins activate acyl-coenzyme A:cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level. J. Biol. Chem. 266: 17040-17048.
19. Rothblat, G. H., and M. Phillips, C. 1982. Mechanism of cholesterol efflux from cells. Effects of acceptor structure and concentration. J. Biol. Chem. 257: 4775-4782.
20. Liscum, L., and K. W. Underwood. 1995. Intracellular cholesterol transport and compartmentation. J. Biol. Chem. 270: 15443-15446.
21. Skarlatos, S. I., M. Rouis, M. J. Chapman, and H. S. Kruth. 1993. Heterogeneity of cellular cholesteryl ester accumulation by human monocyte-derived macrophages. Atherosclerosis. 99: 229-240.
22. Albert, D. H., M. G. Traber, and H. J. Kayden. 1982. Cholesterol metabolism in human monocyte-derived macrophages: stimulation of cholesteryl ester formation and cholesterol excretion by serum lipoproteins. Lipids. 17: 709-715.
23. van de Winkel, J. G., and C. L. Anderson. 1991. Biology of human immunoglobulin G Fc receptors. J. Leukocyte Biol. 49: 511-524.
24. van de Winkel, J. G., and P. J. Capel. 1993. Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol. Today. 14: 215-221.
25. Geng, Y. J., and G. K. Hansson. 1992. Interferon-gamma inhibits scavenger receptor expression and foam cell formation in human monocyte-derived macrophages. J. Clin. Invest. 89: 1322-1330.
26. Guyre, P. M., P. M. Morganelli, and R. Miller. 1983. Recombinant immune interferon increases immunoglobulin G Fc receptors on cultured human mononuclear phagocytes. J. Clin. Invest. 72: 393-397.
27. Ramshaw, A. L., D. E. Roskell, and D. V. Parums. 1994. Cytokine gene expression in aortic adventitial inflammation associated with advanced atherosclerosis (chronic periaortitis). J. Clin. Pathol. 47: 721-727.
28. Geng, Y. J., J. Holm, S. Nygren, M. Bruzelius, S. Stemme, and G. K. Hansson. 1995. Expression of the macrophage scavenger receptor in atheroma. Relationship to immune activation and the T-cell cytokine interferon-gamma. Arterioscler. Thromb. Vasc. Biol. 15: 1995-2002.
29. Stemme, S., B. Faber, J. Holm, O. Wiklund, J. L. Witztum, and G. K. Hansson. 1995. T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proc. Natl. Acad. Sci. USA. 92: 3893-3897.
30. Huang, Y. H., J. Ronnelid, and J. Frostegard. 1995. Oxidized LDL induces enhanced antibody formation and MHC class II-dependent IFN-gamma production in lymphocytes from healthy individuals. Arterioscler. Thromb. Vasc. Biol. 15: 1577-1583.
31. Frostegard, J., Y. H. Huang, J. Ronnelid, and L. Schafer-Elinder. 1997. Platelet-activating factor and oxidized LDL induce immune activation by a common mechanism. Arterioscler. Thromb. Vasc. Biol. 17: 963-968.
32. Gupta, S., A. M. Pablo, X. Jiang, N. Wang, A. R. Tall, and C. Schindler. 1997. IFN-gamma potentiates atherosclerosis in ApoE knockout mice. J. Clin. Invest. 99: 2752-2761.
33. Cadigan, K. M., J. G. Heider, and T. Y. Chang. 1988. Isolation and characterization of Chinese hamster ovary cell mutants deficient in acyl-coenzyme A:cholesterol acyltransferase activity. J. Biol. Chem. 263: 274-282.
34. Goldstein, J. L., K. Basu, and M. I. Brown. 1983. Receptor-mediated endocytosis of of low-density lipoprotein in cultured cells. Methods Enzymol. 98: 241-260.
35. Markwell, M. K., S. M. Haas, L. L. Bieber, and N. E. Tolbert. 1978. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 87: 206-210.
