Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy

Experimental Neurology

Volumn 161, Issue 2, 2000, Pages 714-723

  Vergnes, Marguerite ^a   Boehrer, Any ^a   Reibel, Sophie ^a   Simler, Simone ^a   Marescaux, Christian ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Absence epilepsy; c Fos immunoreactivity; Convulsions; Cortex; GABA receptor antagonists; Rat

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; KAINIC ACID; PROTEIN C FOS; STRYCHNINE;

ABSENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GABAERGIC SYSTEM; IMMUNOHISTOCHEMISTRY; LATENT PERIOD; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT;

EID: 0034105893     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1999.7302     Document Type: Article

References (49)

1. Avoli M., Gloor P. Physiopathogenesis of feline generalized penicillin epilepsy: The role of thalamocortical mechanisms. Malafosse A., Hirsch E., Marescaux C., Broglin D., Bernasconi R. Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects. 1994;111-121 Libbey, London.
2. Bittiger H., Froestl W., Mickel S. J., Olpe H. R. GABA B receptors. Trends Pharmacol. Sci. 14:1993;391-394.
3. Braestrup C., Nielsen M., Honore T., Jensen L. H., Petersen E. N. Benzodiazepine receptor ligands with positive and negative efficacy. Neuropharmacology. 22:1983;1451-1457.
4. Brailowsky S., Montiel T., Boehrer A., Marescaux C., Vergnes M. Susceptibility to focal and generalized seizures in Wistar rats with genetic absence-like epilepsy. Neuroscience. 93:1999;1173-1177.
5. Browning R. A. Anatomy of generalized convulsive seizures. Malafosse A., Hirsch E., Marescaux C., Broglin D., Bernasconi R. Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects. 1994;399-413 Libbey, London.
6. Browning R. A., Wang C., Lanker M. L., Jobe P. C. Electroshock- and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats (GEPRs): Differences in threshold and pattern. Epilepsy Res. 6:1990;1-11.
7. Chagnac-Amitai Y., Connors B. W. Synchronized excitation and inhibition driven by intrinsically bursting neurons in neocortex. J. Neurophysiol. 62:1989;1149-1162.
8. Chevassus-au-Louis N., Rafiki A., Jorquera I., Ben-Ari Y., Represa A. Neocortex in the hippocampus: An anatomical and functional study of CA1 heterotopias after prenatal treatment with methylazoxymethanol in rats. J. Comp. Neurol. 394:1998;520-536.
9. Coenen A. M. L., van Luijtelaar E. L. J. M. The WAG/Rij rat model for absence epilepsy: Age and sex factors. Epilepsy Res. 1:1987;297-301.
10. Contreras D., Destexhe A., Steriade M. Intracellular and computational characterization of the intracortical inhibitory control of synchronized thalamic inputs in vivo. J. Neurophysiol. 78:1997;335-350.
11. Corda M. G., Orlandi M., Lecca D., Osvaldo G. Decrease in GABAergic function induced by pentylenetetrazol kindling in rats: Antagonism by MK-801. J. Pharmacol. Exp. Ther. 262:1992;792-800.
12. Danober L., Deransart C., Depaulis A., Vergnes M., Marescaux C. Pathophysiological mechanisms of genetic absence epilepsy in the rat. Prog. Neurobiol. 55:1998;27-57.
13. Di Pasquale E., Keegan K. D., Noebels J. L. Increased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse stargazer. J. Neurophysiol. 77:1997;621-631.
14. Faingold C. L., Li Y., Evans M. S. Diminished GABA-A receptor-mediated inhibition in the inferior colliculus may subserve audiogenic seizure susceptibility. Epilepsia. 39:1998;37.
15. Franck J. E., Ginter K. L., Schwartzkroin P. A. Developing genetically epilepsy-prone rats have an abnormal seizure response to Flurothyl. Epilepsia. 30:1989;1-6.
16. Fromm G. H. Role of inhibitory mechanisms in staring spells. J. Clin. Neurophysiol. 3:1986;297-311.
17. Gloor P., Fariello R. G. Generalized epilepsy: Some of its cellular mechanisms differ from those of focal epilepsy. Trends Neurosci. 11:1988;63-68.
18. Hiscock J. J., MacKenzie L., Willoughby J. O. Fos induction in subtypes of cerebrocortical neurons following single picrotoxin-induced seizures. Brain Res. 738:1996;301-312.
19. Horton R. W. GABA and seizures induced by inhibitors of glutamic acid decarboxylase. Brain Res. Bull. 5:1980;605-608.
20. Hosford D. A., Sclark Z., Cao Z., Wilson W. A., Lin F., Morrisett R. A., Huin A. The role of GABA B receptor activation in absence seizures of lethargic (lh/lh) mice. Science. 257:1992;398-401.
21. Ikeda-Douglas C. J., Head E., Holsinger R. M. D., Tremblay L., Racine R., Milgram N. W. Selective loss of early suppression in the dentate gyrus precedes kainic acid induced electrographic seizures. Epilepsy Res. 31:1998;143-152.
22. Jando G., Carpi D., Kandel A., Urioste R., Horvath Z., Pierre E., Vadi D., Vadasz C., Buzsaki G. Spike-and-wave epilepsy in rats: Sex differences and inheritance of physiological traits. Neuroscience. 64:1995;301-317.
