ET(B) receptor blockade potentiates the pressor response to big endothelin-1 but not big endothelin-2 in the anesthetized rabbit

Hypertension

Volumn 35, Issue 3, 2000, Pages 726-731

  Gratton, Jean Philippe ^a   Rae, Giles A ^b   Bkaily, Ghassan ^c   D'Orléans Juste, Pedro ^c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^c UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Chromatography; Endothelin; Endothelin converting enzyme; Endothelium derived relaxing factor; Prostacyclin; Receptors

Indexed keywords

BIG ENDOTHELIN 1; BIG ENDOTHELIN 2; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIUM DERIVED RELAXING FACTOR; INDOMETACIN; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; PHOSPHORAMIDON; PROSTACYCLIN;

ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HEMODYNAMICS; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RABBIT; RECEPTOR BLOCKING;

EID: 0034102663     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.35.3.726     Document Type: Article

References (17)

1. Miyauchi T. Pathophysiology of endothelin in the cardiovascular system. Annu Rev Physiol. 1999;61:391-415.
2. D'Orléans-Juste P, Lidbury PS. Télémaque S, Warner TD, Vane JR. Human big endothelin releases prostacyclin in vivo and in vitro through a phosphoramidon-sensitive conversion to endothelin-1. J Cardiovasc Pharmacol. 1991;17:S251-S255.
3. Loffler BM, Jacot GH, Maire JP. Concentrations and ratios of immunoreactive big-endothelin-1 and endothelin-1 in human, rat and rabbit plasma. Biochem Int. 1992;27:755-761.
4. Kos T, Pacher R., Wimmer A., Bojic A, Hulsmann M, Frey B, Mayer G, Yilmaz N, Skvarilova L, Spinar J, Vitovec J, Toman J, Woloszcuk W, Stanek B. Relationship between kidney function, hemodynamic variables and circulating big endothelin levels in patients with severe refractory heart failure. Wien Klin Wochenschrift. 1998;110:89-95.
5. Haleen SJ, Davis LS, LaDouceur DM, Keiser JA. Why big endothelin-1 lacks a vasodilator response. J Cardiovasc Pharmacol. 1993;22:S271-S273.
6. Gratton JP, Cournoyer G, D'Orléans-Juste P. Endothelin-B receptor-dependent modulation of the pressor and prostacyclin-releasing properties of dynamically converted big-endothelin-1 in the anesthetized rabbit. J Cardiovasc Pharmacol. 1998;31:S161-S163.
7. B receptor. Br J Pharmacol. 1993;109:530-534.
8. Gratton JP, Rae GA, Claing A, Télémaque S, D'Orléans-Juste P. Different pressor and bronchoconstrictor properties of human big-endothelin-1, 2 (1-38) and 3 in ketamine/xylazine-anaesthetized guinea-pigs. Br J Pharmacol. 1995;114:720-726.
9. D'Orléans-Juste P, Gratton JP, Bkaily G, Giaid A. Activity and distribution of endothelin-converting enzyme in the lung. In: Goldie RG, Hay DWP, eds. Pulmonary Actions of the Endothelins. Basel, Switzerland: Birkhauser-Verlag, AG; 1999: chapter 4; 53-73.
10. B receptor and nitric oxide synthase blockade induce BQ-123-sensitive pressor effects in the rabbit. Hypertension. 1997;30:1204-1209.
11. De Lombaert SR, Ghai RD, Jeng AY, Trapani AJ, Webb RL. Pharmacological profile of a non peptidic dual inhibitor of neutral endopeptidase 24-11 and endothelin-converting enzyme. Biochem Biophys Res Commun. 1994;204:407-412.
12. B receptors. J Appl Physiol. 1996;81:1510-1515.
13. B receptors in rats. Biochem Biophys Res Commun. 1994;199:1461-1465.
14. Plumpton C, Haynes WG, Webb DJ, Davenport AP. Phosphoramidon inhibition of the in vivo conversion of big endothelin-1 to endothelin-1 in the human forearm. Br J Pharmacol. 1995;116:1821-1828.
15. D'Orléans-Juste P, Lidbury PS, Warner TD, Vane JR. Intravascular big endothelin increases circulating levels of endothelin-1 and prostanoids in the rabbit. Biochem Pharmacol. 1990;39:R21-R22.
16. Corder R, Vane JR. Radioimmunoassay evidence that the pressor effect of big endothelin-1 is due to local conversion to endothelin-1. Biochem Pharmacol. 1995;49:375-380.
17. Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, Masaki T. Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature. 1990;348:732-735.