36. Underwood, K. W., N. L. Jacobs, A. Howley, and L. Liscum. 1998. Evidence for a cholesterol transport pathway from lysosomes to endoplasmic reticulum that is independent of the plasma membrane. J. Biol. Chem. 273: 4266-4274.
37. Basu, S. K., J. L. Goldstein, G. W. Anderson, and M. S. Brown. 1976. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc. Natl. Acad. Sci. USA. 73: 3178-3182.
38. Morganelli, P. M., and P. M. Guyre. 1988. IFN-gamma plus glucocorticoids stimulate the expression of a newly identified human mononuclear phagocyte-specific antigen. J. Immunol. 140: 2296-2304.
39. Fraser, I., A. Doyle, D. Hughes, and S. Gordon. 1994. Use of surface molecules and receptors for studying macrophages and mononuclear phagocytes. J. Immunol. Methods. 174: 95-102.
40. Skiba, P. J., G. A. Keesler, and I. Tabas. 1994. Interferon-gamma down-regulates the lipoprotein(a)/apoprotein(a) receptor activity on macrophage foam cells. Evidence for disruption of ligand-induced receptor recycling by interferon-gamma. J. Biol. Chem. 269: 23059-23067.
41. Fong, L. G., T. S. Albert, and S. E. Hom. 1994. Inhibition of the macrophage-induced oxidation of low density lipoprotein by interferon-gamma. J. Lipid Res. 35: 893-904.
42. Drevon, C. A., A. D. Attie, S. H. Pangburn, and D. Steinberg. 1981. Metabolism of homologous and heterologous lipoproteins by cultured rat and skin fibroblasts. J. Lipid Res. 22: 37-46.
43. Cadigan, K. M., D. M. Spillane, and T. Y. Chang. 1990. Isolation and characterization of Chinese hamster ovary cell mutants defective in intracellular low density lipoprotein-cholesterol trafficking. J. Cell Biol. 110: 295-308.
44. Shechter, I., A. M. Fogelman, M. E. Haberland, J. Seager, M. Hokom, and P. A. Edwards. 1981. The metabolism of native and malondialdehyde-altered low density lipoproteins by human monocyte-macrophages. J. Lipid Res. 22: 63-71.
45. Fogelman, A. M., M. E. Haberland, J. Seager, M. Hokom, and P. A. Edwards. 1981. Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages. J. Lipid Res. 22: 1131-1141.
46. Dunn, W. A., A. L. Hubbard, and N. N. Aronson. 1980. Low temperature selectively inhibits fusion between pinocytic vesicles and lysosomes during heterophagy of 125I-asialofetuin by the perfused rat liver. J. Biol. Chem. 255: 5971-5978.
47. Fogelman, A. M., I. Shechter, J. Seager, M. Hokom, J. S. Child, and P. A. Edwards. 1980. Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages. Proc. Natl. Acad. Sci. USA. 77: 2214-2218.
48. Rinninger, F., J. T. Deichen, S. Jackle, E. Windler, and H. Greten. 1994. Selective uptake of high-density lipoprotein-associated cholesteryl esters and high-density lipoprotein particle uptake by human monocyte-macrophages. Atherosclerosis. 105: 145-157.
49. Rinninger, F., M. Brundert, S. Jackle, T. Kaiser, and H. Greten. 1995. Selective uptake of low-density lipoprotein-associated cholesteryl esters by human fibroblasts, human HepG2 hepatoma cells and J774 macrophages in culture. Biochim. Biophys. Acta. 1255: 141-153.
50. Swarnakar, S., R. E. Temel, M. A. Connelly, S. Azhar, and D. L. Williams. 1999. Scavenger receptor class B, type I, mediates selective uptake of low density lipoprotein cholesteryl ester. J. Biol. Chem. 274: 29733-29739.
51. Green, S. R., and R. C. Pittman. 1991. Selective uptake of cholesteryl esters from low density lipoproteins in vitro and in vivo. J. Lipid Res. 32: 667-678.
