Structure, expression, and chromosomal localization of the mouse atox1 gene

Genomics

Volumn 63, Issue 2, 2000, Pages 294-297

  Hamza, Iqbal ^a   Klomp, Leo W J ^a   Gaedigk, Roger ^b   White, Robert A ^b   Gitlin, Jonathan D ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN S MERCY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 15; COPPER METABOLISM; GENE EXPRESSION; GENE LOCUS; GENE STRUCTURE; HUMAN; HUMAN CELL; MENKES SYNDROME; NONHUMAN; PRIORITY JOURNAL; WILSON DISEASE;

EUKARYOTA; MAMMALIA;

EID: 0034102348     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1999.6046     Document Type: Article

References (14)

1. Altschul S. F., Madden T. L., Schaffer A. A., Zhang J., Miller W., Lipman D. J. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res. 25:1997;3389-3402.
2. Hamza I., Schaefer M., Klomp L. W. J., Gitlin J. D. Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis. Proc. Natl. Acad. Sci. USA. 96:1999;13363-13368.
3. Harris Z. L., Gitlin J. D. Genetic and molecular basis for copper toxicity. Am. J. Clin. Nutr. 63:1996;836S-841S.
4. Hung I. H., Casareno R. L., Labesse G., Mathews F. S., Gitlin J. D. HAH1 is a copper-binding protein with distinct amino acid residues mediating copper homeostasis and antioxidant defense. J. Biol. Chem. 273:1998;1749-1754.
5. Klomp L. W., Lin S. J., Yuan D. S., Klausner R. D., Culotta V. C., Gitlin J. D. Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis. J. Biol. Chem. 272:1997;9221-9226.
6. Lin S. J., Pufahl R. A., Dancis A., O'Halloran T. V., Culotta V. C. A role for the Saccharomyces cerevisiae ATX1 gene in copper trafficking and iron transport. J. Biol. Chem. 272:1997;9215-9220.
7. Nishihara E., Furuyama T., Yamashita S., Mori N. Expression of copper trafficking genes in the mouse brain. Neuroreport. 9:1998;3259-3263.
8. Pena M. M., Lee J., Thiele D. J. A delicate balance: Homeostatic control of copper uptake and distribution. J. Nutr. 129:1999;1251-1260.
9. Portnoy M. E., Rosenzweig A. C., Rae T., Huffman D. L., O'Halloran T. V., Culotta V. C. Structure-function analyses of the ATX1 metallochaperone. J. Biol. Chem. 274:1999;15041-15045.
10. Pufahl R. A., Singer C. P., Peariso K. L., Lin S. J., Schmidt P. J., Fahrni C. J., Culotta V. C., Penner-Hahn J. E., O'Halloran T. V. Metal ion chaperone function of the soluble Cu(I) receptor Atx1. Science. 278:1997;853-856.
11. Rae T. D., Schmidt P. J., Pufahl R. A., Culotta V. C., O'Halloran T. V. Undetectable intracellular free copper: The requirement of a copper chaperone for superoxide dismutase. Science. 284:1999;805-808.
12. Rosenzweig A. C., Huffman D. L., Hou M. Y., Wernimont A. K., Pufahl R. A., O'Halloran T. V. Crystal structure of the Atx1 metallochaperone protein at 1.02 Å resolution. Structure. 7:1999;605-617.
13. Schaefer M., Gitlin J. D. Genetic disorders of membrane transport. IV. Wilson's disease and Menkes disease. Am. J. Physiol. 276:1999;G311-G314.
14. Valentine J. S., Gralla E. B. Delivering copper inside yeast and human cells. Science. 278:1997;817-818.