23. Jobe P. C., Mishra P. K., Adams-Curtis L. E., Ko K. H., Dailey J. W. The GEPR model of the epilepsies. Malafosse A., Hirsch E., Marescaux C., Broglin D., Bernasconi R. Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects. 1994;385-398 Libbey, London.
24. Knight A. R., Bowery N. G. GABA receptors in rats with spontaneous generalized nonconvulsive epilepsy. J. Neural Transm. 35:1992;189-196.
25. Lerma J. Kainate reveals its targets. Neuron. 19:1997;1155-1158.
26. Loiseau P. Human absence epilepsies. J. Neural Transm. 35:1992;1-6.
27. Luhmann H. J., Mittmann T., Van Luijtelaar G., Heinemann U. Impairment of intracortical GABAergic inhibition in a rat model of absence epilepsy. Epilepsy Res. 22:1995;43-51.
28. Luhmann H. J., Prince D. A. Control of NMDA receptor-mediated activity by GABAergic mechanisms in mature and developing rat neocortex. Dev. Brain Res. 54:1990;287-290.
29. Madeja M., Stocker M., Musshoff U., Pongs O., Speckmann E. J. Potassium currents in epilepsy: Effects of the epileptogenic agent pentylenetetrazol on a cloned potassium channel. Brain Res. 656:1994;287-294.
30. Marescaux C., Vergnes M., Depaulis A. Genetic absence epilepsy in rats from Strasbourg - A review. J. Neural Transm. 35:1992;37-69.
31. Medvedev A., Mackenzie L., Hiscock J. J., Willoughby J. O. Frontal cortex leads other brain structures in generalised spike-and-wave spindles and seizure spikes induced by picrotoxin. Electroencephalogr. Clin. Neurophysiol. 98:1996;157-166.
32. Morgan J. I., Curran T. Proto-oncogene transcription factors and epilepsy. Trends Pharmacol. Sci. 12:1991;343-349.
33. Myslobodsky M. S. Petit mal epilepsy: Too little or too much GABA? In. Fariello R. G. Neurotransmitters, Seizures, and Epilepsy II. 1984;337-345 Raven Press, New York.
34. Netopilova M., Drsata J., Haugvicova R., Kubova H., Mares P. Inhibition of glutamate decarboxylase activity by 3-mercaptopropionic acid has different time course in the immature and adult rat brains. Neurosci. Lett. 226:1997;68-70.
35. Noebels J. L. Genetic and phenotypic heterogeneity of inherited spike-and-wave epilepsies. Malafosse A., Hirsch E., Marescaux C., Broglin D., Bernasconi R. Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects. 1994;215-225 Libbey, London.
36. Richards D. A., Lemos T., Whitton P. S., Bowery N. G. Extracellular GABA in the ventrolateral thalamus of rats exhibiting spontaneous absence epilepsy: A microdialysis study. J. Neurochem. 65:1995;1674-1680.
37. Samoriski G. M., Piekut D. T., Applegate C. D. Differential spatial patterns of fos induction following generalized clonic and generalized tonic seizures. Exp. Neurol. 143:1997;255-268.
38. Snead O. C. III. Pathophysiological mechanisms of experimental generalized absence seizures in rats. Malafosse A., Hirsch E., Marescaux C., Broglin D., Bernasconi R. Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects. 1994;133-150 Libbey, London.
39. A receptor complex in experimental absence seizures in rat - An autoradiographic study. Neurosci. Lett. 140:1992;9-12.
40. Spreafico R., Menini T., Danober L., Cagnotto A., Regondi M., Miari A., De Blas A., Vergnes M., Avanzini G. GABA-A receptor impairment in the genetic absence epilepsy rats from Strasbourg (GAERS): An immunocytochemical and receptor binding autoradiographic study. Epilepsy Res. 15:1993;229-238.
41. Squires R. F., Saederup E., Crawley J. N., Skolnick P., Paul S. M. Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/picrotoxin receptor complexes in brain. Life Sci. 35:1984;1439-1444.
42. Steriade M., Contreras D. Spike-wave complexes and fast components of cortically generated seizures. I. Role of neocortex and thalamus. J. Neurophysiol. 80:1998;1439-1455.
43. A receptor subunits in the tottering mouse: An animal model for absence seizures. Epilepsy Res. 28:1997;213-223.
44. Vergnes M., Marescaux C. Pathophysiological mechanisms underlying genetic absence epilepsy in rats. Malafosse A., Hirsch E., Marescaux C., Broglin D., Bernasconi R. Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects. 1994;151-168 Libbey, London.
45. Vergnes M., Marescaux C., Depaulis A. Mapping of spontaneous spike and wave discharges in Wistar rats with genetic generalized non-convulsive epilepsy. Brain Res. 523:1990;87-91.
46. B receptor antagonists on absences and convulsive seizures. Eur. J. Pharmacol. 332:1997;245-255.
47. Vergnes M., Marescaux C., Micheletti G., Depaulis A., Rumbach L., Warter J. M. Enhancement of spike and wave discharges by GABA mimetic drugs in rats with spontaneous petit-mal-like epilepsy. Neurosci. Lett. 44:1984;91-94.
48. Vergnes M., Marescaux C., Micheletti G., Reis J., Depaulis A., Rumbach L., Warter J. M. Spontaneous paroxysmal electroclinical patterns in rat: A model of generalized non convulsive epilepsy. Neurosci. Lett. 33:1982;97-101.
49. Willoughby J. O., Mackenzie L., Medvedev A., Hiscock J. J. Fos induction following systemic kainic acid: Early expression in hippocampus and later widespread expression correlated with seizure. Neuroscience. 77:1997;379-392.