52. Fogelman, A. M., J. Seager, M. E. Haberland, M. Hokom, R. Tanaka, and P. A. Edwards. 1982. Lymphocyte-conditioned medium protects human monocyte-macrophages from cholesteryl ester accumulation. Proc. Natl. Acad. Sci. USA. 79: 922-926.
53. Fogelman, A. M., J. Seager, J. E. Groopman, J. A. Berliner, M. E. Haberland, P. A. Edwards, and D. W. Golde. 1983. Lymphokines secreted by an established lymphocyte line modulate receptor-mediated endocytosis in macrophages derived from human monocytes. J. Immunol. 131: 2368-2373.
54. Garner, B., A. Baoutina, R. T. Dean, and W. Jessup. 1997. Regulation of serum-induced lipid accumulation in human monocyte-derived macrophages by interferon-gamma. Correlations with apolipoprotein E production, lipoprotein lipase activity and LDL receptor-related protein expression. Atherosclerosis. 128: 47-58.
55. Park, H., Y. M. Go, P. L. St John, M. C. Maland, M. P. Lisanti, D. R. Abrahamson, and H. Jo. 1998. Plasma membrane cholesterol is a key molecule in shear stress-dependent activation of extracellular signal-regulated kinase. J Biol Chem. 273: 32304-32311.
56. Bigler, R. D., M. Khoo, S. Lund-Katz, L. Scerbo, and M. Esfahani. 1990. Identification of low density lipoprotein as a regulator of Fc receptor-mediated phagocytosis. Proc. Natl. Acad. Sci. USA. 87: 4981-4985.
57. Harder, T., and K. Simons. 1997. Caveolac, DIGs, and the dynamics of sphingolipid-cholesterol microdomains. Curr. Opin. Cell Biol. 9: 534-542.
58. Khelef, N., X. Buton, N. Beatini, H. Wang, V. Meiner, T. Y. Chang, R. V. Farese, Jr., F. R. Maxfield, and I. Tabas. 1998. Immunolocalization of acyl-coenzyme A:cholesterol O-acyltransferase in macrophages. J. Biol. Chem. 273: 11218-11224.
59. Harrison, P. T., W. Davis, J. C. Norman, A. R. Hockaday, and J. M. Allen. 1994. Binding of monomeric immunoglobulin G triggers Fc gamma RI-mediated endocytosis. J. Biol. Chem. 269: 24396-24402.
60. Tabas, I., S. Lim, X. X. Xu, and F. R. Maxfield. 1990. Endocytosed beta-VLDL and LDL are delivered to different intracellular vesicles in mouse peritoneal macrophages. J. Cell Biol. 111: 929-940.
61. George, J., A. Afek, B. Gilburd, H. Levkovitz, A. Shaish, I. Goldberg, Y. Kopolovic, G. Wick, Y. Shoenfeld, and D. Harats. 1998. Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis. Atherosclerosis. 138: 147-152.
62. Ameli, S., A. Hultgardh-Nilsson, J. Regnstrom, F. Calara, J. Yano, B. Cercek, P. K. Shah, and J. Nilsson. 1996. Effect of immunization with homologous LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits. Arterioscler. Thromb. Vasc. Biol. 16: 1074-1079.
63. Nilsson, J., F. Calara, J. Regnstrom, A. Hultgardh-Nilsson, S. Ameli, B. Cercek, and P. K. Shah. 1997. Immunization with homologous oxidized low density lipoprotein reduces neointimal formation after balloon injury in hypercholesterolemic rabbits. J. Am. Coll. Cardiol. 30: 1886-1891.
64. Freigang, S., S. Horkko, E. Miller, J. L. Witztum, and W. Palinski. 1998. Immunization of LDL receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than induction of high titers of antibodies to oxidative neoepitopes. Arterioscler. Thromb. Vasc. Biol. 18: 1972-1982.
65. Palinski, W., E. Miller, and J. L. Witztum. 1995. Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis. Proc. Natl. Acad. Sci. USA. 92: 821-825.