Distribution of amyloid β42 in relation to the cerebral microvasculature in an elderly cohort with Alzheimer's disease

Annals of the New York Academy of Sciences

Volumn 903, Issue , 2000, Pages 83-88

  Thomas, A J ^a,b   Morris, C M ^a,b   Ferrier, I N ^a,b   Kalaria, R N ^a,b  

^a NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E;

AGED; ALZHEIMER DISEASE; BRAIN MICROCIRCULATION; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GENOTYPE; HOMOZYGOTE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; SUBICULUM; TEMPORAL CORTEX;

EID: 0034101434     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06353.x     Document Type: Conference Paper

References (21)

1. 1. IWATSUBO, T., A. ODAKA, N. SUZUKI, H. MIZUSAWA, N. NUKINA & Y. IHARA. 1994. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron 13: 45-53.
2. 2. KALARIA, R.N., D.L. COHEN, B.D. GREENBERG, M.J. SAVAGE, N.E. BOGDANOVIC, B. WINBLAD, L. LANNFELT & A. ADEM. 1996. Abundance of the longer Aβ42 in neocortical and cerebrovascular amyloid deposits in Swedish familial Alzheimer's disease and Down's syndrome subjects Neuroreport 7: 1377-1381.
3. 3. KALARIA, R.N. & P. HEDERA. 1995. Differential degeneration of the endothelium and basement membrane of capillaries in Alzheimer's disease Neuroreport 6: 477-480.
4. 4. KAWAI, M., R.N. KALARIA, S.I. HARIK & G. PERRY. 1990. The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease Am. J. Pathol. 137: 1435-1446.
5. 5. KALARIA, R.N. & P. HEDERA. 1996. β-Amyloid vasoactivity in Alzheimer's disease. Lancet 347: 1492-1493.
6. 6. KALARIA, R.N. 1997. Cerebrovascular degeneration is related to amyloid-β protein deposition in Alzheimer's disease Ann. N.Y. Acad. Sci. 826: 263-271.
7. 7. MIYAKAWA, T., S. KATSURAGI, Y. HIGUCHI, K. YAMASHITA, T. KIMURA, K. TERAOKA, T. ONO & K. ISHIZUKA. 1997. Changes of microvessels in the brain with Alzheimer's disease Ann. N.Y. Acad. Sci. 826: 428-432.
8. 8. MIYAKAWA, T. 1996. Electron microscopy of amyloid fibrils and microvessels Ann. N.Y. Acad. Sci. 826: 25-34.
9. 9. THOMAS, T., G. THOMAS, C. MCLENDON, T. SUTTON & M. MULLAN. 1996. Beta-amyloid-mediated vasoactivity and vascular endothelial damage Nature 380: 168-171.
10. 10. DAVIS, J., D.H. CRIBBS, C.W. COTMAN & W.E. VAN NOSTRAND. 1999. Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells Amyloid 6: 157-164.
11. 11. WISNIEWSKI, H.M., J. FRACKOWIAK & B. MAZUR-KOLECKA. 1995. In vitro production of beta-amyloid in smooth muscle cells isolated from amyloid angiopathy-affected vessels. Neurosci. Lett. 183: 120-123.
12. 12. KAWAI, M., R.N. KALARIA, P. CRAS, S.L. SIEDLAK, E.R. SHELTON, H.W. CHAN, B.D. GREENBERG & G. PERRY. 1993. Degeneration of amyloid precursor protein-containing smooth muscle cells in cerebral amyloid angiopathy. Brain Res. 623: 142-146.
13. 13. INCE, P.G., F.K. MCARTHUR, E. BJERTNESS, A. TROVIK, J.M. CANDY & J.A. EDWARDSON. 1996. Neuropathological diagnoses in elderly patients in Oslo: Alzheimer's disease, Lewy body disease, vascular lesions. Dementia 6: 162-168.
14. 14. MORRIS, C.M., R. BENJAMIN, A. LEAKE, F.K. MCARTHUR, J.M. CANDY, P.G. INCE, A. TORVIK, E. BJERTNESS & J.A. EDWARDSON. 1995. Effect of apolipoprotein E genotype on Alzheimer's disease neuropathology in a cohort of elderly Norwegians. Neurosci Lett. 201: 45-47.
15. 15. PREMKUMAR, D.L., D.L. COHEN, P. HEDERA, R.P. FRIEDLAND & R.N. KALARIA. 1996. Apolipoprotein E ε4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology in Alzheimer's disease. Am. J. Pathol. 148: 2083-2095.
16. 16. WISNIEWSKI, H.M. & J. WEGIEL. 1994. Beta-amyloid formation by myocytes of leptomeningeal vessels. Acta Neuropathol. (Bed) 87: 233-241.
17. 17. DAVIS-SALINAS, J., S.M. SAPORITO-IRWIN, C.W. COTMAN & W.E. VAN NOSTRAND. 1995. Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells. J. Neurochem. 65: 931-934.
18. 18. KALARIA, R.N., A.B. PAX, D.R.D. PREMKUMAR & I. LIEBERBURG. 1996. Production and increased detection of amyloid β-protein and amyloidogenic fragments in brain microvessels, meningeal vessels and choroid plexus in Alzheimer disease. Mol. Brain Res. 35: 58-68.
19. 19. PRIOR, R., D. D'URSO, R. FRANK, I. PRIKULIS & G. PAVLAKOVIC. 1996. Loss of vessel wall viability in cerebral amyloid angiopathy. Neuroreport 7: 562-564.
20. 20. KALARIA, R.N. 1996. Cerebral vessels in ageing and Alzheimer's disease. Pharmacol. Ther. 72: 193-214.
21. 21. WELLER, R.O., A. MASSEY, T.A. NEWMAN, M. HUTCHINGS, Y.M. KUO & A.E. ROHER. 1998. Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am. J. Pathol. 153: 725-733.